NO881658L - Biofunksjonelle proteiner. - Google Patents

Biofunksjonelle proteiner.

Info

Publication number: NO881658L
Authority: NO; Norway
Prior art keywords: biofunctional; proteins; biofunctional proteins
Prior art date: 1987-04-16

Application number

NO88881658A

Other languages

English (en)

Other versions

NO176922B (no

NO176922C (no

NO881658D0 (no

Inventor

Paul Habermann

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-04-16

Filing date

1988-04-15

Publication date

1988-10-17

1988-04-15 Application filed by Hoechst Ag filed Critical Hoechst Ag

1988-04-15 Publication of NO881658D0 publication Critical patent/NO881658D0/no

1988-10-17 Publication of NO881658L publication Critical patent/NO881658L/no

1995-03-13 Publication of NO176922B publication Critical patent/NO176922B/no

1995-06-21 Publication of NO176922C publication Critical patent/NO176922C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

NO881658A 1987-04-16 1988-04-15 Fremgangsmåte for fremstilling av bifunksjonelle proteiner NO176922C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19873712985 DE3712985A1 (de)	1987-04-16	1987-04-16	Bifunktionelle proteine

Publications (4)

Publication Number	Publication Date
NO881658D0 NO881658D0 (no)	1988-04-15
NO881658L true NO881658L (no)	1988-10-17
NO176922B NO176922B (no)	1995-03-13
NO176922C NO176922C (no)	1995-06-21

Family

ID=6325799

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO881658A NO176922C (no)	1987-04-16	1988-04-15	Fremgangsmåte for fremstilling av bifunksjonelle proteiner

Country Status (20)

Country	Link
EP (1)	EP0288809B1 (no)
JP (1)	JP2667193B2 (no)
KR (1)	KR970000187B1 (no)
AR (1)	AR242991A1 (no)
AT (1)	ATE79135T1 (no)
AU (1)	AU613022B2 (no)
CA (1)	CA1322157C (no)
DE (2)	DE3712985A1 (no)
DK (1)	DK170741B1 (no)
ES (1)	ES2033981T3 (no)
FI (1)	FI98830C (no)
GR (1)	GR3006141T3 (no)
HU (1)	HU204303B (no)
IE (1)	IE61574B1 (no)
IL (1)	IL86086A (no)
NO (1)	NO176922C (no)
NZ (1)	NZ224247A (no)
PH (1)	PH25327A (no)
PT (1)	PT87237B (no)
ZA (1)	ZA882659B (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5662896A (en) *	1988-03-21	1997-09-02	Chiron Viagene, Inc.	Compositions and methods for cancer immunotherapy
US6406697B1 (en)	1989-02-23	2002-06-18	Genentech, Inc.	Hybrid immunoglobulins
US5116964A (en) *	1989-02-23	1992-05-26	Genentech, Inc.	Hybrid immunoglobulins
US5225538A (en) *	1989-02-23	1993-07-06	Genentech, Inc.	Lymphocyte homing receptor/immunoglobulin fusion proteins
WO1990012877A1 (en) *	1989-04-19	1990-11-01	Cetus Corporation	Multifunctional m-csf proteins and genes encoding therefor
EP0489116B1 (en) *	1989-08-22	1994-04-06	Immunex Corporation	Fusion proteins comprising gm-csf and il-3
US5073627A (en) *	1989-08-22	1991-12-17	Immunex Corporation	Fusion proteins comprising GM-CSF and IL-3
US5108910A (en) *	1989-08-22	1992-04-28	Immunex Corporation	DNA sequences encoding fusion proteins comprising GM-CSF and IL-3
US5376367A (en) *	1991-11-22	1994-12-27	Immunex Corporation	Fusion proteins comprising MGF and IL-3
US5723125A (en) *	1995-12-28	1998-03-03	Tanox Biosystems, Inc.	Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
DK1037927T3 (da)	1997-12-08	2004-09-06	Emd Lexigen Res Ct Corp	Heterodimere fusionsproteiner, der er nyttige til målrettet immunterapi og generel immunstimulering
US7067110B1 (en)	1999-07-21	2006-06-27	Emd Lexigen Research Center Corp.	Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
SK782002A3 (en)	1999-07-21	2003-08-05	Lexigen Pharm Corp	FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
PL202058B1 (pl)	1999-08-09	2009-05-29	Merck Patent Gmbh	Wielofunkcyjne białko fuzyjne cytokin i przeciwciała
JP2003514552A (ja)	1999-11-12	2003-04-22	メルクパテントゲゼルシャフトミットベシュレンクテルハフトング	改善された性質を有するエリトロポエチンの形態
JP4553290B2 (ja) *	1999-11-30	2010-09-29	塩野義製薬株式会社	ケモカインｓｌｃ−ｉｌ２融合タンパク質とその遺伝子
DE60122286T2 (de)	2000-02-11	2007-08-02	Merck Patent Gmbh	Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen
ES2288967T3 (es)	2000-06-29	2008-02-01	Merck Patent Gmbh	Reforzamiento de las respuestas inmunes mediadas por la proteina de fusion anticuerpo-citoquina por medio del tratamiento combinado por agentes que mejoran la incorporacion de inmunocitoquina.
BR0207854A (pt)	2001-03-07	2004-08-24	Merck Patent Gmbh	Tecnologia de expressão para proteìnas contendo uma porção de anticorpo de isotipo hìbrido
WO2002079415A2 (en)	2001-03-30	2002-10-10	Lexigen Pharmaceuticals Corp.	Reducing the immunogenicity of fusion proteins
HUP0400284A3 (en)	2001-05-03	2012-09-28	Merck Patent Gmbh	Recombinant tumor specific antibody and use thereof
ES2466024T3 (es)	2001-10-10	2014-06-09	Ratiopharm Gmbh	Remodelación y glicoconjugación de factor de crecimiento de fibroblastos (FGF)
PL206975B1 (pl)	2001-12-04	2010-10-29	Merck Patent Gmbh	Immunocytokiny o modulowanej selektywności oraz ich zastosowanie
RU2366664C2 (ru)	2002-12-17	2009-09-10	Мерк Патент Гмбх	Гуманизированное антитело (н14.18) на основании антитела 14.18 мыши, связывающееся с gd2, и его слияние с il-2
EP1925626A1 (en) *	2003-07-21	2008-05-28	Transgene S.A.	Novel multifunctional cytokines
DE602004031341D1 (de)	2003-07-21	2011-03-24	Transgene Sa	Multifunktionelle cytokine
WO2010001414A1 (en) *	2008-07-03	2010-01-07	Lupin Limited	Expression of heterologous proteins in bacterial system using a gm-csf fusion tag

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1985000817A1 (en) *	1983-08-10	1985-02-28	Amgen	Microbial expression of interleukin ii
GB8327880D0 (en) *	1983-10-18	1983-11-16	Ajinomoto Kk	Saccharomyces cerevisiae
EP0158198A1 (en) *	1984-03-29	1985-10-16	Takeda Chemical Industries, Ltd.	DNA and use thereof
WO1985004673A1 (fr) *	1984-04-10	1985-10-24	Takeda Chemical Industries, Ltd.	Nouvel adn et son utilisation
DE3419995A1 (de) *	1984-05-29	1985-12-05	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von human-interleukin-2 und mittel zur durchfuehrung dieses verfahrens
AU588819B2 (en) *	1984-10-29	1989-09-28	Immunex Corporation	Cloning of human granulocyte-macrophage colony stimulating factor gene
JPS61128889A (ja) *	1984-11-27	1986-06-16	Green Cross Corp:The	組換えｄｎａ及び該ｄｎａによる形質転換体
JPH0646957B2 (ja) *	1985-03-11	1994-06-22	武田薬品工業株式会社	インタ−ロイキン−２の製造方法
JPS63502795A (ja) *	1985-10-03	1988-10-20	バイオジェンインコーポレイテッド	顆粒球‐マクロファージコロニー刺激因子‐様ポリペプチド、ｄｎａ配列、組換えｄｎａ分子並びに微生物細胞中でヒト顆粒球−マクロファ−ジコロニ−刺激因子−様ポリペプチドを高収量で生産する方法
DE3541856A1 (de) *	1985-11-27	1987-06-04	Hoechst Ag	Eukaryotische fusionsproteine, ihre herstellung und verwendung sowie mittel zur durchfuehrung des verfahrens
DE3545568A1 (de) *	1985-12-21	1987-07-16	Hoechst Ag	Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung

1987
- 1987-04-16 DE DE19873712985 patent/DE3712985A1/de not_active Withdrawn
1988
- 1988-04-09 AT AT88105693T patent/ATE79135T1/de not_active IP Right Cessation
- 1988-04-09 ES ES198888105693T patent/ES2033981T3/es not_active Expired - Lifetime
- 1988-04-09 EP EP88105693A patent/EP0288809B1/de not_active Expired - Lifetime
- 1988-04-09 DE DE8888105693T patent/DE3873397D1/de not_active Expired - Fee Related
- 1988-04-14 PT PT87237A patent/PT87237B/pt active IP Right Grant
- 1988-04-14 FI FI881743A patent/FI98830C/fi not_active IP Right Cessation
- 1988-04-14 NZ NZ224247A patent/NZ224247A/en unknown
- 1988-04-15 IL IL8608688A patent/IL86086A/en not_active IP Right Cessation
- 1988-04-15 DK DK209188A patent/DK170741B1/da not_active IP Right Cessation
- 1988-04-15 AU AU14661/88A patent/AU613022B2/en not_active Ceased
- 1988-04-15 ZA ZA882659A patent/ZA882659B/xx unknown
- 1988-04-15 HU HU881966A patent/HU204303B/hu not_active IP Right Cessation
- 1988-04-15 NO NO881658A patent/NO176922C/no not_active IP Right Cessation
- 1988-04-15 IE IE114688A patent/IE61574B1/en not_active IP Right Cessation
- 1988-04-15 JP JP63093321A patent/JP2667193B2/ja not_active Expired - Fee Related
- 1988-04-15 CA CA000564322A patent/CA1322157C/en not_active Expired - Fee Related
- 1988-04-15 AR AR88310585A patent/AR242991A1/es active
- 1988-04-16 KR KR1019880004345A patent/KR970000187B1/ko not_active Expired - Fee Related
1989
- 1989-04-14 PH PH36799A patent/PH25327A/en unknown
1992
- 1992-11-04 GR GR920402185T patent/GR3006141T3/el unknown

Also Published As

Publication number	Publication date
FI881743A0 (fi)	1988-04-14
CA1322157C (en)	1993-09-14
PT87237B (pt)	1992-07-31
ZA882659B (en)	1988-10-14
IE61574B1 (en)	1994-11-16
AU613022B2 (en)	1991-07-25
JP2667193B2 (ja)	1997-10-27
HUT47319A (en)	1989-02-28
FI881743L (fi)	1988-10-17
ES2033981T3 (es)	1993-04-01
GR3006141T3 (no)	1993-06-21
FI98830C (fi)	1997-08-25
KR970000187B1 (ko)	1997-01-06
JPS63301898A (ja)	1988-12-08
NO176922B (no)	1995-03-13
DE3712985A1 (de)	1988-11-03
HU204303B (en)	1991-12-30
KR880012760A (ko)	1988-11-29
DK209188D0 (da)	1988-04-15
DK209188A (da)	1988-10-17
FI98830B (fi)	1997-05-15
NO176922C (no)	1995-06-21
DK170741B1 (da)	1996-01-08
DE3873397D1 (de)	1992-09-10
EP0288809B1 (de)	1992-08-05
IE881146L (en)	1988-10-16
EP0288809A1 (de)	1988-11-02
NO881658D0 (no)	1988-04-15
IL86086A0 (en)	1988-09-30
ATE79135T1 (de)	1992-08-15
NZ224247A (en)	1990-04-26
AR242991A1 (es)	1993-06-30
IL86086A (en)	1995-01-24
PH25327A (en)	1991-04-30
PT87237A (pt)	1988-05-01
AU1466188A (en)	1988-10-20

Publication	Publication Date	Title
NO881658L (no)	1988-10-17	Biofunksjonelle proteiner.
FI884993L (fi)	1989-05-01	Polypeptider.
DE3881291D1 (de)	1993-07-01	Sehapparat.
DE3883705D1 (de)	1993-10-07	Alkenylbicyclohexane.
FI882407A7 (fi)	1988-11-23	Fibrinolyyttisiä proteiinejä.
NO892294L (no)	1989-12-07	Polypeptidforbindelser.
DE3882446D1 (de)	1993-08-26	Polydisilacyclobutasilazane.
FI882283L (fi)	1988-11-17	Proteiner med tnf-verkan.
DK353788A (da)	1988-12-30	Polypeptidderivater
DE68910141D1 (de)	1993-12-02	Fixiergerät.
NO881384D0 (no)	1988-03-29	Peptider.
FI882562L (fi)	1988-12-02	Fibronektinbindande protein och foerfarande foer dess framstaellning.
NO885108D0 (no)	1988-11-16	Peptider.
FI881747A0 (fi)	1988-04-14	Alifatiska karboxiamider.
FI884991L (fi)	1989-04-30	Foerfarande foer reglering av protein glykolysation.
DE3885475D1 (de)	1993-12-16	Eintaschverfahren.
DE3878970D1 (de)	1993-04-15	Praeparative chromatographiesaeule.
FI870472A0 (fi)	1987-02-04	Dykarkompass.
NO892948L (no)	1990-01-22	Modifiserte proteiner.
FI885513A0 (fi)	1988-11-28	Elektrofotografiskt uppteckningselement.
FI892254A0 (fi)	1989-05-10	Anvaendning av a-aminoboronsyraderivat foer stabilisering av peptid- och proteinlaekemedel.
DE68918243D1 (de)	1994-10-20	Fixiergerät.
FI885512A0 (fi)	1988-11-28	Elektrofotografiskt uppteckningselement.
FI870291A0 (fi)	1987-01-23	Skyddsflaens foer rulle.
DK624089D0 (da)	1989-12-11	Polypeptidforbindelser

Legal Events

Date	Code	Title	Description
2003-12-08	MM1K	Lapsed by not paying the annual fees	Free format text: LAPSED IN OCTOBER 2003