NO981970L - FremgangsmÕte for fremstilling av Camptothecin-derivater - Google Patents
FremgangsmÕte for fremstilling av Camptothecin-derivaterInfo
- Publication number
- NO981970L NO981970L NO981970A NO981970A NO981970L NO 981970 L NO981970 L NO 981970L NO 981970 A NO981970 A NO 981970A NO 981970 A NO981970 A NO 981970A NO 981970 L NO981970 L NO 981970L
- Authority
- NO
- Norway
- Prior art keywords
- pct
- date
- camptothecin derivatives
- preparing camptothecin
- sec
- Prior art date
Links
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US613895P | 1995-11-02 | 1995-11-02 | |
| PCT/US1996/017574 WO1997016454A1 (en) | 1995-11-02 | 1996-11-01 | Method for preparing camptothecin derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO981970D0 NO981970D0 (no) | 1998-04-30 |
| NO981970L true NO981970L (no) | 1998-06-30 |
| NO324308B1 NO324308B1 (no) | 2007-09-24 |
Family
ID=21719492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO19981970A NO324308B1 (no) | 1995-11-02 | 1998-04-30 | Fremgangsmate for fremstilling av Camptothecin-derivater, samt produkter av og mellomprodukter for slike forbindelser |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6143891A (no) |
| EP (1) | EP0876373B1 (no) |
| JP (1) | JP3499246B2 (no) |
| AT (1) | ATE301659T1 (no) |
| AU (1) | AU717315B2 (no) |
| CA (1) | CA2236420A1 (no) |
| CZ (1) | CZ133898A3 (no) |
| DE (1) | DE69635057T2 (no) |
| EA (1) | EA001400B1 (no) |
| ES (1) | ES2247606T3 (no) |
| HU (1) | HUP9802407A3 (no) |
| IL (1) | IL124287A (no) |
| IS (1) | IS2274B (no) |
| NO (1) | NO324308B1 (no) |
| NZ (1) | NZ322318A (no) |
| PL (1) | PL186540B1 (no) |
| WO (1) | WO1997016454A1 (no) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5491237A (en) * | 1994-05-03 | 1996-02-13 | Glaxo Wellcome Inc. | Intermediates in pharmaceutical camptothecin preparation |
| US6716982B2 (en) | 1995-11-02 | 2004-04-06 | Osi Pharmaceuticals, Inc. | Method for preparing camptothecin derivatives |
| US6559309B2 (en) | 1996-11-01 | 2003-05-06 | Osi Pharmaceuticals, Inc. | Preparation of a camptothecin derivative by intramolecular cyclisation |
| US6288072B1 (en) * | 1999-12-29 | 2001-09-11 | Monroe E. Wall | Camptothecin β-alanine esters with topoisomerase I inhibition |
| AR035684A1 (es) | 2001-02-21 | 2004-06-23 | Yakult Honsha Kk | Procedimiento para preparar 2'-amino-5'-hidroxipropiofenona, uso de la misma para la preparacion de analogos de camptotecina, procedimiento para prepararlos, compuestos intermediarios, procedimiento para preparar una cetona triciclica utilizada en la sintesis de analogos de camptotecina |
| WO2003068778A1 (en) * | 2002-02-18 | 2003-08-21 | Dr. Reddy's Laboratories Limited | A process for the preparation of 10-hydroxy-9-n,n-dimethylaminomethyl-5-(2'-fluoroethoxy)-20(s)-camptothecin hydrochloride |
| US6593334B1 (en) | 2002-05-02 | 2003-07-15 | The University Of North Carolina At Chapel Hill | Camptothecin-taxoid conjugates as antimitotic and antitumor agents |
| US7067666B2 (en) * | 2003-06-27 | 2006-06-27 | Research Triangle Institute | 7-substituted camptothecin and camptothecin analogs and methods for producing the same |
| KR20070008710A (ko) | 2004-04-27 | 2007-01-17 | 웰스테트 바이올로직스 코포레이션 | 바이러스 및 캄토테신을 이용한 암치료 방법 |
| MX2007015407A (es) | 2005-07-14 | 2008-02-19 | Wellstat Biologics Corp | Tratamiento del cancer utilizando virus, fluoropirimidinas y camptotecinas. |
| CN103288842B (zh) * | 2012-02-24 | 2016-01-13 | 中国人民解放军第二军医大学 | 氟取代e环喜树碱类似物及其作为药物的用途 |
| US10517961B2 (en) | 2015-09-25 | 2019-12-31 | ZY Therapeutics, Inc. | Drug formulation based on particulates comprising polysaccharide-vitamin conjugate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06502642A (ja) * | 1990-10-31 | 1994-03-24 | スミスクライン・ビーチャム・コーポレイション | 置換インドリジノ［１，２−ｂ］キノリノン |
| AU3611093A (en) * | 1992-02-21 | 1993-09-13 | Smithkline Beecham Corporation | Substituted furo(3',4':6,7)indolizino(1,2-b)quinolinones |
-
1996
- 1996-11-01 EP EP96938728A patent/EP0876373B1/en not_active Expired - Lifetime
- 1996-11-01 CZ CZ981338A patent/CZ133898A3/cs unknown
- 1996-11-01 HU HU9802407A patent/HUP9802407A3/hu unknown
- 1996-11-01 ES ES96938728T patent/ES2247606T3/es not_active Expired - Lifetime
- 1996-11-01 AU AU76038/96A patent/AU717315B2/en not_active Ceased
- 1996-11-01 DE DE69635057T patent/DE69635057T2/de not_active Expired - Fee Related
- 1996-11-01 AT AT96938728T patent/ATE301659T1/de not_active IP Right Cessation
- 1996-11-01 WO PCT/US1996/017574 patent/WO1997016454A1/en not_active Ceased
- 1996-11-01 EA EA199800354A patent/EA001400B1/ru not_active IP Right Cessation
- 1996-11-01 US US09/068,185 patent/US6143891A/en not_active Expired - Fee Related
- 1996-11-01 IL IL12428796A patent/IL124287A/en not_active IP Right Cessation
- 1996-11-01 JP JP51758897A patent/JP3499246B2/ja not_active Expired - Fee Related
- 1996-11-01 CA CA002236420A patent/CA2236420A1/en not_active Abandoned
- 1996-11-01 PL PL96326869A patent/PL186540B1/pl not_active IP Right Cessation
- 1996-11-01 NZ NZ322318A patent/NZ322318A/xx unknown
-
1998
- 1998-04-29 IS IS4730A patent/IS2274B/is unknown
- 1998-04-30 NO NO19981970A patent/NO324308B1/no unknown
-
2000
- 2000-08-15 US US09/638,945 patent/US6284891B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997016454A1 (en) | 1997-05-09 |
| AU7603896A (en) | 1997-05-22 |
| AU717315B2 (en) | 2000-03-23 |
| JPH11515028A (ja) | 1999-12-21 |
| PL326869A1 (en) | 1998-10-26 |
| PL186540B1 (pl) | 2004-01-30 |
| US6143891A (en) | 2000-11-07 |
| NZ322318A (en) | 2000-01-28 |
| CZ133898A3 (cs) | 1998-08-12 |
| IL124287A (en) | 2004-06-01 |
| ATE301659T1 (de) | 2005-08-15 |
| NO324308B1 (no) | 2007-09-24 |
| ES2247606T3 (es) | 2006-03-01 |
| EP0876373A1 (en) | 1998-11-11 |
| HUP9802407A3 (en) | 2000-01-28 |
| DE69635057D1 (de) | 2005-09-15 |
| US6284891B1 (en) | 2001-09-04 |
| DE69635057T2 (de) | 2006-06-01 |
| IS4730A (is) | 1998-04-29 |
| EP0876373B1 (en) | 2005-08-10 |
| CA2236420A1 (en) | 1997-05-09 |
| EA001400B1 (ru) | 2001-02-26 |
| HUP9802407A1 (hu) | 1999-04-28 |
| NO981970D0 (no) | 1998-04-30 |
| IS2274B (is) | 2007-09-15 |
| EA199800354A1 (ru) | 1999-02-25 |
| JP3499246B2 (ja) | 2004-02-23 |
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