[go: up one dir, main page]

NO973279L - PIK-related kinase materials and cell cycle checkpoint methods - Google Patents

PIK-related kinase materials and cell cycle checkpoint methods

Info

Publication number
NO973279L
NO973279L NO973279A NO973279A NO973279L NO 973279 L NO973279 L NO 973279L NO 973279 A NO973279 A NO 973279A NO 973279 A NO973279 A NO 973279A NO 973279 L NO973279 L NO 973279L
Authority
NO
Norway
Prior art keywords
pik
cell cycle
cycle checkpoint
mccs1
kinase
Prior art date
Application number
NO973279A
Other languages
Norwegian (no)
Other versions
NO973279D0 (en
Inventor
Merl F Hoekstra
Doug A Holtzman
Kathleen S Keegan
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of NO973279D0 publication Critical patent/NO973279D0/en
Publication of NO973279L publication Critical patent/NO973279L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Gener som koder for cellesyklus- kontrollpunkt-fosfatidyllnositolkinase (PIK)-beslektede proteiner som er vesentlige for DNA-skaderesponser i celler. Disse PIK-beslektede kinaser er nødvendige i regulatoriske reaksjons- veier som stanser cellesyklusen etter DNA-skade, for å tillate DNA-reparasjon før mitose eller initiering av DNA- replikasjon. En ny human cellesyklus- kontrollpunkt-PIK-beslektet kinase, MCCSl, og polynukleotidsekvenser som koder for MCCSl er nærmere beskrevet. Analyser for identifikasjon av modulatorer av MCCSl anvendelige som f.eks. kjemoterapi- og strålings- adjuvanser, er også beskrevet. Analyser for Identifikasjon av modulatorer av det cellesykluskontrollpunkt-fosfat- idylinositolkinase (PIK)-besLektede protein, identifisert som ATM, er også beskrevet.Genes encoding cell cycle checkpoint phosphatidyl nilositol kinase (PIK) -related proteins that are essential for DNA damage responses in cells. These PIK-related kinases are required in regulatory pathways that stop the cell cycle after DNA damage, to allow DNA repair before mitosis or initiation of DNA replication. A new human cell cycle checkpoint PIK-related kinase, MCCS1, and polynucleotide sequences encoding MCCS1 are described in more detail. Assays for identification of modulators of MCCS1 useful as e.g. chemotherapy and radiation adjuvants are also described. Assays for the identification of modulators of the cell cycle checkpoint phosphate-idylinositol kinase (PIK) -related protein, identified as ATM, are also described.

NO973279A 1995-11-16 1997-07-15 PIK-related kinase materials and cell cycle checkpoint methods NO973279L (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55866695A 1995-11-16 1995-11-16
US73129696A 1996-02-27 1996-02-27
US72530496A 1996-10-21 1996-10-21
PCT/US1996/019337 WO1997018323A2 (en) 1995-11-16 1996-11-18 Cell-cycle checkpoint phosphatidylinositol- (pik-) related kinases, genes coding therefor and methods for assaying and modulating enzymatic activity

Publications (2)

Publication Number Publication Date
NO973279D0 NO973279D0 (en) 1997-07-15
NO973279L true NO973279L (en) 1997-09-16

Family

ID=27415779

Family Applications (1)

Application Number Title Priority Date Filing Date
NO973279A NO973279L (en) 1995-11-16 1997-07-15 PIK-related kinase materials and cell cycle checkpoint methods

Country Status (6)

Country Link
CN (1) CN1199420A (en)
AU (1) AU1461197A (en)
IL (1) IL121306A0 (en)
NO (1) NO973279L (en)
PL (1) PL322876A1 (en)
WO (1) WO1997018323A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5777093A (en) * 1995-05-16 1998-07-07 Ramot-University Authority For Applied Research & Industrial Development Ltd. cDNAs associated with ataxia-telangiectasia
US5858661A (en) * 1995-05-16 1999-01-12 Ramot-University Authority For Applied Research And Industrial Development Ataxia-telangiectasia gene and its genomic organization
GB9518220D0 (en) * 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene
WO1999002653A1 (en) * 1997-07-11 1999-01-21 Trustees Of The University Of Pennsylvania Nucleic acid encoding a novel chemotherapy-induced protein, and methods of use
GB9714971D0 (en) 1997-07-16 1997-09-24 Cancer Res Campaign Tech Assays,therapeutic methods and means
GB9718952D0 (en) * 1997-09-05 1997-11-12 Medical Res Council Mammalian chk1 effector cell cycle checkpoint protein kinase materials and methods
CA2216559A1 (en) * 1997-09-25 1999-03-25 Michel Roberge G2 checkpoint inhibitors and assay
GB9722320D0 (en) * 1997-10-22 1997-12-17 Janssen Pharmaceutica Nv Human cell cycle checkpoint proteins
US6071691A (en) * 1998-04-27 2000-06-06 Oregon Health Science University Materials and methods for modulating differentiation
US6387640B1 (en) 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
US6348311B1 (en) * 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
US6670167B1 (en) 1999-11-01 2003-12-30 Agouron Pharmaceuticals, Inc. Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
AU2003286729A1 (en) * 2002-10-25 2004-05-13 University Of Massachusetts Modulation of cellular proliferation
ATE461193T1 (en) 2003-08-13 2010-04-15 Kudos Pharm Ltd AMINOPYRONES AND THEIR USE AS ATM INHIBITORS
TW200616986A (en) 2004-09-20 2006-06-01 Kudos Pharm Ltd DNA-pk inhibitors
JP2008529995A (en) 2005-02-09 2008-08-07 クドス ファーマシューティカルズ リミテッド ATM inhibitor
AR053358A1 (en) 2005-04-15 2007-05-02 Cancer Rec Tech Ltd DNA INHIBITORS - PK

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9518220D0 (en) * 1995-09-06 1995-11-08 Medical Res Council Checkpoint gene

Also Published As

Publication number Publication date
WO1997018323A2 (en) 1997-05-22
PL322876A1 (en) 1998-03-02
CN1199420A (en) 1998-11-18
WO1997018323A3 (en) 1997-10-09
NO973279D0 (en) 1997-07-15
IL121306A0 (en) 1998-01-04
AU1461197A (en) 1997-06-05

Similar Documents

Publication Publication Date Title
NO973279L (en) PIK-related kinase materials and cell cycle checkpoint methods
ATE224454T1 (en) THREE HYBRID SCREENING TEST
McVey et al. Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication
Kaufmann et al. Enzymatic degradation of ribonucleoproteins of chromosomes, nucleoli and cytoplasm
DE69433552D1 (en) CYTOKIN BINDING TO THE HEK CELL SURFACE RECEPTOR
PT770088E (en) NEW DESIGNATED CYTOKIN LERK-5
ATE182628T1 (en) A PROTEIN THAT RECOGNIZES SPECIFIC DNA STRUCTURES AND ITS USES
Boutté et al. Proteomic analysis and brain‐specific systems biology in a rodent model of penetrating ballistic‐like brain injury
NO962084L (en) DNA sequence encoding a BMP receptor
NO331018B1 (en) In vitro method for the determination of pre-neoplastic and / or neoplastic conditions in mammals by purinergic receptor expression, and the use and kit for such screening.
Sluder et al. Nuclear envelope breakdown is under nuclear not cytoplasmic control in sea urchin zygotes.
NO20051347L (en) eNOS mutants useful for gene therapy.
Orii et al. Total Synthesis of O‐GalNAcylated Antifreeze Glycoprotein using the Switchable Reactivity of Peptidyl‐N‐pivaloylguanidine
NO172910C (en) PROCEDURE FOR TESTING A TRIAL OF CELLS WITH REGARD TO THE PRESENTS OF THE CELL SURFACE ANTIGEN
FI973005L (en) Cell cycle checkpoint PIK-related kinase materials and methods
Liebke Multiple SecA protein isoforms in Escherichia coli
MX9705466A (en) Cell cycle checkpoint pik-related kinase materials and methods.
BR9913047A (en) Construction of dna, plant, plant idioplasma, plant seed or plant cell, mammalian cell, and, use of a dna construction
WO1999020761A3 (en) Compositions and methods for identifying and testing therapeutics against hsv infection
Kamada et al. Proteomic analysis of bone marrow‐adherent cells in rheumatoid arthritis and osteoarthritis
HUP9801330A2 (en) Novel pka-binding proteins and uses thereof
Konishi et al. Detection of two DCCD-binding components in the envelope membrane of H. halobium
Foltz et al. Ionic strength-dependent isoforms of sea urchin egg dynein.
Gao et al. Exploration and application of chemico-biology detection methods and patterns for factors inducing protein misfolding
Sikorski et al. The ribosomal proteins of wheat germ. Distribution and phosphorylation in vitro

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application