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NO973551L - Indoler med brostruktur som matriksmetallproteaseinhibitorer - Google Patents

Indoler med brostruktur som matriksmetallproteaseinhibitorer

Info

Publication number
NO973551L
NO973551L NO973551A NO973551A NO973551L NO 973551 L NO973551 L NO 973551L NO 973551 A NO973551 A NO 973551A NO 973551 A NO973551 A NO 973551A NO 973551 L NO973551 L NO 973551L
Authority
NO
Norway
Prior art keywords
indoles
protease inhibitors
bridge structure
matrix metal
metal protease
Prior art date
Application number
NO973551A
Other languages
English (en)
Other versions
NO973551D0 (no
NO311257B1 (no
Inventor
Arlindo L Castelhano
Teng J Liak
Stephen Horne
Zhengyo Yuan
Alexander Krantz
Jian Jeffrey Chen
Harold Van Wart
Paul D Cannon
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of NO973551D0 publication Critical patent/NO973551D0/no
Publication of NO973551L publication Critical patent/NO973551L/no
Publication of NO311257B1 publication Critical patent/NO311257B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
NO19973551A 1995-02-03 1997-08-01 Indoler med brostruktur som matriksmetallproteaseinhibitorer, samt farmasöytiske preparater som omfatter dem NO311257B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/382,818 US6013792A (en) 1993-08-05 1995-02-03 Matrix metalloprotease inhibitors
PCT/US1996/001506 WO1996023791A1 (en) 1995-02-03 1996-02-02 Bridged indoles as matrix metalloprotease inhibitors

Publications (3)

Publication Number Publication Date
NO973551D0 NO973551D0 (no) 1997-08-01
NO973551L true NO973551L (no) 1997-10-03
NO311257B1 NO311257B1 (no) 2001-11-05

Family

ID=23510527

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19973551A NO311257B1 (no) 1995-02-03 1997-08-01 Indoler med brostruktur som matriksmetallproteaseinhibitorer, samt farmasöytiske preparater som omfatter dem

Country Status (18)

Country Link
US (1) US6013792A (no)
EP (1) EP0807114A1 (no)
JP (1) JPH11500109A (no)
KR (1) KR100403687B1 (no)
CN (1) CN1066150C (no)
AR (1) AR002958A1 (no)
AU (1) AU705763B2 (no)
BR (1) BR9606998A (no)
CA (1) CA2212236A1 (no)
CZ (1) CZ293868B6 (no)
FI (1) FI113965B (no)
HU (1) HUP9702073A3 (no)
NO (1) NO311257B1 (no)
PL (1) PL321659A1 (no)
RU (1) RU2191779C2 (no)
UA (1) UA67716C2 (no)
WO (1) WO1996023791A1 (no)
ZA (1) ZA96850B (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL124559A (en) * 1995-12-08 2004-07-25 Agouron Pharma Inhibitors of metalloproteinases, pharmaceutical preparations containing them and their use
US6500948B1 (en) 1995-12-08 2002-12-31 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
US6008243A (en) * 1996-10-24 1999-12-28 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en) 1997-03-25 2001-01-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5985900A (en) * 1997-04-01 1999-11-16 Agouron Pharmaceuticals, Inc. Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
GB9715030D0 (en) * 1997-07-18 1997-09-24 British Biotech Pharm Metalloproteinase inhibitors
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
GB9907055D0 (en) * 1999-03-29 1999-05-19 British Biotech Pharm Antibacterial agents
AR032920A1 (es) * 2001-03-01 2003-12-03 Smithkline Beecham Corp Compuestos inhibidores de las peptido-deformilasas y medios para tratar infecciones bacterianas utilizando dichos inhibidores
UY27813A1 (es) * 2002-05-31 2003-12-31 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
CN1732023A (zh) * 2002-12-27 2006-02-08 血管技术国际股份公司 组合物和使用collajolie的方法
AU2003300076C1 (en) 2002-12-30 2010-03-04 Angiotech International Ag Drug delivery from rapid gelling polymer composition
WO2004066917A2 (en) * 2003-01-17 2004-08-12 Advanced Proteome Therapeutics, Inc Tandem analyses of noncovalently driven effectors for modulatory mapping of activities of protein sites
AU2003902115A0 (en) * 2003-05-02 2003-05-22 The University Of Queensland Method of predicting functional outcome of a stroke using eeg measures
RU2247563C1 (ru) * 2003-06-16 2005-03-10 Пятигорская государственная фармацевтическая академия Способ получения твердой лекарственной формы, содержащей глюкозамина гидрохлорид
US7550431B2 (en) * 2003-07-31 2009-06-23 Tranzyme Pharma Inc. Spatially-defined macrocycles incorporating peptide bond surrogates
RU2257386C1 (ru) * 2004-05-05 2005-07-27 Пермский государственный университет 20-ароил-12-гидрокси-17,17-диметил-3-фенил-3,10,13- триазапентацикло[10.7.1.01,10.04,9.014,19]эйкоза-4,6,8,14(19)-тетраен- 2,11,15- трионы и способ их получения
KR100753796B1 (ko) 2006-07-28 2007-08-31 주식회사 프로메디텍 데포르밀라제 저해제, 이의 제조방법, 및 이를 포함하는조성물
UA108596C2 (xx) * 2007-11-09 2015-05-25 Інгібітори пептиддеформілази
CN105801530A (zh) * 2016-04-13 2016-07-27 成都拿盛科技有限公司 一种4位取代的手性γ-丁内酯的合成方法
KR20220105061A (ko) 2021-01-19 2022-07-26 (주)월드트렌드 밀착력과 착용감 향상 및 수시 교체가 가능한 안경테와 코 받침의 조립구조

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761406A (en) * 1985-06-06 1988-08-02 The Procter & Gamble Company Regimen for treating osteoporosis
GB9000846D0 (en) * 1990-01-15 1990-03-14 Beecham Group Plc Novel compounds
GB9022117D0 (en) * 1990-10-11 1990-11-21 Beecham Group Plc Novel compounds
US5183900A (en) * 1990-11-21 1993-02-02 Galardy Richard E Matrix metalloprotease inhibitors
US5189178A (en) * 1990-11-21 1993-02-23 Galardy Richard E Matrix metalloprotease inhibitors
EP0586537A4 (en) * 1991-05-28 1997-06-25 Merck & Co Inc Substituted n-carboxyalkylpeptidyl derivatives as antidegenerative active agents
GB9122859D0 (en) * 1991-10-28 1991-12-11 Smithkline Beecham Plc Novel compounds
NZ246456A (en) * 1991-12-17 1997-03-24 Procter & Gamble Pharma Use of bone active phosphonate and a parathyroid hormone to prepare medicaments for a thirty day treatment regimen for osteoporosis
DE69405572T2 (de) * 1993-08-05 1998-02-12 Syntex (U.S.A.) Inc., Palo Alto, Calif. Matrix-metalloprotease inhibitoren

Also Published As

Publication number Publication date
CZ293868B6 (cs) 2004-08-18
FI973198A0 (fi) 1997-08-01
UA67716C2 (en) 2004-07-15
CA2212236A1 (en) 1996-08-08
RU2191779C2 (ru) 2002-10-27
NO973551D0 (no) 1997-08-01
WO1996023791A1 (en) 1996-08-08
AU4863696A (en) 1996-08-21
KR100403687B1 (ko) 2004-02-11
ZA96850B (en) 1997-11-03
FI113965B (fi) 2004-07-15
EP0807114A1 (en) 1997-11-19
HUP9702073A3 (en) 1999-05-28
JPH11500109A (ja) 1999-01-06
US6013792A (en) 2000-01-11
CN1066150C (zh) 2001-05-23
PL321659A1 (en) 1997-12-22
FI973198L (fi) 1997-08-01
HUP9702073A2 (hu) 1998-03-30
AU705763B2 (en) 1999-06-03
CZ243197A3 (cs) 1998-01-14
CN1180358A (zh) 1998-04-29
AR002958A1 (es) 1998-05-27
NO311257B1 (no) 2001-11-05
BR9606998A (pt) 1997-10-28

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