NO982441L - Measurement of drug doses, therapeutics and other glycosaminoglycans (GAGS) - Google Patents
Measurement of drug doses, therapeutics and other glycosaminoglycans (GAGS)Info
- Publication number
- NO982441L NO982441L NO982441A NO982441A NO982441L NO 982441 L NO982441 L NO 982441L NO 982441 A NO982441 A NO 982441A NO 982441 A NO982441 A NO 982441A NO 982441 L NO982441 L NO 982441L
- Authority
- NO
- Norway
- Prior art keywords
- agent
- liver
- receptors
- bound
- treatment
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 8
- 229940079593 drug Drugs 0.000 title abstract 3
- 229920002683 Glycosaminoglycan Polymers 0.000 title 2
- 238000005259 measurement Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 8
- 210000004185 liver Anatomy 0.000 abstract 8
- 229940124597 therapeutic agent Drugs 0.000 abstract 3
- 231100000252 nontoxic Toxicity 0.000 abstract 2
- 230000003000 nontoxic effect Effects 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002222 downregulating effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Fremgangsmåte for behandling av en sykdom eller tilstand i et menneske som kan behandles med en medisin og/eller terapeutisk middel som kan bli transportert av et middel til setet som trenger behandling i kroppen og hvor middelet også kan transportere medisinen og/eller det terapeutiske middelet til leveren (f.eks. binding av transportmiddel til reseptorer på leveren) er tilveiebrakt omfattende: (a) administrering av en effekt ikke-toksisk mengde av et første middel som ikke blir bundet til reseptorer ved setet som trenger behandling, men som bindes med reseptorer av leveren for derved å "ned-regulere" leveren; og (b) deretter administrere en effektiv ikke-toksisk mengde av en medisin og/eller et terapeutisk middel og en effektiv mengde av et andre middel som er et transportmiddel og er et annet middel i forhold til det første middelet som blir bundet til setet som trenger behandling og som har evne til å bli bundet til seter av leveren dersom leveren ikke er blitt "nedregulert" slik at dets bindingskapasitet for det andre middelet er blitt vesentlig redusert av opptaket av leveren av det første middelet administrert under under-paragraf (a) med f.eks. binding med oppfangingsreseptorer til leveren.A method of treating a disease or condition in a human being that can be treated with a drug and / or therapeutic agent that can be transported by an agent to the site in need of treatment in the body and wherein the agent can also transport the medicine and / or therapeutic agent to the liver (e.g., binding of carrier to receptors on the liver) is provided comprising: (a) administering an effect non-toxic amount of a first agent which is not bound to receptors at the site in need of treatment but which binds with receptors of the liver, thereby "down-regulating" the liver; and (b) thereafter administering an effective non-toxic amount of a drug and / or a therapeutic agent and an effective amount of a second agent which is a carrier and is another agent relative to the first agent being bound to the seat which need treatment and which are capable of being bound to sites of the liver if the liver has not been "down-regulated" so that its binding capacity for the second agent has been substantially reduced by the uptake of the liver by the first agent administered under subsection (a) with e.g. binding with capture receptors to the liver.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA002164260A CA2164260C (en) | 1995-12-01 | 1995-12-01 | Targeting of dosages of medicines and therapeutic agents |
| CA 2173037 CA2173037A1 (en) | 1996-03-29 | 1996-03-29 | Targeting of dosages of medicines and therapeutic agents and other glycosaminoglycans (gags) |
| PCT/CA1996/000793 WO1997020564A1 (en) | 1995-12-01 | 1996-11-29 | Targeting of dosages of medicine and therapeutic agents and other glycosaminoglycans (gags) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO982441D0 NO982441D0 (en) | 1998-05-28 |
| NO982441L true NO982441L (en) | 1998-05-28 |
Family
ID=25678243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO982441A NO982441L (en) | 1995-12-01 | 1998-05-28 | Measurement of drug doses, therapeutics and other glycosaminoglycans (GAGS) |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0869798A1 (en) |
| JP (1) | JP2000513707A (en) |
| KR (1) | KR19990071628A (en) |
| AU (1) | AU727001B2 (en) |
| BR (1) | BR9611671A (en) |
| HU (1) | HUP9901935A3 (en) |
| IL (1) | IL124647A0 (en) |
| MX (1) | MX9804343A (en) |
| NO (1) | NO982441L (en) |
| PL (1) | PL326970A1 (en) |
| WO (1) | WO1997020564A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPD940054A1 (en) * | 1994-03-23 | 1995-09-23 | Fidia Advanced Biopolymers Srl | SULPHATED POLYSACCHARIDES |
| DK1140198T3 (en) | 1999-01-13 | 2008-03-10 | Alchemia Oncology Pty Ltd | Use of hyaluronan in the manufacture of a drug for enhancing the efficacy of cytotoxic drugs |
| AUPQ879500A0 (en) | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
| US9066919B2 (en) | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
| JP5465431B2 (en) * | 2005-07-27 | 2014-04-09 | アルケミア オンコロジー ピーティーワイ リミテッド | Treatment protocol with hyaluronan |
| BRPI0615619A2 (en) | 2005-09-07 | 2011-05-24 | Alchemia Oncology Pty Ltd | therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340994C (en) * | 1989-09-21 | 2000-05-16 | Rudolf Edgar Dr. Falk | Treatment of conditions and disease |
| WO1996006622A1 (en) * | 1991-07-03 | 1996-03-07 | Hyal Pharmaceutical Corporation | Hyaluronic acid and derivatives for modulation of cellular activity |
| AUPM714794A0 (en) * | 1994-07-29 | 1994-08-18 | International Fluid Separation Pty Limited | Separation apparatus and method |
-
1996
- 1996-11-29 AU AU76878/96A patent/AU727001B2/en not_active Ceased
- 1996-11-29 EP EP96939774A patent/EP0869798A1/en not_active Ceased
- 1996-11-29 KR KR1019980703904A patent/KR19990071628A/en not_active Ceased
- 1996-11-29 JP JP09520818A patent/JP2000513707A/en not_active Ceased
- 1996-11-29 IL IL12474796A patent/IL124647A0/en not_active IP Right Cessation
- 1996-11-29 HU HU9901935A patent/HUP9901935A3/en unknown
- 1996-11-29 WO PCT/CA1996/000793 patent/WO1997020564A1/en not_active Ceased
- 1996-11-29 PL PL96326970A patent/PL326970A1/en unknown
- 1996-11-29 BR BR9611671-4A patent/BR9611671A/en not_active Application Discontinuation
-
1998
- 1998-05-28 NO NO982441A patent/NO982441L/en unknown
- 1998-06-01 MX MX9804343A patent/MX9804343A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX9804343A (en) | 1998-09-30 |
| KR19990071628A (en) | 1999-09-27 |
| AU7687896A (en) | 1997-06-27 |
| NO982441D0 (en) | 1998-05-28 |
| AU727001B2 (en) | 2000-11-30 |
| WO1997020564A1 (en) | 1997-06-12 |
| JP2000513707A (en) | 2000-10-17 |
| HUP9901935A2 (en) | 1999-11-29 |
| PL326970A1 (en) | 1998-11-09 |
| BR9611671A (en) | 1999-12-28 |
| IL124647A0 (en) | 1998-12-06 |
| HUP9901935A3 (en) | 2001-04-28 |
| EP0869798A1 (en) | 1998-10-14 |
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