[go: up one dir, main page]

NO911158L - Hydantoinderivater. - Google Patents

Hydantoinderivater.

Info

Publication number
NO911158L
NO911158L NO91911158A NO911158A NO911158L NO 911158 L NO911158 L NO 911158L NO 91911158 A NO91911158 A NO 91911158A NO 911158 A NO911158 A NO 911158A NO 911158 L NO911158 L NO 911158L
Authority
NO
Norway
Prior art keywords
hydantoin derivatives
alkyl
formula
nrmo
cnr
Prior art date
Application number
NO91911158A
Other languages
English (en)
Other versions
NO911158D0 (no
Inventor
Wolfgang Koenig
Melitta Just
Bernd Jablonka
Original Assignee
Cassella Farbwerke Mainkur Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella Farbwerke Mainkur Ag filed Critical Cassella Farbwerke Mainkur Ag
Publication of NO911158D0 publication Critical patent/NO911158D0/no
Publication of NO911158L publication Critical patent/NO911158L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Det beskrives nye hydantoinderlvater med generell formel I O COOH ^-NrMO^Jn-CK-C . CH2 N-CH2-CO-NH-CK-CO-NH-R2 (I) HN- C n O hvori n er 3 eller 4, R1 er alkyl eller en rest med formelen R "-NE-C-N-R" , hvor R' og R" betyr hydrogen eller alkyl og R2 betyr hydrogen, -NE-CO-NE2 og eventuelt substituert alkyl, samt fremgangsmåter til deres fremstilling og deres anvendelse for hemming av trombocyttaggregeringen .
NO91911158A 1990-03-24 1991-03-22 Hydantoinderivater. NO911158L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4009506A DE4009506A1 (de) 1990-03-24 1990-03-24 Hydantoinderivate

Publications (2)

Publication Number Publication Date
NO911158D0 NO911158D0 (no) 1991-03-22
NO911158L true NO911158L (no) 1991-09-25

Family

ID=6402986

Family Applications (1)

Application Number Title Priority Date Filing Date
NO91911158A NO911158L (no) 1990-03-24 1991-03-22 Hydantoinderivater.

Country Status (18)

Country Link
US (1) US5686421A (no)
EP (1) EP0449079B1 (no)
JP (1) JP3003252B2 (no)
KR (1) KR100197329B1 (no)
AU (1) AU634039B2 (no)
BR (1) BR9101121A (no)
CA (1) CA2038848C (no)
DE (2) DE4009506A1 (no)
DK (1) DK0449079T3 (no)
ES (1) ES2082026T3 (no)
GR (1) GR3018826T3 (no)
IE (1) IE910958A1 (no)
IL (1) IL97657A (no)
NO (1) NO911158L (no)
NZ (1) NZ237548A (no)
PT (1) PT97114B (no)
TW (1) TW213469B (no)
ZA (1) ZA912178B (no)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264420A (en) * 1990-09-27 1993-11-23 Merck & Co., Inc. Fibrinogen receptor antagonists
IL99537A (en) * 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
DE4126277A1 (de) * 1991-08-08 1993-02-11 Cassella Ag Hydantoinderivate
DE4207254A1 (de) * 1992-03-07 1993-09-09 Cassella Ag 4-oxo-2-thioxoimidazolidin-derivate
DE4213634A1 (de) * 1992-04-24 1993-10-28 Cassella Ag 2,4-Dioxo-imidazolidin-Derivate
DE4228717A1 (de) * 1992-08-28 1994-03-03 Cassella Ag Imidazolidin-Derivate
DE4301747A1 (de) * 1993-01-23 1994-07-28 Cassella Ag Substituierte Aminoverbindungen, ihre Herstellung und ihre Verwendung
DE4308034A1 (de) * 1993-03-13 1994-09-15 Cassella Ag Neue Heterocyclen, ihre Herstellung und ihre Verwendung
DE4309867A1 (de) * 1993-03-26 1994-09-29 Cassella Ag Neue Harnstoffderivate, ihre Herstellung und Verwendung
DE4427979A1 (de) 1993-11-15 1996-02-15 Cassella Ag Substituierte 5-Ring-Heterocyclen, ihre Herstellung und ihre Verwendung
ATE212990T1 (de) 1996-03-20 2002-02-15 Hoechst Ag Inhibitoren der knochenresorption und vitronectinrezeptor-antagonisten
KR19990012061A (ko) * 1997-07-26 1999-02-25 성재갑 파네실 전이효소 저해제로 유용한 하이덴토인 유도체
US6384061B1 (en) * 1997-07-26 2002-05-07 Lg Chemical Ltd. Hydantoin compounds and methods related thereto
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
US6492553B1 (en) * 1998-01-29 2002-12-10 Aventis Pharamaceuticals Inc. Methods for preparing N-[(aliphatic or aromatic)carbonyl)]-2-aminoaetamide compounds and for cyclizing such compounds
DE19821483A1 (de) * 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19922462A1 (de) 1999-05-17 2000-11-23 Aventis Pharma Gmbh Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10111877A1 (de) 2001-03-10 2002-09-12 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10137595A1 (de) * 2001-08-01 2003-02-13 Aventis Pharma Gmbh Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4614517A (en) * 1982-08-04 1986-09-30 La Jolla Cancer Research Foundation Tetrapeptide
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
US4683291A (en) * 1985-10-28 1987-07-28 Scripps Clinic And Research Foundation Platelet binding inhibitors
ZW6189A1 (en) * 1988-05-09 1990-05-09 Smithkline Beckman Corp Anti-aggregatory peptides
DE4126277A1 (de) * 1991-08-08 1993-02-11 Cassella Ag Hydantoinderivate

Also Published As

Publication number Publication date
IL97657A0 (en) 1992-06-21
CA2038848C (en) 2002-01-22
DE4009506A1 (de) 1991-09-26
NO911158D0 (no) 1991-03-22
DE59106881D1 (de) 1995-12-21
JPH04217962A (ja) 1992-08-07
IL97657A (en) 1995-08-31
EP0449079A3 (en) 1992-08-26
JP3003252B2 (ja) 2000-01-24
GR3018826T3 (en) 1996-04-30
EP0449079B1 (de) 1995-11-15
BR9101121A (pt) 1991-11-05
DK0449079T3 (da) 1996-03-11
ES2082026T3 (es) 1996-03-16
US5686421A (en) 1997-11-11
KR910016709A (ko) 1991-11-05
CA2038848A1 (en) 1991-09-25
ZA912178B (en) 1991-12-24
TW213469B (no) 1993-09-21
EP0449079A2 (de) 1991-10-02
PT97114B (pt) 1998-08-31
NZ237548A (en) 1992-05-26
AU7365391A (en) 1991-10-03
PT97114A (pt) 1991-11-29
KR100197329B1 (ko) 1999-06-15
IE910958A1 (en) 1991-09-25
AU634039B2 (en) 1993-02-11

Similar Documents

Publication Publication Date Title
NO911158L (no) Hydantoinderivater.
BG95818A (en) Herbicides
ES2167371T3 (es) Derivados de 1h-3-aril-pirrolidin-2,4-diona espirociclicos substituidos.
NZ215008A (en) Heterocyclic compounds and herbicidal compositions
FI982436A0 (fi) Kondensoituneet heterosykliset yhdisteet
ATE119774T1 (de) Imidazopyridinderivate und ihre verwendung.
NO159795C (no) Fremgangsmaate for fremstilling av 2-penemforbindelser.
GR3005072T3 (no)
DK594486D0 (da) Heterocykliske forbindelser
DK0567271T3 (da) Steroidderivater til behandling af prostatahypertrofi, fremgangsmåde til fremstilling heraf og anvendelser heraf
TW325470B (en) Isoxazolylbenzoyl derivatives
NO953052L (no) Nye pyrrolokarbazoler
ES8704445A1 (es) Procedimiento de preparar derivados aminicos
ES2046229T3 (es) Composicion antiulcerosa.
DK147588A (da) Benzoxazinderivat samt fremgangsmaade til fremstilling deraf
NO881199L (no) Imidazolderivater.
DK369289A (da) Anvendelse af imidazopyrazolderivater som analgetica og antiinflammatoriske midler
ATE144900T1 (de) Verwendung von xanthinderivaten gegen magengeschwüre
IE893533L (en) Substituted 3-aminosydnonimines, processes for their¹preparation and their use
JPS6463569A (en) Heteroaryl derivative
TH14567A (no)
ATE189813T1 (de) Prostaglandin-i-analoga
ES8307812A1 (es) Un procedimiento para la preparacion de nuevos amidin derivados del acido clavulawilo.
SE7901316L (sv) Derivat av dehydrocykliciminsyror