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NO952677L - Nye dihydropyrrolopyridinon- og oksazolopyridinonforbindelser, deres fremstilling og farmasöytiske preparater - Google Patents

Nye dihydropyrrolopyridinon- og oksazolopyridinonforbindelser, deres fremstilling og farmasöytiske preparater

Info

Publication number
NO952677L
NO952677L NO952677A NO952677A NO952677L NO 952677 L NO952677 L NO 952677L NO 952677 A NO952677 A NO 952677A NO 952677 A NO952677 A NO 952677A NO 952677 L NO952677 L NO 952677L
Authority
NO
Norway
Prior art keywords
alkyl
radical
cycloalkyl
phenyl
hydrogen
Prior art date
Application number
NO952677A
Other languages
English (en)
Other versions
NO952677D0 (no
Inventor
Gerald Guillaumet
Marie-Claude Viaud
Laurence Savelon
Panayota Pavli
Pierre Renard
Bruno Pfeiffer
Daniel-Henri Caignard
Jean-Guy Bizot-Espiard
Gerard Adam
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9408418A external-priority patent/FR2722195B1/fr
Priority claimed from FR9408419A external-priority patent/FR2722196B1/fr
Application filed by Adir filed Critical Adir
Publication of NO952677D0 publication Critical patent/NO952677D0/no
Publication of NO952677L publication Critical patent/NO952677L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Det beskrives forbindelser med den generelle formel (I): O) R, hvor: - Rx er valgt fra hydrogen, alkyl, alkenyl, cyanoalkyl og arylalkyl, Rg W er valgt fra gruppene ¿A-R., and -(AJ^CH^N X Ra er valgt fra alkyl, cykloalkyl, cykloalkylalkyl, fenyl, fenylalkyl, naftyl og naftylalkyl, R, og R4 er valgt, hver uavhengig av den andre, fra hydrogen, alkyl, fenyl, fenylalkyl, cyclokalkyl og cykloalkylalkyl, eller de danner sammmen med nitrogenatomet som bærer dem, et hetero- cyklisk system valgt fra: ¿N ¿ CH og hvor: a representerer et heltall på fra O til 4, b representerer l eller 2, c, d, e og f representerer et heltall på fra O til 4, g representerer 4 eller 5, Z representerer O, S eller N-R,, hvor R7 representerer et hydrogenatom, eller en alkyl-, fenyl-fenylalkyl-, cyklo- alkyl-, cykloalkylalkyl-, benzhydryl-, naftyl-, pyridyl- eller pyrimidylgruppe, n representerer et heltall fra l til 4 inklusive, m representererr O eller l, O OH \\ l A er valgt fra gruppen ~ C ~ og gruppen ¿ CH ¿, Y representerer et oksygenatom eller en gruppe hvor Rs og R« begge er valgt, uavhengig av hverandre, fra hydrogen, et alkylradikal, et cykloalkylradikal, et cyloalkyl- alkylradikal, et fenylradikal og et benzylradikal, deres eventuelle geometriske og/eller optiske isomerer, i ren form eller i form av en blanding, og deres farmasøytisk akseptable addi- sjonssalter med en syre eller en base.
NO952677A 1994-07-07 1995-07-06 Nye dihydropyrrolopyridinon- og oksazolopyridinonforbindelser, deres fremstilling og farmasöytiske preparater NO952677L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9408418A FR2722195B1 (fr) 1994-07-07 1994-07-07 Nouveaux derives de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2(3h)-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR9408419A FR2722196B1 (fr) 1994-07-07 1994-07-07 Nouveaux derives amines de 1,3-dihydro-2h-pyrrolo(2,3-b) pyridin-2-ones et oxazolo(4,5-b) pyridin-2 (3h)-ones, leur procede de preparation et les compositions pharmaceutique qui les contiennent

Publications (2)

Publication Number Publication Date
NO952677D0 NO952677D0 (no) 1995-07-06
NO952677L true NO952677L (no) 1996-01-08

Family

ID=26231276

Family Applications (1)

Application Number Title Priority Date Filing Date
NO952677A NO952677L (no) 1994-07-07 1995-07-06 Nye dihydropyrrolopyridinon- og oksazolopyridinonforbindelser, deres fremstilling og farmasöytiske preparater

Country Status (9)

Country Link
US (2) US5618819A (no)
EP (1) EP0691339A1 (no)
JP (1) JPH0853447A (no)
CN (1) CN1127254A (no)
AU (1) AU683167B2 (no)
CA (1) CA2153294A1 (no)
FI (1) FI953327A7 (no)
NO (1) NO952677L (no)
NZ (1) NZ272516A (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5618819A (en) * 1994-07-07 1997-04-08 Adir Et Compagnie 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds
US6166274A (en) * 1999-12-15 2000-12-26 Atofina Chemicals, Inc. Catalyzed liquid phase fluorination of 1230za
EP2502925A1 (en) * 2004-10-27 2012-09-26 Janssen Pharmaceutica NV Pyridine imidazoles and aza-indoles as progesterone receptor modulators
DE102005007694A1 (de) * 2005-02-18 2006-09-21 Henkel Kgaa Mittel zum Färben von keratinhaltigen Fasern
AR053710A1 (es) * 2005-04-11 2007-05-16 Xenon Pharmaceuticals Inc Compuestos espiroheterociclicos y sus usos como agentes terapeuticos
MY144968A (en) * 2005-04-11 2011-11-30 Xenon Pharmaceuticals Inc Spiro-oxindole compounds and their uses as therapeutic agents
AR053713A1 (es) * 2005-04-20 2007-05-16 Xenon Pharmaceuticals Inc Compuestos heterociclicos y sus usos como agentes terapeuticos
AU2007254179B2 (en) * 2006-05-18 2013-03-21 Pharmacyclics Llc Intracellular kinase inhibitors
AR063280A1 (es) * 2006-10-12 2009-01-21 Xenon Pharmaceuticals Inc Uso de compuestos de espiro-oxindol como agentes terapeuticos
JP2010522690A (ja) * 2006-10-12 2010-07-08 ゼノン・ファーマシューティカルズ・インコーポレイテッド 三環式スピロオキシインドール誘導体および治療薬としてのその使用
CL2007002953A1 (es) * 2006-10-12 2008-02-01 Xenon Pharmaceuticals Inc Compuestos derivados de espiro-oxindol; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en el tratamiento del dolor, cancer, prurito, hiperplasia prostatica benigna, hipercolesterolemia.
EP2184272A4 (en) * 2007-08-21 2011-11-09 Shionogi & Co PIPERAZINE DERIVATIVE
CA2741029A1 (en) * 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
CA2741024A1 (en) * 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
EP3037421A3 (en) 2008-11-25 2016-11-30 University Of Rochester Mlk inhibitors and methods of use
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
US20110086899A1 (en) * 2009-10-14 2011-04-14 Xenon Pharmaceuticals Inc. Pharmaceutical compositions for oral administration
NZ599334A (en) 2009-10-14 2014-03-28 Xenon Pharmaceuticals Inc Synthetic methods for spiro-oxindole compounds
RU2596488C2 (ru) 2010-02-26 2016-09-10 Ксенон Фармасьютикалз Инк. Фармацевтические композиции спиро-оксиндольного соединения для местного введения и их применение в качестве терапевтических агентов
CN103153994B (zh) 2010-05-24 2016-02-10 罗切斯特大学 双环杂芳基激酶抑制剂及使用方法
EP2707373A1 (de) 2011-05-10 2014-03-19 Bayer Intellectual Property GmbH Bicyclische (thio)carbonylamidine
WO2013030344A1 (en) * 2011-09-01 2013-03-07 Dsm Ip Assets B.V. Process for the alkoxycarbonylation of functionalized alkenes
WO2014085795A1 (en) 2012-11-30 2014-06-05 University Of Rochester Mixed lineage kinase inhibitors for hiv/aids therapies
MA41169A (fr) * 2014-12-17 2017-10-24 Acraf Composés antibactériens à large spectre d'activité
US9682033B2 (en) 2015-02-05 2017-06-20 Teva Pharmaceuticals International Gmbh Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2244507A1 (en) * 1973-06-26 1975-04-18 Inst Nat Sante Rech Med Chalcones and analogues - analgesics having low toxicity
US4038396A (en) * 1975-02-24 1977-07-26 Merck & Co., Inc. Anti-inflammatory oxazole[4,5-b]pyridines
JPS6015635B2 (ja) * 1976-05-28 1985-04-20 久光製薬株式会社 新規なオキサゾロ〔４，５−ｂ〕ピリジン誘導体
US4822794A (en) * 1987-05-08 1989-04-18 Rorer Pharmaceutical Corporation Pyridooxazinone-pyridone compounds, cardiotonic compositions including the same, and their uses
US4866074A (en) * 1987-05-08 1989-09-12 Rorer Pharmaceutical Corporation Naphtheridinone- and pyridooxazinone-pyridone compounds, cardiotonic compositions including same, and their uses
FR2650591B1 (fr) * 1989-08-07 1991-11-15 Science Organisation Nouveaux derives d'oxazolo pyridines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2652085A1 (fr) * 1989-09-20 1991-03-22 Science Organisation Nouveau procede de synthese de derives d'oxazolopyridines.
FI922347L (fi) * 1990-01-05 1992-05-22 Pfizer Azaoxindolderivat.
FR2663929A1 (fr) * 1990-06-29 1992-01-03 Adir Nouveaux derives d'oxazolo pyridines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2669336B1 (fr) * 1990-11-20 1993-01-22 Adir Nouveaux derives d'oxazolo pyridines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5618819A (en) * 1994-07-07 1997-04-08 Adir Et Compagnie 1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-(3H)-one compounds

Also Published As

Publication number Publication date
US5767128A (en) 1998-06-16
JPH0853447A (ja) 1996-02-27
CN1127254A (zh) 1996-07-24
NO952677D0 (no) 1995-07-06
FI953327L (fi) 1996-01-08
CA2153294A1 (fr) 1996-01-08
NZ272516A (en) 1996-10-28
AU2482795A (en) 1996-01-18
AU683167B2 (en) 1997-10-30
EP0691339A1 (fr) 1996-01-10
FI953327A7 (fi) 1996-01-08
FI953327A0 (fi) 1995-07-06
US5618819A (en) 1997-04-08

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