NO874905L - Hirudinvariant og fremgangsmaate til dens fremstilling. - Google Patents

Hirudinvariant og fremgangsmaate til dens fremstilling.

Info

Publication number: NO874905L
Authority: NO; Norway
Prior art keywords: hirud; invariant; procedure; manufacturing; amino acid
Prior art date: 1986-12-01

Application number

NO87874905A

Other languages

English (en)

Other versions

NO874905D0 (no

NO177500C (no

NO177500B (no

Inventor

Michael Courtney

Eric Degryse

Gerard Loison

Yves Lemoine

Original Assignee

Transgene Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-01

Filing date

1987-11-25

Publication date

1988-06-02

1987-11-25 Application filed by Transgene Sa filed Critical Transgene Sa

1987-11-25 Publication of NO874905D0 publication Critical patent/NO874905D0/no

1988-06-02 Publication of NO874905L publication Critical patent/NO874905L/no

1995-06-19 Publication of NO177500B publication Critical patent/NO177500B/no

1995-09-27 Publication of NO177500C publication Critical patent/NO177500C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Wood Science & Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Microbiology (AREA)
Tropical Medicine & Parasitology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Physics & Mathematics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Plant Pathology (AREA)
Epidemiology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Materials For Medical Uses (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

NO874905A 1986-12-01 1987-11-25 Fremgangsmåte til fremstilling av en terapeutisk aktiv hirudinvariant NO177500C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR868616723A FR2607517B2 (fr)	1986-12-01	1986-12-01	Vecteurs d'expression de variants de l'hirudine dans les levures, procede et produit obtenu

Publications (4)

Publication Number	Publication Date
NO874905D0 NO874905D0 (no)	1987-11-25
NO874905L true NO874905L (no)	1988-06-02
NO177500B NO177500B (no)	1995-06-19
NO177500C NO177500C (no)	1995-09-27

Family

ID=9341393

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO874905A NO177500C (no)	1986-12-01	1987-11-25	Fremgangsmåte til fremstilling av en terapeutisk aktiv hirudinvariant

Country Status (24)

Country	Link
US (1)	US5650301A (no)
EP (1)	EP0273800B1 (no)
JP (1)	JP2567263B2 (no)
KR (1)	KR960011918B1 (no)
AT (1)	ATE73462T1 (no)
AU (1)	AU617989B2 (no)
BG (1)	BG49719A3 (no)
CA (1)	CA1341416C (no)
CS (1)	CS276245B6 (no)
DE (1)	DE3777367D1 (no)
DK (1)	DK173247B1 (no)
ES (1)	ES2032465T3 (no)
FI (1)	FI99211C (no)
FR (1)	FR2607517B2 (no)
GR (1)	GR3004556T3 (no)
HU (1)	HU213871B (no)
IE (1)	IE60544B1 (no)
MC (1)	MC1884A1 (no)
NO (1)	NO177500C (no)
PL (1)	PL157254B1 (no)
PT (1)	PT86233B (no)
RO (1)	RO106890B1 (no)
SU (1)	SU1687032A3 (no)
ZA (1)	ZA879011B (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2628429B1 (fr) *	1988-03-08	1990-12-28	Transgene Sa	Variants de l'hirudine, leurs utilisations et les procedes pour les obtenir
GB8817160D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Novel proteins
GB8817161D0 (en) *	1988-07-19	1988-08-24	Ciba Geigy Ag	Modified proteins
US5284768A (en) *	1988-08-24	1994-02-08	Sanofi	Signal peptide, DNA sequences coding for the latter, expression vectors carrying one of these sequences, gram-negative bacteria transformed by these vectors, and process for the periplasmic production of a polypeptide
FR2645174B1 (fr) *	1989-03-31	1994-01-07	Transgene Sa	Souches de levure ameliorees pour la production de proteines heterologues matures en particulier d'hirudine et procede de preparation d'hirudine correspondant
US5879926A (en) *	1989-03-31	1999-03-09	Transgene S.A.	Yeast strains for the production of mature heterologous proteins, especially hirudin
FR2645175B1 (fr) *	1989-03-31	1994-02-18	Transgene Sa	Souche de saccharomyces cerevisiaeproductrice d'une proteine heterologue et procede de preparation de ladite proteine heterologue par fermentation de ladite souche
FR2646437B1 (fr) *	1989-04-28	1991-08-30	Transgene Sa	Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
FR2656531B1 (fr) *	1989-12-29	1992-04-24	Sanofi Sa	Promoteur artificiel pour l'expression de proteines dans le levure.
US5118790A (en) *	1990-07-24	1992-06-02	Sri International	Analogs of hirudin
DK0511393T3 (da) *	1990-11-08	1996-12-09	Japan Energy Corp	Hirudin-mutant, fremstilling af denne, antikoagulant, sekretorisk vektor, mikroorganisme transformeret af vektoren og fremstilling af produkt ud fra mikroorganismen
US5837808A (en) *	1991-08-20	1998-11-17	Baxter International Inc.	Analogs of hirudin
US5407822A (en) *	1991-10-02	1995-04-18	Sanofi	Artificial promoter for the expression of proteins in yeast
WO2020210965A1 (zh) *	2019-04-16	2020-10-22	广东双骏生物科技有限公司	水蛭素突变体的提取纯化方法及其应用
WO2025262265A1 (en)	2024-06-21	2025-12-26	Etablissement Francais Du Sang	Chimeric molecules comprising an anti-fibrin antibody and an antithrombotic molecule

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1985004418A1 (fr) *	1984-03-27	1985-10-10	Transgene S.A.	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
EP0168342B1 (de) *	1984-06-14	1991-07-03	Ciba-Geigy Ag	Verfahren zur Herstellung von Thrombin-Inhibitoren
DE3429430A1 (de) *	1984-08-10	1986-02-20	Hoechst Ag, 6230 Frankfurt	Gentechnologisches verfahren zur herstellung von hirudin und mittel zur durchfuehrung dieses verfahrens
DE3445517C2 (de) *	1984-12-13	1993-11-18	Ciba Geigy	Für ein Hirudin-ähnliches Protein codierende DNA-Sequenz und Verfahren zur Herstellung eines Hirudin-ähnlichen Proteins
FR2593518B1 (fr) *	1985-05-02	1989-09-08	Transgene Sa	Vecteurs d'expression et de secretion de l'hirudine par les levures transformees
EP0209061B1 (de) *	1985-07-17	1994-01-12	Hoechst Aktiengesellschaft	Neue Polypeptide mit blutgerinnungshemmender Wirkung, Verfahren zu deren Herstellung bzw. Gewinnung, deren Verwendung und diese enthaltende Mittel

1986
- 1986-12-01 FR FR868616723A patent/FR2607517B2/fr not_active Expired
1987
- 1987-11-25 NO NO874905A patent/NO177500C/no not_active IP Right Cessation
- 1987-11-27 AU AU81880/87A patent/AU617989B2/en not_active Expired
- 1987-11-27 PT PT86233A patent/PT86233B/pt unknown
- 1987-11-27 IE IE323987A patent/IE60544B1/en not_active IP Right Cessation
- 1987-11-30 RO RO130679A patent/RO106890B1/ro unknown
- 1987-11-30 ES ES198787402696T patent/ES2032465T3/es not_active Expired - Lifetime
- 1987-11-30 DK DK198706276A patent/DK173247B1/da not_active IP Right Cessation
- 1987-11-30 CA CA000553153A patent/CA1341416C/fr not_active Expired - Fee Related
- 1987-11-30 SU SU874203831A patent/SU1687032A3/ru active
- 1987-11-30 EP EP87402696A patent/EP0273800B1/fr not_active Expired - Lifetime
- 1987-11-30 AT AT87402696T patent/ATE73462T1/de not_active IP Right Cessation
- 1987-11-30 DE DE8787402696T patent/DE3777367D1/de not_active Expired - Lifetime
- 1987-12-01 CS CS878732A patent/CS276245B6/cs not_active IP Right Cessation
- 1987-12-01 MC MC871932A patent/MC1884A1/fr unknown
- 1987-12-01 PL PL1987269164A patent/PL157254B1/pl unknown
- 1987-12-01 JP JP62305504A patent/JP2567263B2/ja not_active Expired - Lifetime
- 1987-12-01 ZA ZA879011A patent/ZA879011B/xx unknown
- 1987-12-01 FI FI875295A patent/FI99211C/fi not_active IP Right Cessation
- 1987-12-01 HU HU875394A patent/HU213871B/hu unknown
- 1987-12-01 KR KR1019870013708A patent/KR960011918B1/ko not_active Expired - Fee Related
- 1987-12-01 BG BG082035A patent/BG49719A3/xx unknown
1992
- 1992-05-12 GR GR920400903T patent/GR3004556T3/el unknown
1995
- 1995-06-07 US US08/480,511 patent/US5650301A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
RO106890B1 (ro)	1993-07-30
NO874905D0 (no)	1987-11-25
US5650301A (en)	1997-07-22
PT86233A (fr)	1987-12-01
KR960011918B1 (ko)	1996-09-04
CS8708732A2 (en)	1991-07-16
FR2607517B2 (fr)	1989-12-22
ZA879011B (en)	1988-05-27
EP0273800A3 (en)	1988-07-20
CA1341416C (fr)	2003-01-21
FR2607517A2 (fr)	1988-06-03
DK173247B1 (da)	2000-05-22
ATE73462T1 (de)	1992-03-15
JPS63152987A (ja)	1988-06-25
FI99211B (fi)	1997-07-15
DE3777367D1 (de)	1992-04-16
DK627687A (da)	1988-06-02
PL269164A1 (en)	1988-08-18
ES2032465T3 (es)	1993-02-16
IE873239L (en)	1988-06-01
NO177500C (no)	1995-09-27
BG49719A3 (bg)	1992-01-15
MC1884A1 (fr)	1989-01-24
HU213871B (en)	1997-11-28
AU617989B2 (en)	1991-12-12
SU1687032A3 (ru)	1991-10-23
AU8188087A (en)	1988-06-02
FI875295A0 (fi)	1987-12-01
CS276245B6 (en)	1992-05-13
HUT45564A (en)	1988-07-28
EP0273800A2 (fr)	1988-07-06
IE60544B1 (en)	1994-07-27
FI99211C (fi)	1997-10-27
JP2567263B2 (ja)	1996-12-25
EP0273800B1 (fr)	1992-03-11
FI875295L (fi)	1988-06-02
PL157254B1 (pl)	1992-05-29
NO177500B (no)	1995-06-19
PT86233B (pt)	1990-11-07
GR3004556T3 (no)	1993-04-28
KR880007729A (ko)	1988-08-29
DK627687D0 (da)	1987-11-30

Publication	Publication Date	Title
NO874905D0 (no)	1987-11-25	Hirudinvariant og fremgangsmaate til dens fremstilling.
DE68927088D1 (de)	1996-10-10	Menschlicher Gefässpermeabilitätsfaktor
DE3878381D1 (de)	1993-03-25	Identifizierung von halbleiterplaettchen.
NO881974L (no)	1988-12-30	Varmeherdende silikonsammensetninger innbefattende fumarsure salter som herdekontrolltilsetningsstoff og bruk av disse.
DK565987D0 (da)	1987-10-28	Substituerede aminosyrer
ATE140962T1 (de)	1996-08-15	Dns-klone von menschlichem thrombomodulin
DK131087D0 (da)	1987-03-13	1,2,3,4-tetrahydro-6-substitueret-4-aryl-(eller -heterocyclo-)-3-substitueret-2-thioxo-/eller -oxo)-5-pyrimidincarboxylsyrer og estere
FI864552A0 (fi)	1986-11-10	Human-lysozym.
NO883960L (no)	1988-11-04	Arylcyklobutenylamidoalkensyrer og salter derav.
NO884434D0 (no)	1988-10-05	Aminosyrederivater.
DK429585D0 (da)	1985-09-23	Antibakterielt virksomme 4,5-dihydro-4-oxo-2-((2-trans-phenylcyclopropyl)amino)-3-furancarboxylsyrer og derivater deraf
ATE45675T1 (de)	1989-09-15	Verwendung von interferon gamma (ifn-gamma) zur herstellung von praeparationen zur behandlung rheumatischer erkrankungen.
NO895099D0 (no)	1989-12-18	Heteroatom-inneholdende perfluoralkylterminerte neopentylsyrer og salter derav.
IT1188557B (it)	1988-01-20	Acidi 8-osso-2-ossa-1-azabiciclo (4.2.0)ottano-3-carbossilici
DE3888715D1 (de)	1994-05-05	Reg-Gen und dadurch kodiertes Protein.
DK675688D0 (da)	1988-12-02	Griseolsyremonoestere samt fremgangsmaade og anvendelse deraf
TR23134A (tr)	1989-04-10	(2-siyano-2-(fenil veya naftil)-2-ikaameli-etil)pirazinler ve pridazinler
NO160710C (no)	1989-05-24	N-substituerte aminopropansulfonsyrederivater og plantevekstregulerende midler inneholdende disse.
DK622286A (da)	1987-06-25	Hydroxyalkylphenoxypropan-2-ol-3-amin og fremgangsmaade til fremstilling deraf
IT214012Z2 (it)	1990-03-05	Connettore perfezionato per basi tripolari e/o simili.
ATE103635T1 (de)	1994-04-15	Reg-gen und dadurch kodiertes protein.
DK396988D0 (da)	1988-07-15	Peptider samt fremstilling og anvendelse heraf
IE872024L (en)	1988-01-28	N-(2-cyano-2-alkoxyiminoacyl) amino acids

Legal Events

Date	Code	Title	Description
2007-12-03	MK1K	Patent expired