[go: up one dir, main page]

NO994136L - Faktor X delesjonsmutanter samt analoger derav - Google Patents

Faktor X delesjonsmutanter samt analoger derav

Info

Publication number
NO994136L
NO994136L NO994136A NO994136A NO994136L NO 994136 L NO994136 L NO 994136L NO 994136 A NO994136 A NO 994136A NO 994136 A NO994136 A NO 994136A NO 994136 L NO994136 L NO 994136L
Authority
NO
Norway
Prior art keywords
analogs
factor
well
deletion mutants
mutants
Prior art date
Application number
NO994136A
Other languages
English (en)
Other versions
NO994136D0 (no
NO328022B1 (no
Inventor
Michele Himmelspach
Michael Pfleiderer
Falko-Guenter Falkner
Johann Eibl
Friedrich Dorner
Uwe Schlokat
Original Assignee
Baxter Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Ag filed Critical Baxter Ag
Publication of NO994136D0 publication Critical patent/NO994136D0/no
Publication of NO994136L publication Critical patent/NO994136L/no
Publication of NO328022B1 publication Critical patent/NO328022B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
NO19994136A 1997-02-27 1999-08-26 Faktor XΔ-analog, rekombinant DNA som koder for denne, celler inneholdende slikt DNA samt preparat, anvendelse av preparatet og fremgangsmate for fremstilling av slike preparater inneholdende XΔ-analogene NO328022B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0033697A AT405517B (de) 1997-02-27 1997-02-27 Faktor x-deletionsmutanten und analoge davon
PCT/AT1998/000046 WO1998038318A1 (de) 1997-02-27 1998-02-27 Faktor x-deletionsmutanten und analoge davon

Publications (3)

Publication Number Publication Date
NO994136D0 NO994136D0 (no) 1999-08-26
NO994136L true NO994136L (no) 1999-10-27
NO328022B1 NO328022B1 (no) 2009-11-09

Family

ID=3487892

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19994136A NO328022B1 (no) 1997-02-27 1999-08-26 Faktor XΔ-analog, rekombinant DNA som koder for denne, celler inneholdende slikt DNA samt preparat, anvendelse av preparatet og fremgangsmate for fremstilling av slike preparater inneholdende XΔ-analogene

Country Status (17)

Country Link
US (2) US6562598B1 (no)
EP (1) EP1012303B1 (no)
JP (1) JP4108761B2 (no)
AR (1) AR010119A1 (no)
AT (2) AT405517B (no)
AU (1) AU732953B2 (no)
BR (1) BR9807618A (no)
CA (1) CA2282728A1 (no)
CZ (1) CZ298296B6 (no)
DE (1) DE59813745D1 (no)
ES (1) ES2273405T3 (no)
HU (1) HU225247B1 (no)
IL (2) IL131171A0 (no)
NO (1) NO328022B1 (no)
PL (1) PL191778B1 (no)
SK (1) SK282369B6 (no)
WO (1) WO1998038318A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
AT405517B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
GB9826747D0 (en) * 1998-12-05 1999-01-27 Zeneca Ltd Chemical compounds
AT410216B (de) 1999-08-10 2003-03-25 Baxter Ag Faktor x-analogon mit verbesserter aktivierbarkeit
AU2001249389A1 (en) * 2000-03-22 2001-10-03 The Children's Hospital Of Philadelphia Modified blood clotting factors and methods of use
WO2004101598A2 (en) * 2003-05-09 2004-11-25 Research Development Foundation Insertion of furin protease cleavage sites in membrane proteins and uses thereof
EP1728798A1 (en) 2005-06-01 2006-12-06 ZLB Behring GmbH Coagulation factor X polypeptides with modified activation properties
MX2008006313A (es) 2005-11-15 2008-11-06 Philadelphia Children Hospital Metodos y composiciones para modular la hemostasia.
GB2433592A (en) 2005-12-23 2007-06-27 Pentapharm Ag Assay for thrombin inhibitors
EP1820508A1 (en) * 2006-02-21 2007-08-22 CSL Behring GmbH Coagulation factor X polypeptides with modified activation properties
US20080050776A1 (en) * 2006-05-26 2008-02-28 Kenneth Neet Stable mutated pro nerve growth factors
EP3078743B1 (en) * 2007-09-28 2020-06-24 Portola Pharmaceuticals, Inc. Antidotes for factor xa inhibitors and methods of using the same
JP5709316B2 (ja) 2008-11-14 2015-04-30 ポートラ ファーマシューティカルズ， インコーポレイテッド 第Ｘａ因子阻害剤のための解毒剤および血液凝固剤と組み合わせて該解毒剤を使用する方法
FI3604510T3 (fi) 2009-03-30 2025-06-26 Alexion Pharma Inc Vastalääkkeitä tekijä xa:n estäjille ja menetelmiä niiden käyttämiseksi
WO2011008885A1 (en) 2009-07-15 2011-01-20 Portola Pharmaceuticals, Inc. Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same
WO2013049804A1 (en) * 2011-09-30 2013-04-04 The Children's Hospital Of Philadelphia Compositions and methods for modulating hemostasis
US20130230901A1 (en) * 2012-02-14 2013-09-05 Portola Pharmaceuticals, Inc. Process for making recombinant antidote to factor xa inhibitor
CN104755492A (zh) 2012-07-25 2015-07-01 催化剂生物科学公司 修饰的因子x多肽及其应用
AU2014210830A1 (en) * 2013-01-31 2015-07-16 Pfizer Inc. Compositions and methods for counteracting Factor Xa inhibition
MX373466B (es) 2013-09-24 2020-05-25 Pfizer Composiciones que comprenden poblaciones heterogeneas de proteinas recombinantes humanas de factor xa de coagulacion.
US10676731B2 (en) 2014-08-19 2020-06-09 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor IX function
JP7370974B2 (ja) 2017-11-07 2023-10-30 ラニ セラピューティクス， エルエルシー 嚥下可能薬物送達デバイスを使用する腸管組織への送達のための凝固因子調製物
CA3137539A1 (en) 2019-05-03 2020-10-20 Rani Therapeutics, Llc Clotting factor preparations for delivery into tissue of the intestinal tract using a swallowable drug delivery device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT366916B (de) * 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
US4501731A (en) 1983-06-27 1985-02-26 Tishkoff Garson H Treatment of disparate bleeding disorders with factor X zymogen
AT382783B (de) * 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
US5028424A (en) 1987-10-16 1991-07-02 University Of Georgia Research Foundation Antibodies to receptor and antigen for natural killer and non-specific cytotoxic cells
US5597799A (en) * 1990-09-04 1997-01-28 Cor Therapeutics, Inc. Recombinant agents affecting thrombosis
DK0574402T3 (da) 1990-11-26 1998-05-18 Chiron Corp Ekspression af PACE i værtsceller og fremgangsmåder til anvendelse deraf
US5621039A (en) 1993-06-08 1997-04-15 Hallahan; Terrence W. Factor IX- polymeric conjugates
DE4325872C1 (de) 1993-08-02 1994-08-04 Immuno Ag Virusinaktivierte Faktor Xa-Präparation
AT401270B (de) * 1994-09-26 1996-07-25 Immuno Ag Verfahren zur quantifizierung von genomischer dna
AT404838B (de) 1995-11-24 1999-03-25 Immuno Ag Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
AT405517B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-deletionsmutanten und analoge davon
US6582598B2 (en) * 2000-12-14 2003-06-24 Hubert Patrovsky Wave filter for rotary filter

Also Published As

Publication number Publication date
HUP0000826A1 (en) 2000-07-28
PL191778B1 (pl) 2006-07-31
AU6080898A (en) 1998-09-18
HUP0000826A3 (en) 2002-01-28
DE59813745D1 (de) 2006-11-09
CA2282728A1 (en) 1998-09-03
IL131171A (en) 2007-05-15
US6905846B2 (en) 2005-06-14
ATE340862T1 (de) 2006-10-15
CZ303199A3 (cs) 2000-01-12
JP2001513632A (ja) 2001-09-04
AU732953B2 (en) 2001-05-03
EP1012303A1 (de) 2000-06-28
US6562598B1 (en) 2003-05-13
CZ298296B6 (cs) 2007-08-22
AT405517B (de) 1999-09-27
JP4108761B2 (ja) 2008-06-25
WO1998038318A1 (de) 1998-09-03
ATA33697A (de) 1999-01-15
AR010119A1 (es) 2000-05-17
NO994136D0 (no) 1999-08-26
SK117099A3 (en) 2000-05-16
HU225247B1 (en) 2006-08-28
PL335379A1 (en) 2000-04-25
ES2273405T3 (es) 2007-05-01
IL131171A0 (en) 2001-01-28
NO328022B1 (no) 2009-11-09
EP1012303B1 (de) 2006-09-27
SK282369B6 (sk) 2002-01-07
BR9807618A (pt) 2000-02-15
US20030138914A1 (en) 2003-07-24

Similar Documents

Publication Publication Date Title
NO994136L (no) Faktor X delesjonsmutanter samt analoger derav
FI953499L (fi) Polttoainekoostumus
DE69523432D1 (de) Arylsuccinimide enthaltende Kraftstoffzusammensetzungen
DE69403252D1 (de) Beschleunigungsmessaufnehmer
FI973772A0 (fi) Riktad allmaen saendning i ett radionaet
FI961720L (fi) Uusi koostumus
DE69405962D1 (de) Beschleunigungsmessaufnehmer
NO996108D0 (no) 9-oksinerytromycinderivater
FI961797L (fi) Stabiloitu prostaglandiini E1
DE69400872D1 (de) Kraftstoffzusammensetzungen
DE69416571D1 (de) Beschleunigungsmessaufnehmer
DE69303210D1 (de) Tankverschluss
ITMI942089A0 (it) Composizione di carburante
DE19650512B4 (de) Federspitze
DE69405047D1 (de) Elektrolyseur
FI953566L (fi) Tahdospironia tai sen analogeja sisältäviä koostumuksia
FI973486A0 (fi) Datakommunikationsfoerfarande i ett basstationssystem i ett cellulaert radionaet
DE69411083D1 (de) Kraftstoffzusammensetzung
DK117893A (da) Pensel med holder
FI940554A7 (fi) Parannuksia seinäpinnoitteisiin tai niihin liittyen
ITTO950122A0 (it) Metodo per proteggere l'uso di un elaboratore elettronico.
ITRM940161V0 (it) "cuffia"
KR960026553U (ko) 크레파스 케이스
KR950017690U (ko) 연료 캡
KR950011887U (ko) 연료이온화장치

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees