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NO910213D0 - PROCEDURE FOR THE PREPARATION OF ORAL PHARMACEUTICAL FORMS OF PIMOBENDAN. - Google Patents

PROCEDURE FOR THE PREPARATION OF ORAL PHARMACEUTICAL FORMS OF PIMOBENDAN.

Info

Publication number
NO910213D0
NO910213D0 NO910213A NO910213A NO910213D0 NO 910213 D0 NO910213 D0 NO 910213D0 NO 910213 A NO910213 A NO 910213A NO 910213 A NO910213 A NO 910213A NO 910213 D0 NO910213 D0 NO 910213D0
Authority
NO
Norway
Prior art keywords
pimobendan
procedure
preparation
oral pharmaceutical
pharmaceutical forms
Prior art date
Application number
NO910213A
Other languages
Norwegian (no)
Other versions
NO176305C (en
NO910213L (en
NO176305B (en
Inventor
Peter Gruber
Willy Roth
Gottfried Schepky
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of NO910213D0 publication Critical patent/NO910213D0/en
Publication of NO910213L publication Critical patent/NO910213L/en
Publication of NO176305B publication Critical patent/NO176305B/en
Publication of NO176305C publication Critical patent/NO176305C/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cosmetics (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Pimobendan dosage forms for oral administration contain citric acid, ensuring constantly good absorption even with large pH variations in the gastrointestinal tract.
NO910213A 1990-01-20 1991-01-18 Process for the preparation of oral pharmaceutical forms of pimobendan NO176305C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4001622A DE4001622A1 (en) 1990-01-20 1990-01-20 ORAL DRUGS OF PIMOBENDAN

Publications (4)

Publication Number Publication Date
NO910213D0 true NO910213D0 (en) 1991-01-18
NO910213L NO910213L (en) 1991-07-22
NO176305B NO176305B (en) 1994-12-05
NO176305C NO176305C (en) 1995-03-15

Family

ID=6398467

Family Applications (1)

Application Number Title Priority Date Filing Date
NO910213A NO176305C (en) 1990-01-20 1991-01-18 Process for the preparation of oral pharmaceutical forms of pimobendan

Country Status (18)

Country Link
EP (1) EP0439030B1 (en)
JP (1) JP2608183B2 (en)
KR (1) KR0163056B1 (en)
AT (1) ATE87481T1 (en)
AU (1) AU630536B2 (en)
CA (1) CA2034569C (en)
DE (2) DE4001622A1 (en)
DK (1) DK0439030T3 (en)
ES (1) ES2054379T3 (en)
FI (1) FI96274C (en)
HK (1) HK175796A (en)
HU (1) HU207948B (en)
IE (1) IE64659B1 (en)
IL (1) IL96995A (en)
NO (1) NO176305C (en)
NZ (1) NZ236834A (en)
PT (1) PT96506B (en)
ZA (1) ZA91372B (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2753904B1 (en) * 1996-10-01 1998-10-30 Gattefosse Ets Sa PHARMACEUTICAL COMPOSITION WITH MODIFIED RELEASE OF ACTIVE SUBSTANCE, INCLUDING A MATRIX, AND MANUFACTURING PROCESS
DE102004011512B4 (en) * 2004-03-08 2022-01-13 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical preparation containing pimobendan
US8980894B2 (en) 2004-03-25 2015-03-17 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure
EP1579862A1 (en) 2004-03-25 2005-09-28 Boehringer Ingelheim Vetmedica Gmbh Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure
WO2005107719A2 (en) * 2004-05-06 2005-11-17 Sandoz Ag Pharmaceutical composition comprising hydrophobic drug having improved solubility
WO2005123040A1 (en) * 2004-06-22 2005-12-29 Shionogi & Co., Ltd. Tablet rapidly disintegrating in mouth
JP4572293B2 (en) * 2004-07-21 2010-11-04 トーアエイヨー株式会社 Pimobendan oral dosage formulation
JP4572296B2 (en) * 2004-07-21 2010-11-04 トーアエイヨー株式会社 Pimobendan oral dosage formulation
JP2006028130A (en) * 2004-07-21 2006-02-02 Toa Eiyo Ltd Pimobendan oral dosage formulation
WO2007035874A1 (en) * 2005-09-21 2007-03-29 Bristol-Myers Squibb Company Oral administration of n-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-1,3-thiazole-5-carboxamide and salts thereof
JP4572300B2 (en) * 2006-01-19 2010-11-04 トーアエイヨー株式会社 Pimobendan oral dosage formulation
EP1920785A1 (en) 2006-11-07 2008-05-14 Boehringer Ingelheim Vetmedica Gmbh Liquid preparation comprising a complex of pimobendan and cyclodextrin
PE20081482A1 (en) * 2006-12-20 2008-12-23 Novartis Ag GELATINE CAPSULES CONTAINING AN ACID
FR2934156B1 (en) * 2008-07-23 2010-09-24 Virbac ORAL ADMINISTRATION MEDICAMENT IN SOLID FORM
WO2010055119A2 (en) * 2008-11-17 2010-05-20 Novartis Ag Pharmaceutical composition comprising pimobendan
NZ592927A (en) 2008-11-25 2013-07-26 Boehringer Ingelheim Vetmed PHOSPHODIESTERASE TYPE III (PDE III) INHIBITORS OR CA2+-SENSITIZING AGENTS such as pimobendan FOR THE TREATMENT OF HYPERTROPHIC CARDIOMYOPATHY
NL1037569C2 (en) 2009-12-18 2011-06-21 Eurovet Animal Health B V Crystalline pimobendan, process for the preparation thereof, pharmaceutical composition and use.
WO2011081117A1 (en) * 2009-12-29 2011-07-07 興和株式会社 Solid pharmaceutical composition for oral administration
WO2011081118A1 (en) * 2009-12-29 2011-07-07 興和株式会社 Pharmaceutical composition for oral administration
WO2013135852A1 (en) 2012-03-15 2013-09-19 Boehringer Ingelheim Vetmedica Gmbh Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof
JP6272475B2 (en) 2013-07-19 2018-01-31 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハーＢｏｅｈｒｉｎｇｅｒ Ｉｎｇｅｌｈｅｉｍ Ｖｅｔｍｅｄｉｃａ ＧｍｂＨ Liquid aqueous pharmaceutical composition containing antiseptic etherified cyclodextrin derivative
EA034054B1 (en) * 2013-12-04 2019-12-23 Бёрингер Ингельхайм Ветмедика Гмбх Improved pharmaceutical compositions of pimobendan
US10537570B2 (en) 2016-04-06 2020-01-21 Boehringer Ingelheim Vetmedica Gmbh Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease
CN106729723A (en) * 2016-11-21 2017-05-31 青岛农业大学 A kind of pharmaceutical composition containing UD-CG115BS.acardi and preparation method thereof
KR20220006776A (en) * 2020-07-09 2022-01-18 주식회사유한양행 Pharmaceutical compositions comprising a diaminopyrimidine derivative or pharmaceutically acceptable salt thereof and processes for preparing the same
WO2024126434A1 (en) 2022-12-15 2024-06-20 Boehringer Ingelheim Vetmedica Gmbh Solid dispersions comprising amorphous pimobendan and one or more stabilizing polymers
JP7659339B1 (en) 2023-11-21 2025-04-09 東海カプセル株式会社 Oral film formulation containing pimobendan

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES482789A0 (en) * 1978-08-25 1980-12-01 Thomae Gmbh Dr K PROCEDURE FOR THE PREPARATION OF NEW BENZHIMIDAZOLES REPLACED IN POSITION 5 OR 6 WITH A PYRIDAZINONE RING
DE2837161A1 (en) * 1978-08-25 1980-03-06 Thomae Gmbh Dr K 5-Alkyl:pyridazinyl substd. benzimidazole derivs. - useful as cardiovascular agents, antivirals, interferon inducers and ulcer inhibitors
JPS56110612A (en) * 1980-02-08 1981-09-01 Yamanouchi Pharmaceut Co Ltd Readily disintegrable and absorbable compression molded article of slightly soluble drug
JPS60163823A (en) * 1984-02-03 1985-08-26 Taisho Pharmaceut Co Ltd Orally administered formulation
DE3776269D1 (en) * 1986-11-03 1992-03-05 Schering Corp LABETALOL TABLET WITH DELAYED DELIVERY OF ACTIVE SUBSTANCES.
DE3728244A1 (en) * 1987-08-25 1989-03-09 Thomae Gmbh Dr K NEW (-) - BENZIMIDAZOLE, THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS
EP0306846A3 (en) * 1987-09-11 1990-05-02 Dr. Karl Thomae GmbH Synergistic combination comprising a phosphodiesterase inhibitor and a thromboxane-a2 antagonist, and its use or preparation
DE3805635A1 (en) * 1988-02-24 1989-09-07 Thomae Gmbh Dr K USE OF BENZIMIDAZOLES FOR THE MANUFACTURE OF A MEDICAMENT WITH ANTI-MIXIC EFFECTS ON THE HEART AND ITS COMBINATIONS WITH SS-BLOCKERS OR BRADYCARDICA
JPH01258621A (en) * 1988-04-06 1989-10-16 Fujimoto Seiyaku Kk Dilazep tablet with regulated absorption
JPH023609A (en) * 1988-06-21 1990-01-09 Fujimoto Seiyaku Kk Long-acting drug preparation containing nicardipine hydrochloride as active component

Also Published As

Publication number Publication date
NO176305C (en) 1995-03-15
PT96506B (en) 1998-06-30
KR0163056B1 (en) 1998-12-01
HU910177D0 (en) 1991-08-28
ES2054379T3 (en) 1994-08-01
NZ236834A (en) 1995-10-26
AU6945491A (en) 1991-07-25
FI96274B (en) 1996-02-29
HK175796A (en) 1996-09-27
EP0439030A2 (en) 1991-07-31
IL96995A (en) 1994-11-11
IE64659B1 (en) 1995-08-23
KR910014120A (en) 1991-08-31
DK0439030T3 (en) 1993-08-16
IE910165A1 (en) 1991-07-31
ATE87481T1 (en) 1993-04-15
IL96995A0 (en) 1992-03-29
CA2034569A1 (en) 1991-07-21
NO910213L (en) 1991-07-22
FI96274C (en) 1996-06-10
JP2608183B2 (en) 1997-05-07
DE4001622A1 (en) 1991-07-25
PT96506A (en) 1991-10-15
HU207948B (en) 1993-07-28
JPH04210919A (en) 1992-08-03
EP0439030A3 (en) 1991-10-16
HUT56494A (en) 1991-09-30
CA2034569C (en) 2002-03-19
FI910263L (en) 1991-07-21
FI910263A0 (en) 1991-01-18
DE59100067D1 (en) 1993-05-06
AU630536B2 (en) 1992-10-29
ZA91372B (en) 1992-09-30
NO176305B (en) 1994-12-05
EP0439030B1 (en) 1993-03-31

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Legal Events

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MK1K Patent expired