NO885221L - ESTERS OF PHARMACOLOGICALLY ACTIVE CARBOXYLIC ACIDS. - Google Patents
ESTERS OF PHARMACOLOGICALLY ACTIVE CARBOXYLIC ACIDS.Info
- Publication number
- NO885221L NO885221L NO88885221A NO885221A NO885221L NO 885221 L NO885221 L NO 885221L NO 88885221 A NO88885221 A NO 88885221A NO 885221 A NO885221 A NO 885221A NO 885221 L NO885221 L NO 885221L
- Authority
- NO
- Norway
- Prior art keywords
- lower alkyl
- group
- aryl
- carboxylic acids
- esters
- Prior art date
Links
- 150000001735 carboxylic acids Chemical class 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003158 alcohol group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000005277 alkyl imino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Det er beskrevet nye, under fysiologiske betingelser spaltbare estere av farmakologisk virksomme karbonsyrer, spesielt antiblotisk aktive karbonsyrer av gruppen 0-laktam antibiotika, hvilke er særpreget ved at alkoholdelen av esteren er en gruppe av formel. 1 2. hvor R er H eller lavere alkyl, R er H, lavere alkyl, lavere halogenalkyl, lavere alkenyl, lavere alkoksy-k ar bo ny 1, aryi eller heteroaryl, eller sammen med Rlavere alkylen. Rer H, lavere alkyl eller lavere alkoksykarbonyl, R 4 er gruppen -COOR 5 , -COR £ , -SOj-R 6,. -CONReller -PO(OR), hvor Rer en substituert eller usubstituert hydrokarbonrest med opp til 12 karbonatomer, hvori opp til to metylengrupper kan være utbyttet med oksygenatomer, aryl eller aryl-lavere alkyl, R 6 er lavere alkyl eller aryl, R 7 og R 8 er hver H eller lavere alkyl eller sammen lavere alkylen, hvori en metylengruppe kan vatre erstattet med et oksygen-. eiler svovelatom eller med en imino- eller lavere alkyl-iminogruppe, og R q er lavere alkyl. Slike estere kan, såfremt det foreligger en basisk substituent,også eksistere i form av farmasøytisk fordragellge syreaddlsjonssalter.New physiologically cleavable esters of pharmacologically active carboxylic acids have been described, in particular antiblotically active carboxylic acids of the group O-lactam antibiotics, which are characterized in that the alcohol moiety of the ester is a group of formula. 1 wherein R is H or lower alkyl, R is H, lower alkyl, lower haloalkyl, lower alkenyl, lower alkoxy-carbonyl 1, aryl or heteroaryl, or together with R lower alkylene. R 1 is H, lower alkyl or lower alkoxycarbonyl, R 4 is the group -COOR 5, -COR -CONR or -PO (OR), wherein R 1 is a substituted or unsubstituted hydrocarbon radical having up to 12 carbon atoms, in which up to two methylene groups may be exchanged with oxygen atoms, aryl or aryl-lower alkyl, R 6 is lower alkyl or aryl, R 7 and R 8 is each H or lower alkyl or together lower alkylene, wherein a methylene group may be replaced with an oxygen-. or sulfur atom or with an imino or lower alkyl imino group, and R q is lower alkyl. Such esters, if a basic substituent is present, may also exist in the form of pharmaceutically acceptable acid addition salts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO921057A NO921057D0 (en) | 1987-11-24 | 1992-03-18 | 7-AMINOCEFALOSPORINDERIVATER |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH457087 | 1987-11-24 | ||
| CH316588 | 1988-08-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO885221D0 NO885221D0 (en) | 1988-11-23 |
| NO885221L true NO885221L (en) | 1989-05-25 |
Family
ID=25692354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO88885221A NO885221L (en) | 1987-11-24 | 1988-11-23 | ESTERS OF PHARMACOLOGICALLY ACTIVE CARBOXYLIC ACIDS. |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0318767A3 (en) |
| JP (1) | JPH01165585A (en) |
| KR (1) | KR890008082A (en) |
| AU (1) | AU614793B2 (en) |
| DK (1) | DK637888A (en) |
| FI (1) | FI885330A7 (en) |
| HU (1) | HU207522B (en) |
| IL (1) | IL88403A0 (en) |
| MC (1) | MC1991A1 (en) |
| NO (1) | NO885221L (en) |
| NZ (1) | NZ226989A (en) |
| PT (1) | PT89080B (en) |
| SU (1) | SU1598880A3 (en) |
| YU (2) | YU216188A (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL99898A (en) * | 1990-11-09 | 1996-10-31 | Eisai Co Ltd | 7-Acyl-3-substituted carbamoyloxy cephem compounds their preparation and antibacterial compositions containing them |
| WO1996034869A1 (en) * | 1995-05-03 | 1996-11-07 | Smithkline Beecham Plc | Esters of carbapenems |
| BR112014004716A2 (en) * | 2011-08-31 | 2017-03-28 | Mallinckrodt Llc | remote assembly of targeted nanoparticles using h-phosphonate-en / y-hydrophosphonylation reactions |
| WO2013036783A2 (en) | 2011-09-09 | 2013-03-14 | Cubist Pharmaceuticals, Inc. | Methods for treating intrapulmonary infections |
| US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
| US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
| UA121298C2 (en) | 2013-03-15 | 2020-05-12 | Мерк Шарп І Доум Корп. | ANTIBIOTIC COMPOSITION BASED ON CEFTOLOSAN AND TAZOBACTAM |
| US20140274997A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Cephalosporin pharmaceutical compositions |
| US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
| EP3043797B1 (en) | 2013-09-09 | 2020-04-08 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
| US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2476087A1 (en) * | 1980-02-18 | 1981-08-21 | Roussel Uclaf | NOVEL OXIMES DERIVED FROM 3-ALKYLOXY OR 3-ALKYL-THIOMETHYL 7-AMINO THIAZOLYL ACETAMIDO CEPHALOSPORANIC ACID, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS |
| JPS5984889A (en) * | 1982-11-05 | 1984-05-16 | Sumitomo Chem Co Ltd | Cephalosporin derivative and its preparation |
-
1988
- 1988-11-15 DK DK637888A patent/DK637888A/en not_active Application Discontinuation
- 1988-11-17 FI FI885330A patent/FI885330A7/en not_active Application Discontinuation
- 1988-11-17 NZ NZ226989A patent/NZ226989A/en unknown
- 1988-11-17 EP EP19880119145 patent/EP0318767A3/en not_active Withdrawn
- 1988-11-17 IL IL88403A patent/IL88403A0/en unknown
- 1988-11-21 JP JP63292541A patent/JPH01165585A/en active Pending
- 1988-11-21 AU AU25785/88A patent/AU614793B2/en not_active Ceased
- 1988-11-21 HU HU885974A patent/HU207522B/en unknown
- 1988-11-21 MC MC882016A patent/MC1991A1/en unknown
- 1988-11-22 KR KR1019880015325A patent/KR890008082A/en not_active Withdrawn
- 1988-11-23 NO NO88885221A patent/NO885221L/en unknown
- 1988-11-23 SU SU884356966A patent/SU1598880A3/en active
- 1988-11-24 YU YU02161/88A patent/YU216188A/en unknown
- 1988-11-24 PT PT89080A patent/PT89080B/en not_active IP Right Cessation
-
1989
- 1989-10-03 YU YU01915/89A patent/YU191589A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT89080B (en) | 1993-04-30 |
| EP0318767A2 (en) | 1989-06-07 |
| AU2578588A (en) | 1989-05-25 |
| PT89080A (en) | 1988-12-01 |
| IL88403A0 (en) | 1989-06-30 |
| NZ226989A (en) | 1992-05-26 |
| DK637888A (en) | 1989-05-25 |
| FI885330A0 (en) | 1988-11-17 |
| HU207522B (en) | 1993-04-28 |
| HUT48895A (en) | 1989-07-28 |
| NO885221D0 (en) | 1988-11-23 |
| EP0318767A3 (en) | 1991-03-20 |
| AU614793B2 (en) | 1991-09-12 |
| DK637888D0 (en) | 1988-11-15 |
| YU191589A (en) | 1991-02-28 |
| FI885330A7 (en) | 1989-05-25 |
| YU216188A (en) | 1990-04-30 |
| MC1991A1 (en) | 1989-11-30 |
| KR890008082A (en) | 1989-07-08 |
| SU1598880A3 (en) | 1990-10-07 |
| JPH01165585A (en) | 1989-06-29 |
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