NO951201D0 - Fremgangsmåte for fremstilling av taxanderivater - Google Patents

Fremgangsmåte for fremstilling av taxanderivater

Info

Publication number: NO951201D0
Authority: NO; Norway
Prior art keywords: pct; vii; date; alkyl; alkenyl
Prior art date: 1992-10-05

Application number

NO951201A

Other languages

English (en)

Other versions

NO951201L (no

NO309089B1 (no

Inventor

Jean-Manuel Mas

Viviane Massonneau

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-05

Filing date

1995-03-29

Publication date

1995-03-29

1995-03-29 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1995-03-29 Publication of NO951201L publication Critical patent/NO951201L/no

1995-03-29 Publication of NO951201D0 publication Critical patent/NO951201D0/no

2000-12-11 Publication of NO309089B1 publication Critical patent/NO309089B1/no

Links

238000000034 method Methods 0.000 title abstract 2
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title abstract 2
125000003342 alkenyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 abstract 1
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 abstract 1
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000010933 acylation Effects 0.000 abstract 1
238000005917 acylation reaction Methods 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
150000001412 amines Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
150000001602 bicycloalkyls Chemical group 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000008030 elimination Effects 0.000 abstract 1
238000003379 elimination reaction Methods 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

NO951201A 1992-10-05 1995-03-29 FremgangsmÕte for fremstilling av taxanderivater NO309089B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9211741A FR2696458B1 (fr)	1992-10-05	1992-10-05	Procédé de préparation de dérivés du taxane.
PCT/FR1993/000967 WO1994007877A1 (fr)	1992-10-05	1993-10-04	Procede de preparation de derives du taxane

Publications (3)

Publication Number	Publication Date
NO951201L NO951201L (no)	1995-03-29
NO951201D0 true NO951201D0 (no)	1995-03-29
NO309089B1 NO309089B1 (no)	2000-12-11

Family

ID=9434119

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO951201A NO309089B1 (no)	1992-10-05	1995-03-29	FremgangsmÕte for fremstilling av taxanderivater

Country Status (24)

Country	Link
US (3)	US5616739A (no)
EP (1)	EP0663906B1 (no)
JP (1)	JP3014760B2 (no)
KR (1)	KR100311198B1 (no)
AT (1)	ATE146174T1 (no)
AU (1)	AU689080B2 (no)
CA (1)	CA2146250C (no)
CZ (1)	CZ283261B6 (no)
DE (1)	DE69306591T2 (no)
DK (1)	DK0663906T3 (no)
ES (1)	ES2095081T3 (no)
FI (1)	FI109793B (no)
FR (1)	FR2696458B1 (no)
GR (1)	GR3021997T3 (no)
HU (1)	HU226412B1 (no)
MX (1)	MX9305766A (no)
NO (1)	NO309089B1 (no)
NZ (1)	NZ256445A (no)
PL (1)	PL182284B1 (no)
RU (1)	RU2116303C1 (no)
SK (1)	SK280627B6 (no)
TW (1)	TW419472B (no)
WO (1)	WO1994007877A1 (no)
ZA (1)	ZA937318B (no)

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US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
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US5136060A (en) *	1989-11-14	1992-08-04	Florida State University	Method for preparation of taxol using an oxazinone
MX9102128A (es) *	1990-11-23	1992-07-08	Rhone Poulenc Rorer Sa	Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5319112A (en) *	1992-08-18	1994-06-07	Virgnia Tech Intellectual Properties, Inc.	Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol

1992
- 1992-10-05 FR FR9211741A patent/FR2696458B1/fr not_active Expired - Lifetime
1993
- 1993-09-21 MX MX9305766A patent/MX9305766A/es unknown
- 1993-10-01 ZA ZA937318A patent/ZA937318B/xx unknown
- 1993-10-02 TW TW082108117A patent/TW419472B/zh not_active IP Right Cessation
- 1993-10-04 US US08/411,692 patent/US5616739A/en not_active Expired - Lifetime
- 1993-10-04 HU HU9500971A patent/HU226412B1/hu unknown
- 1993-10-04 AT AT93921982T patent/ATE146174T1/de active
- 1993-10-04 CZ CZ95841A patent/CZ283261B6/cs not_active IP Right Cessation
- 1993-10-04 PL PL93308241A patent/PL182284B1/pl unknown
- 1993-10-04 WO PCT/FR1993/000967 patent/WO1994007877A1/fr not_active Ceased
- 1993-10-04 RU RU95113717A patent/RU2116303C1/ru active
- 1993-10-04 CA CA002146250A patent/CA2146250C/fr not_active Expired - Lifetime
- 1993-10-04 NZ NZ256445A patent/NZ256445A/en not_active IP Right Cessation
- 1993-10-04 DE DE69306591T patent/DE69306591T2/de not_active Expired - Lifetime
- 1993-10-04 SK SK436-95A patent/SK280627B6/sk not_active IP Right Cessation
- 1993-10-04 ES ES93921982T patent/ES2095081T3/es not_active Expired - Lifetime
- 1993-10-04 KR KR1019950701302A patent/KR100311198B1/ko not_active Expired - Lifetime
- 1993-10-04 JP JP6508787A patent/JP3014760B2/ja not_active Expired - Lifetime
- 1993-10-04 AU AU51150/93A patent/AU689080B2/en not_active Expired
- 1993-10-04 EP EP93921982A patent/EP0663906B1/fr not_active Expired - Lifetime
- 1993-10-04 DK DK93921982.0T patent/DK0663906T3/da active
1995
- 1995-03-29 NO NO951201A patent/NO309089B1/no not_active IP Right Cessation
- 1995-04-04 FI FI951595A patent/FI109793B/fi not_active IP Right Cessation
1996
- 1996-10-31 US US08/742,101 patent/US5677462A/en not_active Expired - Lifetime
- 1996-12-12 GR GR960402201T patent/GR3021997T3/el unknown
1997
- 1997-08-08 US US08/908,806 patent/US5869680A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP3014760B2 (ja)	2000-02-28
CZ84195A3 (en)	1995-09-13
FR2696458B1 (fr)	1994-11-10
MX9305766A (es)	1995-01-31
CA2146250A1 (fr)	1994-04-14
JPH08501788A (ja)	1996-02-27
ES2095081T3 (es)	1997-02-01
CZ283261B6 (cs)	1998-02-18
HU226412B1 (en)	2008-11-28
PL182284B1 (pl)	2001-12-31
NO951201L (no)	1995-03-29
ATE146174T1 (de)	1996-12-15
PL308241A1 (en)	1995-07-24
EP0663906B1 (fr)	1996-12-11
NO309089B1 (no)	2000-12-11
ZA937318B (en)	1994-04-25
DE69306591D1 (de)	1997-01-23
US5677462A (en)	1997-10-14
RU95113717A (ru)	1996-12-27
CA2146250C (fr)	2003-03-11
RU2116303C1 (ru)	1998-07-27
FI951595A0 (fi)	1995-04-04
HUT72679A (en)	1996-05-28
US5616739A (en)	1997-04-01
SK43695A3 (en)	1995-08-09
DK0663906T3 (da)	1996-12-30
AU689080B2 (en)	1998-03-26
FR2696458A1 (fr)	1994-04-08
WO1994007877A1 (fr)	1994-04-14
GR3021997T3 (en)	1997-03-31
NZ256445A (en)	1997-01-29
HU9500971D0 (en)	1995-06-28
FI109793B (fi)	2002-10-15
AU5115093A (en)	1994-04-26
EP0663906A1 (fr)	1995-07-26
SK280627B6 (sk)	2000-05-16
KR100311198B1 (ko)	2002-04-24
DE69306591T2 (de)	1997-04-17
KR950703546A (ko)	1995-09-20
US5869680A (en)	1999-02-09
TW419472B (en)	2001-01-21
FI951595L (fi)	1995-04-04

Publication	Publication Date	Title
NO951201D0 (no)	1995-03-29	Fremgangsmåte for fremstilling av taxanderivater
ATE148882T1 (de)	1997-02-15	Verfahren zur herstellung von taxan-derivaten
ATE147735T1 (de)	1997-02-15	Verfahren zur herstellung von taxan-derivaten
HUT72616A (en)	1996-05-28	Novel method of esterification of baccatine iii and 10-deacetylbaccatine iii

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2013-11-11	MK1K	Patent expired