[go: up one dir, main page]

NO944888L - 5- (1,2,4-Triazol-1-ylmethyl) -3H-isobenzofuran-1-one derivatives, their preparation and use as aromatase inhibitors - Google Patents

5- (1,2,4-Triazol-1-ylmethyl) -3H-isobenzofuran-1-one derivatives, their preparation and use as aromatase inhibitors

Info

Publication number
NO944888L
NO944888L NO944888A NO944888A NO944888L NO 944888 L NO944888 L NO 944888L NO 944888 A NO944888 A NO 944888A NO 944888 A NO944888 A NO 944888A NO 944888 L NO944888 L NO 944888L
Authority
NO
Norway
Prior art keywords
preparation
isobenzofuran
triazol
ylmethyl
derivatives
Prior art date
Application number
NO944888A
Other languages
Norwegian (no)
Other versions
NO944888D0 (en
Inventor
Peter Clive Cherry
Michael Walter Foxton
Andrew Thomas Merritt
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929212833A external-priority patent/GB9212833D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of NO944888D0 publication Critical patent/NO944888D0/en
Publication of NO944888L publication Critical patent/NO944888L/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Foreliggende oppfinnelse angår heterocykliske forbindel- ser som er inhibitorer for enzymet aromatase, fremgangsmåter for fremstilling av dem, farmasøytiske preparater som innehol- der dem og anvendelse av dem innen medisin. Spesielle forbindelser ifølge oppfinnelsen er forbindel- ser med formel (I) (I) hvor R1 er en cyano- eller nitro-gruppe; R2 er hydrogen eller ett eller flere halogenatomer; R3 er en C^-alkylgruppe og R* er hydrogen eller en Cj. gruppe, eller R3 og R* sammen er en C3_6-cykloalkylgruppe; og Rs er hydrogen eller ett eller flere halogenatomer eller C^j alkoksy-grupper, og farmasøytisk godtagbare salter og solvater derav.The present invention relates to heterocyclic compounds which are inhibitors of the enzyme aromatase, processes for their preparation, pharmaceutical compositions containing them and their use in medicine. Particular compounds of the invention are compounds of formula (I) (I) wherein R 1 is a cyano or nitro group; R 2 is hydrogen or one or more halogen atoms; R 3 is a C 1-4 alkyl group and R * is hydrogen or a C 3. group, or R3 and R * together are a C3-6 cycloalkyl group; and R 5 is hydrogen or one or more halogen atoms or C 1-6 alkoxy groups, and pharmaceutically acceptable salts and solvates thereof.

NO944888A 1992-06-17 1994-12-16 5- (1,2,4-Triazol-1-ylmethyl) -3H-isobenzofuran-1-one derivatives, their preparation and use as aromatase inhibitors NO944888L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929212833A GB9212833D0 (en) 1992-06-17 1992-06-17 Chemical compounds
PCT/EP1993/001520 WO1993025548A1 (en) 1992-06-17 1993-06-14 5-(1,2,4-triazol-1-ylmethyl)-3h-isobenzofuran-1-one derivatives, their preparation and use as aromatase inhibitors

Publications (2)

Publication Number Publication Date
NO944888D0 NO944888D0 (en) 1994-12-16
NO944888L true NO944888L (en) 1995-02-16

Family

ID=26070036

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944888A NO944888L (en) 1992-06-17 1994-12-16 5- (1,2,4-Triazol-1-ylmethyl) -3H-isobenzofuran-1-one derivatives, their preparation and use as aromatase inhibitors

Country Status (1)

Country Link
NO (1) NO944888L (en)

Also Published As

Publication number Publication date
NO944888D0 (en) 1994-12-16

Similar Documents

Publication Publication Date Title
NO986055D0 (en) New heterocyclic compounds, their preparation, pharmaceutical preparations
AU572405B2 (en) Heterocyclic-substituted indole
YU16899A (en) Aralkyl and aralkylidene heterocyclic lactams and imides
ATE241617T1 (en) PYRIMIDINE COMPOUNDS
WO2002051819A3 (en) Heterocyclic compounds having antibacterial activity, process for their preparation and pharmaceutical compositions containing them
NO975987L (en) 4-Phenylaminothiazole derivatives, process for their preparation and pharmaceutical compositions containing said derivatives
AU7517400A (en) N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
NO20053133L (en) Chemical connections.
NZ330973A (en) Azolobenzazepine derivatives as neurologically active agents
NO20003451L (en) 2,3-substituted indole compounds as cox-2 inhibitors
NO954681L (en) Chemical connections
NO20000722L (en) 2- (4-aryl or heteroaryl-piperazin-1-ylmethyl) -1H-indole derivatives
YU86601A (en) Purine derivatives, preparation method and pharmaceutical compositions containing same
NO934836L (en) Process for the preparation and use as a medicament or diagnostic of 2,4-substituted 5- (N-substituted-sulfamoyl) -benzoylguanidines, and medicaments containing them
NO20022232L (en) Imidazole compounds for use as inhibitors of phosphodiesterase VII
IL148875A0 (en) Sulfonyl hydrazide derivatives, their preparation and pharmaceutical compositions containing them
NO964698L (en) Bicyclic amine derivatives as inhibitors of nitric oxide synthetase
NZ516100A (en) Streptogramin derivatives, preparation and compositions containing them
MX9306310A (en) ANTAGONIST COMPOUNDS OF THE 5-HT4 RECEPTOR, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
NO994659L (en) New pyridine derivatives and pharmaceutical preparations containing them
NO960441L (en) Benzopyrans and pharmaceutical compounds containing them
NO20045132L (en) Benzo (c) quinolizine derivatives, their preparation and use as 5alpha-reductase inhibitors
NO944888L (en) 5- (1,2,4-Triazol-1-ylmethyl) -3H-isobenzofuran-1-one derivatives, their preparation and use as aromatase inhibitors
AR027035A1 (en) PIRROLES REPLACED
EP0656355A4 (en) Biphenylmethane derivative and medicine containing the same.