NO931844L - Forbedrede matriks metallproteasehemmere - Google Patents
Forbedrede matriks metallproteasehemmereInfo
- Publication number
- NO931844L NO931844L NO93931844A NO931844A NO931844L NO 931844 L NO931844 L NO 931844L NO 93931844 A NO93931844 A NO 93931844A NO 931844 A NO931844 A NO 931844A NO 931844 L NO931844 L NO 931844L
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- protease inhibitors
- matrix metal
- lower alkyl
- metal protease
- Prior art date
Links
- 239000002184 metal Substances 0.000 title abstract 3
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000011159 matrix material Substances 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyclic amine Chemical class 0.000 abstract 2
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 abstract 1
- 102000035195 Peptidases Human genes 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 150000001408 amides Chemical group 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
Forbindelser med formler: (1) eller (2) der hver R1 er uavhengig av hverandre H eller alkyl (1-8C) og R2 er alkyl (1-8C) eller der prokslmal R1 og R2 tatt sammen er -(CB2)p¿ hvori p - 3-5; R3 er H eller alkyl (1-4C); R4 er samnensmeltet eller konjugert usubstltuert eller substituert bicykloarylmetylen; n er O, l eller 2; m er O eller 1; og X er OR5 eller NHR5 der R5 er H eller substituert eller usubstltuert alkyl (1-12C), aryl (6-12C), arylalkyl (6- 16C); R7 er lavere alkyl (1-4C) eller en acylgruppe, eller X er et amlnosyreresldu eller amld derav; eller X er residuet av et cykllsk amln eller heterocykllsk amln; Y blir valgt fra gruppen som består av R7ONR6CONR6- , R62NCONOR7-, og R6CONOR7-, der hver R6 er uavhengig av hverandre H eller lavere alkyl (1-4C); R7 er lavere alkyl (1-4C) eller en acylgruppe. der -CONR3- er eventuelt l modifisert Isosterlsk form. Forbindelsene er hemnere av matrlksmetallproteaser .
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/615,798 US5183900A (en) | 1990-11-21 | 1990-11-21 | Matrix metalloprotease inhibitors |
| US07/747,751 US5239078A (en) | 1990-11-21 | 1991-08-20 | Matrix metalloprotease inhibitors |
| PCT/US1991/008722 WO1992009563A1 (en) | 1990-11-21 | 1991-11-21 | Improved matrix metalloprotease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO931844D0 NO931844D0 (no) | 1993-05-19 |
| NO931844L true NO931844L (no) | 1993-07-09 |
Family
ID=27376843
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO93931844A NO931844L (no) | 1990-11-21 | 1993-05-19 | Forbedrede matriks metallproteasehemmere |
Country Status (1)
| Country | Link |
|---|---|
| NO (1) | NO931844L (no) |
-
1993
- 1993-05-19 NO NO93931844A patent/NO931844L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO931844D0 (no) | 1993-05-19 |
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