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NO962238L - Prolylendopeptidaseinhibitorer - Google Patents

Prolylendopeptidaseinhibitorer

Info

Publication number
NO962238L
NO962238L NO962238A NO962238A NO962238L NO 962238 L NO962238 L NO 962238L NO 962238 A NO962238 A NO 962238A NO 962238 A NO962238 A NO 962238A NO 962238 L NO962238 L NO 962238L
Authority
NO
Norway
Prior art keywords
compounds
formula
present
prolylendopeptidaseinhibitorer
memory
Prior art date
Application number
NO962238A
Other languages
Norwegian (no)
Other versions
NO962238D0 (en
Inventor
Norton Paul Peet
Joseph Paul Burkhart
Shujaath Mehdi
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of NO962238L publication Critical patent/NO962238L/en
Publication of NO962238D0 publication Critical patent/NO962238D0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

The present invention relates to compounds of formula 1, <IMAGE> Formula 1 including all of its stereoisomers, compositions, and processes for preparation of the same. The compounds of the present invention are also useful in their pharmacological activities as they directly act as inhibitors of prolyl endopeptidase and thereby provide a methods for memory enhancement, preventing or slowing the affects of amnesia or memory deficits.
NO962238A 1993-12-02 1996-05-31 Prolylendopeptidaseinhibitorer NO962238D0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16110693A 1993-12-02 1993-12-02
PCT/US1994/012865 WO1995015310A1 (en) 1993-12-02 1994-11-08 Prolyl endopeptidase inhibitors

Publications (2)

Publication Number Publication Date
NO962238L true NO962238L (en) 1996-05-31
NO962238D0 NO962238D0 (en) 1996-05-31

Family

ID=22579844

Family Applications (1)

Application Number Title Priority Date Filing Date
NO962238A NO962238D0 (en) 1993-12-02 1996-05-31 Prolylendopeptidaseinhibitorer

Country Status (19)

Country Link
US (1) US5661167A (en)
EP (1) EP0731788B1 (en)
JP (1) JPH09506090A (en)
KR (1) KR100341982B1 (en)
CN (1) CN1136806A (en)
AT (1) ATE223894T1 (en)
AU (1) AU684861B2 (en)
CA (1) CA2177821C (en)
DE (1) DE69431359T2 (en)
DK (1) DK0731788T3 (en)
ES (1) ES2179093T3 (en)
HU (1) HUT74687A (en)
IL (1) IL111775A (en)
NO (1) NO962238D0 (en)
NZ (1) NZ276600A (en)
PT (1) PT731788E (en)
TW (1) TW280818B (en)
WO (1) WO1995015310A1 (en)
ZA (1) ZA949302B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
US7371871B2 (en) 2003-05-05 2008-05-13 Probiodrug Ag Inhibitors of glutaminyl cyclase
WO2005049027A2 (en) 2003-11-03 2005-06-02 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
EP1824846A2 (en) 2003-11-03 2007-08-29 Probiodrug AG Novel compounds for the treatment of neurological disorders
BRPI0507485A (en) 2004-02-05 2007-07-10 Probiodrug Ag new glutaminyl cyclase inhibitors
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
ATE554085T1 (en) 2006-11-30 2012-05-15 Probiodrug Ag NEW INHIBITORS OF GLUTAMINYL CYCLASE
EA200901140A1 (en) 2007-03-01 2010-04-30 Пробиодруг Аг NEW USE OF GLUTAMINYL CYCLLASE INHIBITORS
JP5667440B2 (en) 2007-04-18 2015-02-12 プロビオドルグ エージー Thiourea derivatives as glutaminyl cyclase inhibitors
US8524654B2 (en) * 2007-05-21 2013-09-03 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
CN102695546B (en) 2009-09-11 2014-09-10 前体生物药物股份公司 Heterocylcic derivatives as inhibitors of glutaminyl cyclase
US9181233B2 (en) 2010-03-03 2015-11-10 Probiodrug Ag Inhibitors of glutaminyl cyclase
US8269019B2 (en) 2010-03-10 2012-09-18 Probiodrug Ag Inhibitors
JP5945532B2 (en) 2010-04-21 2016-07-05 プロビオドルグ エージー Benzimidazole derivatives as inhibitors of glutaminyl cyclase
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
WO2015116590A1 (en) 2014-01-28 2015-08-06 Spirit Global Energy Solutions, Inc. Down-hole gas and solids separator utilized in production hydrocarbons
PL3461819T3 (en) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitors of glutaminyl cyclase

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518528A (en) * 1983-05-19 1985-05-21 Rasnick David W α Amino fluoro ketones
ZA86746B (en) * 1985-02-04 1986-09-24 Merrell Dow Pharma Novel peptidase inhibitors
DE3712365A1 (en) * 1987-04-11 1988-10-27 Hoechst Ag NEW 2-ACYLPYRROLIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, CONTAINERS AND THE USE THEREOF
US4855303A (en) * 1987-07-01 1989-08-08 Pfizer Inc. Fluorine containing renin inhibitors
JPH0662591B2 (en) * 1988-12-14 1994-08-17 株式会社ヤクルト本社 Novel thioproline derivative
EP0419683A4 (en) * 1989-04-13 1992-03-11 Japan Tobacco Inc. New amino acid derivatives having prolylendopeptidase inhibitor activity

Also Published As

Publication number Publication date
KR100341982B1 (en) 2002-11-30
EP0731788A1 (en) 1996-09-18
CA2177821A1 (en) 1995-06-08
ZA949302B (en) 1995-08-07
AU684861B2 (en) 1998-01-08
AU1091795A (en) 1995-06-19
NO962238D0 (en) 1996-05-31
EP0731788B1 (en) 2002-09-11
IL111775A (en) 1998-06-15
NZ276600A (en) 1997-09-22
JPH09506090A (en) 1997-06-17
DE69431359T2 (en) 2003-07-31
PT731788E (en) 2003-01-31
US5661167A (en) 1997-08-26
WO1995015310A1 (en) 1995-06-08
DE69431359D1 (en) 2002-10-17
ATE223894T1 (en) 2002-09-15
HU9601472D0 (en) 1996-07-29
CN1136806A (en) 1996-11-27
IL111775A0 (en) 1995-01-24
DK0731788T3 (en) 2003-01-20
HUT74687A (en) 1997-01-28
ES2179093T3 (en) 2003-01-16
TW280818B (en) 1996-07-11
CA2177821C (en) 2000-03-28

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application