NO972017D0 - Substituted tetracyclic azepine derivatives having affinity for 5-HT 2 receptors - Google Patents

Substituted tetracyclic azepine derivatives having affinity for 5-HT 2 receptors

Info

Publication number: NO972017D0
Authority: NO; Norway
Prior art keywords: receptors; affinity; substituted tetracyclic; azepine derivatives; tetracyclic azepine
Prior art date: 1994-11-02

Application number

NO972017A

Other languages

Norwegian (no)

Other versions

NO972017L (en

NO308035B1 (en

Inventor

Victor Karel Sipido

Francisco Javi Fernandez-Gadea

Jose Ignacio Andres-Gil

Theo Frans Meert

Pilar Gil-Lopetegui

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-02

Filing date

1997-04-30

Publication date

1997-04-30

1997-04-30 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1997-04-30 Publication of NO972017L publication Critical patent/NO972017L/en

1997-04-30 Publication of NO972017D0 publication Critical patent/NO972017D0/en

2000-07-10 Publication of NO308035B1 publication Critical patent/NO308035B1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO972017A 1994-11-02 1997-04-30 Substituted tetracyclic azepine derivatives having affinity for 5-HT 2 receptors NO308035B1 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP94203178		1994-11-02
US08/457,968 US5552399A (en)	1994-11-02	1995-05-31	Substituted tetracyclic azepine derivatives
PCT/EP1995/004196 WO1996014320A1 (en)	1994-11-02	1995-10-25	Substituted tetracyclic azepine derivatives which have affinity for 5-ht2 receptors

Publications (3)

Publication Number	Publication Date
NO972017L NO972017L (en)	1997-04-30
NO972017D0 true NO972017D0 (en)	1997-04-30
NO308035B1 NO308035B1 (en)	2000-07-10

Family

ID=8217337

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO972017A NO308035B1 (en)	1994-11-02	1997-04-30	Substituted tetracyclic azepine derivatives having affinity for 5-HT 2 receptors

Country Status (30)

Country	Link
US (1)	US5552399A (en)
EP (1)	EP0789701B1 (en)
JP (1)	JP3818541B2 (en)
KR (1)	KR100392060B1 (en)
CN (1)	CN1085667C (en)
AR (1)	AR002238A1 (en)
AT (1)	ATE199087T1 (en)
AU (1)	AU704285B2 (en)
BR (1)	BR9509552A (en)
CA (1)	CA2203661A1 (en)
CZ (1)	CZ286945B6 (en)
DE (1)	DE69520070T2 (en)
DK (1)	DK0789701T3 (en)
ES (1)	ES2155898T3 (en)
FI (1)	FI113050B (en)
GR (1)	GR3035680T3 (en)
HR (1)	HRP950537A2 (en)
HU (1)	HUT77408A (en)
IL (1)	IL115819A (en)
MY (1)	MY113325A (en)
NO (1)	NO308035B1 (en)
NZ (1)	NZ295656A (en)
PL (1)	PL183686B1 (en)
PT (1)	PT789701E (en)
RU (1)	RU2163240C2 (en)
SI (1)	SI0789701T1 (en)
TR (1)	TR199501356A2 (en)
TW (1)	TW349950B (en)
WO (1)	WO1996014320A1 (en)
ZA (1)	ZA959215B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6156747A (en) *	1996-04-12	2000-12-05	Janssen Pharmaceutica N.V.	Isoxazolidine derivatives
UA52778C2 (en)	1997-10-10	2003-01-15	Янссен Фармацевтика Н.В.	Tetrahydrofurane halogen substituted tetracyclic derivatives, a process for production and compositions on basis thereof
HRP20020305A8 (en)	2002-04-10	2009-03-31	GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o.	2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
HRP20030885A2 (en) *	2003-11-03	2005-08-31	Pliva-Istra�iva�ki institut d.o.o.	USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS
HRP20030953A2 (en) *	2003-11-21	2005-10-31	Pliva-Istra�iva�ki institut d.o.o.	PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS
US20110086086A1 (en) *	2005-07-26	2011-04-14	Pfizer Inc	Transdermal system for varenicline
EP3651751A4 (en) *	2017-07-13	2021-03-31	Tonix Pharmaceuticals Holding Corp.	CYCLOBENZAPRINE ANALOGA AND AMITRYPTILES

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT338799B (en) *	1974-03-02	1977-09-12	Boehringer Sohn Ingelheim	PROCESS FOR PREPARING NEW SUBSTITUTED 6-ARYL-4H-S-TRIAZOLO- (3,4C) -THIENO- (2,3E) -1,4-DIAZEPINE AND THEIR SALTS
NL7414038A (en) *	1974-10-28	1976-05-03	Akzo Nv	NEW TETRACYCLIC PYRROLIDINO DERIVATIVES.
DE2647114A1 (en) *	1975-10-21	1977-05-05	Hans Fickler	Linear motion drive from rotary motor - has drums of different dia. to produce high load without reduction gear
JPS5572177A (en) *	1978-11-27	1980-05-30	Shionogi & Co Ltd	4,1-benzoxazepine or 4,1-benzothiazepine
IE903557A1 (en) *	1989-10-05	1991-04-10	Sankyo Co	Novel tetracyclic compounds having anti-allergic and¹anti-asthmatic activities, their preparation and use
US5512563A (en) *	1993-07-29	1996-04-30	American Cyanamid Company	Tricyclic benzazepine vasopressin antagonists

1995
- 1995-05-31 US US08/457,968 patent/US5552399A/en not_active Expired - Fee Related
- 1995-10-20 TW TW084111063A patent/TW349950B/en active
- 1995-10-25 DE DE69520070T patent/DE69520070T2/en not_active Expired - Fee Related
- 1995-10-25 CN CN95195969A patent/CN1085667C/en not_active Expired - Fee Related
- 1995-10-25 SI SI9530482T patent/SI0789701T1/en unknown
- 1995-10-25 AT AT95937006T patent/ATE199087T1/en not_active IP Right Cessation
- 1995-10-25 CZ CZ19971323A patent/CZ286945B6/en not_active IP Right Cessation
- 1995-10-25 WO PCT/EP1995/004196 patent/WO1996014320A1/en not_active Ceased
- 1995-10-25 HU HU9702298A patent/HUT77408A/en unknown
- 1995-10-25 KR KR1019970702800A patent/KR100392060B1/en not_active Expired - Fee Related
- 1995-10-25 EP EP95937006A patent/EP0789701B1/en not_active Expired - Lifetime
- 1995-10-25 CA CA002203661A patent/CA2203661A1/en not_active Abandoned
- 1995-10-25 RU RU97108691/04A patent/RU2163240C2/en not_active IP Right Cessation
- 1995-10-25 PT PT95937006T patent/PT789701E/en unknown
- 1995-10-25 JP JP51500996A patent/JP3818541B2/en not_active Expired - Fee Related
- 1995-10-25 AU AU39249/95A patent/AU704285B2/en not_active Ceased
- 1995-10-25 DK DK95937006T patent/DK0789701T3/en active
- 1995-10-25 NZ NZ295656A patent/NZ295656A/en unknown
- 1995-10-25 BR BR9509552A patent/BR9509552A/en not_active IP Right Cessation
- 1995-10-25 ES ES95937006T patent/ES2155898T3/en not_active Expired - Lifetime
- 1995-10-25 PL PL95319939A patent/PL183686B1/en not_active IP Right Cessation
- 1995-10-31 ZA ZA959215A patent/ZA959215B/en unknown
- 1995-10-31 IL IL11581995A patent/IL115819A/en not_active IP Right Cessation
- 1995-10-31 HR HR08/457,968A patent/HRP950537A2/en not_active Application Discontinuation
- 1995-11-01 AR ARP950100010A patent/AR002238A1/en unknown
- 1995-11-02 MY MYPI95003312A patent/MY113325A/en unknown
- 1995-11-02 TR TR95/01356A patent/TR199501356A2/en unknown
1997
- 1997-04-30 NO NO972017A patent/NO308035B1/en unknown
- 1997-04-30 FI FI971854A patent/FI113050B/en not_active IP Right Cessation
2001
- 2001-03-30 GR GR20010400530T patent/GR3035680T3/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU704285B2 (en)	1999-04-15
CN1085667C (en)	2002-05-29
KR100392060B1 (en)	2003-11-28
WO1996014320A1 (en)	1996-05-17
AU3924995A (en)	1996-05-31
FI971854A0 (en)	1997-04-30
EP0789701B1 (en)	2001-02-07
IL115819A0 (en)	1996-01-19
NZ295656A (en)	1998-10-28
BR9509552A (en)	1997-09-16
ES2155898T3 (en)	2001-06-01
GR3035680T3 (en)	2001-06-29
HUT77408A (en)	1998-04-28
SI0789701T1 (en)	2001-08-31
TR199501356A2 (en)	1996-06-21
CZ132397A3 (en)	1998-01-14
FI113050B (en)	2004-02-27
FI971854A7 (en)	1997-04-30
EP0789701A1 (en)	1997-08-20
ATE199087T1 (en)	2001-02-15
NO972017L (en)	1997-04-30
US5552399A (en)	1996-09-03
TW349950B (en)	1999-01-11
DK0789701T3 (en)	2001-06-18
IL115819A (en)	1998-10-30
DE69520070T2 (en)	2001-09-13
RU2163240C2 (en)	2001-02-20
JP3818541B2 (en)	2006-09-06
JPH10508308A (en)	1998-08-18
HRP950537A2 (en)	1997-08-31
CA2203661A1 (en)	1996-05-17
AR002238A1 (en)	1998-03-11
PT789701E (en)	2001-07-31
MX9703255A (en)	1997-07-31
DE69520070D1 (en)	2001-03-15
PL183686B1 (en)	2002-06-28
MY113325A (en)	2002-01-31
CN1162313A (en)	1997-10-15
CZ286945B6 (en)	2000-08-16
PL319939A1 (en)	1997-09-01
NO308035B1 (en)	2000-07-10
ZA959215B (en)	1997-04-30

Publication	Publication Date	Title
FI973205A0 (en)	1997-08-01	Indole derivatives as 5-HT receptor antagonists
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NO20010603D0 (en)	2001-02-05	2-substituted-1-piperidylbenzimidazole compounds as ORL 1 receptor agonists
FI943247L (en)	1994-07-07	Piperazine derivatives as 5-HT receptor antagonists
DE69605430D1 (en)	2000-01-05	CHINOLIN-2-ON DERIVATIVES AS SEROTONIN ANTAGONISTS
DK0856001T3 (en)	2002-12-30	Pyrimidine derivatives as 5-HT 2C receptor antagonists
FI943941L (en)	1994-10-26	Benzodiazepine derivatives useful as CCK receptor antagonists
NO304693B1 (en)	1999-02-01	Kinoxaline derivatives with affinity for quisqualate receptors
NO974043D0 (en)	1997-09-03	Indole derivatives as EAA antagonists
DK0708105T3 (en)	1999-08-23	5-HT 4 receptor agonists
AU2314195A (en)	1995-11-29	Benzofuran derivatives as d4 receptor antagonists
NO985970D0 (en)	1998-12-18	Indoline derivatives useful as 5_HT-2C receptor antagonists
NO972017L (en)	1997-04-30	Substituted tetracyclic azepine derivatives having affinity for 5-HT 2 receptors
FI951798A0 (en)	1995-04-13	Bentzofuran derivatives as 5-HT1-like receptor antagonists
KR970013921U (en)	1997-04-28	Multi-purpose bracket for construction
DK0836606T3 (en)	2000-11-20	Condensed thiazole derivatives having 5-HT receptor affinity
NO985972D0 (en)	1998-12-18	Indoline derivatives useful as 5-HT-2C receptor antagonists
NO20006041D0 (en)	2000-11-29	N-Benzodioxanylmethyl-1-piperidylmethylamine compounds with affinity for 5-HT receptors
NO943101D0 (en)	1994-08-23	2,6-methano-2H-quinolizine derivative as a 5-HT 3 receptor antagonist
NO963775L (en)	1996-09-09	Indole derivatives as CCK receptor antagonists
KR960013523U (en)	1996-05-17	Boring bar for inner diameter adjustment