[go: up one dir, main page]

NO940310D0 - Modifiserte oligodeoksyribonukleotider, deres fremstilling og deres terapeutiske anvendelse - Google Patents

Modifiserte oligodeoksyribonukleotider, deres fremstilling og deres terapeutiske anvendelse

Info

Publication number
NO940310D0
NO940310D0 NO940310A NO940310A NO940310D0 NO 940310 D0 NO940310 D0 NO 940310D0 NO 940310 A NO940310 A NO 940310A NO 940310 A NO940310 A NO 940310A NO 940310 D0 NO940310 D0 NO 940310D0
Authority
NO
Norway
Prior art keywords
compounds
groups
sulfur
oxygen
preparation
Prior art date
Application number
NO940310A
Other languages
English (en)
Other versions
NO309427B1 (no
NO940310L (no
Inventor
Hidehiko Furukawa
Kenji Momota
Hitoshi Hotoda
Makoto Koizumi
Masakutsu Kaneko
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of NO940310D0 publication Critical patent/NO940310D0/no
Publication of NO940310L publication Critical patent/NO940310L/no
Publication of NO309427B1 publication Critical patent/NO309427B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C12N15/1132—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses against retroviridae, e.g. HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/336—Modified G
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • AIDS & HIV (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
NO940310A 1993-01-29 1994-01-28 Modifiserte oligodeoksyribonukleotider, preparat for behandling eller profylakse av virusinfeksjoner, anvendelse av forbindelsene til fremstilling av preparatene, samt mellomprodukter for fremstilling av forbindelsene NO309427B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP1350993 1993-01-29
JP13557393 1993-06-07
JP13851793 1993-06-10

Publications (3)

Publication Number Publication Date
NO940310D0 true NO940310D0 (no) 1994-01-28
NO940310L NO940310L (no) 1994-08-01
NO309427B1 NO309427B1 (no) 2001-01-29

Family

ID=27280283

Family Applications (1)

Application Number Title Priority Date Filing Date
NO940310A NO309427B1 (no) 1993-01-29 1994-01-28 Modifiserte oligodeoksyribonukleotider, preparat for behandling eller profylakse av virusinfeksjoner, anvendelse av forbindelsene til fremstilling av preparatene, samt mellomprodukter for fremstilling av forbindelsene

Country Status (18)

Country Link
US (2) US5674856A (no)
EP (1) EP0611075B1 (no)
KR (1) KR100318796B1 (no)
CN (2) CN1039014C (no)
AT (1) ATE146479T1 (no)
AU (1) AU670154B2 (no)
CA (1) CA2114355A1 (no)
CZ (1) CZ287050B6 (no)
DE (1) DE69401136T2 (no)
DK (1) DK0611075T3 (no)
ES (1) ES2098866T3 (no)
FI (1) FI111265B (no)
GR (1) GR3022821T3 (no)
HU (1) HU222834B1 (no)
IL (1) IL108467A (no)
NO (1) NO309427B1 (no)
NZ (2) NZ250795A (no)
RU (1) RU2111971C1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2114355A1 (en) * 1993-01-29 1994-07-30 Hidehiko Furukawa Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
US6291438B1 (en) 1993-02-24 2001-09-18 Jui H. Wang Antiviral anticancer poly-substituted phenyl derivatized oligoribonucleotides and methods for their use
CN1060177C (zh) * 1997-06-28 2001-01-03 中国科学院上海生物化学研究所 3′－单磷酸化寡核苷酸
GB9823646D0 (en) 1997-12-19 1998-12-23 Brax Genomics Ltd Compounds for mass spectrometry
US6995259B1 (en) 1998-10-23 2006-02-07 Sirna Therapeutics, Inc. Method for the chemical synthesis of oligonucleotides
DE10041809A1 (de) * 2000-08-25 2002-03-07 Giesing Michael Arrays immobilisierter Biomoleküle, deren Herstellung und Verwendung
US7205399B1 (en) 2001-07-06 2007-04-17 Sirna Therapeutics, Inc. Methods and reagents for oligonucleotide synthesis
US9394167B2 (en) 2005-04-15 2016-07-19 Customarray, Inc. Neutralization and containment of redox species produced by circumferential electrodes
US20070065877A1 (en) * 2005-09-19 2007-03-22 Combimatrix Corporation Microarray having a base cleavable succinate linker
US8633304B2 (en) * 2009-12-08 2014-01-21 Gifu University Oligonucleotide derivative comprising an aromatic compound
US9927434B2 (en) 2010-01-20 2018-03-27 Customarray, Inc. Multiplex microarray of serially deposited biomolecules on a microarray
CN102766183B (zh) * 2011-05-05 2016-09-14 中国人民解放军军事医学科学院毒物药物研究所 具有抗hiv-1融合活性的修饰的核酸结构
CN116496335B (zh) * 2023-03-21 2024-03-08 中国药科大学 一种修饰核苷酸及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU542967B2 (en) * 1980-02-29 1985-03-28 University Patents Inc. Preparation of oligonucleotides
US4849513A (en) * 1983-12-20 1989-07-18 California Institute Of Technology Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
FR2568254B1 (fr) * 1984-07-25 1988-04-29 Centre Nat Rech Scient Application d'oligonucleotides lies a un agent intercalant, notamment a titre de medicament
US5252760A (en) * 1985-03-28 1993-10-12 Chiron Corporation Method of using colored phosphorylating reagents
US4950745A (en) * 1986-10-30 1990-08-21 Daicel Chemical Industries, Ltd. Process for synthesis of oligonucleotides and compound for forming polymeric protecting group
ATE87932T1 (de) * 1986-12-02 1993-04-15 Centre Nat Rech Scient Alpha-oligonukleotide.
US5276019A (en) * 1987-03-25 1994-01-04 The United States Of America As Represented By The Department Of Health And Human Services Inhibitors for replication of retroviruses and for the expression of oncogene products
US4904582A (en) * 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
WO1990012022A1 (en) * 1989-03-31 1990-10-18 University Patents, Inc. Polynucleotide phosphorodithioates as therapeutic agents for retroviral infections
WO1992008729A1 (en) * 1990-11-20 1992-05-29 Sankyo Company, Limited Antisense nucleic acid derivative
US5672697A (en) * 1991-02-08 1997-09-30 Gilead Sciences, Inc. Nucleoside 5'-methylene phosphonates
US5220003A (en) * 1991-03-29 1993-06-15 The Regents Of The University Of California Process for the synthesis of 2',3'-dideoxynucleosides
JP3061659B2 (ja) * 1991-08-01 2000-07-10 ヤマサ醤油株式会社 ２−｛２−（モノメトキシトリチルオキシ）エチルチオ｝エチル基および該基の使用法
US5646261A (en) * 1992-01-22 1997-07-08 Hoechst Aktiengesellschaft 3'-derivatized oligonucleotide analogs with non-nucleotidic groupings, their preparation and use
KR930016437A (ko) * 1992-01-22 1993-08-26 귀틀라인, 슈미트 올리고뉴클레오티드 유사체, 이의 제조방법 및 용도
CA2114355A1 (en) * 1993-01-29 1994-07-30 Hidehiko Furukawa Modified oligodeoxyribonucleotides, their preparation and their therapeutic use
JPH09208729A (ja) * 1996-02-02 1997-08-12 Sekisui Chem Co Ltd 帯電防止プラスチックプレートもしくはシートの製造方法

Also Published As

Publication number Publication date
CA2114355A1 (en) 1994-07-30
CN1193013A (zh) 1998-09-16
US5807837A (en) 1998-09-15
AU670154B2 (en) 1996-07-04
ATE146479T1 (de) 1997-01-15
DE69401136T2 (de) 1997-07-10
EP0611075B1 (en) 1996-12-18
IL108467A0 (en) 1994-04-12
NO309427B1 (no) 2001-01-29
IL108467A (en) 1999-09-22
AU5473194A (en) 1994-08-04
HUT66266A (en) 1994-10-28
CN1098107A (zh) 1995-02-01
FI111265B (fi) 2003-06-30
FI940425A7 (fi) 1994-11-04
DK0611075T3 (da) 1997-07-07
DE69401136D1 (de) 1997-01-30
HK1000191A1 (en) 1998-01-27
CN1039014C (zh) 1998-07-08
HK1016151A1 (en) 1999-10-29
NZ250795A (en) 1997-04-24
KR940018394A (ko) 1994-08-16
US5674856A (en) 1997-10-07
KR100318796B1 (ko) 2002-06-20
CZ287050B6 (en) 2000-08-16
RU2111971C1 (ru) 1998-05-27
GR3022821T3 (en) 1997-06-30
HU222834B1 (hu) 2003-11-28
CZ19094A3 (en) 1994-12-15
CN1065238C (zh) 2001-05-02
NO940310L (no) 1994-08-01
EP0611075A1 (en) 1994-08-17
HU9400246D0 (en) 1994-05-30
NZ280616A (en) 1997-04-24
ES2098866T3 (es) 1997-05-01
FI940425A0 (fi) 1994-01-28

Similar Documents

Publication Publication Date Title
ATE282614T1 (de) Phenylharnstoff und phenylthioharnstoffderivate
EP1035123A4 (en) NEW HETEROCYCLIC CONNECTIONS
DE3588100D1 (de) Carbamidsäureester-Derivate, Mittel und Herstellungsverfahren
DK0611075T3 (da) Modificerede oligodeoxyribonukleotider, deres fremstilling og terapeutiske anvendelse
DK202388D0 (da) Hidtil ukendte forbindelser
NO942452D0 (no) Amid- og ureaderivater med antihyperkolesteremisk aktivitet, deres fremstilling og terapeutiske anvendelser
DE69120581D1 (de) 1,8-Naphthyridin-2-on-Derivate
DE69522703D1 (de) Aminotetrazol-derivate verwendbar als stickstoff-oxid-synthase inhibitoren
PT90623A (pt) Processo para a preparacao de n-heterociclil-4-guanilalquil-benzamidas uteis como inibidores de protease
DE68908737D1 (de) Imidazol-Verbindungen und diese enthaltende Textilbehandlungs-Zusammenstellungen.
FI881104A0 (fi) Menetelmä antidiabeettisina aineina käytettävien bentsoksatsiinijohdannaisten valmistamiseksi
NO961077L (no) Substituerte benzoltienylpiperaziner, deres anvendelse som medikamenter og fremgangsmåter for fremstilling
DK0745083T3 (da) 2-Heteroaryl-5, 11-dihydro-6H-dipyrido[3, 2-b:2', 3'-e][1, 4]diazepiner og deres anvendelse til forebyggelse eller behandli
ATE137759T1 (de) S'-adenosyl-methionin-decarboxylase-inhibitoren
ATE205209T1 (de) Chinolincarbonsäurederivate und ihre salze
NO961537D0 (no) Salpetersyreestere fra derivater av 2-(2,6-dihalofenylamino)-fenylacetoksyeddiksyre, og deres fremstillingsprosedyrer
DE69116838D1 (de) Bisphosphonsäurederivate, ihre Produktion und ihre Verwendung
ES2077697T3 (es) Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.
ATE44741T1 (de) 2-(n-substituierte guanidino)-4heteroarylthiazole als mittel gegen geschwuere.