[go: up one dir, main page]

NO933455L - Bis-naftalimider som inneholder aminosyreavledete linkere, for anvendelse som antikreftmidler - Google Patents

Bis-naftalimider som inneholder aminosyreavledete linkere, for anvendelse som antikreftmidler

Info

Publication number
NO933455L
NO933455L NO933455A NO933455A NO933455L NO 933455 L NO933455 L NO 933455L NO 933455 A NO933455 A NO 933455A NO 933455 A NO933455 A NO 933455A NO 933455 L NO933455 L NO 933455L
Authority
NO
Norway
Prior art keywords
bis
amino acid
containing amino
anticancer agents
naphthalimides
Prior art date
Application number
NO933455A
Other languages
English (en)
Other versions
NO180584C (no
NO933455D0 (no
NO180584B (no
Inventor
Jung-Hui Sun
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of NO933455D0 publication Critical patent/NO933455D0/no
Publication of NO933455L publication Critical patent/NO933455L/no
Publication of NO180584B publication Critical patent/NO180584B/no
Publication of NO180584C publication Critical patent/NO180584C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/44—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers
    • C07C209/50—Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of carboxylic acid amides

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO933455A 1991-03-27 1993-09-27 Bisnaftalimider som inneholder aminosyreavledete linkere, for anvendelse som antikreftmidler, samt farmasöytiske preparater NO180584C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67606191A 1991-03-27 1991-03-27
US07/805,044 US5206249A (en) 1991-03-27 1991-12-11 Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
PCT/US1992/002134 WO1992017453A1 (en) 1991-03-27 1992-03-25 Bis-naphthalimides containing amino-acid derived linkers as anticancer agents

Publications (4)

Publication Number Publication Date
NO933455D0 NO933455D0 (no) 1993-09-27
NO933455L true NO933455L (no) 1993-11-26
NO180584B NO180584B (no) 1997-02-03
NO180584C NO180584C (no) 1997-05-14

Family

ID=27101469

Family Applications (1)

Application Number Title Priority Date Filing Date
NO933455A NO180584C (no) 1991-03-27 1993-09-27 Bisnaftalimider som inneholder aminosyreavledete linkere, for anvendelse som antikreftmidler, samt farmasöytiske preparater

Country Status (17)

Country Link
US (1) US5206249A (no)
EP (2) EP0506008A1 (no)
JP (1) JPH06506229A (no)
CZ (1) CZ281868B6 (no)
FI (1) FI934225A7 (no)
HU (1) HUT68969A (no)
IE (1) IE920958A1 (no)
IL (1) IL101380A (no)
MA (1) MA22476A1 (no)
MX (1) MX9201355A (no)
MY (1) MY108433A (no)
NO (1) NO180584C (no)
NZ (1) NZ242126A (no)
SK (1) SK107193A3 (no)
TW (1) TW205547B (no)
WO (1) WO1992017453A1 (no)
YU (1) YU30092A (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5329048A (en) * 1991-03-27 1994-07-12 The Dupont Merck Pharmaceutical Company Process of preparing tetraamino intermediates
US5461176A (en) * 1991-03-27 1995-10-24 The Du Pont Merck Pharmaceutical Company Processes for preparing bis-naphthalimides containing amino-acid derived linkers
WO1993012092A1 (en) * 1991-12-11 1993-06-24 The Du Pont Merck Pharmaceutical Company Highly water soluble bis-naphthalimides useful as anticancer agents
US5235045A (en) * 1992-03-19 1993-08-10 Microbiomed Corporation Non-azo naphthalimide dyes
US5376664A (en) * 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
US5364867A (en) * 1992-11-30 1994-11-15 Sterling Winthrop Inc. 4-phenylpiperdine agents for treating cns disorders
US5359070A (en) * 1993-02-11 1994-10-25 The Du Pont Merck Pharmaceutical Company Unsymmetrical bis-imides as anticancer agents
US5416089A (en) * 1993-06-24 1995-05-16 The Du Pont Merck Pharmaceutical Company Polycyclic and heterocyclic chromophores for bis-imide tumoricidals
US5766600A (en) * 1993-08-09 1998-06-16 Microbiomed Corporation Non-azo naphtalimide dyes and uses for same
IL110460A (en) * 1993-08-18 2001-01-11 Basf Ag Bis-naphthalimides, their preparation and pharmaceutical compositions containing them
US6204243B1 (en) 1993-09-01 2001-03-20 Novatis Ag Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis
AU7831694A (en) * 1993-09-24 1995-04-10 Du Pont Merck Pharmaceutical Company, The Improved methods for preparing bis-imide compounds
US5561042A (en) * 1994-07-22 1996-10-01 Cancer Therapy And Research Center Diamine platinum naphthalimide complexes as antitumor agents
US5604095A (en) * 1994-07-22 1997-02-18 Cancer Therapy & Research Center Unsymmetrically linked bisnaphthalimides as antitumor agents
US5641782A (en) * 1995-02-16 1997-06-24 The Dupont Merck Pharmaceutical Company 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides
FR2751655B1 (fr) * 1996-07-26 1998-08-28 Adir Nouveaux derives de bis-imides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
GB9723407D0 (en) 1997-11-05 1998-01-07 Ciba Geigy Ag Organic compounds
KR100364205B1 (ko) * 1998-07-03 2002-12-11 다이호야쿠힌고교 가부시키가이샤 나프탈이미도벤즈아미드 유도체 또는 그의 염
WO2000051998A1 (en) * 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
US6420344B1 (en) 1999-03-16 2002-07-16 The Regents Of The University Of California Glycosylated polyamines
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
GB0003111D0 (en) 2000-02-10 2000-03-29 Novartis Ag Organic compounds
EP1539150A4 (en) * 2002-07-08 2006-10-11 Chemgenex Pharmaceuticals Inc SYNTHESIS OF NAPHTHALIMIDES, INCLUDING AMONAFIDS, AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME
WO2005074599A2 (en) * 2004-01-30 2005-08-18 Chemgenex Pharmaceuticals, Inc. Naphthalimide dosing by n-acetyl transferase genotyping
AU2005249593A1 (en) * 2004-06-04 2005-12-15 Chemgenex Pharmaceuticals Inc. Methods of treating cellular proliferative disease using naphthalimide and PARP-1 inhibitors
US7947839B2 (en) * 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
US8420665B2 (en) 2008-01-11 2013-04-16 Northwestern University Anti-cancer compounds
BR112012007965B1 (pt) * 2009-10-08 2021-08-17 Angus Chemical Company Composto de poliaminas contendo oxigênio de baixo voc, e, métodos para produzir o mesmo
CN109490291B (zh) * 2018-11-20 2021-05-11 上海应用技术大学 基于吸电子基取代的1,8-萘酰亚胺类化合物作为氟离子的显色试剂的用途
CA3124681A1 (en) * 2018-12-27 2020-07-02 Alucent Biomedical, Inc. Methods for making dimeric naphthalimides and solid state forms of the same

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146720A (en) * 1976-10-27 1979-03-27 Laboratorios Made, S.A. N-aminoethyl-substituted-3-nitronaphthalimides
EP0125439B1 (en) * 1983-04-01 1990-01-24 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
US4665071A (en) * 1984-02-21 1987-05-12 Warner-Lambert Company 3,6-disubstituted-1,8-naphthalimides and methods for their production and use
DE3535496A1 (de) * 1985-10-04 1987-04-16 Bayer Ag Verfahren zur fluoreszenzloeschung und neue kationische naphthalin-peri-dicarbonsaeureimid-derivate
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents

Also Published As

Publication number Publication date
MY108433A (en) 1996-09-30
WO1992017453A1 (en) 1992-10-15
CZ206093A3 (en) 1994-03-16
MX9201355A (es) 1992-10-01
TW205547B (no) 1993-05-11
SK107193A3 (en) 1994-08-10
CZ281868B6 (cs) 1997-03-12
MA22476A1 (fr) 1992-10-01
HU9302719D0 (en) 1993-12-28
JPH06506229A (ja) 1994-07-14
AU666847B2 (en) 1996-02-29
EP0577753A1 (en) 1994-01-12
FI934225L (fi) 1993-10-15
IL101380A (en) 1996-10-31
YU30092A (sr) 1996-01-09
FI934225A0 (fi) 1993-09-27
HUT68969A (en) 1995-08-28
NZ242126A (en) 1996-09-25
EP0506008A1 (en) 1992-09-30
NO180584C (no) 1997-05-14
IL101380A0 (en) 1992-11-15
FI934225A7 (fi) 1993-10-15
NO933455D0 (no) 1993-09-27
NO180584B (no) 1997-02-03
AU1767692A (en) 1992-11-02
IE920958A1 (en) 1992-10-07
US5206249A (en) 1993-04-27

Similar Documents

Publication Publication Date Title
NO933455L (no) Bis-naftalimider som inneholder aminosyreavledete linkere, for anvendelse som antikreftmidler
FI922222A7 (fi) Kopplingsanordning, som foermaor laosa spinalosteosyntesfaestanordningar
FI925615L (fi) Stabiliserade farmaceutiska kompositioner, som innehaoller en HMG-CoA-reduktas-inhibitorfoerening
SE9704545D0 (sv) Novel compounds
SE9704544D0 (sv) Novel compounds
FI924091A7 (fi) Autoriseringsprotokoll som foersiktighetshjaelpmedel
FI933167A0 (fi) N-alkylkinuklidiniumsalter som substans-p antagonister
FI921182A0 (fi) Velangummi som snabbt hydratiseras.
FI921556L (fi) Plasttillslutning som visar otillboerlig anvaendning
FI923281L (fi) Foerbaettrade desinfektionsloesningar, som innehaoller vaeteperoxid
FI920271L (fi) Polyamintioler som straolningsskyddande aemnen.
NO921256D0 (no) Aminosyre-beta-lyaseenzyminhibitor som deodoranter
IT1231012B (it) Composizione farmaceutica per uso orale contenente nac.
FI935944L (fi) Pyratsolopyrimidin- samt pyrimidinylbisfosfonestrar som anti- inflammatorer
FI925330L (fi) Substituerade fenylfenoler som leukotrienantagonister
DE58902438D1 (de) Verpackung fuer kleinteile.
FI921133L (fi) Faktor, som stimulerar neu-receptorn
NO900741D0 (no) Tris-hydroxymethyl-lavere-alkanestere som fettimitasjoner.
FI923841A7 (fi) Substituerade mandelsyraderivat, foerfarande foer deras framstaellning och deras anvaendning som laekemedel
FI930342A0 (fi) Pentapeptider som reglerar immun- och nervsystem
FI903585A0 (fi) Germisidinen koostumus
FI935867L (fi) Tetrahydrobensazepinderivat som inhibiterar lipoxigenas
ES1024388Y (es) Envase para empaquetado.
FI933508L (fi) Bicyklopolyazamakrocyklokarboxylsyrakomplex, konjugat daerav, foerfarande foer deras framstaellning och anvaendning som radiofarmaceutiska medel
ITPR910044A0 (it) Isoparallelometro per uso odontotecnico.