NO983669D0 - Coralyne analoger som topoisomeraseinhibitorer - Google Patents
Coralyne analoger som topoisomeraseinhibitorerInfo
- Publication number
- NO983669D0 NO983669D0 NO983669A NO983669A NO983669D0 NO 983669 D0 NO983669 D0 NO 983669D0 NO 983669 A NO983669 A NO 983669A NO 983669 A NO983669 A NO 983669A NO 983669 D0 NO983669 D0 NO 983669D0
- Authority
- NO
- Norway
- Prior art keywords
- coralyne
- analogues
- topoisomerase inhibitors
- topoisomerase
- inhibitors
- Prior art date
Links
- PDYBUYVOPAJLKP-UHFFFAOYSA-M 2,3,10,11-tetramethoxy-8-methylisoquinolino[2,1-b]isoquinolin-7-ium;chloride Chemical class [Cl-].C1=C(OC)C(OC)=CC2=CC3=C(C=C(C(OC)=C4)OC)C4=CC=[N+]3C(C)=C21 PDYBUYVOPAJLKP-UHFFFAOYSA-M 0.000 title 1
- 239000003534 dna topoisomerase inhibitor Substances 0.000 title 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1145296P | 1996-02-12 | 1996-02-12 | |
| US3216196P | 1996-10-01 | 1996-10-01 | |
| PCT/US1997/001676 WO1997029106A1 (en) | 1996-02-12 | 1997-02-11 | Coralyne analogs as topoisomerase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO983669D0 true NO983669D0 (no) | 1998-08-11 |
| NO983669L NO983669L (no) | 1998-09-23 |
Family
ID=26682407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO983669A NO983669L (no) | 1996-02-12 | 1998-08-11 | Coralyne analoger som topoisomeraseinhibitorer |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0888346B1 (no) |
| JP (1) | JP2000504687A (no) |
| KR (1) | KR19990082488A (no) |
| CN (1) | CN1067070C (no) |
| AU (1) | AU710070C (no) |
| BR (1) | BR9707425A (no) |
| CA (1) | CA2241551A1 (no) |
| CZ (1) | CZ254498A3 (no) |
| DE (1) | DE69705112T2 (no) |
| ES (1) | ES2161442T3 (no) |
| HU (1) | HUP9900413A3 (no) |
| IL (1) | IL124803A0 (no) |
| NO (1) | NO983669L (no) |
| NZ (1) | NZ330705A (no) |
| PL (1) | PL328402A1 (no) |
| PT (1) | PT888346E (no) |
| TR (1) | TR199801555T2 (no) |
| WO (1) | WO1997029106A1 (no) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW460464B (en) * | 1996-11-25 | 2001-10-21 | Nippon Kayaku Kk | Novel phenanthridinium derivative having an anti-tumor activity and pharmaceutical composition containing the same |
| US6140328A (en) | 1997-12-12 | 2000-10-31 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| US6063801A (en) * | 1998-02-12 | 2000-05-16 | Rutgers, The State University Of New Jersey | Heterocyclic topoisomerase poisons |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| CN1093129C (zh) * | 1999-08-19 | 2002-10-23 | 广州市海科生物技术有限公司 | 一种具有抗肿瘤生理活性的尖叶唐松草阿原碱及其提取方法 |
| US6740650B2 (en) | 1999-10-29 | 2004-05-25 | Rutgers, The State University Of New Jersey | Heterocyclic cytotoxic agents |
| PT1465625E (pt) | 2001-11-14 | 2010-03-09 | Univ Rutgers | Venenos de topoisomerase solubilizados |
| MXPA04004607A (es) | 2001-11-14 | 2004-09-10 | Univ Rutgers | Agentes de venenos de topoisomerasa solubilizados. |
| AU2002364953A1 (en) | 2001-11-14 | 2003-06-17 | Edmond J. Lavoie | Topoisomerase poison agents |
| AU2003268075A1 (en) | 2002-08-09 | 2004-02-25 | Edmond J. Lavoie | Nitro and amino substituted dibenzonaphthyridines as topoisomerase agents |
| US6992088B2 (en) | 2002-08-09 | 2006-01-31 | Rutgers, The State University Of New Jersey | Nitro and amino substituted heterocycles as topoisomerase I targeting agents |
| WO2004014918A1 (en) | 2002-08-09 | 2004-02-19 | Rutgers, The State University | Nitro and amino substituted topoisomerase agents |
| JP4774212B2 (ja) | 2002-11-12 | 2011-09-14 | ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー | トポイソメラーゼ−ターゲッティング剤 |
| AU2006275514B2 (en) | 2005-07-29 | 2012-04-05 | Resverlogix Corp. | Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices |
| KR101444489B1 (ko) | 2007-02-01 | 2014-09-24 | 리스버로직스 코퍼레이션 | 심혈관 질환을 예방 및 치료하기 위한 화합물 |
| EP2014651A1 (en) * | 2007-07-12 | 2009-01-14 | Exonhit Therapeutics SA | Compounds and methods for modulating Rho GTPases |
| US8114995B2 (en) | 2008-06-26 | 2012-02-14 | Resverlogix Corp. | Methods of preparing quinazolinone derivatives |
| ES2542835T3 (es) | 2009-01-08 | 2015-08-12 | Resverlogix Corporation | Compuestos para la prevención y el tratamiento de enfermedades cardiovasculares |
| WO2010102219A1 (en) | 2009-03-06 | 2010-09-10 | Rutgers, The State University Of New Jersey | Methylenedioxybenzo [i] phenanthridine derivatives used to treat cancer |
| KR101841003B1 (ko) | 2009-03-18 | 2018-03-22 | 리스버로직스 코퍼레이션 | 신규한 소염제 |
| US9757368B2 (en) | 2009-04-22 | 2017-09-12 | Resverlogix Corp. | Anti-inflammatory agents |
| WO2010127363A1 (en) | 2009-05-01 | 2010-11-04 | Rutgers, The State University Of New Jersey | Toposiomerase inhibitors |
| US8188109B2 (en) * | 2009-07-20 | 2012-05-29 | Naxospharma S.R.L. | Benzoquinolizinium salt derivatives as anticancer agents |
| CN102746292B (zh) * | 2011-04-18 | 2015-03-18 | 中国医学科学院医药生物技术研究所 | 环化的小檗碱衍生物及其制备方法和用途 |
| US9610251B2 (en) | 2011-11-01 | 2017-04-04 | Resverlogix Corp. | Pharmaceutical compositions for substituted quinazolinones |
| WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
| US9765039B2 (en) | 2012-11-21 | 2017-09-19 | Zenith Epigenetics Ltd. | Biaryl derivatives as bromodomain inhibitors |
| WO2014096965A2 (en) | 2012-12-21 | 2014-06-26 | Rvx Therapeutics Inc. | Novel heterocyclic compounds as bromodomain inhibitors |
| WO2014144097A1 (en) * | 2013-03-15 | 2014-09-18 | Georgetown University | Antifungal drugs |
| NZ718190A (en) | 2013-08-23 | 2017-10-27 | Neupharma Inc | Substituted quinazolines for inhibiting kinase activity |
| AU2016220219B2 (en) * | 2015-02-17 | 2020-05-14 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| CN107530356A (zh) | 2015-03-13 | 2018-01-02 | 雷斯韦洛吉克斯公司 | 用于治疗补体相关疾病之组合物及治疗方法 |
| CN105541714A (zh) * | 2015-12-16 | 2016-05-04 | 浙江普洛康裕制药有限公司 | 一种罂粟碱及盐酸罂粟碱的制备方法 |
| WO2017176648A1 (en) | 2016-04-04 | 2017-10-12 | Rutgers, The State University Of New Jersey | Topoisomerase poisons |
| AU2017312561B2 (en) | 2016-08-15 | 2022-06-30 | Neupharma, Inc. | Certain chemical entities, compositions, and methods |
| CN110759963A (zh) * | 2018-07-25 | 2020-02-07 | 中山大学 | 一种稠环类化合物及其制备方法和用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5126351A (en) * | 1991-01-24 | 1992-06-30 | Glaxo Inc. | Antitumor compounds |
| US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
-
1997
- 1997-02-11 PT PT97906466T patent/PT888346E/pt unknown
- 1997-02-11 TR TR1998/01555T patent/TR199801555T2/xx unknown
- 1997-02-11 IL IL12480397A patent/IL124803A0/xx unknown
- 1997-02-11 BR BR9707425A patent/BR9707425A/pt unknown
- 1997-02-11 HU HU9900413A patent/HUP9900413A3/hu unknown
- 1997-02-11 PL PL97328402A patent/PL328402A1/xx unknown
- 1997-02-11 NZ NZ330705A patent/NZ330705A/en unknown
- 1997-02-11 CN CN97192211A patent/CN1067070C/zh not_active Expired - Fee Related
- 1997-02-11 EP EP97906466A patent/EP0888346B1/en not_active Expired - Lifetime
- 1997-02-11 KR KR1019980706221A patent/KR19990082488A/ko not_active Withdrawn
- 1997-02-11 CA CA002241551A patent/CA2241551A1/en not_active Abandoned
- 1997-02-11 WO PCT/US1997/001676 patent/WO1997029106A1/en not_active Ceased
- 1997-02-11 ES ES97906466T patent/ES2161442T3/es not_active Expired - Lifetime
- 1997-02-11 AU AU21155/97A patent/AU710070C/en not_active Ceased
- 1997-02-11 JP JP9528606A patent/JP2000504687A/ja active Pending
- 1997-02-11 DE DE69705112T patent/DE69705112T2/de not_active Expired - Fee Related
- 1997-02-11 CZ CZ982544A patent/CZ254498A3/cs unknown
-
1998
- 1998-08-11 NO NO983669A patent/NO983669L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR9707425A (pt) | 1999-07-20 |
| HUP9900413A3 (en) | 2002-02-28 |
| EP0888346B1 (en) | 2001-06-06 |
| NO983669L (no) | 1998-09-23 |
| WO1997029106A1 (en) | 1997-08-14 |
| CZ254498A3 (cs) | 1998-12-16 |
| PT888346E (pt) | 2001-10-31 |
| DE69705112D1 (en) | 2001-07-12 |
| CN1067070C (zh) | 2001-06-13 |
| AU2115597A (en) | 1997-08-28 |
| EP0888346A1 (en) | 1999-01-07 |
| HUP9900413A2 (hu) | 1999-05-28 |
| DE69705112T2 (de) | 2002-03-21 |
| IL124803A0 (en) | 1999-01-26 |
| TR199801555T2 (xx) | 1998-11-23 |
| ES2161442T3 (es) | 2001-12-01 |
| CN1211252A (zh) | 1999-03-17 |
| NZ330705A (en) | 2000-03-27 |
| KR19990082488A (ko) | 1999-11-25 |
| AU710070B2 (en) | 1999-09-16 |
| AU710070C (en) | 2001-08-30 |
| CA2241551A1 (en) | 1997-08-14 |
| PL328402A1 (en) | 1999-01-18 |
| JP2000504687A (ja) | 2000-04-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |