[go: up one dir, main page]

NO922291L - 7-azaisoindolinyl-kinolon- og naftyridonkarboksylsyrederivater - Google Patents

7-azaisoindolinyl-kinolon- og naftyridonkarboksylsyrederivater

Info

Publication number
NO922291L
NO922291L NO92922291A NO922291A NO922291L NO 922291 L NO922291 L NO 922291L NO 92922291 A NO92922291 A NO 92922291A NO 922291 A NO922291 A NO 922291A NO 922291 L NO922291 L NO 922291L
Authority
NO
Norway
Prior art keywords
hydroxy
amino
methyl
acid derivatives
methylamino
Prior art date
Application number
NO92922291A
Other languages
English (en)
Other versions
NO922291D0 (no
Inventor
Uwe Petersen
Andreas Krebs
Thomas Schenke
Klaus Grohe
Klaus-Dieter Bremm
Rainer Endermann
Karl-Georg Metzger
Hans-Joachim Zeiler
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of NO922291D0 publication Critical patent/NO922291D0/no
Publication of NO922291L publication Critical patent/NO922291L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Kinolin- og naftyridonkarboksylsyre-derivater med formel (I). der. Xbetyr halogen,. betyr hydrogen, amino, C-alkylamino, di-C-alkylamino,. hydroksy, C,.-alkoksy, merkapto, C-alkyltio, aryltio,. halogen eller metyl,. betyr C,.-alkyl, C.-alkenyl, C-cykloalkyl, 2-hydroksye-. tyl, 2-fluoretyl, metoksy, amino, metylamino, etylamino,. dimetylamino, eventuelt med 1 eller 2 fluoratomer sub-. stituerte fenyl,. Rbetyr hydrogen, eventuelt med hydroksy, metoksy, amino,. metylamino eller dimetylamino substituert C-alkyl eller (5-metyl-2-okso-l,3-dioksol-4-yl)-metyl,. Z betyr en rest med strukteren. der substituentene har forskjellige betydninger, og disses farmasøytisk godtagbare hydrater og syreaddisjonssalter samt alkali-, jordalkali-, sølv- og guanidiniumsalter.orbindelsene rapporteres å ha antibakteriell virkning. Forbindelsenes fremstilling beskrives.
NO92922291A 1991-06-27 1992-06-11 7-azaisoindolinyl-kinolon- og naftyridonkarboksylsyrederivater NO922291L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4121214A DE4121214A1 (de) 1991-06-27 1991-06-27 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate

Publications (2)

Publication Number Publication Date
NO922291D0 NO922291D0 (no) 1992-06-11
NO922291L true NO922291L (no) 1992-12-28

Family

ID=6434855

Family Applications (1)

Application Number Title Priority Date Filing Date
NO92922291A NO922291L (no) 1991-06-27 1992-06-11 7-azaisoindolinyl-kinolon- og naftyridonkarboksylsyrederivater

Country Status (17)

Country Link
US (2) US5312823A (no)
EP (1) EP0520277A3 (no)
JP (1) JPH05213947A (no)
KR (1) KR930000514A (no)
CN (1) CN1068114A (no)
AU (2) AU647627B2 (no)
CA (1) CA2072207A1 (no)
CZ (1) CZ192892A3 (no)
DE (1) DE4121214A1 (no)
FI (1) FI922953A7 (no)
HU (1) HUT61545A (no)
IE (1) IE922099A1 (no)
IL (1) IL102288A0 (no)
MX (1) MX9203228A (no)
NO (1) NO922291L (no)
TW (1) TW209218B (no)
ZA (1) ZA924743B (no)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
AU4272793A (en) * 1993-04-24 1994-11-21 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
DE4339134A1 (de) * 1993-11-16 1995-05-18 Bayer Ag 1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
DE4427530A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
DE4435479A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
DE19500792A1 (de) * 1995-01-13 1996-07-18 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
EP1358185A2 (en) 2001-02-07 2003-11-05 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods
GEP20105124B (en) 2005-07-25 2010-11-25 Array Biopharma Inc Novel macrocyclic inhibitors of hepatitis c virus replication
FR2891274B1 (fr) * 2005-09-27 2007-11-23 Pierre Fabre Medicament Sa Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires.
CN102443015A (zh) * 2010-10-13 2012-05-09 南京明生医药技术有限公司 一种7-取代喹啉羧酸衍生物及其制备方法和在抗菌抗结核上的应用
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
CN103351348A (zh) * 2013-07-15 2013-10-16 黄河三角洲京博化工研究院有限公司 一种2-甲胺基嘧啶盐酸盐的合成方法
UA118201C2 (uk) 2013-11-26 2018-12-10 Ф. Хоффманн-Ля Рош Аг НОВИЙ ОКТАГІДРОЦИКЛОБУТА[1,2-c;3,4-c']ДИПІРОЛ-2-ІЛ
JP6466461B2 (ja) 2014-02-03 2019-02-06 ヴァイティー ファーマシューティカルズ，インコーポレイテッド Ｒｏｒガンマのジヒドロピロロピリジン阻害剤
CA2937616A1 (en) 2014-03-26 2015-10-01 F. Hoffmann-La Roche Ag Bicyclic compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
WO2016046837A1 (en) * 2014-09-22 2016-03-31 Cadila Healthcare Limited An improved process for preparation of pyrrolo[3,4- c] pyrrole compounds and intermediates thereof
EP3207043B3 (en) 2014-10-14 2019-10-02 Vitae Pharmaceuticals, LLC Dihydropyrrolopyridine inhibitors of ror-gamma
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
EP3331876B1 (en) 2015-08-05 2020-10-07 Vitae Pharmaceuticals, LLC Modulators of ror-gamma
PE20180479A1 (es) 2015-09-04 2018-03-07 Hoffmann La Roche Nuevos derivados de fenoximetilo
AU2016328535A1 (en) 2015-09-24 2017-11-09 F. Hoffmann-La Roche Ag Bicyclic compounds as ATX inhibitors
JP6845230B2 (ja) 2015-09-24 2021-03-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物
EP3353178B1 (en) * 2015-09-24 2021-07-14 F. Hoffmann-La Roche AG Bicyclic compounds as dual atx/ca inhibitors
JP6914257B2 (ja) 2015-11-20 2021-08-04 ヴァイティー ファーマシューティカルズ，エルエルシー Ｒｏｒ−ガンマのモジュレーター
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
JP7090099B2 (ja) 2017-03-16 2022-06-23 エフ．ホフマン－ラ ロシュ アーゲー Ａｔｘインヒビターとしての新規二環式化合物
CN110392679B (zh) 2017-03-16 2023-04-07 豪夫迈·罗氏有限公司 可用作双重atx/ca抑制剂的杂环化合物
SMT201900517T1 (it) 2017-03-20 2019-11-13 Forma Therapeutics Inc Composizioni di pirrolopirrolo come attivatori di piruvato chinasi (pkr)
WO2019023207A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. Inhibitors of rorϒ
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
US20200129485A1 (en) 2018-09-19 2020-04-30 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
CN113226356B (zh) 2018-09-19 2025-03-04 诺沃挪第克健康护理股份公司 活化丙酮酸激酶r
CN109942488A (zh) * 2019-04-04 2019-06-28 山东省联合农药工业有限公司 一种喹啉羧酸酯类化合物及其制备方法与用途
CN114615977B (zh) 2019-09-19 2025-01-14 诺沃挪第克健康护理股份公司 丙酮酸激酶r(pkr)活化组合物
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
CN113307768B (zh) * 2021-04-29 2023-12-12 中国农业科学院兰州畜牧与兽药研究所 喹诺酮类衍生物及其制备方法和用途
CN115251064B (zh) * 2021-04-29 2023-08-29 山东省联合农药工业有限公司 一种杀菌杀虫组合物及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
DE3577089D1 (de) * 1984-01-26 1990-05-17 Abbott Lab Antibakterielle chinolinderivate.
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
JPH0262875A (ja) * 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
KR910009333B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
KR910009330B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
DE4123918A1 (de) * 1991-07-19 1993-01-21 Bayer Ag 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren
US5412098A (en) * 1991-12-27 1995-05-02 Wakunaga Seiyaku Kabushiki Kaisha Quinolone derivative or salt thereof and antibacterial containing the same
TW209865B (no) * 1992-01-10 1993-07-21 Bayer Ag

Also Published As

Publication number Publication date
DE4121214A1 (de) 1993-01-14
AU5304094A (en) 1994-03-03
IL102288A0 (en) 1993-01-14
CA2072207A1 (en) 1992-12-28
KR930000514A (ko) 1993-01-15
FI922953A0 (fi) 1992-06-25
NO922291D0 (no) 1992-06-11
EP0520277A3 (en) 1993-01-13
HUT61545A (en) 1993-01-28
MX9203228A (es) 1992-12-01
EP0520277A2 (de) 1992-12-30
AU1803092A (en) 1993-01-07
US5371090A (en) 1994-12-06
CZ192892A3 (en) 1993-01-13
ZA924743B (en) 1993-03-31
US5312823A (en) 1994-05-17
FI922953A7 (fi) 1992-12-28
IE922099A1 (en) 1992-12-30
TW209218B (no) 1993-07-11
CN1068114A (zh) 1993-01-20
HU9202145D0 (en) 1992-10-28
JPH05213947A (ja) 1993-08-24
AU647627B2 (en) 1994-03-24

Similar Documents

Publication Publication Date Title
NO922291L (no) 7-azaisoindolinyl-kinolon- og naftyridonkarboksylsyrederivater
PL292101A1 (en) Method of obtaining novel derivatives of cyclopentylpurine and cyclopentylpyrimidine
ATE157368T1 (de) 6-0-methylerythromycin a-derivat
ES474215A1 (es) Procedimiento para la preparacion de derivados imidazolile- tiloxialcoxilicos y sus analogos con agrupacion tio
DK616388A (da) Quinolincarboxylsyre-derivater og fysiologisk acceptable salte deraf med antibakteriel virkning
OA06263A (fr) Dérivés acylés.
DK538886A (da) 3-oxadiazol- og 3-carbonsyre-beta-carbolinderivater, deres fremstilling og deres anvendelse som laegemiddel
LV5269A3 (lv) Pristinamicina p beta atvasinajumu iegusanas panemiens izomeru vai to maisijuma veida vai skabju-aditivo saju veida
SE7710873L (sv) Nya 1h-pyrazolo(3,4-b)pyridiner
ES8609328A1 (es) Un procedimiento para la preparacion de nuevos derivados de guanina.
DE68919945D1 (de) Substituierte beta-Diketone.
DK327286D0 (da) Indolcarboxamidderivater og salte deraf, deres fremstilling og anvendelse som laegemidler samt mellemprodukter til deres fremstilling
EP0677522A4 (en) 8-methoxyquinolonecarboxylic acid derivative.
IL74556A (en) Derivatives of 1,5-diaryl-1,2,4-thiadiazine 1-oxide,their preparation and pharmaceutical compositions containing them
ES2121576T3 (es) Compuestos antibioticos de carbapenem.
DK96086A (da) 8-thiotetrahydroquinolinderivater, deres fremstilling og anvendelse som laegemidler
ES547604A0 (es) Un procedimiento para preparar derivados de 2-piridin-tiol
DK0538517T3 (da) Nye organo-tinforbindelser med antitumoraktivitet og antitumormidler
ATE119907T1 (de) Thiadiazolylacetamid-cephemderivate.
IE873442L (en) Cephalosporin derivative
NZ221004A (en) 2,6-piperazinediones and pharamceutical compositions
ATE115582T1 (de) Cephalosporinderivate.
DE69301639D1 (de) Tetrahydronaphtalenderivate, ihre Herstellung und ihre therapeutische Verwendung
GR3002417T3 (en) Derivatives of 8-phenylthiotetrahydroquinolines and their salts, their synthesis for use as medicaments and compositions containing them
SE8400451L (sv) Bronkutvidgande azapinol(1-2-a)pyrimidinderivat och syraadditionssalter derav samt farmaceutiska kompositioner innehallande desamma