NO941128L - Fremgangsmåte til syntese av semisyntetiske glukosaminoglykaner med heparin eller en heparinstruktur modifisert i 2-posisjon av - Google Patents
Fremgangsmåte til syntese av semisyntetiske glukosaminoglykaner med heparin eller en heparinstruktur modifisert i 2-posisjon avInfo
- Publication number
- NO941128L NO941128L NO941128A NO941128A NO941128L NO 941128 L NO941128 L NO 941128L NO 941128 A NO941128 A NO 941128A NO 941128 A NO941128 A NO 941128A NO 941128 L NO941128 L NO 941128L
- Authority
- NO
- Norway
- Prior art keywords
- heparin
- synthesis
- semi
- structure modified
- synthetic
- Prior art date
Links
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical group OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 4
- 229920000669 heparin Polymers 0.000 title abstract 4
- 229960002897 heparin Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract 2
- 229920002971 Heparan sulfate Chemical group 0.000 abstract 2
- 230000000269 nucleophilic effect Effects 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT93BO000125A IT1264101B1 (it) | 1993-03-29 | 1993-03-29 | Processo per la sintesi di glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO941128D0 NO941128D0 (no) | 1994-03-28 |
| NO941128L true NO941128L (no) | 1994-09-30 |
| NO305994B1 NO305994B1 (no) | 1999-08-30 |
Family
ID=11338858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO941128A NO305994B1 (no) | 1993-03-29 | 1994-03-28 | Fremgangsmåte til syntese av semisyntetiske glukosaminoglykaner med heparin- eller en heparanstruktur modifisert i 2-posisjonen av <alfa>-L-iduron-2-O-sulfatsyre |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US5405949A (no) |
| EP (1) | EP0618234B1 (no) |
| JP (1) | JP2731721B2 (no) |
| KR (1) | KR100194122B1 (no) |
| AT (1) | ATE154039T1 (no) |
| AU (1) | AU664939B2 (no) |
| CA (1) | CA2114862C (no) |
| DE (1) | DE69403537T2 (no) |
| DK (1) | DK0618234T3 (no) |
| ES (1) | ES2102087T3 (no) |
| FI (1) | FI105101B (no) |
| GR (1) | GR3024416T3 (no) |
| IL (1) | IL108689A (no) |
| IT (1) | IT1264101B1 (no) |
| NO (1) | NO305994B1 (no) |
| NZ (1) | NZ250815A (no) |
| TW (1) | TW266215B (no) |
| ZA (1) | ZA94970B (no) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6255295B1 (en) | 1996-12-23 | 2001-07-03 | Nutramax Laboratories, Inc. | Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue |
| US7259152B2 (en) | 2000-06-07 | 2007-08-21 | Alfa Wasserman, Inc. | Methods and compositions using sulodexide for the treatment of diabetic nephropathy |
| EP1353556A4 (en) | 2001-01-23 | 2009-09-09 | Massachusetts Inst Technology | SYNTHESIS OF HEPARIN AND OTHER GLYCOSAMINOGLYCANS IN SOLID PHASE AND SOLUTION PHASE |
| PT2343077E (pt) | 2001-09-12 | 2013-08-29 | Sigma Tau Res Switzerland Sa | Derivados de glicosaminoglicanos totalmente n-dessulfatados como inibidores da heparanase, capazes de atividade antiangiogénica e desprovidos de efeito anticoagulante |
| GB0216861D0 (en) * | 2002-07-19 | 2002-08-28 | Univ Birmingham | Saccharide libraries |
| DK3428175T3 (da) | 2016-03-09 | 2024-11-11 | Glytech Inc | Fremgangsmåde til fremstilling af oligosaccharider og polysaccharider med ikke-beskyttede sulfat-grupper |
| WO2021128253A1 (zh) * | 2019-12-27 | 2021-07-01 | 深圳市海普瑞药业集团股份有限公司 | 一种糖胺聚糖衍生物及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4987223A (en) * | 1981-12-23 | 1991-01-22 | Choay S.A. | Derivatives of the uronic acid |
| US6174999B1 (en) * | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
| IT1234508B (it) * | 1988-06-10 | 1992-05-19 | Alfa Wassermann Spa | Derivati eparinici e procedimento per la loro preparazione |
| IT1234826B (it) * | 1989-01-30 | 1992-05-29 | Alfa Wassermann Spa | Derivati eparinici e procedimento per la loro preparazione |
| US5011919A (en) * | 1989-01-30 | 1991-04-30 | Ajorca S.A. | Modified heparins and obtention process |
| IT1242604B (it) * | 1990-11-13 | 1994-05-16 | Alfa Wassermann Spa | Sali di glicosaminoglicani con esteri di aminoacidi, loro preparazione e formulazioni farmaceutiche che li contengono. |
| IT1260137B (it) * | 1992-04-17 | 1996-03-28 | Alfa Wassermann Spa | Glicosaminoglicani semisintetici a struttura eparinica od eparanica modificati nella posizione 2 dell'acido alfa-l-iduronico-2-0-solfato |
| IT1260136B (it) * | 1992-04-17 | 1996-03-28 | Alfa Wassermann Spa | Glicosaminoglicani semisintetici contenenti acido alfa-l-galatturonicosostituito con radicali nucleofili in posizione 3 |
| BE1006134A6 (fr) * | 1992-08-25 | 1994-05-24 | Syntex Sa | Procede de preparation de derives 2-desoxy-2-amino hexuronyles d'heparine, derives tels qu'ainsi obtenus et leur utilisation. |
-
1993
- 1993-03-29 IT IT93BO000125A patent/IT1264101B1/it active IP Right Grant
-
1994
- 1994-02-03 CA CA002114862A patent/CA2114862C/en not_active Expired - Fee Related
- 1994-02-03 NZ NZ250815A patent/NZ250815A/en unknown
- 1994-02-10 AU AU55085/94A patent/AU664939B2/en not_active Ceased
- 1994-02-11 ZA ZA94970A patent/ZA94970B/xx unknown
- 1994-02-17 IL IL108689A patent/IL108689A/en not_active IP Right Cessation
- 1994-02-18 TW TW083101327A patent/TW266215B/zh active
- 1994-03-07 US US08/206,980 patent/US5405949A/en not_active Expired - Lifetime
- 1994-03-18 DE DE69403537T patent/DE69403537T2/de not_active Expired - Fee Related
- 1994-03-18 ES ES94104306T patent/ES2102087T3/es not_active Expired - Lifetime
- 1994-03-18 AT AT94104306T patent/ATE154039T1/de not_active IP Right Cessation
- 1994-03-18 DK DK94104306.9T patent/DK0618234T3/da active
- 1994-03-18 EP EP94104306A patent/EP0618234B1/en not_active Expired - Lifetime
- 1994-03-25 KR KR1019940006018A patent/KR100194122B1/ko not_active Expired - Fee Related
- 1994-03-28 FI FI941431A patent/FI105101B/fi not_active IP Right Cessation
- 1994-03-28 NO NO941128A patent/NO305994B1/no not_active IP Right Cessation
- 1994-03-29 JP JP6059447A patent/JP2731721B2/ja not_active Expired - Fee Related
-
1997
- 1997-08-13 GR GR970402059T patent/GR3024416T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE154039T1 (de) | 1997-06-15 |
| EP0618234A1 (en) | 1994-10-05 |
| TW266215B (no) | 1995-12-21 |
| AU5508594A (en) | 1994-10-06 |
| DK0618234T3 (da) | 1997-08-25 |
| ITBO930125A1 (it) | 1994-09-29 |
| JP2731721B2 (ja) | 1998-03-25 |
| IL108689A (en) | 1998-03-10 |
| NZ250815A (en) | 1996-02-27 |
| GR3024416T3 (en) | 1997-11-28 |
| IL108689A0 (en) | 1994-05-30 |
| IT1264101B1 (it) | 1996-09-10 |
| ITBO930125A0 (it) | 1993-03-29 |
| CA2114862C (en) | 1999-05-25 |
| EP0618234B1 (en) | 1997-06-04 |
| AU664939B2 (en) | 1995-12-07 |
| FI941431A0 (fi) | 1994-03-28 |
| FI105101B (fi) | 2000-06-15 |
| DE69403537D1 (de) | 1997-07-10 |
| FI941431L (fi) | 1994-09-30 |
| NO305994B1 (no) | 1999-08-30 |
| ES2102087T3 (es) | 1997-07-16 |
| ZA94970B (en) | 1994-08-24 |
| KR100194122B1 (ko) | 1999-06-15 |
| CA2114862A1 (en) | 1994-09-30 |
| DE69403537T2 (de) | 1997-09-18 |
| US5405949A (en) | 1995-04-11 |
| JPH06298805A (ja) | 1994-10-25 |
| NO941128D0 (no) | 1994-03-28 |
| KR940021582A (ko) | 1994-10-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO305992B1 (no) | Halvsyntetiske glykosaminglykosaner med heparin- eller heparanstruktur og fremgangsmåte til fremstilling derav | |
| DE68917009D1 (de) | Sulfaminoderivate von Chondroitinsulfat, Dermatansulfat und Hyaluronsäure und ihre pharmakologischen Eigenschaften. | |
| ES2077071T3 (es) | Derivados de quinolin-3-carboxamida. | |
| FI931740A0 (fi) | Semisyntetiska glukosaminoglykaner innehaollande a-l-galakturonsyra somaer substituerad i 3-staellning med nukleofila radikaler | |
| NO941128D0 (no) | Fremgangsmåte til syntese av semisyntetiske glukosaminoglykaner med heparin eller en heparinstruktur modifisert i 2-posisjon av | |
| NO305993B1 (no) | Fremgangsmåte for syntese av semisyntetiske glykosaminoglykaner inneholdende <alfa>-L-galakturonsyre substituert med nukleofile radikaler i 3-stilling |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM1K | Lapsed by not paying the annual fees |