[go: up one dir, main page]

NO934836D0 - Process for the preparation and use as a medicament or diagnostic of 2,4-substituted 5- (N-substituted-sulfamoyl) -benzoylgu anidines, and medicaments containing them - Google Patents

Process for the preparation and use as a medicament or diagnostic of 2,4-substituted 5- (N-substituted-sulfamoyl) -benzoylgu anidines, and medicaments containing them

Info

Publication number
NO934836D0
NO934836D0 NO934836A NO934836A NO934836D0 NO 934836 D0 NO934836 D0 NO 934836D0 NO 934836 A NO934836 A NO 934836A NO 934836 A NO934836 A NO 934836A NO 934836 D0 NO934836 D0 NO 934836D0
Authority
NO
Norway
Prior art keywords
substituted
benzoylgu
anidines
sulfamoyl
medicament
Prior art date
Application number
NO934836A
Other languages
Norwegian (no)
Other versions
NO934836L (en
Inventor
Andreas Weichert
Jacques Mauger
Hans-Jochen Lang
Wolfgang Scholz
Udo Albus
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of NO934836D0 publication Critical patent/NO934836D0/en
Publication of NO934836L publication Critical patent/NO934836L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/64—X and Y being nitrogen atoms, e.g. N-sulfonylguanidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
NO934836A 1992-12-28 1993-12-27 Process for the preparation and use as a medicament or diagnostic of 2,4-substituted 5- (N-substituted-sulfamoyl) -benzoylguanidines, and medicaments containing them NO934836L (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4244318 1992-12-28

Publications (2)

Publication Number Publication Date
NO934836D0 true NO934836D0 (en) 1993-12-27
NO934836L NO934836L (en) 1994-06-29

Family

ID=6476700

Family Applications (1)

Application Number Title Priority Date Filing Date
NO934836A NO934836L (en) 1992-12-28 1993-12-27 Process for the preparation and use as a medicament or diagnostic of 2,4-substituted 5- (N-substituted-sulfamoyl) -benzoylguanidines, and medicaments containing them

Country Status (7)

Country Link
EP (1) EP0604852A1 (en)
JP (1) JPH06234730A (en)
AU (1) AU5271693A (en)
CA (1) CA2112194A1 (en)
FI (1) FI935825A7 (en)
HU (1) HU9303749D0 (en)
NO (1) NO934836L (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW250479B (en) * 1992-12-15 1995-07-01 Hoechst Ag
DE4328352A1 (en) 1993-08-24 1995-03-02 Hoechst Ag Substituted N, N'-di-benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
IL114670A0 (en) * 1994-08-05 1995-11-27 Fujisawa Pharmaceutical Co Guanidine derivatives pharmaceutical compositions containing the same and processes for the preparation thereof
DE4430213A1 (en) * 1994-08-28 1996-02-29 Merck Patent Gmbh Arylbenzoylguanidine
DE4432105A1 (en) * 1994-09-09 1996-03-14 Hoechst Ag Fluoro-alkyl / alkenyl-substituted benzoylguanidines, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
TW372967B (en) * 1994-12-27 1999-11-01 Kanebo Ltd 1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof
US6057322A (en) * 1995-01-30 2000-05-02 Hoechst Aktiengesellschaft Basically-substituted benzoylguanidines, a process for preparing them, their use as a medicament or diagnostic agent, and a medicament containing them
ATE185557T1 (en) * 1995-01-30 1999-10-15 Hoechst Ag BASIC-SUBSTITUTED BENZOYLGUANIDINES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICATION OR DIAGNOSTIC AND THE MEDICATION CONTAINING THEM
DE19529612A1 (en) * 1995-08-11 1997-02-13 Merck Patent Gmbh Sulfonyl or sulfinyl benzoylguanidine derivatives
EP0765867A1 (en) * 1995-09-27 1997-04-02 Hoechst Aktiengesellschaft Substituted benzoyl guanidines, process for their preparation, their use as antiarrhythmics or diagnostic agent as well as pharmaceuticals containing them
DE19540995A1 (en) * 1995-11-03 1997-05-07 Hoechst Ag Substituted sulfonimidamides, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
DE19542306A1 (en) * 1995-11-14 1997-05-15 Hoechst Ag Sulfonylamino-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic agent, and medicament containing them
PL316439A1 (en) * 1995-11-20 1997-05-26 Hoechst Ag Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such
DE19546736A1 (en) * 1995-12-14 1997-06-19 Hoechst Ag Substituted chromanylsulfonyl (thio) ureas, process for their preparation and their use in the manufacture of pharmaceutical preparations
DE19603425A1 (en) * 1996-01-31 1997-08-07 Hoechst Ag Substituted diaryldicarboxylic acid diguanidides, processes for their preparation, their use as medicaments or diagnostic agents and medicaments containing them
JPH09291076A (en) * 1996-04-24 1997-11-11 Sumitomo Pharmaceut Co Ltd Substituted guanidine derivative and process for producing the same
BE1012386A3 (en) * 1999-01-15 2000-10-03 Univ Liege SULFONAMIDES benzene DERIVATIVES AND USES THEREOF.
DE19951418A1 (en) * 1999-10-26 2001-05-03 Merck Patent Gmbh Process for the preparation of N- (4,5-bismethanesulfonyl-2-methyl-benzoyl) guanidine, hydrochloride
DE10060809A1 (en) * 2000-12-07 2002-06-20 Aventis Pharma Gmbh Substituted anthranilic acids, their use as medicaments or diagnostic agents, as well as medicaments containing them, and a combined pharmaceutical preparation with a sodium / hydrogen exchange (NHE) blocker

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3929582A1 (en) * 1989-09-06 1991-03-07 Hoechst Ag BENZOYLGUANIDINE, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICINE AND THE MEDICINE CONTAINING IT

Also Published As

Publication number Publication date
FI935825L (en) 1994-06-29
JPH06234730A (en) 1994-08-23
AU5271693A (en) 1994-07-07
CA2112194A1 (en) 1994-06-29
FI935825A7 (en) 1994-06-29
HU9303749D0 (en) 1994-04-28
FI935825A0 (en) 1993-12-23
EP0604852A1 (en) 1994-07-06
NO934836L (en) 1994-06-29

Similar Documents

Publication Publication Date Title
NO934836D0 (en) Process for the preparation and use as a medicament or diagnostic of 2,4-substituted 5- (N-substituted-sulfamoyl) -benzoylgu anidines, and medicaments containing them
FI930601A7 (en) 3,5-substituted benzoylguanidines, a process for their preparation, their use as a medicinal substance or diagnostic substance, and a medicinal substance containing them
PH23014A (en) Novel insulin derivatives,their use and pharmaceutical agents for the treatment of diabetes mellitus
FI911718A7 (en) 3,5-substituted 2-isoxazolines and isoxazoles, a process for their preparation, medicaments containing them and their use
NO880473L (en) PROCEDURE FOR THE PREPARATION OF SUBSTITUTED 3,4-DIHYDRO-2H-BENZOPYRANES AND THEIR USE AS A MEDICINE.
NO883465D0 (en) PROCEDURE AND INTERMEDIATE PRODUCTS FOR THE PREPARATION OF 1-PHENYL-3- (1-PIPERAZINYL) -1H-INDAZOLES, AND USE THEREOF AS MEDICINES.
NO960364L (en) Basic-substituted benzolguanidines, process for their preparation, their use as a drug or diagnostic, and drug containing the compound
NO308527B1 (en) Substituted 2-naphthoylguanidines, their use in the manufacture of a medicament and medicaments and preparations containing the compounds
AU4246489A (en) New benzoxazolinone derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
NO964053D0 (en) Substituted benzoylguanidines, processes for their preparation, their use as a drug or diagnostic, and medicaments containing the compounds
NO862198D0 (en) 1,8-BROWN-CONNECTED 4-CHINOLON-3-CARBOXYLIC ACIDS, PROCEDURES FOR THEIR PREPARATION, AND THEIR PRODUCTS CONTAINING THEM, AND THEIR USE FOR THE PREPARATION OF THE MEDICINAL PRODUCT.
DK617684A (en) 1,3-DIOXOLANEL DERIVATIVES, PROCEDURES FOR THEIR PREPARATION, THEIR USE AND THE MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
NO883986D0 (en) PROCEDURE FOR THE PREPARATION OF N- (SUBSTITUTED ALKYLIDE) -1,2,3,4-TETRAHYDRO-9 ACRIDINAMINES AND USE THEREOF AS MEDICINES.
NO306993B1 (en) Piperidinylmethyloxyzolidin-2-one derivatives, pharmaceutical preparations containing such, and use of the compounds in the manufacture of medicinal products
FI960688L (en) Substituted benzenesulfonylureas and thioureas, a process for their preparation and the use of pharmaceutical preparations based on these compounds, and medicaments containing them
NO972434L (en) Substituted 1-Naphthoylguanidines, Methods of Preparation thereof, Their Use as a Drug or Diagnostic, and Medicines Containing the Compounds
DK410185D0 (en) 7-OXO-4-THIA-1-AZABICYCLO (3,2,0) HEPT-2-EN-DERIVATIVES, THEIR PREPARATION AND USE AS MEDICINAL PRODUCTS, AND THE PRODUCT USED INTERMEDIATELY
DK256689A (en) 1,2-DITHIOL-3-THION-S-OXIDE COMPOUNDS FOR USE AS MEDICINAL PRODUCTS
NO894516D0 (en) PROCEDURE FOR THE PREPARATION OF 1-AMINOALKYL-3-OXO SUBSTITUTED-4-ARYL-1,3,4,5-TETRAHYDRO-2H-1,3-BENZODIAZEPIN-2-ON, AND THEIR USE AS MEDICINES.
FI950575A7 (en) 3- and 5-substituted 1,2,3,4-oxatriazol-5-imine compounds, their preparation process, pharmaceutical preparation containing said compounds and use of said compounds for the preparation of medicaments
DK365087A (en) 1,3,5-TRITHIAND DERIVATIVES, PROCEDURES FOR THE PREPARATION OF SUCH COMPOUNDS AND MEDICINAL CONTAINING THESE
NO308793B1 (en) Orthosubstituted benzoylguanidines, their use in the manufacture of medicaments and medicinal products containing the compounds
NO960411D0 (en) Substituted thiophenylsulfonylureas and thioureas, their method of preparation, their use as a medicament or diagnostic, and medicaments containing them
NO901892D0 (en) PROCEDURE FOR THE PREPARATION OF (2,1-C) (1,3) -BENZODIAZEPINES AND THEIR USE AS MEDICINES.
AU2273088A (en) Pharmaceutical products containing a 7-diphenylmethylene- bicycloheptane or 7-diphenylmethylenebicycloheptene derivative, the use of these compounds as medicaments, and new 7-diphenylmethylenebicycloheptanes and 7-diphenylmethylene-bicycloheptenes and processes for the preparation thereof