NO973247L - Fremgangsmåte for fremstilling av 4,10-diacetoksy-2<alfa>-benzoyl-oksy-5<beta>,20-epoksy-1,7<beta>-dihydroksy-9-okso-tax-11-en-13<alfa>-YL (2R,3S)-3-benzoylamino-2-hydroksy-3-fenylpropionat.trihydrat - Google Patents

Fremgangsmåte for fremstilling av 4,10-diacetoksy-2<alfa>-benzoyl-oksy-5<beta>,20-epoksy-1,7<beta>-dihydroksy-9-okso-tax-11-en-13<alfa>-YL (2R,3S)-3-benzoylamino-2-hydroksy-3-fenylpropionat.trihydrat

Info

Publication number: NO973247L
Authority: NO; Norway
Prior art keywords: beta; diacetoxy; benzoylamino; oxy; benzoyl
Prior art date: 1995-01-25

Application number

NO973247A

Other languages

English (en)

Other versions

NO973247D0 (no

NO316987B1 (no

Inventor

Jean-Rene Authelin

Eric Didier

Franck Leveiller

Isabelle Taillpied

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-25

Filing date

1997-07-11

Publication date

1997-07-11

1997-07-11 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1997-07-11 Publication of NO973247L publication Critical patent/NO973247L/no

1997-07-11 Publication of NO973247D0 publication Critical patent/NO973247D0/no

2004-07-19 Publication of NO316987B1 publication Critical patent/NO316987B1/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Hematology (AREA)
Oncology (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO19973247A 1995-01-25 1997-07-11 Fremgangsmate for fremstilling av 4,10-diacetoksy-2<alfa>-benzoyloksy-5<beta>,20-epoksy-1,7<beta>-dihydroksy-9-okso-tax-11-en-13<alfa>-YL (2R,3S)-3-benzoylamino-2-hydroksy-3-fenylpropionat-trihydrat og den oppnadde forbindelse NO316987B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9500816A FR2729666A1 (fr)	1995-01-25	1995-01-25	Procede de preparation du trihydrate du (2r, 3s)- benzoylamino-2-hydroxy-3-phenylpropionate de 4,10-diacetoxy- 2alpha-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo- tax-11-en-13alpha-yle
PCT/FR1996/000104 WO1996022984A1 (fr)	1995-01-25	1996-01-23	PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-BENZOYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4,10-DIACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β-DIHYDROXY-9-OXO-TAX-11-EN-13α-YLE

Publications (3)

Publication Number	Publication Date
NO973247L true NO973247L (no)	1997-07-11
NO973247D0 NO973247D0 (no)	1997-07-11
NO316987B1 NO316987B1 (no)	2004-07-19

Family

ID=9475464

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19973247A NO316987B1 (no)	1995-01-25	1997-07-11	Fremgangsmate for fremstilling av 4,10-diacetoksy-2<alfa>-benzoyloksy-5<beta>,20-epoksy-1,7<beta>-dihydroksy-9-okso-tax-11-en-13<alfa>-YL (2R,3S)-3-benzoylamino-2-hydroksy-3-fenylpropionat-trihydrat og den oppnadde forbindelse

Country Status (43)

Country	Link
US (1)	US6002022A (no)
EP (1)	EP0805806B1 (no)
JP (1)	JP3782449B2 (no)
KR (1)	KR100384773B1 (no)
CN (1)	CN1067997C (no)
AP (1)	AP750A (no)
AT (1)	ATE187719T1 (no)
AU (1)	AU707603B2 (no)
BG (1)	BG62769B1 (no)
BR (1)	BR9606853A (no)
CO (1)	CO4700286A1 (no)
CZ (1)	CZ287079B6 (no)
DE (1)	DE69605651T2 (no)
DK (1)	DK0805806T3 (no)
DZ (1)	DZ1977A1 (no)
EE (1)	EE03396B1 (no)
ES (1)	ES2139332T3 (no)
FI (1)	FI119245B (no)
FR (1)	FR2729666A1 (no)
GE (1)	GEP19991833B (no)
GR (1)	GR3032110T3 (no)
HU (1)	HU223352B1 (no)
IL (1)	IL116903A (no)
IN (1)	IN184427B (no)
IS (1)	IS2033B (no)
MA (1)	MA23782A1 (no)
MY (1)	MY113230A (no)
NO (1)	NO316987B1 (no)
NZ (1)	NZ300958A (no)
OA (1)	OA10438A (no)
PE (1)	PE64896A1 (no)
PL (1)	PL183773B1 (no)
PT (1)	PT805806E (no)
RO (1)	RO115728B1 (no)
RU (1)	RU2154642C2 (no)
SK (1)	SK281958B6 (no)
TN (1)	TNSN96011A1 (no)
TR (1)	TR199700676T1 (no)
TW (1)	TW356469B (no)
UA (1)	UA47420C2 (no)
UY (1)	UY24149A1 (no)
WO (1)	WO1996022984A1 (no)
ZA (1)	ZA96523B (no)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL203300B1 (pl) *	2000-10-31	2009-09-30	Akad Medyczna	Stabilna postać farmaceutyczna leku przeciwnowotworowego oraz sposób wytwarzania stabilnej postaci farmaceutycznej leku przeciwnowotworowego
US6891050B2 (en) *	2001-08-10	2005-05-10	Dabur India Limited	Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6894456B2 (en)	2001-11-07	2005-05-17	Quallion Llc	Implantable medical power module
US6881852B2 (en) *	2002-02-05	2005-04-19	Dabur India Limited	Process of purification of paclitaxel and docetaxel
US7247738B2 (en) *	2002-05-07	2007-07-24	Dabur India Limited	Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) *	2002-05-10	2005-05-31	Dabur India Limited	Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) *	2002-12-16	2005-01-04	Dabur India Limited	Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
DE602004020506D1 (de)	2003-12-12	2009-05-20	Quiral Quimica Do Brasil	Verfahren zur herstellung von wasserfreien und hydratisierten pharmazeutischen wirkstoffen (apis); aus diesen hergestellte stabile pharmazeutische zusammensetzungen und anwendungen für diese zusammensetzungen
CN100420681C (zh) *	2005-04-29	2008-09-24	上海奥锐特国际贸易有限公司	多烯紫杉醇三水物的制备方法
EP2285792A2 (en) *	2008-05-07	2011-02-23	Ivax Research, Llc	Processes for preparation of taxanes and intermediates thereof
US8633240B2 (en) *	2012-06-01	2014-01-21	The University Of Utah Research Foundation	Paclitaxel trihydrates and methods of making thereof
CN103833693B (zh) *	2014-03-04	2016-02-24	悦康药业集团有限公司	一种紫杉醇化合物及含该紫杉醇化合物的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6409094A (en) *	1993-03-15	1994-10-11	Yale University	Diagnosis of human inflammatory bowel diseases and nucleic acid reagents therefor
FR2703049B1 (fr) *	1993-03-22	1995-04-21	Rhone Poulenc Rorer Sa	Procédé de purification des taxoïdes.
CA2163837C (en) *	1994-12-13	1999-07-20	Robert K. Perrone	Crystalline paclitaxel hydrates

1995
- 1995-01-25 FR FR9500816A patent/FR2729666A1/fr active Granted
1996
- 1996-01-15 PE PE1996000035A patent/PE64896A1/es not_active Application Discontinuation
- 1996-01-17 UY UY24149A patent/UY24149A1/es not_active IP Right Cessation
- 1996-01-22 DZ DZ960018A patent/DZ1977A1/fr active
- 1996-01-23 EE EE9700157A patent/EE03396B1/xx not_active IP Right Cessation
- 1996-01-23 EP EP96901832A patent/EP0805806B1/fr not_active Expired - Lifetime
- 1996-01-23 GE GEAP19963849A patent/GEP19991833B/en unknown
- 1996-01-23 US US08/875,625 patent/US6002022A/en not_active Expired - Lifetime
- 1996-01-23 ES ES96901832T patent/ES2139332T3/es not_active Expired - Lifetime
- 1996-01-23 PL PL96321493A patent/PL183773B1/pl not_active IP Right Cessation
- 1996-01-23 AU AU46255/96A patent/AU707603B2/en not_active Ceased
- 1996-01-23 MA MA24137A patent/MA23782A1/fr unknown
- 1996-01-23 PT PT96901832T patent/PT805806E/pt unknown
- 1996-01-23 DE DE69605651T patent/DE69605651T2/de not_active Expired - Lifetime
- 1996-01-23 CN CN96191612A patent/CN1067997C/zh not_active Expired - Fee Related
- 1996-01-23 BR BR9606853A patent/BR9606853A/pt not_active IP Right Cessation
- 1996-01-23 WO PCT/FR1996/000104 patent/WO1996022984A1/fr not_active Ceased
- 1996-01-23 AT AT96901832T patent/ATE187719T1/de active
- 1996-01-23 JP JP52266996A patent/JP3782449B2/ja not_active Expired - Lifetime
- 1996-01-23 AP APAP/P/1997/001035A patent/AP750A/en active
- 1996-01-23 SK SK1008-97A patent/SK281958B6/sk not_active IP Right Cessation
- 1996-01-23 TR TR97/00676T patent/TR199700676T1/xx unknown
- 1996-01-23 RU RU97114134/04A patent/RU2154642C2/ru not_active IP Right Cessation
- 1996-01-23 NZ NZ300958A patent/NZ300958A/en not_active IP Right Cessation
- 1996-01-23 KR KR1019970705017A patent/KR100384773B1/ko not_active Expired - Fee Related
- 1996-01-23 TW TW085100768A patent/TW356469B/zh not_active IP Right Cessation
- 1996-01-23 UA UA97063414A patent/UA47420C2/uk unknown
- 1996-01-23 DK DK96901832T patent/DK0805806T3/da active
- 1996-01-23 RO RO97-01401A patent/RO115728B1/ro unknown
- 1996-01-23 CZ CZ19972362A patent/CZ287079B6/cs not_active IP Right Cessation
- 1996-01-23 ZA ZA96523A patent/ZA96523B/xx unknown
- 1996-01-23 HU HU9801437A patent/HU223352B1/hu not_active IP Right Cessation
- 1996-01-24 TN TNTNSN96011A patent/TNSN96011A1/fr unknown
- 1996-01-24 CO CO96002860A patent/CO4700286A1/es unknown
- 1996-01-24 IN IN152DE1996 patent/IN184427B/en unknown
- 1996-01-25 MY MYPI96000282A patent/MY113230A/en unknown
- 1996-01-25 IL IL11690396A patent/IL116903A/xx not_active IP Right Cessation
1997
- 1997-07-11 NO NO19973247A patent/NO316987B1/no not_active IP Right Cessation
- 1997-07-22 IS IS4529A patent/IS2033B/is unknown
- 1997-07-24 OA OA70055A patent/OA10438A/fr unknown
- 1997-07-24 FI FI973105A patent/FI119245B/fi not_active IP Right Cessation
- 1997-07-25 BG BG101794A patent/BG62769B1/bg unknown
1999
- 1999-12-16 GR GR990402251T patent/GR3032110T3/el unknown

Also Published As

Publication number	Publication date
FR2729666B1 (no)	1997-02-28
PL321493A1 (en)	1997-12-08
RO115728B1 (ro)	2000-05-30
EE9700157A (et)	1997-12-15
PE64896A1 (es)	1997-02-23
FR2729666A1 (fr)	1996-07-26
KR19980701623A (ko)	1998-06-25
IL116903A0 (en)	1996-05-14
HU223352B1 (hu)	2004-06-28
MX9705460A (es)	1997-10-31
EE03396B1 (et)	2001-04-16
GEP19991833B (en)	1999-11-05
AP9701035A0 (en)	1997-07-31
FI973105L (fi)	1997-07-24
DE69605651D1 (de)	2000-01-20
CO4700286A1 (es)	1998-12-29
AU707603B2 (en)	1999-07-15
TW356469B (en)	1999-04-21
JPH10512871A (ja)	1998-12-08
CZ236297A3 (en)	1997-11-12
WO1996022984A1 (fr)	1996-08-01
AU4625596A (en)	1996-08-14
CN1067997C (zh)	2001-07-04
NO973247D0 (no)	1997-07-11
FI119245B (fi)	2008-09-15
IS2033B (is)	2005-08-15
TNSN96011A1 (fr)	2005-03-15
SK281958B6 (sk)	2001-09-11
BG101794A (en)	1998-10-30
BG62769B1 (bg)	2000-07-31
DZ1977A1 (fr)	2002-07-20
GR3032110T3 (en)	2000-03-31
EP0805806B1 (fr)	1999-12-15
DE69605651T2 (de)	2000-07-06
BR9606853A (pt)	1997-11-25
ATE187719T1 (de)	2000-01-15
IL116903A (en)	2003-01-12
SK100897A3 (en)	1998-01-14
IN184427B (no)	2000-08-26
FI973105A0 (fi)	1997-07-24
EP0805806A1 (fr)	1997-11-12
JP3782449B2 (ja)	2006-06-07
ES2139332T3 (es)	2000-02-01
PL183773B1 (pl)	2002-07-31
TR199700676T1 (xx)	1998-01-21
ZA96523B (en)	1996-10-15
HUP9801437A1 (hu)	1999-09-28
UY24149A1 (es)	1996-05-20
KR100384773B1 (ko)	2003-08-21
MA23782A1 (fr)	1996-10-01
OA10438A (fr)	2002-03-22
RU2154642C2 (ru)	2000-08-20
CZ287079B6 (en)	2000-08-16
DK0805806T3 (da)	2000-05-01
UA47420C2 (uk)	2002-07-15
PT805806E (pt)	2000-05-31
NO316987B1 (no)	2004-07-19
IS4529A (is)	1997-07-22
US6002022A (en)	1999-12-14
NZ300958A (en)	1999-09-29
HUP9801437A3 (en)	2001-02-28
CN1169724A (zh)	1998-01-07
MY113230A (en)	2001-12-31
AP750A (en)	1999-07-06

Publication	Publication Date	Title
FI970069L (fi)	1997-01-07	Menetelmä (2R-3S)-(4-asetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi-1,7beta,10beta-trihydroksi-9-oksotaks-11-en-13alfa-yyli)-3-tert-butoksikarbonyyliamino-3-fenyyli-2-hydroksipropionaatin trihydraatin valmistamiseksi
FI914213A0 (fi)	1991-09-06	Anordning foer foerflyttande av patient.
FI906383L (fi)	1991-06-28	Pao retikulerade polyorganosiloxan baserade magnetiserbara core-shell-mikrobollar, foerfarande foer framstaellning av dessa och anvaendning av desamma i biologi.
NO881537L (no)	1988-10-10	Fremgangsmaate for fremstilling av 6-substituert-2',3'-dideoksynukleosider.
NO973247L (no)	1997-07-11	Fremgangsmåte for fremstilling av 4,10-diacetoksy-2<alfa>-benzoyl-oksy-5<beta>,20-epoksy-1,7<beta>-dihydroksy-9-okso-tax-11-en-13<alfa>-YL (2R,3S)-3-benzoylamino-2-hydroksy-3-fenylpropionat.trihydrat
FI923031A0 (fi)	1992-06-30	1,4-bis-(amino-hydroxialkylamino)- antrakinoner foer inhibering av proteinkinas c.
NO986086D0 (no)	1998-12-23	FremgangsmÕte for fremstilling av 17-estere av 9<alfa>,21-dihalo-pregnan-11
FI934748L (fi)	1994-04-28	Foerfarande foer framstaellning av L-5-(2-acetoxipropionylamino)-2,4,6-trijod-isoftalsyradiklorid
FI891050A0 (fi)	1989-03-06	Temperaturgradient-inkubator foer undersoekning av temperatur-avhaengiga fenomen.
MX9202076A (es)	1992-11-30	Proceso de hidroconversion novedoso.
FI906009L (fi)	1991-06-08	Foerfarande foer framstaellning av des(64,65)-proinsulin.
FI924881L (fi)	1993-05-16	Foerfarande foer framstaellning av (2R, 3E)-4-halo-3-buten-2-oler
FI904038A0 (fi)	1990-08-15	Foerfarande och anordning foer direkt kontinuerlig gjutning av tunna metallprodukter.
NO894623D0 (no)	1989-11-21	Biologisk fremgangsmaate for bleking av pulp.
Reinhart	1994	This is not the April 13th we hoped for
DE69021494D1 (de)	1995-09-14	1,1,1-Trifluor-2-Hydroxyverbindungen.
FI890065A0 (fi)	1989-01-06	Foerfarande foer framstaellning av 5,8,13, 14-tetrahydrobenz/5,6/isoindolo/2,1-b/isokinolin-8,13-dionderivat.
SI0805806T1 (en)	2000-02-29	Method for preparing 4,10-diacetoxy-2alfa-benzoyloxy-5beta,20-epoxy-1,7beta-dihydroxy-9-oxo-tax-11-en-13alfa-yl (2r,3s)-3-benzoylamino-2-hydroxy-3-phenylpropionate trihydrate
ITTO910981A1 (it)	1993-06-13	Procedimento per la realizzazione di ingranaggi, particolarmente per cambi di velocita' di autoveicoli.
ITTO920160A1 (it)	1993-08-26	Macchina per la tempera del cioccolato.
FI893355A0 (fi)	1989-07-11	Foerfarande foer framstaellning av material foer den katalytiskt aktiva sektionen i reningskatalysatorn foer avgaser.
FI890610A0 (fi)	1989-02-09	Anordning foer lyftande av fiskar.
HU9700775D0 (en)	1997-06-30	Process for producing taxane derivatives with using (2r,3s)-beta-phenyl-isoserine
ZA965896B (en)	1997-02-26	Process for the preparation of alpha, omega-bromochloroalkanes.
FI894432A0 (fi)	1989-09-19	Anordning foer dragavlastning av ledning.

Legal Events

Date	Code	Title	Description
2014-08-25	MM1K	Lapsed by not paying the annual fees