NO910016D0 - Fremgangsmaate for fremstilling av 3-aminopiperidinderivater og beslektede nitrogenholdige heterocykliske forbindelser. - Google Patents

Fremgangsmaate for fremstilling av 3-aminopiperidinderivater og beslektede nitrogenholdige heterocykliske forbindelser.

Info

Publication number: NO910016D0
Authority: NO; Norway
Prior art keywords: preparation; aminopiperide; ingredients; procedure; containing heterocyclic
Prior art date: 1990-01-04

Application number

NO910016A

Other languages

English (en)

Other versions

NO910016L (no

NO178187B (no

NO178187C (no

Inventor

Manoj C Desai

Terry J Rosen

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-01-04

Filing date

1991-01-03

Publication date

1991-01-03

1991-01-03 Application filed by Pfizer filed Critical Pfizer

1991-01-03 Publication of NO910016D0 publication Critical patent/NO910016D0/no

1991-07-05 Publication of NO910016L publication Critical patent/NO910016L/no

1995-10-30 Publication of NO178187B publication Critical patent/NO178187B/no

1996-02-07 Publication of NO178187C publication Critical patent/NO178187C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Immunology (AREA)
Psychiatry (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Anesthesiology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Dermatology (AREA)
Addiction (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

NO910016A 1990-01-04 1991-01-03 Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-aminopiperidin-derivater og beslektede nitrogenholdige heterocykliske forbindelser NO178187C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1990/000116 WO1991009844A1 (en)	1990-01-04	1990-01-04	Substance p antagonists

Publications (4)

Publication Number	Publication Date
NO910016D0 true NO910016D0 (no)	1991-01-03
NO910016L NO910016L (no)	1991-07-05
NO178187B NO178187B (no)	1995-10-30
NO178187C NO178187C (no)	1996-02-07

Family

ID=22220614

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO910016A NO178187C (no)	1990-01-04	1991-01-03	Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-aminopiperidin-derivater og beslektede nitrogenholdige heterocykliske forbindelser

Country Status (27)

Country	Link
EP (2)	EP0558156A3 (no)
JP (1)	JPH0757748B2 (no)
KR (1)	KR930009441B1 (no)
CN (2)	CN1035944C (no)
AT (1)	ATE115127T1 (no)
AU (1)	AU625511B2 (no)
BR (1)	BR9100016A (no)
CA (1)	CA2033497C (no)
CZ (1)	CZ289485B6 (no)
DE (1)	DE69014848T2 (no)
DK (1)	DK0436334T3 (no)
ES (1)	ES2064667T3 (no)
FI (2)	FI114096B (no)
GR (1)	GR3014940T3 (no)
HU (5)	HU222724B1 (no)
IE (1)	IE63770B1 (no)
IL (3)	IL96821A (no)
MY (1)	MY105438A (no)
NO (1)	NO178187C (no)
NZ (1)	NZ236581A (no)
PL (5)	PL164244B1 (no)
PT (1)	PT96405B (no)
RU (1)	RU2105758C1 (no)
UA (1)	UA41251C2 (no)
WO (1)	WO1991009844A1 (no)
YU (1)	YU48026B (no)
ZA (1)	ZA9136B (no)

Families Citing this family (125)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6218364B1 (en)	1988-06-20	2001-04-17	Scott L. Harbeson	Fluorinated neurokinin A antagonists
US5830863A (en) *	1988-06-20	1998-11-03	Merrell Pharmaceuticals Inc.	Neurokinin A antagonists
US5232929A (en) *	1990-11-28	1993-08-03	Pfizer Inc.	3-aminopiperidine derivatives and related nitrogen containing heterocycles and pharmaceutical compositions and use
US5332817A (en) *	1990-01-04	1994-07-26	Pfizer Inc.	3-aminopiperidine derivatives and related nitrogen containing heterocycles
ES2093099T3 (es) *	1990-05-31	1996-12-16	Pfizer	Preparacion de piperidinas sustituidas.
US5364943A (en) *	1991-11-27	1994-11-15	Pfizer Inc.	Preparation of substituted piperidines
US5451586A (en) *	1990-06-01	1995-09-19	Pfizer Inc.	3-amino-2-aryl quinuclidines
CA2086434C (en) *	1990-07-23	1998-09-22	John A. Lowe, Iii	Quinuclidine derivatives
CA2106200C (en) *	1991-03-26	1996-11-19	Terry J. Rosen	Stereoselective preparation of substituted piperidines
US5716965A (en) *	1991-05-22	1998-02-10	Pfizer Inc.	Substituted 3-aminoquinuclidines
SK282203B6 (sk) *	1991-06-20	2001-12-03	Pfizer Inc.	Fluoroalkoxybenzylamínové deriváty heterocyklov obsahujúcich dusík, spôsob ich prípravy, medziprodukty, spôsob prípravy medziproduktov, použitie a farmaceutický prostriedok
TW202432B (no) *	1991-06-21	1993-03-21	Pfizer
EP0600952B1 (en) *	1991-08-20	1996-04-17	MERCK SHARP & DOHME LTD.	Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them
EP1082959A1 (en) *	1991-09-20	2001-03-14	Glaxo Group Limited	NK1 Antagonists for the treatment of depression
GB9201179D0 (en) *	1992-01-21	1992-03-11	Glaxo Group Ltd	Chemical compounds
FR2688219B1 (fr)	1992-03-03	1994-07-08	Sanofi Elf	Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
US5444074A (en) *	1992-04-15	1995-08-22	Merck Sharp & Dohme Limited	Piperidine tachykinin receptor antagonists
CA2133077A1 (en) *	1992-04-15	1993-10-28	Raymond Baker	Azacyclic compounds
JP2757234B2 (ja) *	1992-05-18	1998-05-25	ファイザーインク．	Ｐ物質拮抗薬としての架橋アザ二環式誘導体
CA2099233A1 (en) *	1992-06-29	1993-12-30	Conrad P. Dorn	Morpholine and thiomorpholine tachykinin receptor antagonists
US5637699A (en) *	1992-06-29	1997-06-10	Merck & Co., Inc.	Process for preparing morpholine tachykinin receptor antagonists
US5719147A (en) *	1992-06-29	1998-02-17	Merck & Co., Inc.	Morpholine and thiomorpholine tachykinin receptor antagonists
US6048859A (en)	1992-06-29	2000-04-11	Merck & Co., Inc.	Morpholine and thiomorpholine tachykinin receptor antagonists
DE69322275T2 (de) *	1992-07-28	1999-06-24	Merck Sharp & Dohme Ltd., Hoddesdon, Hertfordshire	Azazyklische verbindungen
JPH07506379A (ja) *	1992-08-04	1995-07-13	ファイザー・インコーポレーテッド	物質ｐ受容体アンタゴニストとしての３−ベンジルアミノ−２−フェニル−ピペリジン
GB9216911D0 (en) *	1992-08-10	1992-09-23	Merck Sharp & Dohme	Therapeutic agents
US5387595A (en) *	1992-08-26	1995-02-07	Merck & Co., Inc.	Alicyclic compounds as tachykinin receptor antagonists
US5563161A (en) *	1992-09-10	1996-10-08	Merck Sharp & Dohme Ltd.	Alcohols and ethers with aromatic substituents as tachykinin-antagonists
GB9220286D0 (en) *	1992-09-25	1992-11-11	Merck Sharp & Dohme	Therapeutic agents
US6369074B1 (en) *	1992-12-10	2002-04-09	Pfizer Inc.	Aminomethylene substituted non-aromatic heterocycles and use as substance P antagonists
PT675886E (pt) *	1992-12-10	2000-12-29	Pfizer	Heterociclos nao aromaticos com substituintes aminometileno e sua utilizacao como antagonistas da substancia p
US5344830A (en) *	1992-12-10	1994-09-06	Merck & Co., Inc.	N,N-diacylpiperazine tachykinin antagonists
US5830854A (en) *	1992-12-14	1998-11-03	Merck Sharp & Dohme, Limited	Method of treating cystic fibrosis using a tachykinin receptor antagonist
GB9300051D0 (en) *	1993-01-04	1993-03-03	Merck Sharp & Dohme	Therapeutic agents
EP0683767B1 (en) *	1993-02-18	1998-06-03	MERCK SHARP & DOHME LTD.	Azacyclic compounds, compositions containing them and their use as tachykinin antagonists
US5496833A (en) *	1993-04-13	1996-03-05	Merck Sharp & Dohme Limited	Piperidine tachykinin receptor antagonists
FI955708L (fi) *	1993-05-28	1995-11-27	Pfizer	Menetelmä 2-fenyyli-3-aminopiperidiinin valmistamiseksi ja erottamiseksi
US5348955A (en) *	1993-06-22	1994-09-20	Merck & Co., Inc.	N,N-diacylpiperazines
GB9317104D0 (en) *	1993-08-17	1993-09-29	Zeneca Ltd	Therapeutic heterocycles
WO1995007908A1 (en) *	1993-09-17	1995-03-23	Pfizer Inc.	Heteroarylamino and heteroarylsulfonamido substituted 3-benzylaminomethyl piperidines and related compounds
DK0719253T3 (da) *	1993-09-17	2004-07-26	Pfizer	3-amino-5-carboxy-substituerede piperidiner og 3-amino-4-carboxy-substituerede pyrrolidiner som tachykininantagonister
US6083943A (en) *	1993-09-17	2000-07-04	Pfizer Inc	Substituted azaheterocyclecarboxylic acid
IS4208A (is) *	1993-09-22	1995-03-23	Glaxo Group Limited	3-(tetrazólýl-benzyl)amínó-piperadidín afleiður
TW263498B (no) *	1993-11-10	1995-11-21	Takeda Pharm Industry Co Ltd
JPH09508376A (ja) *	1994-01-28	1997-08-26	メルクシヤープエンドドームリミテツド	アラルキル置換アザシクロ系の治療薬
US5610165A (en) *	1994-02-17	1997-03-11	Merck & Co., Inc.	N-acylpiperidine tachykinin antagonists
IL112778A0 (en) *	1994-03-04	1995-05-26	Merck & Co Inc	Substituted heterocycles, their preparation and pharmaceutical compositions containing them
GB9408872D0 (en) *	1994-05-03	1994-06-22	Zeneca Ltd	Heterocyclic compounds
GB9418545D0 (en) *	1994-09-15	1994-11-02	Merck Sharp & Dohme	Therapeutic agents
FR2725900B1 (fr) *	1994-10-21	1997-07-18	Sanofi Sa	Utilisation d'antagonistes des recepteurs nk1 pour la preparation de medicaments a action cardioregulatrice
EP0709375B1 (en) *	1994-10-25	2005-05-18	AstraZeneca AB	Therapeutic heterocycles
US5998444A (en) *	1995-10-24	1999-12-07	Zeneca Ltd.	Piperidinyl compounds as NK1 or NK2 antagonists
US6008223A (en) *	1994-10-27	1999-12-28	Zeneca Limited	Therapeutic compounds
FR2728169A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728165A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
FR2729954B1 (fr) *	1995-01-30	1997-08-01	Sanofi Sa	Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2729952B1 (fr) *	1995-01-30	1997-04-18	Sanofi Sa	Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
PT780375E (pt)	1995-12-21	2002-12-31	Pfizer	3-¬(benzilo substituido em 5)amino\|-2-phenilpiperidinas como antagonistas da substancia p
AU2462097A (en) *	1996-10-04	1998-04-24	Alcon Laboratories, Inc.	The use of a substance p antagonist for the manufacture of medicament for the treatment of ocular pain
US5750549A (en) *	1996-10-15	1998-05-12	Merck & Co., Inc.	Cycloalkyl tachykinin receptor antagonists
JP2001524960A (ja) *	1997-04-24	2001-12-04	メルクシヤープエンドドームリミテツド	摂食障害を治療するためのｎｋ−１受容体拮抗薬の使用
GB9716457D0 (en) *	1997-08-04	1997-10-08	Merck Sharp & Dohme	Therapeutic agents
AU737019B2 (en) *	1997-08-04	2001-08-09	Merck Sharp & Dohme Limited	Use of NK-1 receptor antagonists for treating aggressive behaviour disorders
WO1999007376A1 (en) *	1997-08-04	1999-02-18	Merck Sharp & Dohme Limited	Use of nk-1 receptor antagonists for treating mania
GB9716463D0 (en) *	1997-08-04	1997-10-08	Merck Sharp & Dohme	Therapeutic agents
GB9816897D0 (en) *	1998-08-04	1998-09-30	Merck Sharp & Dohme	Therapeutic use
CN1216598C (zh) *	1998-08-25	2005-08-31	诺瓦提斯公司	药物用途
RU2309953C2 (ru)	1999-11-03	2007-11-10	Эймр Текнолоджи, Инк.	Арил- и гетероарилзамещенные тетрагидроизохинолины, фармацевтическая композиция и способ лечения на их основе
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
OA12323A (en)	2000-03-21	2006-05-15	Smithkline Beecham Corp	Protease inhibitors.
WO2002004455A2 (en)	2000-07-11	2002-01-17	Albany Molecular Research, Inc	4-phenyl substituted tetrahydroisoquinolines and therapeutic use thereof
AU2001292320A1 (en) *	2000-10-02	2002-04-15	Tanabe Seiyaku Co., Ltd.	Benzylamine compound, process for producing the same, and intermediate therefor
US6709651B2 (en)	2001-07-03	2004-03-23	B.M.R.A. Corporation B.V.	Treatment of substance P-related disorders
US20050038072A1 (en) *	2001-12-28	2005-02-17	Takeda Chemical Industries, Ltd.	Nitrogeneous cyclic ketone derivative, process for producing the same, and use
US7220098B2 (en)	2003-05-27	2007-05-22	General Electric Company	Wear resistant variable stator vane assemblies
US7541357B2 (en)	2004-07-15	2009-06-02	Amr Technology, Inc.	Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
MX2007004661A (es)	2004-10-18	2007-06-22	Lilly Co Eli	Derivados de 1-(hetero)aril-3-amino-pirrolidina para usarse como antagonistas del receptor mglur3.
GB0423356D0 (en) *	2004-10-21	2004-11-24	Merck Sharp & Dohme	Therapeutic agents
US7543992B2 (en)	2005-04-28	2009-06-09	General Electric Company	High temperature rod end bearings
EP1888050B1 (en)	2005-05-17	2012-03-21	Merck Sharp & Dohme Ltd.	cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid for the treatment of cancer
JP5258561B2 (ja)	2005-07-15	2013-08-07	アルバニーモレキュラーリサーチ，インコーポレイテッド	アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
CN101277960A (zh)	2005-09-29	2008-10-01	默克公司	作为黑皮质素-4受体调节剂的酰化螺哌啶衍生物
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
EP2698157B1 (en)	2006-09-22	2015-05-20	Merck Sharp & Dohme Corp.	Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EP2109608B1 (en)	2007-01-10	2011-03-23	Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A.	Amide substituted indazoles as poly(adp-ribose)polymerase (parp) inhibitors
JP2010516731A (ja)	2007-01-24	2010-05-20	グラクソグループリミテッド	２−メトキシ−５−（５−トリフルオロメチル−テトラゾール−１−イル）−ベンジル］−（２ｓ−フェニル−ピペリジン−３ｓ−イル）−アミンを含む医薬組成物
JP5319518B2 (ja)	2007-04-02	2013-10-16	Ｍｓｄ株式会社	インドールジオン誘導体
US8389553B2 (en)	2007-06-27	2013-03-05	Merck Sharp & Dohme Corp.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US8598184B2 (en)	2008-03-03	2013-12-03	Tiger Pharmatech	Protein kinase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
UA105182C2 (ru)	2008-07-03	2014-04-25	Ньюрексон, Інк.	Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
MA32947B1 (fr) *	2009-01-27	2012-01-02	Hoffmann La Roche	Piperidines substitues par aroylamino et heteroaroylamino comme inhibiteurs de glyt-1
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
DK2429296T3 (en)	2009-05-12	2018-03-12	Albany Molecular Res Inc	7 - ([1,2,4,] TRIAZOLO [1,5, -A] PYRIDIN-6-YL) -4- (3,4-DICHLORPHENYL) -1,2,3,4- TETRAHYDROISOQUINOLINE AND USE thereof
EP2429293B1 (en)	2009-05-12	2014-10-29	Bristol-Myers Squibb Company	CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
KR20120034644A (ko)	2009-05-12	2012-04-12	알바니 몰레큘라 리써치, 인크.	아릴, 헤테로아릴, 및 헤테로사이클 치환된 테트라하이드로이소퀴놀린 및 이의 용도
BR112012008849A2 (pt)	2009-10-14	2015-09-22	Schering Corp	composto, composição farmacêutica, e, uso de um composto
WO2011163330A1 (en)	2010-06-24	2011-12-29	Merck Sharp & Dohme Corp.	Novel heterocyclic compounds as erk inhibitors
EP2601293B1 (en)	2010-08-02	2017-12-06	Sirna Therapeutics, Inc.	RNA INTERFERENCE MEDIATED INHIBITION OF CATENIN (CADHERIN-ASSOCIATED PROTEIN), BETA 1 (CTNNB1) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
JP2013537423A (ja)	2010-08-17	2013-10-03	メルク・シャープ・エンド・ドーム・コーポレイション	低分子干渉核酸（ｓｉＮＡ）を用いたＢ型肝炎ウイルス（ＨＢＶ）遺伝子発現のＲＮＡ干渉媒介性阻害
EP2608669B1 (en)	2010-08-23	2016-06-22	Merck Sharp & Dohme Corp.	NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
WO2012030685A2 (en)	2010-09-01	2012-03-08	Schering Corporation	Indazole derivatives useful as erk inhibitors
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
WO2012058210A1 (en)	2010-10-29	2012-05-03	Merck Sharp & Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
WO2012087772A1 (en)	2010-12-21	2012-06-28	Schering Corporation	Indazole derivatives useful as erk inhibitors
CN103732592A (zh)	2011-04-21	2014-04-16	默沙东公司	胰岛素样生长因子-1受体抑制剂
US9023865B2 (en)	2011-10-27	2015-05-05	Merck Sharp & Dohme Corp.	Compounds that are ERK inhibitors
US20150299696A1 (en)	2012-05-02	2015-10-22	Sirna Therapeutics, Inc.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
EP2900241B1 (en)	2012-09-28	2018-08-08	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
AU2013352568B2 (en)	2012-11-28	2019-09-19	Merck Sharp & Dohme Llc	Compositions and methods for treating cancer
TW201429969A (zh)	2012-12-20	2014-08-01	Merck Sharp & Dohme	作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
EP2951180B1 (en)	2013-01-30	2018-05-02	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
EP3041938A1 (en)	2013-09-03	2016-07-13	Moderna Therapeutics, Inc.	Circular polynucleotides
US10975084B2 (en)	2016-10-12	2021-04-13	Merck Sharp & Dohme Corp.	KDM5 inhibitors
EP3706742B1 (en)	2017-11-08	2023-03-15	Merck Sharp & Dohme LLC	Prmt5 inhibitors
WO2019094312A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
CN111918647A (zh) *	2018-02-26	2020-11-10	圣拉斐尔医院有限公司	用于治疗眼痛的nk-1拮抗剂
BR112021002267A8 (pt)	2018-08-07	2023-02-07	Merck Sharp & Dohme	Inibidores de prmt5
WO2020033284A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
WO2020033282A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE535451A (no) *	1954-02-05
GB1060160A (en) *	1964-08-05	1967-03-01	Allen & Hanburys Ltd	4-phenylpiperidine derivatives
US3560510A (en) *	1969-03-05	1971-02-02	Aldrich Chem Co Inc	2-benzhydrylquinuclidines
US3992389A (en) *	1970-09-03	1976-11-16	John Wyeth & Brother Limited	Heterocyclic compounds
WO1990005525A1 (en) *	1988-11-23	1990-05-31	Pfizer Inc.	Quinuclidine derivatives as substance p antagonists
ES2093099T3 (es) *	1990-05-31	1996-12-16	Pfizer	Preparacion de piperidinas sustituidas.

1990
- 1990-01-04 UA UA5010406A patent/UA41251C2/uk unknown
- 1990-01-04 WO PCT/US1990/000116 patent/WO1991009844A1/en not_active Ceased
- 1990-12-14 AT AT90313680T patent/ATE115127T1/de not_active IP Right Cessation
- 1990-12-14 DE DE69014848T patent/DE69014848T2/de not_active Expired - Fee Related
- 1990-12-14 ES ES90313680T patent/ES2064667T3/es not_active Expired - Lifetime
- 1990-12-14 EP EP19930201034 patent/EP0558156A3/en not_active Ceased
- 1990-12-14 EP EP90313680A patent/EP0436334B1/en not_active Expired - Lifetime
- 1990-12-14 DK DK90313680.2T patent/DK0436334T3/da active
- 1990-12-20 NZ NZ236581A patent/NZ236581A/xx unknown
- 1990-12-28 IL IL96821A patent/IL96821A/xx not_active IP Right Cessation
- 1990-12-28 JP JP2409476A patent/JPH0757748B2/ja not_active Expired - Fee Related
- 1990-12-28 IL IL112348A patent/IL112348A/en not_active IP Right Cessation
1991
- 1991-01-02 PT PT96405A patent/PT96405B/pt active IP Right Grant
- 1991-01-02 PL PL91293389A patent/PL164244B1/pl unknown
- 1991-01-02 PL PL91293392A patent/PL164205B1/pl not_active IP Right Cessation
- 1991-01-02 PL PL91288592A patent/PL163967B1/pl not_active IP Right Cessation
- 1991-01-02 PL PL91293390A patent/PL164203B1/pl not_active IP Right Cessation
- 1991-01-02 HU HU9203403A patent/HU222724B1/hu not_active IP Right Cessation
- 1991-01-02 HU HU916A patent/HUT60719A/hu unknown
- 1991-01-02 CA CA002033497A patent/CA2033497C/en not_active Expired - Fee Related
- 1991-01-02 PL PL91293391A patent/PL164204B1/pl not_active IP Right Cessation
- 1991-01-02 MY MYPI91000002A patent/MY105438A/en unknown
- 1991-01-02 HU HU9203403A patent/HUT68130A/hu unknown
- 1991-01-02 HU HU9203405A patent/HUT68179A/hu unknown
- 1991-01-02 AU AU68621/91A patent/AU625511B2/en not_active Ceased
- 1991-01-02 HU HU9203404A patent/HU220602B1/hu unknown
- 1991-01-03 ZA ZA9136A patent/ZA9136B/xx unknown
- 1991-01-03 YU YU491A patent/YU48026B/sh unknown
- 1991-01-03 CN CN91100039A patent/CN1035944C/zh not_active Expired - Fee Related
- 1991-01-03 KR KR1019910000001A patent/KR930009441B1/ko not_active Expired - Fee Related
- 1991-01-03 FI FI910034A patent/FI114096B/fi active
- 1991-01-03 IE IE791A patent/IE63770B1/en not_active IP Right Cessation
- 1991-01-03 BR BR919100016A patent/BR9100016A/pt not_active Application Discontinuation
- 1991-01-03 NO NO910016A patent/NO178187C/no unknown
- 1991-01-04 CZ CS199110A patent/CZ289485B6/cs not_active IP Right Cessation
- 1991-12-23 RU SU5010406A patent/RU2105758C1/ru not_active IP Right Cessation
1993
- 1993-08-20 CN CN93116286A patent/CN1045595C/zh not_active Expired - Fee Related
1995
- 1995-01-16 IL IL11234895A patent/IL112348A0/xx unknown
- 1995-02-01 GR GR950400206T patent/GR3014940T3/el unknown
2004
- 2004-04-01 FI FI20040479A patent/FI20040479A7/fi not_active Application Discontinuation

Also Published As

Publication number	Publication date
PL163967B1 (pl)	1994-06-30
HUT68180A (en)	1995-05-29
HUT68179A (en)	1995-05-29
FI910034A0 (fi)	1991-01-03
AU6862191A (en)	1991-07-18
CA2033497A1 (en)	1991-07-05
EP0436334B1 (en)	1994-12-07
KR930009441B1 (ko)	1993-10-04
HU222724B1 (hu)	2003-09-29
IL96821A (en)	1997-03-18
CS1091A3 (en)	1991-08-13
BR9100016A (pt)	1991-10-22
PL293390A1 (en)	1992-07-13
IL112348A0 (en)	1995-03-30
YU48026B (sh)	1996-10-09
PL293391A1 (en)	1992-07-13
HUT60719A (en)	1992-10-28
FI20040479A7 (fi)	2004-04-01
PL164204B1 (pl)	1994-06-30
IL112348A (en)	1998-06-15
MY105438A (en)	1994-10-31
UA41251C2 (uk)	2001-09-17
NZ236581A (en)	1992-10-28
FI910034L (fi)	1991-07-05
CN1053060A (zh)	1991-07-17
EP0436334A2 (en)	1991-07-10
WO1991009844A1 (en)	1991-07-11
NO910016L (no)	1991-07-05
DK0436334T3 (da)	1995-02-13
HUT68130A (en)	1995-05-29
YU491A (sh)	1994-01-20
JPH04103570A (ja)	1992-04-06
CN1035944C (zh)	1997-09-24
RU2105758C1 (ru)	1998-02-27
ES2064667T3 (es)	1995-02-01
IL96821A0 (en)	1991-09-16
GR3014940T3 (en)	1995-05-31
FI114096B (fi)	2004-08-13
PL164203B1 (pl)	1994-06-30
HU220602B1 (hu)	2002-03-28
PL164244B1 (en)	1994-07-29
EP0436334A3 (en)	1992-05-27
CA2033497C (en)	1997-01-07
CN1087083A (zh)	1994-05-25
CN1045595C (zh)	1999-10-13
PL293389A1 (en)	1992-07-13
CZ289485B6 (cs)	2002-02-13
PT96405B (pt)	1998-06-30
NO178187B (no)	1995-10-30
HU910006D0 (en)	1991-08-28
IE910007A1 (en)	1991-07-17
PL164205B1 (en)	1994-06-30
KR910014350A (ko)	1991-08-31
PL288592A1 (en)	1992-06-15
EP0558156A3 (en)	1993-10-06
PT96405A (pt)	1991-10-15
AU625511B2 (en)	1992-07-16
IE63770B1 (en)	1995-06-14
ATE115127T1 (de)	1994-12-15
EP0558156A2 (en)	1993-09-01
DE69014848T2 (de)	1995-05-04
ZA9136B (en)	1992-08-26
JPH0757748B2 (ja)	1995-06-21
DE69014848D1 (de)	1995-01-19
NO178187C (no)	1996-02-07
PL293392A1 (en)	1992-07-13

Publication	Publication Date	Title
NO910016D0 (no)	1991-01-03	Fremgangsmaate for fremstilling av 3-aminopiperidinderivater og beslektede nitrogenholdige heterocykliske forbindelser.
AU566960B2 (en)	1987-11-05	7-aminoazolo (1,5-alpha) pyrimidines
HU895815D0 (en)	1990-01-28	Insecticide compositions containing heterocyclic compounds and process for the preparation of such compounds
PT86974A (pt)	1988-04-01	Process for the preparation of imidazol compounds and of biociddal compositions containing the same
IL96507A0 (en)	1991-08-16	Nitrogen-containing spirocycles and pharmaceutical compositions containing them
MY101784A (en)	1992-01-17	Novel pharmacological compounds
DK166088C (da)	1993-08-23	2'-deoxy-5-fluoruridinderivater, fremgangsmaade til fremstilling deraf, anticancermidler indeholdende saadanne forbindelser og anvendelse af saadanne forbindelser til fremstilling af anticancermidler
HUT46507A (en)	1988-11-28	Insecticidal composition comprising 5-member heterocyclic derivatives of n'-substituted-n,n'-diacylhydrazine compounds and process for producing such compounds
AP8800109A0 (en)	1989-01-31	"Heterocyclic insecticides".
GR3005254T3 (no)	1993-05-24
PT86925A (pt)	1988-04-01	Process for the preparation of imidazodiazepine derivatives and of pharmaceutical compositions containing the same
NO903386D0 (no)	1990-08-01	Fremgangsmaate for fremstilling av 4-(n-substituert amino)-2-butynyl-1-karbamater og -tiokarbamater og derivater derav.
GB2247237B (en)	1994-05-18	1-(N'-Cyanoguanyl) derivatives of N-containing five-membered ring heterocycles
FI915518A7 (fi)	1992-05-25	Menetelmä lääkinnällisesti vaikuttavien heterosyklisesti substituoitujen piperatsinoalkyylibentsoksatsiini- ja -tiatsiiniyhdisteiden valmistamiseksi
ATA265887A (de)	1988-09-15	Neue n-1h-tetrazol-5-yl-(5-ring)-carboxamidderivate sowie verwendung derartiger verbindungen
DE69002027D1 (de)	1993-07-29	(3-diethylaminopropyl)-1-amino-5-methyldipyrido(4,3-b)(3,4-f)indoltrihydrochlorid.
NO954076L (no)	1992-06-09	Fremgangsmåte for fremstilling av en krystallform og et farmasöytisk preparat derav