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NO960927L - Fremgangsmåte ved fremstilling av 9-(2-hydroksy)-etoksymetylguanin - Google Patents

Fremgangsmåte ved fremstilling av 9-(2-hydroksy)-etoksymetylguanin

Info

Publication number
NO960927L
NO960927L NO960927A NO960927A NO960927L NO 960927 L NO960927 L NO 960927L NO 960927 A NO960927 A NO 960927A NO 960927 A NO960927 A NO 960927A NO 960927 L NO960927 L NO 960927L
Authority
NO
Norway
Prior art keywords
hydroxy
preparation
ethoxymethylguanine
diacyloxybutane
formylguanine
Prior art date
Application number
NO960927A
Other languages
English (en)
Other versions
NO960927D0 (no
Inventor
Stefano Turchetta
Sabina Pucci
Gianfranco Piccoli
Giovanni Frare
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT93RM000608A external-priority patent/IT1266486B1/it
Priority claimed from IT93MI002324A external-priority patent/IT1266654B1/it
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Publication of NO960927D0 publication Critical patent/NO960927D0/no
Publication of NO960927L publication Critical patent/NO960927L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Oppfinnelsen vedrører en ny fremgangsmåte ved frem- stilling av 9-(2-hydroksy)etoksymetyl-guanin (acyk- lovir) ved alkylering av N2-formylguanin med 2-oxa- 1,4-diacyloksybutan og med etterfølgende hydrolyse av det dannede mellomprodukt.
NO960927A 1993-09-10 1996-03-07 Fremgangsmåte ved fremstilling av 9-(2-hydroksy)-etoksymetylguanin NO960927L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT93RM000608A IT1266486B1 (it) 1993-09-10 1993-09-10 Procedimento per la preparazione della 9-(2-idrossi)etossimetil- guanina.
IT93MI002324A IT1266654B1 (it) 1993-11-03 1993-11-03 Procedimento per la purificazione della 9-(2-idrossi) etossimetilguanina
PCT/EP1994/000308 WO1995007281A1 (en) 1993-09-10 1994-02-03 A process for the preparation of 9-(2-hydroxy)-ethoxymethyl-guanine

Publications (2)

Publication Number Publication Date
NO960927D0 NO960927D0 (no) 1996-03-07
NO960927L true NO960927L (no) 1996-03-07

Family

ID=26331057

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960927A NO960927L (no) 1993-09-10 1996-03-07 Fremgangsmåte ved fremstilling av 9-(2-hydroksy)-etoksymetylguanin

Country Status (21)

Country Link
US (1) US5756737A (no)
EP (1) EP0717744B1 (no)
JP (1) JPH09502707A (no)
CN (1) CN1041632C (no)
AT (1) ATE152722T1 (no)
AU (1) AU685774B2 (no)
BG (1) BG61569B1 (no)
BR (1) BR9407426A (no)
CA (1) CA2171283A1 (no)
DE (1) DE69403087T2 (no)
DK (1) DK0717744T3 (no)
ES (1) ES2103575T3 (no)
FI (1) FI961054A0 (no)
GR (1) GR3024343T3 (no)
HU (1) HU214841B (no)
NO (1) NO960927L (no)
NZ (1) NZ261573A (no)
PL (1) PL174765B1 (no)
RU (1) RU2125570C1 (no)
SK (1) SK29396A3 (no)
WO (1) WO1995007281A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
IN179493B (no) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
EP0806425B1 (en) * 1996-04-09 2001-08-29 Lupin Laboratories Limited An improved regiospecific process for synthesis of acyclic nucleosides
US6440980B1 (en) * 1996-09-17 2002-08-27 Avanir Pharmaceuticals Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs
US20050176956A1 (en) * 2001-10-15 2005-08-11 Babu Jayachandra S. Process for the preparation of ganciclovir intermediate n2-acetyl-9-(1,3-diacetoxy-2-propoxymethyl) guanine
JP2005519868A (ja) * 2001-10-16 2005-07-07 アバニール・ファーマシューティカルズ ｎ−ドコサノールによるウイルス阻害
WO2004048380A1 (en) * 2002-11-22 2004-06-10 Ranbaxy Laboratories Limited Process for the synthesis of ganciclovir
ES2289650T3 (es) * 2004-03-03 2008-02-01 Chemi S.P.A. Sal monosodica del acido 3-piridil-1-hidroxietiliden-1,1-bifosfonico amorfa y procedimiento para la preparacion de la misma.
US7700694B2 (en) * 2006-04-28 2010-04-20 Tsrc Corporation Catalyst composition and method for hydrogenating a polymer having a conjugated diene
CN117551100B (zh) * 2024-01-12 2024-03-12 苏州诺维康生物科技有限公司 (s)-9-[3-(4,4'-双甲氧基三苯甲基)-2-羟基丙基]-n2-乙酰基鸟嘌呤的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146715A (en) * 1975-08-27 1979-03-27 Burroughs Wellcome Co. 2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines
YU41079B (en) * 1976-08-27 1986-12-31 Wellcome Found Process for the synthesis of substituted purine compounds
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
US4609661A (en) * 1982-08-09 1986-09-02 Syntex (U.S.A.) Inc. Substituted 9-(1-O- or 3-O-monosubstituted or 1,3-di-O-substituted propoxymethyl)purines as antiviral agents
JPS5980685A (ja) * 1982-10-29 1984-05-10 Fujisawa Pharmaceut Co Ltd Ｎ−低級アルカノイルグアニン誘導体およびそれを用いる方法
YU45690B (sh) * 1984-12-22 1992-07-20 Krka Tovarna Zdraviln.Sol.O. Postopek za pripravo 9-(2-hidroksietoksimetil)-gvanina
SU1705296A1 (ru) * 1988-03-31 1992-01-15 Институт Органического Синтеза Ан Латвсср Способ получени 9-(2-оксиэтоксиметил)гуанина
JP3225545B2 (ja) * 1991-09-18 2001-11-05 味の素株式会社 非環状ヌクレオシド類の製造法

Also Published As

Publication number Publication date
FI961054L (fi) 1996-03-07
FI961054A7 (fi) 1996-03-07
CA2171283A1 (en) 1995-03-16
BR9407426A (pt) 1996-04-09
DK0717744T3 (da) 1997-12-08
EP0717744A1 (en) 1996-06-26
HUT74295A (en) 1996-11-28
RU2125570C1 (ru) 1999-01-27
ES2103575T3 (es) 1997-09-16
AU6038394A (en) 1995-03-27
HU9600556D0 (en) 1996-05-28
PL174765B1 (pl) 1998-09-30
ATE152722T1 (de) 1997-05-15
BG100395A (bg) 1996-09-30
NO960927D0 (no) 1996-03-07
BG61569B1 (en) 1997-12-30
CN1130382A (zh) 1996-09-04
WO1995007281A1 (en) 1995-03-16
US5756737A (en) 1998-05-26
NZ261573A (en) 1997-02-24
DE69403087T2 (de) 1997-08-14
EP0717744B1 (en) 1997-05-07
AU685774B2 (en) 1998-01-29
JPH09502707A (ja) 1997-03-18
SK29396A3 (en) 1996-10-02
DE69403087D1 (de) 1997-06-12
HU214841B (hu) 1998-06-29
PL313322A1 (en) 1996-06-24
CN1041632C (zh) 1999-01-13
GR3024343T3 (en) 1997-10-31
FI961054A0 (fi) 1996-03-07

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