NO884406D0 - Fremgangsmaate for fremstilling av heterocykliske spiroforbindelser. - Google Patents

Fremgangsmaate for fremstilling av heterocykliske spiroforbindelser.

Info

Publication number: NO884406D0
Authority: NO; Norway
Prior art keywords: group; formula; atom; alkyl; chem
Prior art date: 1987-10-05

Application number

NO884406A

Other languages

English (en)

Other versions

NO171109B (no

NO884406L (no

NO171109C (no

Inventor

Shin-Ichi Tsukamoto

Hitoshi Nagaoka

Shinji Usuda

Masatomi Harada

Toshinari Tamura

Original Assignee

Yamanouchi Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-05

Filing date

1988-10-04

Publication date

1988-10-04

1988-10-04 Application filed by Yamanouchi Pharma Co Ltd filed Critical Yamanouchi Pharma Co Ltd

1988-10-04 Publication of NO884406D0 publication Critical patent/NO884406D0/no

1989-04-06 Publication of NO884406L publication Critical patent/NO884406L/no

1992-10-19 Publication of NO171109B publication Critical patent/NO171109B/no

1993-01-27 Publication of NO171109C publication Critical patent/NO171109C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Other In-Based Heterocyclic Compounds (AREA)

NO884406A 1987-10-05 1988-10-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske spiroforbindelser NO171109C (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP25210487		1987-10-05
JP28629787		1987-11-12
JP8432788		1988-04-05

Publications (4)

Publication Number	Publication Date
NO884406D0 true NO884406D0 (no)	1988-10-04
NO884406L NO884406L (no)	1989-04-06
NO171109B NO171109B (no)	1992-10-19
NO171109C NO171109C (no)	1993-01-27

Family

ID=27304516

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO884406A NO171109C (no)	1987-10-05	1988-10-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske spiroforbindelser

Country Status (14)

Country	Link
US (4)	US4940795A (no)
EP (1)	EP0311313B1 (no)
JP (1)	JPH0236183A (no)
KR (1)	KR970007947B1 (no)
CN (1)	CN1036653C (no)
AT (1)	ATE122353T1 (no)
AU (1)	AU621559B2 (no)
CA (1)	CA1337817C (no)
DE (1)	DE3853758T2 (no)
DK (1)	DK554288A (no)
ES (1)	ES2074441T3 (no)
GR (1)	GR3016995T3 (no)
HU (1)	HU211687A9 (no)
NO (1)	NO171109C (no)

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ATE122353T1 (de) *	1987-10-05	1995-05-15	Yamanouchi Pharma Co Ltd	Heterozyklische spiroverbindungen und ihre herstellung.
US5412096A (en) *	1987-10-05	1995-05-02	Yamanouchi Pharmaceutical Co., Ltd.	Hydrochloride salts of heterocyclic spiro compounds
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US5075317A (en) *	1989-06-21	1991-12-24	Fisons Corporation	Spirofurane derivatives
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US5534520A (en) *	1990-04-10	1996-07-09	Fisher; Abraham	Spiro compounds containing five-membered rings
US5073560A (en) *	1990-07-20	1991-12-17	Fisons Corporation	Spiro-isoxazolidine derivatives as cholinergic agents
IE914238A1 (en) *	1990-12-19	1992-07-01	Fisons Corp	Novel spirofurane derivatives
ES2118814T3 (es) *	1991-05-15	1998-10-01	Yamanouchi Pharma Co Ltd	L-tartrato de (-)-(s)-2,8-dimetil-3-metilen-1-oxa-8-azaspiro(4,5)decano.
WO1994017045A1 (en) *	1993-01-28	1994-08-04	Merck & Co., Inc.	Spiro-substituted azacycles as tachykinin receptor antagonists
DE69318854T2 (de) *	1993-03-04	1998-10-08	Pfizer	Spiroazacyclischderivate als substanz p antagonisten
JP2983141B2 (ja) *	1993-10-06	1999-11-29	株式会社三和化学研究所	新規化合物及び該化合物を有効成分とする脳機能改善剤
ATE254618T1 (de)	1997-05-30	2003-12-15	Neurosearch As	Spiro chinuclidin-derivate, ihre herstellung und verwendung
US6528529B1 (en)	1998-03-31	2003-03-04	Acadia Pharmaceuticals Inc.	Compounds with activity on muscarinic receptors
SE9900100D0 (sv) *	1999-01-15	1999-01-15	Astra Ab	New compounds
JP2003506468A (ja) *	1999-08-13	2003-02-18	アベンティス・クロップサイエンス・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	農薬としての複素環式スピロ化合物
EP1328261A2 (en) *	2000-04-12	2003-07-23	Minerva Biotechnologies Corporation	Treatment of neurodegenerative disease
JP2003063964A (ja) *	2001-08-28	2003-03-05	Senju Pharmaceut Co Ltd	ドライアイまたはドライアイを伴なう疾病の予防治療剤
EP1802258A4 (en)	2004-09-13	2015-09-23	Chrono Therapeutics Inc	BIOSYNCHRONE TRANSDERMAL MEDICINES
WO2007013661A1 (ja) *	2005-07-26	2007-02-01	Senju Pharmaceutical Co., Ltd.	眼科用経皮吸収型製剤
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2620333A1 (en)	2005-08-26	2007-03-01	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
AU2006304787A1 (en)	2005-10-21	2007-04-26	Braincells, Inc.	Modulation of neurogenesis by PDE inhibition
EP2314289A1 (en)	2005-10-31	2011-04-27	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
WO2007104035A1 (en) *	2006-03-08	2007-09-13	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
US20100009983A1 (en) *	2006-05-09	2010-01-14	Braincells, Inc.	5 ht receptor mediated neurogenesis
EP2021000A2 (en)	2006-05-09	2009-02-11	Braincells, Inc.	Neurogenesis by modulating angiotensin
JP2009536667A (ja)	2006-05-09	2009-10-15	ブレインセルス，インコーポレイティド	５ｈｔ受容体介在性の神経新生
ITMI20061279A1 (it) *	2006-06-30	2008-01-01	Consiglio Nazionale Ricerche	Agonisti nicotinici selettivi per il sottotipo recettoriale alfa7,procedimento per la loro preparazione e relative composizioni farmaceutiche
MX2009002496A (es)	2006-09-08	2009-07-10	Braincells Inc	Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
US20080103165A1 (en) *	2006-09-19	2008-05-01	Braincells, Inc.	Ppar mediated modulation of neurogenesis
CA2664421A1 (en) *	2006-09-22	2008-03-27	Braincells, Inc.	Hmg coa reductase mediated modulation of neurogenesis
ES2521494T3 (es)	2007-04-02	2014-11-12	Parkinson's Institute	Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos
US9034891B2 (en)	2009-01-26	2015-05-19	Israel Institute For Biological Research	Bicyclic heterocyclic spiro compounds
CA2750777C (en) *	2009-01-26	2018-04-03	Israel Institute For Biological Research	Bicyclic heterocyclic spiro compounds
US20100216805A1 (en)	2009-02-25	2010-08-26	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
DK2882428T3 (en)	2012-07-13	2019-04-15	Pain Therapeutics Inc	PROCEDURE TO INHIBIT TAU PHOSPHORIZATION
US9433604B2 (en)	2013-10-08	2016-09-06	Pain Therapeutics Inc.	Method for inhibiting growth of cancer cells
JP2018511355A (ja)	2015-01-28	2018-04-26	クロノセラピューティクスインコーポレイテッドＣｈｒｏｎｏＴｈｅｒａｐｅｕｔｉｃｓＩｎｃ．	薬剤送達方法及びシステム
JP2020503950A (ja)	2017-01-06	2020-02-06	クロノセラピューティクスインコーポレイテッドＣｈｒｏｎｏＴｈｅｒａｐｅｕｔｉｃｓＩｎｃ．	経皮薬剤送達の装置及び方法
US11596779B2 (en)	2018-05-29	2023-03-07	Morningside Venture Investments Limited	Drug delivery methods and systems
CA3119992A1 (en)	2018-11-16	2020-05-22	Morningside Venture Investments Limited	Thermally regulated transdermal drug delivery system
CN115124545B (zh) *	2022-08-31	2023-01-03	南京远淑医药科技有限公司	一种促性腺激素释放激素受体拮抗剂中间体的合成方法

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SU434735A1 (ru) *	1972-03-01	1975-12-15	Научно-исследовательский институт химии Саратовского государственного университета им.Н.Г.Чернышевского	Способ получени 7-метил-(или 2,7диметил)-2-метокси- -пропионитрил1-окса-6-азаспиро-(4,4)-нонана
SU465399A1 (ru) *	1973-07-19	1975-03-30	Научно-исследовательский институт химии при Саратовском государственном университете им.Н.Г.Чернышевского	Способ получени натриевых солей 2-метокси- -карбоксиэтил-1-окса6-азаспиро-(4,4)-нонана
IL48452A (en) *	1975-11-11	1979-07-25	Purdue Frederick Co	Spiro (1,3-dioxolane-4,3') quinuclidines,their preparationand pharmaceutical compositions comprising them
US4321379A (en) *	1981-01-28	1982-03-23	American Cyanamid Company	4-Aryl-1-oxa-8-azaspiro[4,5]dec-3-en-2-ones
SU1002294A1 (ru) *	1981-08-14	1983-03-07	Ордена Трудового Красного Знамени Институт Тонкой Органической Химии Им.А.Л.Мнджояна	2,2-Диалкил-3-тиа-8-азаспиро/5,5/ундеканы
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US4981858A (en) *	1987-08-13	1991-01-01	State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research	Optical isomers
ATE122353T1 (de) *	1987-10-05	1995-05-15	Yamanouchi Pharma Co Ltd	Heterozyklische spiroverbindungen und ihre herstellung.
US5073560A (en) *	1990-07-20	1991-12-17	Fisons Corporation	Spiro-isoxazolidine derivatives as cholinergic agents

1988
- 1988-09-30 AT AT88309095T patent/ATE122353T1/de not_active IP Right Cessation
- 1988-09-30 EP EP88309095A patent/EP0311313B1/en not_active Expired - Lifetime
- 1988-09-30 DE DE3853758T patent/DE3853758T2/de not_active Expired - Lifetime
- 1988-09-30 ES ES88309095T patent/ES2074441T3/es not_active Expired - Lifetime
- 1988-10-03 CA CA000579193A patent/CA1337817C/en not_active Expired - Fee Related
- 1988-10-04 NO NO884406A patent/NO171109C/no unknown
- 1988-10-04 JP JP63251489A patent/JPH0236183A/ja active Granted
- 1988-10-04 DK DK554288A patent/DK554288A/da not_active Application Discontinuation
- 1988-10-05 US US07/254,375 patent/US4940795A/en not_active Ceased
- 1988-10-05 CN CN88109138A patent/CN1036653C/zh not_active Expired - Fee Related
- 1988-10-05 KR KR1019880012963A patent/KR970007947B1/ko not_active Expired - Fee Related
- 1988-10-05 AU AU23449/88A patent/AU621559B2/en not_active Ceased
1990
- 1990-01-25 US US07/470,093 patent/US5041549A/en not_active Expired - Fee Related
- 1990-01-25 US US07/470,091 patent/US4996210A/en not_active Expired - Fee Related
1992
- 1992-07-07 US US07/909,639 patent/USRE34653E/en not_active Expired - Lifetime
1995
- 1995-06-30 HU HU95P/P00638P patent/HU211687A9/hu unknown
- 1995-08-02 GR GR950402111T patent/GR3016995T3/el unknown

Also Published As

Publication number	Publication date
CN1036653C (zh)	1997-12-10
DK554288D0 (da)	1988-10-04
AU621559B2 (en)	1992-03-19
GR3016995T3 (en)	1995-11-30
ES2074441T3 (es)	1995-09-16
EP0311313A3 (en)	1990-12-05
USRE34653E (en)	1994-07-05
AU2344988A (en)	1989-04-06
ATE122353T1 (de)	1995-05-15
US4996210A (en)	1991-02-26
DK554288A (da)	1989-05-26
JPH0544948B2 (no)	1993-07-07
CN1033629A (zh)	1989-07-05
NO171109B (no)	1992-10-19
EP0311313A2 (en)	1989-04-12
NO884406L (no)	1989-04-06
CA1337817C (en)	1995-12-26
DE3853758T2 (de)	1995-09-07
KR890006649A (ko)	1989-06-15
JPH0236183A (ja)	1990-02-06
NO171109C (no)	1993-01-27
HU211687A9 (en)	1995-12-28
EP0311313B1 (en)	1995-05-10
US4940795A (en)	1990-07-10
DE3853758D1 (de)	1995-06-14
KR970007947B1 (ko)	1997-05-19
US5041549A (en)	1991-08-20

Publication	Publication Date	Title
NO884406D0 (no)	1988-10-04	Fremgangsmaate for fremstilling av heterocykliske spiroforbindelser.
DE3853477D1 (de)	1995-05-04	Makrozyklische verbindungen.
ATE79380T1 (de)	1992-08-15	2-substituierte-e-kondensierte(1,2,4>triazolo(1,5-c>pyrimidine, pharmazeutische zubereitungen und ihre verwendung.
AU2178497A (en)	1997-10-29	Cephem compounds and drugs containing the compounds
SE8501421D0 (sv)	1985-03-22	1-(hydroximetyl)-1,6,7,11b-tetrahydro-2h,4h-(1,3)-oxazino- eller -tiazino(4,3-a)isokinolinderivat, forfarande for deras framstellning och farmaceutiska kompositioner innehallande dem
IL75273A (en)	1991-06-10	Cephalosporin derivatives,process for their preparation and pharmaceutical compositions containing them
IL76175A0 (en)	1985-12-31	Tricyclic oxindole derivatives and pharmaceutical compositions containing them
DE69129165D1 (de)	1998-05-07	Prozess zur Darstellung von Lactamderivaten
IL103271A0 (en)	1993-02-21	Benzo(1,8)naphthyridine derivatives,their preparation and compositions containing them
GR3019921T3 (en)	1996-08-31	Alkylaminoalkylamino and -ether compounds as well as processes and intermediates for their preparation, and medicaments containing these compounds
NZ228803A (en)	1992-01-29	Sulphonanilides and anti-hypertensive compositions
AU546679B2 (en)	1985-09-12	Hydrogenated 1,4 thiazepine (thiazine) dione derivatives
ZA905407B (en)	1991-04-24	Pyrrolo(2,1-b)thiozle derivatives
GB8617907D0 (en)	1986-08-28	Tetracyclic indole derivatives
DE3883434D1 (de)	1993-09-30	Mitomycinanaloge, Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen.
HUP9801716A1 (hu)	1998-11-30	5H,10H-Imidazo[1,2-a]indeno[1,2-e]pirazin-4-on-származékok, eljárás előállításukra,az ezeket tartalmazó gyógyszerkészítmények és a vegyületek intermedierjei
NZ238238A (en)	1993-06-25	5h,10h-pyrido(3,4-b)pyrrolo(1,2-e)(1,4,5)oxadiazepine derivatives and pharmaceutical compositions thereof having analgesic activity
KR860004040A (ko)	1986-06-16	3,4-디아졸 유도체의 제조방법
ATE29885T1 (de)	1987-10-15	3-(2-(mono- und dialkylamino)propyl)-1,2,3,4tetrahydro-5h-(1)benzopyrano(3,4-c)pyridin-5-on und derivate dieser verbindungen, verfahren zu ihrer herstellung und solche verbindungen enthaltende pharmazeutische zusammensetzungen.