NO840419L - Cellekulturapparat og fremgangsmaate for et immobilisert cellekomposittprodukt - Google Patents

Cellekulturapparat og fremgangsmaate for et immobilisert cellekomposittprodukt

Info

Publication number: NO840419L
Authority: NO; Norway
Prior art keywords: carrier; cells; medium; cell; channels
Prior art date: 1983-02-04

Application number

NO840419A

Other languages

English (en)

Norwegian (no)

Inventor

Lee Allen Noll

Wayne Harold Pitcher Jr

Bjorn Kenneth Lydersen

Gordon Grimshaw Pugh

Bhavender Paul Sharma

Original Assignee

Corning Glass Works

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-02-04

Filing date

1984-02-03

Publication date

1984-08-06

1983-02-04 Priority claimed from US06/464,040 external-priority patent/US4514499A/en

1984-02-03 Application filed by Corning Glass Works filed Critical Corning Glass Works

1984-08-06 Publication of NO840419L publication Critical patent/NO840419L/no

Links

238000000034 method Methods 0.000 title claims description 53
239000000203 mixture Substances 0.000 title claims description 46
210000001822 immobilized cell Anatomy 0.000 title claims description 17
238000004113 cell culture Methods 0.000 title claims description 15
210000004027 cell Anatomy 0.000 claims description 157
239000002609 medium Substances 0.000 claims description 77
235000015097 nutrients Nutrition 0.000 claims description 32
241001465754 Metazoa Species 0.000 claims description 20
239000000463 material Substances 0.000 claims description 20
239000011521 glass Substances 0.000 claims description 19
230000010261 cell growth Effects 0.000 claims description 17
239000001963 growth medium Substances 0.000 claims description 17
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 11
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 11
239000008103 glucose Substances 0.000 claims description 11
230000008859 change Effects 0.000 claims description 10
230000007704 transition Effects 0.000 claims description 10
229910052878 cordierite Inorganic materials 0.000 claims description 9
JSKIRARMQDRGJZ-UHFFFAOYSA-N dimagnesium dioxido-bis[(1-oxido-3-oxo-2,4,6,8,9-pentaoxa-1,3-disila-5,7-dialuminabicyclo[3.3.1]nonan-7-yl)oxy]silane Chemical compound [Mg++].[Mg++].[O-][Si]([O-])(O[Al]1O[Al]2O[Si](=O)O[Si]([O-])(O1)O2)O[Al]1O[Al]2O[Si](=O)O[Si]([O-])(O1)O2 JSKIRARMQDRGJZ-UHFFFAOYSA-N 0.000 claims description 9
238000011081 inoculation Methods 0.000 claims description 9
231100000252 nontoxic Toxicity 0.000 claims description 9
230000003000 nontoxic effect Effects 0.000 claims description 9
238000012546 transfer Methods 0.000 claims description 8
239000006285 cell suspension Substances 0.000 claims description 7
239000003795 chemical substances by application Substances 0.000 claims description 7
230000000295 complement effect Effects 0.000 claims description 7
239000007788 liquid Substances 0.000 claims description 7
239000002207 metabolite Substances 0.000 claims description 7
238000012544 monitoring process Methods 0.000 claims description 7
238000003306 harvesting Methods 0.000 claims description 6
210000002966 serum Anatomy 0.000 claims description 6
KZHJGOXRZJKJNY-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Si]=O.O=[Al]O[Al]=O.O=[Al]O[Al]=O.O=[Al]O[Al]=O KZHJGOXRZJKJNY-UHFFFAOYSA-N 0.000 claims description 5
229910052863 mullite Inorganic materials 0.000 claims description 5
239000000377 silicon dioxide Substances 0.000 claims description 5
235000012239 silicon dioxide Nutrition 0.000 claims description 5
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 4
QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims description 4
CNLWCVNCHLKFHK-UHFFFAOYSA-N aluminum;lithium;dioxido(oxo)silane Chemical compound [Li+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O CNLWCVNCHLKFHK-UHFFFAOYSA-N 0.000 claims description 4
239000003153 chemical reaction reagent Substances 0.000 claims description 4
239000010445 mica Substances 0.000 claims description 4
229910052618 mica group Inorganic materials 0.000 claims description 4
229910052642 spodumene Inorganic materials 0.000 claims description 4
229910052726 zirconium Inorganic materials 0.000 claims description 4
230000000694 effects Effects 0.000 claims description 3
238000010438 heat treatment Methods 0.000 claims description 3
230000003134 recirculating effect Effects 0.000 claims description 3
238000004064 recycling Methods 0.000 claims description 3
230000001376 precipitating effect Effects 0.000 claims 4
TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 claims 3
OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 claims 3
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 2
230000036284 oxygen consumption Effects 0.000 claims 2
RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 claims 2
229910001928 zirconium oxide Inorganic materials 0.000 claims 2
229910010293 ceramic material Inorganic materials 0.000 claims 1
239000007787 solid Substances 0.000 description 12
239000000969 carrier Substances 0.000 description 11
239000000243 solution Substances 0.000 description 11
230000012010 growth Effects 0.000 description 9
241000196324 Embryophyta Species 0.000 description 8
239000007789 gas Substances 0.000 description 8
239000004033 plastic Substances 0.000 description 8
229920003023 plastic Polymers 0.000 description 8
239000000725 suspension Substances 0.000 description 8
102000004169 proteins and genes Human genes 0.000 description 7
108090000623 proteins and genes Proteins 0.000 description 7
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
239000000919 ceramic Substances 0.000 description 5
238000013461 design Methods 0.000 description 5
102000004190 Enzymes Human genes 0.000 description 4
108090000790 Enzymes Proteins 0.000 description 4
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
230000008901 benefit Effects 0.000 description 4
238000010276 construction Methods 0.000 description 4
229940088598 enzyme Drugs 0.000 description 4
239000012091 fetal bovine serum Substances 0.000 description 4
238000012423 maintenance Methods 0.000 description 4
239000001301 oxygen Substances 0.000 description 4
229910052760 oxygen Inorganic materials 0.000 description 4
230000008569 process Effects 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 3
229910002092 carbon dioxide Inorganic materials 0.000 description 3
238000010586 diagram Methods 0.000 description 3
238000005259 measurement Methods 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
239000002699 waste material Substances 0.000 description 3
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
102000035195 Peptidases Human genes 0.000 description 2
108091005804 Peptidases Proteins 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
102000004142 Trypsin Human genes 0.000 description 2
108090000631 Trypsin Proteins 0.000 description 2
238000007792 addition Methods 0.000 description 2
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
230000003698 anagen phase Effects 0.000 description 2
239000000872 buffer Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000011575 calcium Substances 0.000 description 2
238000004364 calculation method Methods 0.000 description 2
239000001569 carbon dioxide Substances 0.000 description 2
239000012876 carrier material Substances 0.000 description 2
239000006143 cell culture medium Substances 0.000 description 2
239000012141 concentrate Substances 0.000 description 2
238000011109 contamination Methods 0.000 description 2
210000004748 cultured cell Anatomy 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
210000002950 fibroblast Anatomy 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
230000007246 mechanism Effects 0.000 description 2
238000010899 nucleation Methods 0.000 description 2
239000002953 phosphate buffered saline Substances 0.000 description 2
239000000523 sample Substances 0.000 description 2
229920006395 saturated elastomer Polymers 0.000 description 2
238000004062 sedimentation Methods 0.000 description 2
238000000926 separation method Methods 0.000 description 2
239000012679 serum free medium Substances 0.000 description 2
230000001954 sterilising effect Effects 0.000 description 2
238000004659 sterilization and disinfection Methods 0.000 description 2
239000012588 trypsin Substances 0.000 description 2
210000003501 vero cell Anatomy 0.000 description 2
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
244000283763 Acetobacter aceti Species 0.000 description 1
235000007847 Acetobacter aceti Nutrition 0.000 description 1
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
241000282693 Cercopithecidae Species 0.000 description 1
CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
229930182816 L-glutamine Natural products 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
239000006087 Silane Coupling Agent Substances 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
238000003556 assay Methods 0.000 description 1
230000000712 assembly Effects 0.000 description 1
238000000429 assembly Methods 0.000 description 1
239000012298 atmosphere Substances 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
229910052810 boron oxide Inorganic materials 0.000 description 1
239000005388 borosilicate glass Substances 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
210000002421 cell wall Anatomy 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000004590 computer program Methods 0.000 description 1
238000010924 continuous production Methods 0.000 description 1
238000012364 cultivation method Methods 0.000 description 1
238000002716 delivery method Methods 0.000 description 1
JKWMSGQKBLHBQQ-UHFFFAOYSA-N diboron trioxide Chemical compound O=BOB=O JKWMSGQKBLHBQQ-UHFFFAOYSA-N 0.000 description 1
238000009826 distribution Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000003480 eluent Substances 0.000 description 1
238000010828 elution Methods 0.000 description 1
238000011067 equilibration Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000005187 foaming Methods 0.000 description 1
239000010200 folin Substances 0.000 description 1
210000003953 foreskin Anatomy 0.000 description 1
229940072360 garamycin Drugs 0.000 description 1
238000001879 gelation Methods 0.000 description 1
239000003349 gelling agent Substances 0.000 description 1
230000005484 gravity Effects 0.000 description 1
230000007773 growth pattern Effects 0.000 description 1
239000002654 heat shrinkable material Substances 0.000 description 1
239000012510 hollow fiber Substances 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
238000007373 indentation Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
238000011835 investigation Methods 0.000 description 1
210000003292 kidney cell Anatomy 0.000 description 1
238000009630 liquid culture Methods 0.000 description 1
238000011068 loading method Methods 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
210000004962 mammalian cell Anatomy 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
238000000386 microscopy Methods 0.000 description 1
239000004005 microsphere Substances 0.000 description 1
239000007758 minimum essential medium Substances 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
235000006286 nutrient intake Nutrition 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
238000012809 post-inoculation Methods 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000004886 process control Methods 0.000 description 1
229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
238000005086 pumping Methods 0.000 description 1
230000009666 qualitative growth Effects 0.000 description 1
238000011002 quantification Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000001850 reproductive effect Effects 0.000 description 1
239000004017 serum-free culture medium Substances 0.000 description 1
238000010008 shearing Methods 0.000 description 1
239000002002 slurry Substances 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
235000017550 sodium carbonate Nutrition 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
238000011179 visual inspection Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/06—Tubular
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/06—Plates; Walls; Drawers; Multilayer plates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/10—Hollow fibers or tubes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/12—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by pressure

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Wood Science & Technology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Sustainable Development (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Clinical Laboratory Science (AREA)
Inorganic Chemistry (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Immobilizing And Processing Of Enzymes And Microorganisms (AREA)

NO840419A 1983-02-04 1984-02-03 Cellekulturapparat og fremgangsmaate for et immobilisert cellekomposittprodukt NO840419L (no)

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US46402883A	1983-02-04	1983-02-04
US46401183A	1983-02-04	1983-02-04
US46402783A	1983-02-04	1983-02-04
US46401283A	1983-02-04	1983-02-04
US46412683A	1983-02-04	1983-02-04
US06/464,040 US4514499A (en)	1983-02-04	1983-02-04	Cell culture using a monolithic support

Publications (1)

Publication Number	Publication Date
NO840419L true NO840419L (no)	1984-08-06

Family

ID=27560023

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO840419A NO840419L (no)	1983-02-04	1984-02-03	Cellekulturapparat og fremgangsmaate for et immobilisert cellekomposittprodukt

Country Status (9)

Country	Link
EP (1)	EP0121981B1 (pt)
AU (1)	AU580949B2 (pt)
BR (1)	BR8400350A (pt)
CA (1)	CA1221045A (pt)
DE (1)	DE3478860D1 (pt)
DK (1)	DK50184A (pt)
IL (1)	IL70840A (pt)
NO (1)	NO840419L (pt)
NZ (1)	NZ207037A (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8508976D0 (en) *	1985-04-04	1985-05-09	Davies G A	Reactor unit
DE3855758T2 (de) *	1987-02-26	1997-07-31	Bio Polymers Pty Ltd	Substanz aus pflanzlichem gummi und ihre verwendung in lebensmitteln
US5422270A (en) *	1987-05-19	1995-06-06	The United States Of America As Represented By The Department Of Health And Human Services	One-step tray test for release of soluble mediators and apparatus therefore
GB8721018D0 (en) *	1987-09-07	1987-10-14	Alcan Int Ltd	Porous inorganic membrane support
US5240854A (en) *	1989-06-05	1993-08-31	Berry Eric S	Continuous high-density cell culture system
DE69026954T2 (de) *	1990-09-19	1996-09-05	Mark J Ramberg	Kontinuierliche zellkulturanlage von hoher dichtheit
US6271001B1 (en)	1995-03-23	2001-08-07	Bio Polymers Pty. Ltd.	Cultured plant cell gums for food, pharmaceutical, cosmetic and industrial applications
JP3680739B2 (ja) *	2001-02-06	2005-08-10	日産自動車株式会社	無段変速機の変速制御装置
KR101678796B1 (ko)	2012-09-06	2016-11-23	플루리스템 리미티드	세포 배양 장치 및 방법
WO2014085440A1 (en) *	2012-11-30	2014-06-05	Corning Incorporated	Chitosan-functionalized cordierite monoliths as heavy metal sorbents
WO2024058942A1 (en) *	2022-09-16	2024-03-21	Corning Incorporated	Substrate for bioreactor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5642584A (en) *	1979-09-18	1981-04-20	Asahi Chem Ind Co Ltd	Cell cultivation method
ZA839242B (en) *	1982-12-15	1984-09-26	Bio Response Inc	A method and system for culturing and treating substances disposed in a flowing culture fluid

1984
- 1984-01-20 CA CA000445806A patent/CA1221045A/en not_active Expired
- 1984-01-27 BR BR8400350A patent/BR8400350A/pt unknown
- 1984-01-31 DE DE8484300607T patent/DE3478860D1/de not_active Expired
- 1984-01-31 EP EP84300607A patent/EP0121981B1/en not_active Expired
- 1984-01-31 IL IL70840A patent/IL70840A/xx unknown
- 1984-01-31 AU AU23909/84A patent/AU580949B2/en not_active Ceased
- 1984-02-03 NZ NZ207037A patent/NZ207037A/en unknown
- 1984-02-03 NO NO840419A patent/NO840419L/no unknown
- 1984-02-03 DK DK50184A patent/DK50184A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP0121981B1 (en)	1989-07-05
DK50184D0 (da)	1984-02-03
EP0121981A1 (en)	1984-10-17
NZ207037A (en)	1988-01-08
IL70840A (en)	1987-12-20
AU2390984A (en)	1984-08-09
BR8400350A (pt)	1984-10-09
IL70840A0 (en)	1984-04-30
AU580949B2 (en)	1989-02-09
DE3478860D1 (en)	1989-08-10
CA1221045A (en)	1987-04-28
DK50184A (da)	1984-08-05

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