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NO934700L - Abrin variants, abrin immunotoxins and pharmaceutical compositions containing these - Google Patents

Abrin variants, abrin immunotoxins and pharmaceutical compositions containing these

Info

Publication number
NO934700L
NO934700L NO934700A NO934700A NO934700L NO 934700 L NO934700 L NO 934700L NO 934700 A NO934700 A NO 934700A NO 934700 A NO934700 A NO 934700A NO 934700 L NO934700 L NO 934700L
Authority
NO
Norway
Prior art keywords
abrin
immunotoxins
variants
pharmaceutical compositions
compositions containing
Prior art date
Application number
NO934700A
Other languages
Norwegian (no)
Other versions
NO934700D0 (en
Inventor
Aslak Godal
Original Assignee
Hafslund Nycomed As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hafslund Nycomed As filed Critical Hafslund Nycomed As
Publication of NO934700D0 publication Critical patent/NO934700D0/en
Publication of NO934700L publication Critical patent/NO934700L/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C07K14/42—Lectins, e.g. concanavalin, phytohaemagglutinin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6819—Plant toxins
    • A61K47/6821—Plant heterodimeric toxins, e.g. abrin or modeccin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6819—Plant toxins
    • A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Visse naturlig forekommende holotoksin varianter av plantetoksinet abrin er beskrevet. Holotoksin variantene mangler celle-bindende aktivitet og kan kobles til ligander som for eksempel antistoffer eller lektiner for fremstilling av immunotoksiner. Immuno-toksinene kan formuleres i farmasøytiske blandinger.Certain naturally occurring holotoxin variants of the plant toxin abrin are described. The holotoxin variants lack cell-binding activity and can be linked to ligands such as antibodies or lectins to produce immunotoxins. The immunotoxins can be formulated in pharmaceutical compositions.

NO934700A 1991-06-21 1993-12-20 Abrin variants, abrin immunotoxins and pharmaceutical compositions containing these NO934700L (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919113475A GB9113475D0 (en) 1991-06-21 1991-06-21 Chemical compound
PCT/EP1992/001419 WO1993000367A1 (en) 1991-06-21 1992-06-20 Abrin variants and immunnotoxins

Publications (2)

Publication Number Publication Date
NO934700D0 NO934700D0 (en) 1993-12-20
NO934700L true NO934700L (en) 1993-12-20

Family

ID=10697123

Family Applications (1)

Application Number Title Priority Date Filing Date
NO934700A NO934700L (en) 1991-06-21 1993-12-20 Abrin variants, abrin immunotoxins and pharmaceutical compositions containing these

Country Status (5)

Country Link
EP (1) EP0590011A1 (en)
JP (1) JPH06510525A (en)
GB (1) GB9113475D0 (en)
NO (1) NO934700L (en)
WO (1) WO1993000367A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994002174A1 (en) * 1992-07-28 1994-02-03 Toray Industries, Inc. Immunocomplex
KR20090073255A (en) * 2006-10-27 2009-07-02 트르스티스 오브 보스톤 유니버시티 Targeted fission biomolecular conjugates for treating diseases, malignancies and disorders, and methods of generating the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2575160B1 (en) * 1984-12-21 1987-03-20 Sanofi Sa MONOVALENT CARBOXYLIC IONOPHORE COMPOUNDS
JPH02502251A (en) * 1987-11-13 1990-07-26 ヘルマン　カーティンガー Human monoclonal anti-HIV-1-antibodies

Also Published As

Publication number Publication date
EP0590011A1 (en) 1994-04-06
NO934700D0 (en) 1993-12-20
WO1993000367A1 (en) 1993-01-07
GB9113475D0 (en) 1991-08-07
JPH06510525A (en) 1994-11-24

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