NO332978B1 - Anvendelse av (11ß,17ß)-11-(1,3-benzodioksol-5-yl)-17-hydroksy-17-(1-propynyl)-ostra-4,9-dien-3-on for behandling av alvorlig depressiv forstyrrelse - Google Patents

Anvendelse av (11ß,17ß)-11-(1,3-benzodioksol-5-yl)-17-hydroksy-17-(1-propynyl)-ostra-4,9-dien-3-on for behandling av alvorlig depressiv forstyrrelse

Info

Publication number: NO332978B1
Authority: NO; Norway
Prior art keywords: treatment; patients; org; cortisol; propynyl
Prior art date: 2001-10-26

Application number

NO20041651A

Other languages

English (en)

Norwegian (no)

Other versions

NO20041651L (no

Inventor

Cornelis Sennef

Nernardus Wijnand Mathys Marie Peeters

Original Assignee

Pop Test Cortisol Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-10-26

Filing date

2004-04-23

Publication date

2013-02-11

2004-04-23 Application filed by Pop Test Cortisol Llc filed Critical Pop Test Cortisol Llc

2004-04-23 Publication of NO20041651L publication Critical patent/NO20041651L/no

2013-02-11 Publication of NO332978B1 publication Critical patent/NO332978B1/no

Links

238000011282 treatment Methods 0.000 title claims abstract description 21
-1 1,3-benzodioxol-5-yl Chemical group 0.000 title 1
125000000530 1-propynyl group Chemical group [H]C([H])([H])C#C* 0.000 title 1
230000003001 depressive effect Effects 0.000 title 1
239000003814 drug Substances 0.000 claims abstract description 6
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims description 44
229960000890 hydrocortisone Drugs 0.000 claims description 22
208000024714 major depressive disease Diseases 0.000 claims description 12
229960003957 dexamethasone Drugs 0.000 claims description 9
UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 9
229940079593 drug Drugs 0.000 claims description 5
230000001629 suppression Effects 0.000 claims description 5
238000012360 testing method Methods 0.000 claims description 5
238000002360 preparation method Methods 0.000 claims description 4
150000001875 compounds Chemical class 0.000 claims description 3
230000036470 plasma concentration Effects 0.000 claims description 2
DFELGYQKEOCHOA-BZAFBGKRSA-N (8s,11r,13s,14s,17s)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=C1 DFELGYQKEOCHOA-BZAFBGKRSA-N 0.000 abstract description 23
208000020401 Depressive disease Diseases 0.000 abstract description 3
238000004519 manufacturing process Methods 0.000 abstract description 3
239000000825 pharmaceutical preparation Substances 0.000 abstract description 2
230000001430 anti-depressive effect Effects 0.000 description 11
239000002775 capsule Substances 0.000 description 10
230000000694 effects Effects 0.000 description 10
VKHAHZOOUSRJNA-GCNJZUOMSA-N mifepristone Chemical compound C1([C@@H]2C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]3CC[C@@]([C@]3(C2)C)(O)C#CC)=CC=C(N(C)C)C=C1 VKHAHZOOUSRJNA-GCNJZUOMSA-N 0.000 description 10
230000015572 biosynthetic process Effects 0.000 description 8
229960003248 mifepristone Drugs 0.000 description 8
150000003431 steroids Chemical class 0.000 description 8
238000003786 synthesis reaction Methods 0.000 description 8
AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 description 7
AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 description 7
239000000935 antidepressant agent Substances 0.000 description 7
229940005513 antidepressants Drugs 0.000 description 7
239000003862 glucocorticoid Substances 0.000 description 7
229960002296 paroxetine Drugs 0.000 description 7
230000000994 depressogenic effect Effects 0.000 description 6
239000003112 inhibitor Substances 0.000 description 6
230000004179 hypothalamic–pituitary–adrenal axis Effects 0.000 description 5
230000009471 action Effects 0.000 description 4
230000008859 change Effects 0.000 description 4
239000003850 glucocorticoid receptor antagonist Substances 0.000 description 4
230000001965 increasing effect Effects 0.000 description 4
102400000739 Corticotropin Human genes 0.000 description 3
101800000414 Corticotropin Proteins 0.000 description 3
239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 3
102000003676 Glucocorticoid Receptors Human genes 0.000 description 3
108090000079 Glucocorticoid Receptors Proteins 0.000 description 3
208000028017 Psychotic disease Diseases 0.000 description 3
IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 3
229960000258 corticotropin Drugs 0.000 description 3
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
102000012289 Corticotropin-Releasing Hormone Human genes 0.000 description 2
108010022152 Corticotropin-Releasing Hormone Proteins 0.000 description 2
208000014311 Cushing syndrome Diseases 0.000 description 2
206010054089 Depressive symptom Diseases 0.000 description 2
241000700159 Rattus Species 0.000 description 2
230000001919 adrenal effect Effects 0.000 description 2
210000004100 adrenal gland Anatomy 0.000 description 2
229940041967 corticotropin-releasing hormone Drugs 0.000 description 2
KLVRDXBAMSPYKH-RKYZNNDCSA-N corticotropin-releasing hormone (human) Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)[C@@H](C)CC)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(C)C)C(C)C)C1=CNC=N1 KLVRDXBAMSPYKH-RKYZNNDCSA-N 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
201000010099 disease Diseases 0.000 description 2
229940126013 glucocorticoid receptor antagonist Drugs 0.000 description 2
238000011835 investigation Methods 0.000 description 2
238000000034 method Methods 0.000 description 2
239000002395 mineralocorticoid Substances 0.000 description 2
239000000902 placebo Substances 0.000 description 2
229940068196 placebo Drugs 0.000 description 2
230000003389 potentiating effect Effects 0.000 description 2
201000009395 primary hyperaldosteronism Diseases 0.000 description 2
230000004044 response Effects 0.000 description 2
229940037128 systemic glucocorticoids Drugs 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
206010001367 Adrenal insufficiency Diseases 0.000 description 1
208000019901 Anxiety disease Diseases 0.000 description 1
201000001320 Atherosclerosis Diseases 0.000 description 1
208000010412 Glaucoma Diseases 0.000 description 1
229940127421 Glucocorticoid Synthesis Inhibitors Drugs 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
102000003979 Mineralocorticoid Receptors Human genes 0.000 description 1
108090000375 Mineralocorticoid Receptors Proteins 0.000 description 1
208000001132 Osteoporosis Diseases 0.000 description 1
208000007913 Pituitary Neoplasms Diseases 0.000 description 1
206010048675 Pituitary enlargement Diseases 0.000 description 1
208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
230000005856 abnormality Effects 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
208000017515 adrenocortical insufficiency Diseases 0.000 description 1
VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
ROBVIMPUHSLWNV-UHFFFAOYSA-N aminoglutethimide Chemical compound C=1C=C(N)C=CC=1C1(CC)CCC(=O)NC1=O ROBVIMPUHSLWNV-UHFFFAOYSA-N 0.000 description 1
229960003437 aminoglutethimide Drugs 0.000 description 1
102000001307 androgen receptors Human genes 0.000 description 1
108010080146 androgen receptors Proteins 0.000 description 1
230000008485 antagonism Effects 0.000 description 1
239000005557 antagonist Substances 0.000 description 1
230000003466 anti-cipated effect Effects 0.000 description 1
230000002800 anti-glucocorticoid effect Effects 0.000 description 1
230000001838 anti-progestagenic effect Effects 0.000 description 1
230000036506 anxiety Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000033228 biological regulation Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
230000001364 causal effect Effects 0.000 description 1
210000001175 cerebrospinal fluid Anatomy 0.000 description 1
230000010485 coping Effects 0.000 description 1
206010012601 diabetes mellitus Diseases 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
230000004064 dysfunction Effects 0.000 description 1
230000008482 dysregulation Effects 0.000 description 1
230000002124 endocrine Effects 0.000 description 1
229940011871 estrogen Drugs 0.000 description 1
239000000262 estrogen Substances 0.000 description 1
102000015694 estrogen receptors Human genes 0.000 description 1
108010038795 estrogen receptors Proteins 0.000 description 1
238000009472 formulation Methods 0.000 description 1
230000006589 gland dysfunction Effects 0.000 description 1
239000008187 granular material Substances 0.000 description 1
231100000086 high toxicity Toxicity 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000006698 induction Effects 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
229940127021 low-dose drug Drugs 0.000 description 1
229960004465 metyrapone Drugs 0.000 description 1
FJLBFSROUSIWMA-UHFFFAOYSA-N metyrapone Chemical compound C=1C=CN=CC=1C(C)(C)C(=O)C1=CC=CN=C1 FJLBFSROUSIWMA-UHFFFAOYSA-N 0.000 description 1
RONZAEMNMFQXRA-UHFFFAOYSA-N mirtazapine Chemical compound C1C2=CC=CN=C2N2CCN(C)CC2C2=CC=CC=C21 RONZAEMNMFQXRA-UHFFFAOYSA-N 0.000 description 1
230000009907 neuroendocrine response Effects 0.000 description 1
230000027758 ovulation cycle Effects 0.000 description 1
230000007170 pathology Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
208000010916 pituitary tumor Diseases 0.000 description 1
229940037129 plain mineralocorticoids for systemic use Drugs 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
102000003998 progesterone receptors Human genes 0.000 description 1
108090000468 progesterone receptors Proteins 0.000 description 1
208000020016 psychiatric disease Diseases 0.000 description 1
230000000306 recurrent effect Effects 0.000 description 1
229940023942 remeron Drugs 0.000 description 1
238000012552 review Methods 0.000 description 1
208000011581 secondary neoplasm Diseases 0.000 description 1
230000000580 secretagogue effect Effects 0.000 description 1
229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 1
239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 1
208000019116 sleep disease Diseases 0.000 description 1
239000000243 solution Substances 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
210000001541 thymus gland Anatomy 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
230000002485 urinary effect Effects 0.000 description 1
230000004584 weight gain Effects 0.000 description 1
235000019786 weight gain Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20041651A 2001-10-26 2004-04-23 Anvendelse av (11ß,17ß)-11-(1,3-benzodioksol-5-yl)-17-hydroksy-17-(1-propynyl)-ostra-4,9-dien-3-on for behandling av alvorlig depressiv forstyrrelse NO332978B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01204072		2001-10-26
PCT/EP2002/011732 WO2003037354A1 (en)	2001-10-26	2002-10-21	USE OF (11β, 17β)-11-(1,3-BENZODIOXOL-5-YL)-17-HYDROXY-17-(1-PROPYNYL)-ESTRA-4,9-DIEN-3-ONE IN THE TREATMENT OF MAJOR DEPRESSIVE DISORDER

Publications (2)

Publication Number	Publication Date
NO20041651L NO20041651L (no)	2004-04-23
NO332978B1 true NO332978B1 (no)	2013-02-11

Family

ID=8181136

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20041651A NO332978B1 (no)	2001-10-26	2004-04-23	Anvendelse av (11ß,17ß)-11-(1,3-benzodioksol-5-yl)-17-hydroksy-17-(1-propynyl)-ostra-4,9-dien-3-on for behandling av alvorlig depressiv forstyrrelse

Country Status (26)

Country	Link
US (1)	US20040266863A1 (is)
EP (2)	EP1652526B1 (is)
JP (1)	JP4647909B2 (is)
KR (1)	KR20050038580A (is)
CN (1)	CN100531738C (is)
AT (2)	ATE420649T1 (is)
AU (1)	AU2002348996B2 (is)
BR (1)	BR0213466A (is)
CA (1)	CA2463446C (is)
CY (1)	CY1110173T1 (is)
DE (2)	DE60209248D1 (is)
DK (1)	DK1652526T3 (is)
EC (1)	ECSP045080A (is)
ES (1)	ES2319563T3 (is)
HR (1)	HRP20040370B1 (is)
HU (1)	HUP0500070A3 (is)
IL (2)	IL161248A0 (is)
IS (1)	IS2702B (is)
MX (1)	MXPA04003781A (is)
NO (1)	NO332978B1 (is)
NZ (1)	NZ532429A (is)
PL (1)	PL206687B1 (is)
PT (1)	PT1652526E (is)
RU (1)	RU2302245C2 (is)
WO (1)	WO2003037354A1 (is)
ZA (1)	ZA200403088B (is)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050080061A1 (en) *	2003-07-23	2005-04-14	Corcept Therapeutics, Inc.	Antiglucocorticoid therapy for the prevention of neurological damage in premature infants
MX2007006045A (es) *	2004-11-19	2007-06-13	Organon Nv	Combinacion farmaceutica que comprende inhibidor selectivo de reabsorcion de serotonina y antagonista del receptor de glucocorticoide para tratamiento de depresion.
AU2011236053B2 (en) *	2004-11-19	2014-06-26	Merck Sharpe & Dohme B.V.	Drug combination comprising a selective serotonin reuptake inhibitor and a glucocorticoid receptor antagonist for the treatment of depression
JP2009535430A (ja) *	2006-05-02	2009-10-01	コーセプトセラピューティクス，インコーポレイテッド	Ｉｌ−２を摂取している患者における抑うつを処置するためのグルココルチコイドレセプターｉｉアンタゴニストの使用
JP5804395B2 (ja) *	2011-02-03	2015-11-04	ポップテストオンコロジーエルエルシー	診断と治療のためのシステムおよび方法
WO2012145258A1 (en) *	2011-04-18	2012-10-26	Pop Test Cortisol Llc	Hair loss treatment
US8986677B2 (en) *	2012-07-30	2015-03-24	Pop Test Cortisol Llc	Therapeutic compositions and methods

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4814333A (en) *	1987-07-28	1989-03-21	The Trustees Of Dartmouth College	Method for treatment of hypercortisolemic, depressed patients
DE4447401A1 (de) *	1994-12-23	1996-07-04	Schering Ag	14,17-C¶2¶-überbrückte Steroide
IL118974A (en) *	1995-08-17	2001-09-13	Akzo Nobel Nv	History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them
DE19727772A1 (de) *	1997-06-30	1999-01-28	Forschungszentrum Juelich Gmbh	Magnetflußsensor mit ringförmiger Sonde
CN1919199A (zh) *	1997-10-06	2007-02-28	利兰·斯坦福青年大学托管委员会	治疗糖皮质素功能失调相关性精神病的方法
KR100895662B1 (ko) *	2001-03-23	2009-05-07	코어셉트 쎄라퓨틱스, 잉크.	글루코코르티코이드 수용체 특이적 길항제를 이용한스트레스 장애의 치료 방법
DE60238671D1 (de) *	2001-05-04	2011-02-03	Corcept Therapeutics Inc	Verwendung von glucocorticoid-rezeptor-spezifischen antagonisten zur behandlung von delirium
NZ531477A (en) *	2001-08-31	2006-10-27	Corcept Therapeutics Inc	Use of a glucocorticoid receptor antagonist comprising a steroidal skeleton with at least one phenyl-containing moiety in the 11-beta position of the steroidal skeleton to decrease cognitive deterioration in adults with Down's syndrome

2002
- 2002-10-21 JP JP2003539697A patent/JP4647909B2/ja not_active Expired - Fee Related
- 2002-10-21 PT PT06101005T patent/PT1652526E/pt unknown
- 2002-10-21 KR KR1020047006050A patent/KR20050038580A/ko not_active Ceased
- 2002-10-21 NZ NZ532429A patent/NZ532429A/en not_active IP Right Cessation
- 2002-10-21 MX MXPA04003781A patent/MXPA04003781A/es active IP Right Grant
- 2002-10-21 HR HRP20040370AA patent/HRP20040370B1/xx not_active IP Right Cessation
- 2002-10-21 WO PCT/EP2002/011732 patent/WO2003037354A1/en not_active Ceased
- 2002-10-21 DK DK06101005T patent/DK1652526T3/da active
- 2002-10-21 BR BR0213466-7A patent/BR0213466A/pt not_active IP Right Cessation
- 2002-10-21 AT AT06101005T patent/ATE420649T1/de active
- 2002-10-21 ES ES06101005T patent/ES2319563T3/es not_active Expired - Lifetime
- 2002-10-21 RU RU2004116082/15A patent/RU2302245C2/ru not_active IP Right Cessation
- 2002-10-21 AU AU2002348996A patent/AU2002348996B2/en not_active Ceased
- 2002-10-21 AT AT02781273T patent/ATE317700T1/de active
- 2002-10-21 US US10/493,981 patent/US20040266863A1/en not_active Abandoned
- 2002-10-21 DE DE60209248T patent/DE60209248D1/de not_active Expired - Lifetime
- 2002-10-21 DE DE60230936T patent/DE60230936D1/de not_active Expired - Lifetime
- 2002-10-21 CN CNB028210417A patent/CN100531738C/zh not_active Expired - Fee Related
- 2002-10-21 IL IL16124802A patent/IL161248A0/xx unknown
- 2002-10-21 HU HU0500070A patent/HUP0500070A3/hu unknown
- 2002-10-21 CA CA2463446A patent/CA2463446C/en not_active Expired - Fee Related
- 2002-10-21 EP EP06101005A patent/EP1652526B1/en not_active Expired - Lifetime
- 2002-10-21 EP EP02781273A patent/EP1441739B1/en not_active Expired - Lifetime
- 2002-10-21 PL PL369261A patent/PL206687B1/pl not_active IP Right Cessation
2004
- 2004-03-31 IS IS7204A patent/IS2702B/is unknown
- 2004-04-01 IL IL161248A patent/IL161248A/en not_active IP Right Cessation
- 2004-04-22 ZA ZA200403088A patent/ZA200403088B/en unknown
- 2004-04-23 NO NO20041651A patent/NO332978B1/no not_active IP Right Cessation
- 2004-04-23 EC EC2004005080A patent/ECSP045080A/es unknown
2009
- 2009-02-02 CY CY20091100116T patent/CY1110173T1/el unknown

Also Published As

Publication number	Publication date
NO20041651L (no)	2004-04-23
RU2302245C2 (ru)	2007-07-10
MXPA04003781A (es)	2004-07-30
EP1652526B1 (en)	2009-01-14
CN100531738C (zh)	2009-08-26
IL161248A (en)	2010-12-30
DE60230936D1 (de)	2009-03-05
CA2463446C (en)	2010-02-23
DK1652526T3 (da)	2009-05-18
EP1652526A2 (en)	2006-05-03
ATE420649T1 (de)	2009-01-15
DE60209248D1 (de)	2006-04-20
WO2003037354A1 (en)	2003-05-08
ATE317700T1 (de)	2006-03-15
HUP0500070A2 (hu)	2005-04-28
JP2005521637A (ja)	2005-07-21
AU2002348996B2 (en)	2008-06-05
HRP20040370B1 (hr)	2012-09-30
HUP0500070A3 (en)	2012-09-28
JP4647909B2 (ja)	2011-03-09
IL161248A0 (en)	2004-09-27
PT1652526E (pt)	2009-02-06
BR0213466A (pt)	2004-11-09
NZ532429A (en)	2004-10-29
RU2004116082A (ru)	2005-05-10
EP1441739B1 (en)	2006-02-15
ECSP045080A (es)	2004-06-28
HRP20040370A2 (en)	2004-08-31
EP1441739A1 (en)	2004-08-04
CN1582153A (zh)	2005-02-16
PL206687B1 (pl)	2010-09-30
KR20050038580A (ko)	2005-04-27
ES2319563T3 (es)	2009-05-08
CA2463446A1 (en)	2003-05-08
PL369261A1 (en)	2005-04-18
CY1110173T1 (el)	2015-01-14
HK1087357A1 (en)	2006-10-13
IS7204A (is)	2004-03-31
ZA200403088B (en)	2005-01-24
EP1652526A3 (en)	2006-08-02
US20040266863A1 (en)	2004-12-30
IS2702B (is)	2010-11-15

Publication	Publication Date	Title
AU616208B2 (en)	1991-10-24	Compounds having antiprogestational and anti-estrogenic activities for induction of labor and for termination of pregnancy, as well as for the treatment of gynaecological disorders
Ashraf et al.	2006	Estrogen and hypertension
Genazzani et al.	1999	Menopause and the central nervous system: intervention options
JP2011021044A (ja)	2011-02-03	片頭痛を処置するための方法
KR20090067198A (ko)	2009-06-24	자궁내막 증식을 억제하는 조성물과 방법
KR20210153056A (ko)	2021-12-16	인슐린 감수성 개선 방법
EP2576582B1 (en)	2019-09-18	Treatment of muscular dystrophy
Rapkin et al.	2006	Oral contraceptives and neuroactive steroids
US8193172B2 (en)	2012-06-05	Methods for the treatment of major depressive disorder using glucocorticoid receptor antagonists
NO332978B1 (no)	2013-02-11	Anvendelse av (11ß,17ß)-11-(1,3-benzodioksol-5-yl)-17-hydroksy-17-(1-propynyl)-ostra-4,9-dien-3-on for behandling av alvorlig depressiv forstyrrelse
CA2459033C (en)	2012-05-22	Methods for inhibiting cognitive deterioration in adults with down's syndrome
AU2002348996A1 (en)	2003-07-10	Use of (11beta, 17beta)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one in the treatement of major depressive disorder
HK1087357B (en)	2009-04-09	Use of (11beta, 17beta)-11-(1,3-benzodioxol-5-yl)-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one in the treatment of major depressive disorder
TW200950788A (en)	2009-12-16	Compositions and methods for male contraception
TW200822931A (en)	2008-06-01	Compositions and methods for suppressing endometrial proliferation

Legal Events

Date	Code	Title	Description
2014-05-26	MM1K	Lapsed by not paying the annual fees