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NO960056L - Bicyclic tetrahydropyrazolopyridines - Google Patents

Bicyclic tetrahydropyrazolopyridines

Info

Publication number
NO960056L
NO960056L NO960056A NO960056A NO960056L NO 960056 L NO960056 L NO 960056L NO 960056 A NO960056 A NO 960056A NO 960056 A NO960056 A NO 960056A NO 960056 L NO960056 L NO 960056L
Authority
NO
Norway
Prior art keywords
tetrahydropyrazolopyridines
bicyclic
bicyclic tetrahydropyrazolopyridines
Prior art date
Application number
NO960056A
Other languages
Norwegian (no)
Other versions
NO960056D0 (en
NO305029B1 (en
Inventor
Allen Jacob Duplantier
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO960056L publication Critical patent/NO960056L/en
Publication of NO960056D0 publication Critical patent/NO960056D0/en
Publication of NO305029B1 publication Critical patent/NO305029B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO960056A 1993-07-06 1996-01-05 Bicyclic tetrahydropyrazolopyridines NO305029B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8829293A 1993-07-06 1993-07-06
PCT/IB1994/000156 WO1995001980A1 (en) 1993-07-06 1994-06-16 Bicyclic tetrahydro pyrazolopyridines

Publications (3)

Publication Number Publication Date
NO960056L true NO960056L (en) 1996-01-05
NO960056D0 NO960056D0 (en) 1996-01-05
NO305029B1 NO305029B1 (en) 1999-03-22

Family

ID=22210524

Family Applications (1)

Application Number Title Priority Date Filing Date
NO960056A NO305029B1 (en) 1993-07-06 1996-01-05 Bicyclic tetrahydropyrazolopyridines

Country Status (20)

Country Link
EP (1) EP0707585A1 (en)
JP (1) JP2944048B2 (en)
KR (1) KR100228949B1 (en)
CN (1) CN1048015C (en)
AU (1) AU695301B2 (en)
BR (1) BR9406946A (en)
CA (1) CA2166721C (en)
CZ (1) CZ3696A3 (en)
EG (1) EG20513A (en)
FI (1) FI943208L (en)
HU (1) HUT74170A (en)
IL (1) IL110175A (en)
MX (1) MX9405132A (en)
NO (1) NO305029B1 (en)
NZ (1) NZ266525A (en)
PL (1) PL312426A1 (en)
RU (1) RU2131876C1 (en)
TW (1) TW316904B (en)
WO (1) WO1995001980A1 (en)
ZA (1) ZA944844B (en)

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NZ292991A (en) * 1994-10-20 1999-02-25 Pfizer Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them
DE69525978T2 (en) * 1995-06-06 2002-12-19 Pfizer TRICYCLIC 5,6-DIHYDRO-9H-PYRAZOLO (3,4-C) -1,2,4-TRIAZOLO (4,3-ALPHA) PYRIDINE
AP932A (en) * 1996-08-26 2001-02-02 Pfizer Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines.
JP3554337B2 (en) * 1996-09-04 2004-08-18 ファイザー・インク Indazole derivatives and use of the indazole derivatives as inhibitors of phosphodiesterase (PDE) type 4 and tumor necrosis factor (TNF) production
IL158649A0 (en) * 1997-09-26 2004-05-12 Zentaris Gmbh Azabenzimidazole-based compounds for modulating serine/threonine protein kinase function
US6858616B2 (en) 1998-12-23 2005-02-22 Bristol-Myers Squibb Pharma Company Nitrogen containing heterobicycles as factor Xa inhibitors
IL142959A0 (en) 1998-12-23 2002-04-21 Du Pont Pharm Co Nitrogen containing heterobicycles as factor xa inhibitors
US6326495B2 (en) 1999-04-30 2001-12-04 Pfizer Inc. Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein
EP1671651B1 (en) 1999-08-21 2009-11-11 Nycomed GmbH Synergistic combination of pumafentrine and salmeterol
TWI243055B (en) * 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
BR0113176A (en) * 2000-08-10 2003-06-17 Pharmacia Italia Spa Bicyclo-pyrazole compounds, pharmaceutical compositions comprising the compounds, use of the compounds in the manufacture of medicaments, processes for the preparation of the compounds, combinatorial chemical collection and methods for the treatment of mammals including humans using the compounds.
DE60118004T2 (en) * 2000-08-14 2006-11-16 Ortho-Mcneil Pharmaceutical, Inc. SUBSTITUTED PYRAZOLE
US6960595B2 (en) * 2001-03-23 2005-11-01 Bristol-Myers Squibb Pharma Company 5-6 to 5-7 Heterobicycles as factor Xa inhibitors
US6750225B2 (en) 2001-04-18 2004-06-15 Bristol-Myers Squibb Pharms Company 1,4,5,6-tetrahydropyrazolo-[3,4,-c]-pyridin-7-ones useful as factor Xa inhibitors
CA2441772A1 (en) 2001-04-18 2002-10-31 Bristol-Myers Squibb Company 1,4,5,6-tetrahydropyrazolo-¬3,4-c|-pyridin-7-ones as factor xa inhibitors
JP4196678B2 (en) * 2001-04-26 2008-12-17 味の素株式会社 Heterocyclic compounds
IL160693A0 (en) * 2001-09-21 2004-08-31 Bristol Myers Squibb Co Lactam-containing compounds and derivatives thereof as factor xa inhibitors
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
US7468376B2 (en) 2003-02-27 2008-12-23 Palau Pharma, S.A. Pyrazolopyridine derivates
US7135469B2 (en) * 2003-03-18 2006-11-14 Bristol Myers Squibb, Co. Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors
WO2004087211A2 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
AR050188A1 (en) * 2004-08-03 2006-10-04 Uriach Y Compania S A J CONDENSED HETEROCICLIC COMPOUNDS USED IN THERAPY AS INHIBITORS OF P38 KINASES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE102005031580A1 (en) * 2005-07-06 2007-01-11 Aicuris Gmbh & Co. Kg Substituted sulfolanylpyrazoles and their use
PE20081889A1 (en) * 2007-03-23 2009-03-05 Smithkline Beecham Corp INDOL CARBOXAMIDES AS INHIBITORS OF IKK2
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
DK2681236T3 (en) 2011-03-01 2018-04-16 Synergy Pharmaceuticals Inc PROCEDURE FOR MANUFACTURING GUANYLATE CYCLASE-C-AGONISTS
CA2902348C (en) 2013-02-25 2021-11-30 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
HK1220611A1 (en) 2013-03-15 2017-05-12 Bausch Health Ireland Limited Compositions useful for the treatment of gastrointestinal disorders
CN113388007A (en) 2013-06-05 2021-09-14 博士医疗爱尔兰有限公司 Ultra-pure agonists of guanylate cyclase C, methods of making and using the same
BR112016002789A2 (en) 2013-08-09 2017-11-21 Ardelyx Inc compounds and methods for inhibiting phosphate transport
CN110357888A (en) * 2018-04-09 2019-10-22 南京药捷安康生物科技有限公司 Heterocycle phosphodiesterase inhibitors and application thereof
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3365459A (en) * 1964-09-08 1968-01-23 Ciba Geigy Corp Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives
FR1463883A (en) * 1964-09-08 1966-07-22 Ciba Geigy Process for the preparation of bicyclic triaza-compounds
US3340269A (en) * 1964-09-08 1967-09-05 Ciba Geigy Corp 1-substituted 4-acyl-2, 3-dioxo-piperidine
HU183325B (en) * 1981-02-11 1984-04-28 Richter Gedeon Vegyeszet Process for preparing new apovincaminol-3',4',5'-trimethoxy-benzoates substituted with a nitro group
DE3269604D1 (en) * 1981-06-26 1986-04-10 Schering Corp Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them
FR2525602A1 (en) * 1982-04-21 1983-10-28 Synthelabo IMIDAZO (1,2-A) PYRIDINES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US5356897A (en) * 1991-09-09 1994-10-18 Fujisawa Pharmaceutical Co., Ltd. 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines

Also Published As

Publication number Publication date
FI943208A7 (en) 1995-01-07
MX9405132A (en) 1995-01-31
RU2131876C1 (en) 1999-06-20
FI943208A0 (en) 1994-07-05
HUT74170A (en) 1996-11-28
KR960703852A (en) 1996-08-31
AU6805794A (en) 1995-02-06
CA2166721C (en) 1999-07-27
EP0707585A1 (en) 1996-04-24
WO1995001980A1 (en) 1995-01-19
NZ266525A (en) 1997-10-24
EG20513A (en) 1999-06-30
NO960056D0 (en) 1996-01-05
BR9406946A (en) 1996-08-06
CA2166721A1 (en) 1995-01-19
CN1048015C (en) 2000-01-05
TW316904B (en) 1997-10-01
CZ3696A3 (en) 1997-06-11
IL110175A0 (en) 1994-10-07
ZA944844B (en) 1996-01-05
FI943208L (en) 1995-01-07
NO305029B1 (en) 1999-03-22
PL312426A1 (en) 1996-04-29
JPH08507084A (en) 1996-07-30
HU9503934D0 (en) 1996-03-28
IL110175A (en) 2000-01-31
JP2944048B2 (en) 1999-08-30
CN1129940A (en) 1996-08-28
AU695301B2 (en) 1998-08-13
KR100228949B1 (en) 1999-11-01

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