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NO920277D0 - Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen - Google Patents

Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen

Info

Publication number
NO920277D0
NO920277D0 NO920277A NO920277A NO920277D0 NO 920277 D0 NO920277 D0 NO 920277D0 NO 920277 A NO920277 A NO 920277A NO 920277 A NO920277 A NO 920277A NO 920277 D0 NO920277 D0 NO 920277D0
Authority
NO
Norway
Prior art keywords
compound
preparing
procedure
chemical
chemical compound
Prior art date
Application number
NO920277A
Other languages
English (en)
Other versions
NO920277L (no
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of NO920277L publication Critical patent/NO920277L/no
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Priority to NO920277A priority Critical patent/NO920277D0/no
Publication of NO920277D0 publication Critical patent/NO920277D0/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04Heterocyclic radicals containing only oxygen as ring hetero atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
NO920277A 1987-08-04 1992-01-22 Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen NO920277D0 (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO920277A NO920277D0 (no) 1987-08-04 1992-01-22 Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives
NO883299A NO170284C (no) 1987-08-04 1988-07-26 Analogifremgangsmaate til fremstilling av farmakologisk aktive 4'-fo sfatderivater av 4'-demetylepipodofyllotoksinglukosider
NO920277A NO920277D0 (no) 1987-08-04 1992-01-22 Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen

Publications (2)

Publication Number Publication Date
NO920277L NO920277L (no) 1989-02-24
NO920277D0 true NO920277D0 (no) 1992-01-22

Family

ID=26765636

Family Applications (4)

Application Number Title Priority Date Filing Date
NO883299A NO170284C (no) 1987-08-04 1988-07-26 Analogifremgangsmaate til fremstilling av farmakologisk aktive 4'-fo sfatderivater av 4'-demetylepipodofyllotoksinglukosider
NO920277A NO920277D0 (no) 1987-08-04 1992-01-22 Kjemisk forbindelse og fremgangsmaate til fremstilling derav, samt anvendelse av forbindelsen
NO920665A NO172440C (no) 1987-08-04 1992-02-20 Kjemisk forbindelse
NO1998002C NO1998002I1 (no) 1987-08-04 1998-01-14 Etoposide-fosfat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO883299A NO170284C (no) 1987-08-04 1988-07-26 Analogifremgangsmaate til fremstilling av farmakologisk aktive 4'-fo sfatderivater av 4'-demetylepipodofyllotoksinglukosider

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO920665A NO172440C (no) 1987-08-04 1992-02-20 Kjemisk forbindelse
NO1998002C NO1998002I1 (no) 1987-08-04 1998-01-14 Etoposide-fosfat

Country Status (34)

Country Link
US (3) US4904768A (no)
JP (1) JPH0699465B2 (no)
KR (1) KR900006230B1 (no)
CN (1) CN1027169C (no)
AT (1) AT398974B (no)
BE (1) BE1002982A4 (no)
CA (1) CA1310637C (no)
CH (1) CH676716A5 (no)
CY (1) CY1625A (no)
CZ (1) CZ286893B6 (no)
DD (2) DD299067A5 (no)
DE (1) DE3826562A1 (no)
DK (2) DK169344B1 (no)
ES (1) ES2010775A6 (no)
FI (1) FI87790C (no)
FR (1) FR2622193B1 (no)
GB (1) GB2207674B (no)
GR (1) GR1000490B (no)
HK (1) HK6392A (no)
HU (3) HU202547B (no)
IE (1) IE61040B1 (no)
IL (1) IL87290A (no)
IT (1) IT1226825B (no)
LU (2) LU87290A1 (no)
MX (1) MX173843B (no)
MY (1) MY104321A (no)
NL (2) NL192683C (no)
NO (4) NO170284C (no)
NZ (1) NZ225615A (no)
PT (1) PT88186B (no)
SE (1) SE502214C2 (no)
SG (1) SG101291G (no)
SK (1) SK541288A3 (no)
YU (3) YU143688A (no)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
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US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) * 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (no) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
JP2000507577A (ja) 1996-04-01 2000-06-20 エピックス メディカル,インコーポレイテッド 画像診断用の生物活性造影剤
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
AP2003002831A0 (en) * 2001-10-26 2003-09-30 Centre Nat Rech Scient Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
EP2283868B1 (en) 2002-07-15 2016-03-30 Board of Regents, The University of Texas System Peptides binding to phosphatidylethanolamine and their use in treating viral infections and cancer
WO2004060403A2 (en) * 2003-01-06 2004-07-22 Angiochem Inc. Aprotinin and anglos as carriers across the blood-brain barrier
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FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (no) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481095A (de) * 1966-12-13 1969-11-15 Sandoz Ag Vefahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd 4′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
HU202547B (en) 1991-03-28
GB8818462D0 (en) 1988-09-07
FR2622193B1 (fr) 1993-12-17
USRE35524E (en) 1997-06-03
NO883299L (no) 1989-02-24
US5041424A (en) 1991-08-20
FI883596A7 (fi) 1989-02-05
HK6392A (en) 1992-01-17
DK434088A (da) 1989-02-05
MY104321A (en) 1994-03-31
YU10490A (en) 1990-06-30
CY1625A (en) 1992-07-10
HU211960A9 (en) 1996-01-29
SK279325B6 (sk) 1998-10-07
IE61040B1 (en) 1994-09-07
NO920277L (no) 1989-02-24
SE502214C2 (sv) 1995-09-18
YU143688A (en) 1990-04-30
NO883299D0 (no) 1988-07-26
LU90138I2 (fr) 1997-11-26
US4904768A (en) 1990-02-27
IE882378L (en) 1989-02-04
NO172440C (no) 1993-07-21
AU2030688A (en) 1989-06-08
NL970042I2 (no) 2005-06-01
DK11992D0 (da) 1992-01-31
GR880100512A (en) 1989-05-25
HUT47303A (en) 1989-02-28
PT88186B (pt) 1995-07-03
DE3826562C2 (no) 1993-04-08
NO170284C (no) 1992-09-30
NO1998002I1 (no) 1998-01-14
IT8821535A0 (it) 1988-07-28
FR2622193A1 (fr) 1989-04-28
NL970042I1 (nl) 1998-03-02
DE3826562A1 (de) 1989-02-16
CN1061225A (zh) 1992-05-20
NO172440B (no) 1993-04-13
DK11992A (da) 1992-01-31
CZ541288A3 (cs) 1999-12-15
ATA195588A (de) 1994-07-15
CA1310637C (en) 1992-11-24
NL192683C (nl) 1997-12-02
PT88186A (pt) 1989-06-30
GR1000490B (el) 1992-07-30
IL87290A0 (en) 1989-01-31
SE8802815L (sv) 1989-02-05
MX173843B (es) 1994-03-30
LU87290A1 (fr) 1990-02-07
GB2207674A (en) 1989-02-08
DK169344B1 (da) 1994-10-10
HU905862D0 (en) 1991-03-28
IT1226825B (it) 1991-02-19
ES2010775A6 (es) 1989-12-01
JPH0699465B2 (ja) 1994-12-07
CN1027169C (zh) 1994-12-28
SK541288A3 (en) 1998-10-07
SE8802815D0 (sv) 1988-08-03
MX9202851A (es) 1992-06-30
DD274423A5 (de) 1989-12-20
BE1002982A4 (fr) 1991-10-15
NO920665L (no) 1989-02-24
FI87790C (fi) 1993-02-25
NZ225615A (en) 1991-06-25
JPH01100188A (ja) 1989-04-18
IL87290A (en) 1993-01-31
DK434088D0 (da) 1988-08-03
KR890003790A (ko) 1989-04-18
NO170284B (no) 1992-06-22
NL192683B (no) 1997-08-01
FI883596A0 (fi) 1988-08-01
NO920665D0 (no) 1992-02-20
KR900006230B1 (ko) 1990-08-27
NL8801934A (nl) 1989-03-01
DD299067A5 (de) 1992-03-26
CZ286893B6 (cs) 2000-07-12
FI87790B (fi) 1992-11-13
YU10390A (en) 1990-06-30
CH676716A5 (no) 1991-02-28
AT398974B (de) 1995-02-27
AU610619B2 (en) 1991-05-23
SG101291G (en) 1992-01-17
HU208147B (en) 1993-08-30
GB2207674B (en) 1991-09-11

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