NO328035B1 - Sammensetninger som innbefatter et ecteinascidin og et disakkarid, en fremgangsmate for fremstilling derav, av et beger inneholdende en slik og av en losning for intravenos infusjon, en fremgansgmate for a redusere dannelsen av et ET-701 i en formulering av ET-743, samt anvendelse av losningen. - Google Patents

Sammensetninger som innbefatter et ecteinascidin og et disakkarid, en fremgangsmate for fremstilling derav, av et beger inneholdende en slik og av en losning for intravenos infusjon, en fremgansgmate for a redusere dannelsen av et ET-701 i en formulering av ET-743, samt anvendelse av losningen. Download PDF

Info

Publication number: NO328035B1
Authority: NO; Norway
Prior art keywords: solution; approx; ecteinascidin; formulations; formulation
Prior art date: 2004-10-29

Application number

NO20072713A

Other languages

English (en)

Norwegian (no)

Other versions

NO20072713L (no

Inventor

Pilar Calvo Salve

Bastiaan Nuijen

Jacob Hendrik Beijnen

Mar A Tobio Barreira

Original Assignee

Pharma Mar Sa Soc Unipersonal

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-10-29

Filing date

2007-05-29

Publication date

2009-11-10

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35432682&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO328035(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2007-05-29 Application filed by Pharma Mar Sa Soc Unipersonal filed Critical Pharma Mar Sa Soc Unipersonal

2007-07-19 Publication of NO20072713L publication Critical patent/NO20072713L/no

2009-11-10 Publication of NO328035B1 publication Critical patent/NO328035B1/no

Links

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Polysaccharides And Polysaccharide Derivatives (AREA)
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Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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NO20072713A 2004-10-29 2007-05-29 Sammensetninger som innbefatter et ecteinascidin og et disakkarid, en fremgangsmate for fremstilling derav, av et beger inneholdende en slik og av en losning for intravenos infusjon, en fremgansgmate for a redusere dannelsen av et ET-701 i en formulering av ET-743, samt anvendelse av losningen. NO328035B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US62381304P	2004-10-29	2004-10-29
PCT/GB2005/050184 WO2006046079A1 (en)	2004-10-29	2005-10-12	Formulations comprising ecteinascidin and a disaccharide

Publications (2)

Publication Number	Publication Date
NO20072713L NO20072713L (no)	2007-07-19
NO328035B1 true NO328035B1 (no)	2009-11-10

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NO20072713A NO328035B1 (no)	2004-10-29	2007-05-29	Sammensetninger som innbefatter et ecteinascidin og et disakkarid, en fremgangsmate for fremstilling derav, av et beger inneholdende en slik og av en losning for intravenos infusjon, en fremgansgmate for a redusere dannelsen av et ET-701 i en formulering av ET-743, samt anvendelse av losningen.

Country Status (36)

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US (2)	US8895557B2 (sl)
EP (1)	EP1658848B1 (sl)
JP (1)	JP4268163B2 (sl)
KR (1)	KR101188691B1 (sl)
CN (2)	CN1823794A (sl)
AR (2)	AR051653A1 (sl)
AT (1)	ATE368461T1 (sl)
AU (1)	AU2005227421B2 (sl)
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CA (1)	CA2520979C (sl)
CY (1)	CY1107773T1 (sl)
DE (1)	DE602005001833T2 (sl)
DK (1)	DK1658848T3 (sl)
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GT (1)	GT200500314A (sl)
HN (1)	HN2005029978A (sl)
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JO (1)	JO2464B1 (sl)
MX (1)	MXPA05011650A (sl)
MY (1)	MY139049A (sl)
NO (1)	NO328035B1 (sl)
NZ (1)	NZ554761A (sl)
PA (1)	PA8650801A1 (sl)
PE (2)	PE20100089A1 (sl)
PL (1)	PL1658848T3 (sl)
PT (1)	PT1658848E (sl)
RS (1)	RS50510B (sl)
RU (1)	RU2382647C2 (sl)
SI (1)	SI1658848T1 (sl)
SV (1)	SV2006002283A (sl)
TW (1)	TWI296523B (sl)
UA (1)	UA91032C2 (sl)
UY (1)	UY29183A1 (sl)
WO (1)	WO2006046079A1 (sl)
ZA (1)	ZA200703450B (sl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY164077A (en) *	1999-05-13	2017-11-30	Pharma Mar Sa	Compositions and uses of et743 for treating cancer
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
WO2002036135A2 (en) *	2000-11-06	2002-05-10	Pharma Mar, S.A.	Compositions for antitumour treatment containing ecteinascidin 743
GB0117402D0 (en) *	2001-07-17	2001-09-05	Pharma Mar Sa	New antitumoral derivatives of et-743
BR0213424A (pt) *	2001-10-19	2004-12-14	Pharma Mar Sa	Uso aperfeiçoado de composto antitumoral na terapia contra câncer
GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) *	2003-05-29	2003-07-02	Pharma Mar Sau	Treatment
GB0324201D0 (en) *	2003-10-15	2003-11-19	Pharma Mar Sau	Improved antitumoral combinations
EP1689404B9 (en) *	2003-11-13	2009-04-22	Pharma Mar, S.A.U.	Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer
GB0326486D0 (en) *	2003-11-14	2003-12-17	Pharma Mar Sau	Combination treatment
EP1691809A1 (en) *	2003-11-14	2006-08-23	Pharma Mar, S.A.	Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
NZ552607A (en) *	2004-07-09	2009-07-31	Pharma Mar Sa	Prognostic molecular markers
CN101068596A (zh) *	2004-09-29	2007-11-07	法马马私人股份有限公司	艾可特耐思地作抗炎药
US20090117176A1 (en) *	2004-10-26	2009-05-07	Pharma Mar, S.A. Sociedad Unipersonal	Anticancer Treatments
NZ554761A (en)	2004-10-29	2010-01-29	Pharma Mar Sa	Formulations comprising ecteinascidin and a disaccharide
GB0522082D0 (en) *	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
JP2011500046A (ja) *	2007-10-19	2011-01-06	ファルマ・マール・ソシエダード・アノニマ	Ｅｔ−７４３治療のための予後分子マーカー
US20100196272A1 (en) *	2009-01-30	2010-08-05	Neoprobe Corporation	Compositions for radiolabeling diethylenetriaminepentaacetic acid (dtpa)-dextran
EP2786756B1 (en)	2010-11-12	2020-03-11	Pharma Mar, S.A.	Combination therapy with a topoisomerase inhibitor
HRP20221355T1 (hr) *	2011-04-28	2022-12-23	Oncopeptides Ab	Liofilizirani pripravak citotoksičnih dipeptida
CN106853252B (zh) *	2015-12-09	2020-03-13	江苏恒瑞医药股份有限公司	曲贝替定药物组合物及其制备方法
CN106880592B (zh) *	2015-12-15	2021-04-06	江苏恒瑞医药股份有限公司	一种曲贝替定的纳米乳及其制备方法
JP2019504061A (ja) *	2016-02-04	2019-02-14	ジエンスヘンルイメデイシンカンパニーリミテッドＪｉａｎｇｓｕＨｅｎｇｒｕｉＭｅｄｉｃｉｎｅＣｏ．，Ｌｔｄ．	トラベクテジンの注射可能な胃腸外用医薬組成物及びその製造方法
JOP20190254A1 (ar)	2017-04-27	2019-10-27	Pharma Mar Sa	مركبات مضادة للأورام
WO2020239478A1 (en)	2019-05-28	2020-12-03	Pharma Mar, S.A.	Trabectedin for treating sarcomas based on genomic markers
US20210169873A1 (en) *	2019-10-21	2021-06-10	RK Pharma Solutions LLC	Storage-stable ready-to-use injectable formulations of Trabectedin
PH12022551216A1 (en) *	2019-11-21	2023-07-17	Pharma Mar Sa	Methods of treating small cell lung cancer with lurbinectedin formulations
JP7715732B2 (ja)	2020-04-15	2025-07-30	エバーバリンジェクトゲーエムベーハー	トラベクテジンおよびアミノ酸を含む組成物
US12303506B2 (en)	2022-01-20	2025-05-20	Extrovis Ag	Trabectedin composition
CN120379668A (zh) *	2022-12-22	2025-07-25	博瑞生物医药（苏州）股份有限公司	一种含卢比替定的药物组合物及其制备方法和应用

Family Cites Families (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4537883A (en)	1982-11-12	1985-08-27	Mead Johnson & Company	Lyophilized cyclophosphamide
US5149804A (en)	1990-11-30	1992-09-22	The Board Of Trustees Of The University Of Illinois	Ecteinascidins 736 and 722
US5256663A (en)	1986-06-09	1993-10-26	The Board Of Trustees Of The University Of Illinois	Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
FI885726A7 (fi) *	1986-06-09	1988-12-09	Univ Of Illinois	Ekteinaskidiinit 729, 743, 745, 759A, 759B ja 770
US5089273A (en) *	1986-06-09	1992-02-18	Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759A, 759B and 770
DE3635711A1 (de) *	1986-10-21	1988-04-28	Knoll Ag	5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung
US5013556A (en) *	1989-10-20	1991-05-07	Liposome Technology, Inc.	Liposomes with enhanced circulation time
US5336669A (en) *	1991-12-10	1994-08-09	Erbamont, Inc.	Cyclophosphamide monohydrate and lactose
FR2697752B1 (fr) *	1992-11-10	1995-04-14	Rhone Poulenc Rorer Sa	Compositions antitumorales contenant des dérivés du taxane.
DE4242863A1 (de)	1992-12-18	1994-06-23	Boehringer Mannheim Gmbh	Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
US5478932A (en)	1993-12-02	1995-12-26	The Board Of Trustees Of The University Of Illinois	Ecteinascidins
GB9401447D0 (en)	1994-01-26	1994-03-23	Ciba Geigy Ag	Pharmaceutical compositions
US20040059112A1 (en) *	1994-02-18	2004-03-25	Rinehart Kenneth L.	Ecteinascidins
GB9508195D0 (en) *	1995-04-20	1995-06-07	Univ British Columbia	Novel biologically active compounds and compositions,their use and derivation
US5721362A (en)	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US5985876A (en)	1997-04-15	1999-11-16	Univ Illinois	Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
WO1998052598A1 (en)	1997-05-21	1998-11-26	Genentech, Inc.	Novel administration of thrombopoietin
KR100603219B1 (ko)	1998-04-06	2006-07-20	더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈	반합성 엑테이나시딘
AU759281B2 (en)	1998-05-11	2003-04-10	Pharma Mar S.A.	Metabolites of ecteinascidin 743
JP2000081438A (ja)	1998-06-25	2000-03-21	Sekisui Chem Co Ltd	被験者の癌化学療法による免疫機能低下の測定方法
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
MY164077A (en)	1999-05-13	2017-11-30	Pharma Mar Sa	Compositions and uses of et743 for treating cancer
AR035842A1 (es)	1999-05-14	2004-07-21	Pharma Mar Sa	Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
GB9918178D0 (en)	2000-05-15	1999-10-06	Pharma Mar Sa	Synthetic methods
JP5219323B2 (ja)	2000-04-12	2013-06-26	ファルマ・マール・ソシエダード・アノニマ	抗腫瘍性エクチナサイジン誘導体
US7247892B2 (en) *	2000-04-24	2007-07-24	Taylor Geoff W	Imaging array utilizing thyristor-based pixel elements
US7420051B2 (en) *	2000-05-15	2008-09-02	Pharma Mar, S.A.	Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
CA2418320A1 (en) *	2000-08-11	2002-02-21	City Of Hope	The anti-neoplastic agent et-743 inhibits trans activation by sxr
BR0114912A (pt) *	2000-10-31	2003-10-14	Pharma Mar Sa	Kahalalide f
EP1339713A2 (en)	2000-11-03	2003-09-03	President And Fellows Of Harvard College	Saframycins, analogues and uses thereof
WO2002036135A2 (en)	2000-11-06	2002-05-10	Pharma Mar, S.A.	Compositions for antitumour treatment containing ecteinascidin 743
CZ20032022A3 (cs) *	2001-01-25	2004-04-14	Bristol-Myers Squibb Company	Parenterální prostředek obsahující epothilonová analoga
WO2002064843A1 (en) *	2001-02-09	2002-08-22	The Regents Of The University Of California	Ecteinascidin family compounds: compositions and methods
YU69903A (sh)	2001-03-06	2006-08-17	Bristol-Myers Squibb Company	Postupak i dozni oblik za lečenje tumora primenom tegafura, uracila, folne kiseline, paklitaksela i karboplatina
WO2002078678A2 (en)	2001-03-30	2002-10-10	Shire Biochem Inc.	Methods of treating cancer using cyplastin combined with a dioxolane nucleoside such as troxacitabine
GB0121285D0 (en)	2001-09-03	2001-10-24	Cancer Res Ventures Ltd	Anti-cancer combinations
BR0213424A (pt) *	2001-10-19	2004-12-14	Pharma Mar Sa	Uso aperfeiçoado de composto antitumoral na terapia contra câncer
US20040019027A1 (en) *	2002-04-12	2004-01-29	Barry Forman	Method of treating cerebrotendinous xanthomatosis
GB0312407D0 (en) *	2003-05-29	2003-07-02	Pharma Mar Sau	Treatment
GB0324201D0 (en) *	2003-10-15	2003-11-19	Pharma Mar Sau	Improved antitumoral combinations
EP1689404B9 (en)	2003-11-13	2009-04-22	Pharma Mar, S.A.U.	Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer
GB0326486D0 (en) *	2003-11-14	2003-12-17	Pharma Mar Sau	Combination treatment
EP1691809A1 (en) *	2003-11-14	2006-08-23	Pharma Mar, S.A.	Combination therapy comprising the use of et-743 and paclitaxel for treating cancer
WO2005118584A2 (en)	2004-05-26	2005-12-15	Axys Pharmaceuticals, Inc.	Saframycin analogs as therapeutic agents in the treatment of cancer
NZ552607A (en) *	2004-07-09	2009-07-31	Pharma Mar Sa	Prognostic molecular markers
CN101068596A (zh) *	2004-09-29	2007-11-07	法马马私人股份有限公司	艾可特耐思地作抗炎药
US20090117176A1 (en) *	2004-10-26	2009-05-07	Pharma Mar, S.A. Sociedad Unipersonal	Anticancer Treatments
NZ554761A (en)	2004-10-29	2010-01-29	Pharma Mar Sa	Formulations comprising ecteinascidin and a disaccharide
WO2006066183A2 (en)	2004-12-16	2006-06-22	Axys Pharmaceuticals, Inc.	Novel saframycin analogs as therapeutic agents
EP1962843B1 (en) *	2005-11-25	2011-02-23	Pharma Mar S.A., Sociedad Unipersonal	Use of parp-1 inhibitors
WO2007134203A2 (en) *	2006-05-12	2007-11-22	Pharma Mar, S.A.	Anticancer treatments with a combination of docetaxel and ecteinascidin

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ZA200703450B (en)	2008-09-25
NZ554761A (en)	2010-01-29
ES2290844T3 (es)	2008-02-16
AR051653A1 (es)	2007-01-31
CA2520979A1 (en)	2006-02-15
PA8650801A1 (es)	2006-09-22
WO2006046079A1 (en)	2006-05-04
DE602005001833D1 (de)	2007-09-13
TWI296523B (en)	2008-05-11
KR20070091121A (ko)	2007-09-07
PE20100089A1 (es)	2010-03-01
RS50510B (sr)	2010-03-02
MY139049A (en)	2009-08-28
RU2007119724A (ru)	2008-12-10
NO20072713L (no)	2007-07-19
CN102018714B (zh)	2014-01-08
CY1107773T1 (el)	2013-06-19
US10322183B2 (en)	2019-06-18
AU2005227421A1 (en)	2006-05-18
DK1658848T3 (da)	2007-11-26
CN102018714A (zh)	2011-04-20
EP1658848A1 (en)	2006-05-24
JP2006124393A (ja)	2006-05-18
HN2005029978A (es)	2009-10-27
BRPI0517238A (pt)	2008-10-07
US20060094687A1 (en)	2006-05-04
SV2006002283A (es)	2006-07-20
RU2382647C2 (ru)	2010-02-27
HK1091724A1 (en)	2007-01-26
PE20060925A1 (es)	2006-10-23
PL1658848T3 (pl)	2007-12-31
CA2520979C (en)	2009-03-24
AR110986A2 (es)	2019-05-22
HRP20070374T3 (en)	2007-10-31
UY29183A1 (es)	2006-05-31
JP4268163B2 (ja)	2009-05-27
UA91032C2 (en)	2010-06-25
IL182776A (en)	2010-06-30
IL182776A0 (en)	2007-08-19
US20150094313A1 (en)	2015-04-02
MXPA05011650A (es)	2006-05-17
US8895557B2 (en)	2014-11-25
ATE368461T1 (de)	2007-08-15
CN1823794A (zh)	2006-08-30
AU2005227421B2 (en)	2007-06-28
TW200621256A (en)	2006-07-01
SI1658848T1 (sl)	2007-12-31
BRPI0517238B1 (pt)	2021-11-09
JO2464B1 (en)	2009-01-20
DE602005001833T2 (de)	2008-04-17
KR101188691B1 (ko)	2012-10-09
EP1658848B1 (en)	2007-08-01
GT200500314A (es)	2007-03-22
PT1658848E (pt)	2007-11-05

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