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NO984344L - Ny asymmetriske syntese av R-<alfa>-propylpiperonyalamin og dets analoger - Google Patents

Ny asymmetriske syntese av R-<alfa>-propylpiperonyalamin og dets analoger

Info

Publication number
NO984344L
NO984344L NO984344A NO984344A NO984344L NO 984344 L NO984344 L NO 984344L NO 984344 A NO984344 A NO 984344A NO 984344 A NO984344 A NO 984344A NO 984344 L NO984344 L NO 984344L
Authority
NO
Norway
Prior art keywords
analogs
propylpiperonyalamine
alfa
asymmetric synthesis
new asymmetric
Prior art date
Application number
NO984344A
Other languages
English (en)
Other versions
NO984344D0 (no
Inventor
Hui-Yin Li
Luigi Anzalone
Robert Eugebe Waltermire
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of NO984344L publication Critical patent/NO984344L/no
Publication of NO984344D0 publication Critical patent/NO984344D0/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Det er beskrevet fremgangsmåter for fremstilling av R-a-propyl-piperonylamin og dets analoger, slike forbindleser er nyttige mellomprodukter ved fremstillingen av elastase inhibitorer, og mellomprodukter som er nyttige for fremstilling av R-a- propylpiperonylamin.
NO984344A 1996-03-22 1998-09-18 Ny asymmetriske syntese av R-<alfa>-propylpiperonyalamin og dets analoger NO984344D0 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1395596P 1996-03-22 1996-03-22
PCT/US1997/003466 WO1997034887A1 (en) 1996-03-22 1997-03-17 NOVEL ASYMMETRIC SYNTHESIS OF R-α-PROPYL-PIPERONYL AMINE AND ITS ANALOGS

Publications (2)

Publication Number Publication Date
NO984344L true NO984344L (no) 1998-09-18
NO984344D0 NO984344D0 (no) 1998-09-18

Family

ID=21762727

Family Applications (1)

Application Number Title Priority Date Filing Date
NO984344A NO984344D0 (no) 1996-03-22 1998-09-18 Ny asymmetriske syntese av R-<alfa>-propylpiperonyalamin og dets analoger

Country Status (23)

Country Link
US (1) US5932749A (no)
EP (1) EP0888329A1 (no)
JP (1) JP2000506891A (no)
KR (1) KR20000064735A (no)
CN (1) CN1218463A (no)
AR (1) AR006521A1 (no)
AU (1) AU719633B2 (no)
BR (1) BR9708233A (no)
CA (1) CA2249401A1 (no)
CZ (1) CZ295098A3 (no)
EA (1) EA001207B1 (no)
EE (1) EE9800299A (no)
HR (1) HRP970165A2 (no)
IL (1) IL126223A0 (no)
LT (1) LT4540B (no)
LV (1) LV12259B (no)
NO (1) NO984344D0 (no)
NZ (1) NZ331875A (no)
PL (1) PL329070A1 (no)
SI (1) SI9720023A (no)
SK (1) SK127398A3 (no)
WO (1) WO1997034887A1 (no)
ZA (1) ZA972342B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012474A1 (en) 1998-08-31 2000-03-09 Du Pont Pharmaceuticals Company An efficient process for the preparation of a human leukocyte elastase inhibitor
BR0212443A (pt) * 2001-09-12 2005-03-15 Anormed Inc Sìntese de anéis bicìclicos fundidos, amino substituìdos enanciomericamente puros
JP2012512172A (ja) * 2008-12-15 2012-05-31 タイゲン バイオテクノロジー カンパニー，リミテッド ピペリジン誘導体の立体選択的合成
AR090100A1 (es) 2012-02-21 2014-10-22 Celgene Corp Procesos para la preparacion de la (s)-1-(3-etoxi-4-metoxifenil)-2-metanosulfoniletilamina
US9126906B2 (en) 2012-02-21 2015-09-08 Celgene Corporation Asymmetric synthetic processes for the preparation of aminosulfone compounds
JP6958820B2 (ja) 2015-12-14 2021-11-02 エックス４ ファーマシューティカルズ， インコーポレイテッド がんを処置する方法
CA3008272A1 (en) 2015-12-14 2017-06-22 X4 Pharmaceuticals, Inc. Methods for treating cancer
JP7055380B2 (ja) 2015-12-22 2022-04-18 エックス４ ファーマシューティカルズ， インコーポレイテッド 免疫不全疾患を処置するための方法
US11337969B2 (en) 2016-04-08 2022-05-24 X4 Pharmaceuticals, Inc. Methods for treating cancer
CN109641838A (zh) 2016-06-21 2019-04-16 X4 制药有限公司 Cxcr4抑制剂及其用途
WO2017223229A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
CN116554168B (zh) 2016-06-21 2025-09-23 X4制药有限公司 Cxcr4抑制剂及其用途
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
EP4117662A4 (en) 2020-03-10 2024-04-03 X4 Pharmaceuticals, Inc. Methods for treating neutropenia
US12492178B2 (en) 2021-09-01 2025-12-09 Empathbio, Inc. Stable polymorph of R-MDMA HCl
CA3230380A1 (en) 2021-09-01 2023-03-09 Nicholas MORRA Synthesis of mdma or its optically active (r)- or (s)-mdma isomers
EP4401725A4 (en) * 2021-09-17 2025-12-17 ATAI Life Sciences AG Production of optically active enantiomers of piperonylamines by separation of the diastereomeric salts
WO2023056102A1 (en) 2021-10-01 2023-04-06 ATAI Life Sciences AG Novel prodrugs of mdma, mda, and derivatives thereof
WO2023129958A2 (en) 2021-12-28 2023-07-06 ATAI Life Sciences AG Nitric oxide releasing prodrugs of mda and mdma

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3819438A1 (de) * 1987-06-30 1989-01-19 Basf Ag Verfahren zur herstellung von optisch aktiven 1-arylethylaminen
IL99658A0 (en) * 1990-10-15 1992-08-18 Merck & Co Inc Substituted azetidinones and pharmaceutical compositions containing them
US5149838A (en) * 1991-09-20 1992-09-22 Merck & Co., Inc. Intermediates for substituted azetidinones useful as anti-inflammatory and antidegenerative agents

Also Published As

Publication number Publication date
AU2196897A (en) 1997-10-10
IL126223A0 (en) 1999-05-09
CN1218463A (zh) 1999-06-02
HRP970165A2 (en) 1998-04-30
NZ331875A (en) 2000-01-28
SK127398A3 (en) 1999-04-13
NO984344D0 (no) 1998-09-18
US5932749A (en) 1999-08-03
LV12259B (en) 1999-09-20
LV12259A (lv) 1999-04-20
EP0888329A1 (en) 1999-01-07
KR20000064735A (ko) 2000-11-06
EA001207B1 (ru) 2000-12-25
EE9800299A (et) 1999-06-15
LT98132A (en) 1999-03-25
PL329070A1 (en) 1999-03-15
WO1997034887A1 (en) 1997-09-25
SI9720023A (sl) 1999-04-30
AU719633B2 (en) 2000-05-11
CA2249401A1 (en) 1997-09-25
CZ295098A3 (cs) 1999-03-17
AR006521A1 (es) 1999-09-08
BR9708233A (pt) 2000-01-04
JP2000506891A (ja) 2000-06-06
EA199800844A1 (ru) 1999-02-25
ZA972342B (en) 1998-09-18
LT4540B (lt) 1999-08-25

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