NO904135L - Fremgangsmaate for fremstilling av nye substituerte alkylpiperidiner og deres anvendelse som inhibitorer av kolesterolsyntese. - Google Patents
Fremgangsmaate for fremstilling av nye substituerte alkylpiperidiner og deres anvendelse som inhibitorer av kolesterolsyntese.Info
- Publication number
- NO904135L NO904135L NO90904135A NO904135A NO904135L NO 904135 L NO904135 L NO 904135L NO 90904135 A NO90904135 A NO 90904135A NO 904135 A NO904135 A NO 904135A NO 904135 L NO904135 L NO 904135L
- Authority
- NO
- Norway
- Prior art keywords
- substituted alkyl
- inhibitors
- procedure
- preparation
- cholesterol synthesis
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 235000012000 cholesterol Nutrition 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000003053 piperidines Chemical class 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- -1 substituted alkyl piperidines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41203789A | 1989-09-22 | 1989-09-22 | |
| US55709190A | 1990-07-27 | 1990-07-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO904135D0 NO904135D0 (no) | 1990-09-21 |
| NO904135L true NO904135L (no) | 1991-03-25 |
Family
ID=27021609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO90904135A NO904135L (no) | 1989-09-22 | 1990-09-21 | Fremgangsmaate for fremstilling av nye substituerte alkylpiperidiner og deres anvendelse som inhibitorer av kolesterolsyntese. |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP0420116B1 (no) |
| JP (1) | JP3053418B2 (no) |
| KR (1) | KR100191231B1 (no) |
| CN (1) | CN1050380A (no) |
| AT (1) | ATE156125T1 (no) |
| AU (1) | AU633973B2 (no) |
| CA (1) | CA2025490C (no) |
| DE (1) | DE69031154T2 (no) |
| ES (1) | ES2108004T3 (no) |
| FI (1) | FI904663A7 (no) |
| HU (1) | HUT55362A (no) |
| IE (1) | IE903423A1 (no) |
| IL (1) | IL95727A0 (no) |
| NO (1) | NO904135L (no) |
| NZ (1) | NZ235370A (no) |
| PT (1) | PT95390A (no) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5348964A (en) * | 1990-07-25 | 1994-09-20 | Merrell Dow Pharmaceuticals Inc. | Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis |
| US5350758A (en) * | 1992-07-08 | 1994-09-27 | Merrell Dow Pharmaceuticals Inc. | Piperidyl sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis |
| US5466687A (en) * | 1992-10-22 | 1995-11-14 | Dr. Karl Thomae Gmbh | Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation |
| DE4303840A1 (de) * | 1992-10-22 | 1994-08-11 | Thomae Gmbh Dr K | Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| FR2697250B1 (fr) * | 1992-10-28 | 1995-01-20 | Fournier Ind & Sante | Dérivés de beta,beta-diméthyl-4-pipéridineéthanol et de 1,2,3,6-tétrahydro-beta,beta-diméthyl-4-pyridineéthanol, leur procédé de préparation et leur utilisation en thérapeutique. |
| FR2705343B1 (fr) * | 1993-05-17 | 1995-07-21 | Fournier Ind & Sante | Dérivés de beta,beta-diméthyl-4-pipéridineéthanamine, leur procédé de préparation et leur utilisation en thérapeutique. |
| DE19754795A1 (de) * | 1997-12-10 | 1999-06-17 | Boehringer Ingelheim Pharma | Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| CN102304031A (zh) * | 2011-05-13 | 2012-01-04 | 华东理工大学 | 苯甲醛衍生物及其在制备加兰他敏中的应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE866193C (de) * | 1937-06-02 | 1953-02-09 | Hydrierwerke A G Deutsche | Verfahren zur Herstellung von in der Amidgruppe substituierten Carbonsaeureamiden |
| US2580411A (en) * | 1948-10-23 | 1952-01-01 | Searle & Co | Dihexyl alanine dialkylamides |
| FR1261160A (fr) * | 1955-07-28 | 1961-05-19 | Procédé de préparation de n-t-alkyl-dialkylamino-amides | |
| NL109859C (no) * | 1957-09-27 | |||
| US3185678A (en) * | 1961-08-04 | 1965-05-25 | Colgate Palmolive Co | Polymethyleniminoalkylamides |
| DE1719388B2 (de) * | 1968-02-09 | 1976-04-29 | Bayer Ag, 5090 Leverkusen | Verfahren zum faerben von fasermaterialien aus polyacrylnitril oder acrylnitrilhaltigen mischpolymerisaten |
| FR2116244A1 (en) | 1970-11-30 | 1972-07-13 | Anvar | Alkylene diamines - and phosphoramides - from bromoalkylamines and diesterified orthophosphoric acid halides |
| GB1415682A (en) * | 1972-06-30 | 1975-11-26 | Wyeth John & Brother Ltd | Amides and thioamides |
| GB1420758A (en) | 1972-07-12 | 1976-01-14 | Wyeth John & Brother Ltd | Anti-ulcer compositions |
| US3968211A (en) * | 1974-02-11 | 1976-07-06 | The Upjohn Company | Compositions and methods of use of amidines for anti-arrhythmic purposes |
| JPS55129255A (en) * | 1979-03-28 | 1980-10-06 | Kuraray Co Ltd | Farnesylacetamide compounds or their salts |
| DE2947649A1 (de) * | 1979-11-27 | 1981-08-06 | C.F. Spiess & Sohn GmbH & Co, 6719 Kleinkarlbach | Insektizide mittel |
| US4326067A (en) * | 1980-12-03 | 1982-04-20 | The Dow Chemical Company | Process for making N-(2-aminoethyl)amides |
| IN164200B (no) * | 1986-02-01 | 1989-01-28 | Nippon Chemiphar Co | |
| US4897423A (en) | 1988-08-02 | 1990-01-30 | Merck & Co. Inc. | Dinitrobenzenesulfonamides |
-
1990
- 1990-09-17 CA CA002025490A patent/CA2025490C/en not_active Expired - Fee Related
- 1990-09-18 IL IL95727A patent/IL95727A0/xx unknown
- 1990-09-18 NZ NZ235370A patent/NZ235370A/en unknown
- 1990-09-19 JP JP2247636A patent/JP3053418B2/ja not_active Expired - Fee Related
- 1990-09-21 HU HU906010A patent/HUT55362A/hu unknown
- 1990-09-21 IE IE342390A patent/IE903423A1/en unknown
- 1990-09-21 AU AU63061/90A patent/AU633973B2/en not_active Ceased
- 1990-09-21 PT PT95390A patent/PT95390A/pt not_active Application Discontinuation
- 1990-09-21 NO NO90904135A patent/NO904135L/no unknown
- 1990-09-21 FI FI904663A patent/FI904663A7/fi not_active Application Discontinuation
- 1990-09-21 CN CN90107855A patent/CN1050380A/zh active Pending
- 1990-09-22 KR KR1019900015119A patent/KR100191231B1/ko not_active Expired - Fee Related
- 1990-09-24 DE DE69031154T patent/DE69031154T2/de not_active Expired - Fee Related
- 1990-09-24 ES ES90118331T patent/ES2108004T3/es not_active Expired - Lifetime
- 1990-09-24 AT AT90118331T patent/ATE156125T1/de not_active IP Right Cessation
- 1990-09-24 EP EP90118331A patent/EP0420116B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NZ235370A (en) | 1994-03-25 |
| FI904663A0 (fi) | 1990-09-21 |
| DE69031154D1 (de) | 1997-09-04 |
| AU633973B2 (en) | 1993-02-11 |
| CA2025490A1 (en) | 1991-03-23 |
| ATE156125T1 (de) | 1997-08-15 |
| EP0420116A2 (en) | 1991-04-03 |
| JP3053418B2 (ja) | 2000-06-19 |
| IL95727A0 (en) | 1991-06-30 |
| KR910006231A (ko) | 1991-04-27 |
| HU906010D0 (en) | 1991-03-28 |
| DE69031154T2 (de) | 1998-01-02 |
| ES2108004T3 (es) | 1997-12-16 |
| JPH03130262A (ja) | 1991-06-04 |
| KR100191231B1 (ko) | 1999-06-15 |
| FI904663A7 (fi) | 1991-03-23 |
| IE903423A1 (en) | 1991-04-10 |
| AU6306190A (en) | 1991-01-31 |
| EP0420116A3 (en) | 1991-09-18 |
| CA2025490C (en) | 2003-09-16 |
| EP0420116B1 (en) | 1997-07-30 |
| NO904135D0 (no) | 1990-09-21 |
| HUT55362A (en) | 1991-05-28 |
| PT95390A (pt) | 1991-05-22 |
| CN1050380A (zh) | 1991-04-03 |
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