NO326421B1 - Heterocykiske tripeptider, farmasoytisk preparat omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom - Google Patents

Heterocykiske tripeptider, farmasoytisk preparat omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom Download PDF

Info

Publication number: NO326421B1
Authority: NO; Norway
Prior art keywords: compound; formula; hcv; butyl; hydroxy
Prior art date: 2002-02-01

Application number

NO20043642A

Other languages

English (en)

Norwegian (no)

Other versions

NO20043642L (no

Inventor

Montse Llinas-Brunet

Murray D Bailey

Elise Ghiro

Original Assignee

Boehringer Ingelheim Int

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-01

Filing date

2004-08-31

Publication date

2008-12-01

2004-08-31 Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int

2004-08-31 Publication of NO20043642L publication Critical patent/NO20043642L/no

2008-12-01 Publication of NO326421B1 publication Critical patent/NO326421B1/no

Links

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NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 1
229960004231 thymalfasin Drugs 0.000 description 1
LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
206010043778 thyroiditis Diseases 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000013518 transcription Methods 0.000 description 1
230000035897 transcription Effects 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
229950002819 valtorcitabine Drugs 0.000 description 1
230000029812 viral genome replication Effects 0.000 description 1
201000001862 viral hepatitis Diseases 0.000 description 1
230000008957 viral persistence Effects 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NO20043642A 2002-02-01 2004-08-31 Heterocykiske tripeptider, farmasoytisk preparat omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom NO326421B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CA002369970A CA2369970A1 (en)	2002-02-01	2002-02-01	Hepatitis c inhibitor tri-peptides
PCT/CA2003/000091 WO2003064416A1 (en)	2002-02-01	2003-01-24	Heterocyclic tripeptides as hepatitis c inhibitors

Publications (2)

Publication Number	Publication Date
NO20043642L NO20043642L (no)	2004-08-31
NO326421B1 true NO326421B1 (no)	2008-12-01

Family

ID=27626567

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20043642A NO326421B1 (no)	2002-02-01	2004-08-31	Heterocykiske tripeptider, farmasoytisk preparat omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom

Country Status (29)

Country	Link
US (1)	US20030191067A1 (es)
EP (1)	EP1474423B1 (es)
JP (1)	JP4073872B2 (es)
KR (1)	KR20040081167A (es)
CN (1)	CN1304416C (es)
AR (1)	AR038382A1 (es)
AT (1)	ATE369364T1 (es)
AU (1)	AU2003202348B2 (es)
BR (1)	BR0307517A (es)
CA (1)	CA2369970A1 (es)
CO (1)	CO5611112A2 (es)
DE (1)	DE60315420T2 (es)
EA (1)	EA007739B1 (es)
EC (1)	ECSP045224A (es)
ES (1)	ES2290425T3 (es)
HR (1)	HRP20040696A2 (es)
MX (1)	MXPA04007446A (es)
MY (1)	MY133719A (es)
NO (1)	NO326421B1 (es)
NZ (1)	NZ534730A (es)
PE (1)	PE20030854A1 (es)
PL (1)	PL371283A1 (es)
RS (1)	RS67104A (es)
SA (1)	SA03240006B1 (es)
TW (1)	TWI274056B (es)
UA (1)	UA77757C2 (es)
UY (1)	UY27638A1 (es)
WO (1)	WO2003064416A1 (es)
ZA (1)	ZA200406014B (es)

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2002
- 2002-02-01 CA CA002369970A patent/CA2369970A1/en not_active Abandoned
- 2002-12-17 US US10/320,979 patent/US20030191067A1/en not_active Abandoned
2003
- 2003-01-24 NZ NZ534730A patent/NZ534730A/en not_active IP Right Cessation
- 2003-01-24 PL PL03371283A patent/PL371283A1/xx not_active Application Discontinuation
- 2003-01-24 WO PCT/CA2003/000091 patent/WO2003064416A1/en not_active Ceased
- 2003-01-24 AT AT03700745T patent/ATE369364T1/de active
- 2003-01-24 RS YU67104A patent/RS67104A/sr unknown
- 2003-01-24 ES ES03700745T patent/ES2290425T3/es not_active Expired - Lifetime
- 2003-01-24 DE DE60315420T patent/DE60315420T2/de not_active Expired - Lifetime
- 2003-01-24 EP EP03700745A patent/EP1474423B1/en not_active Expired - Lifetime
- 2003-01-24 KR KR10-2004-7011888A patent/KR20040081167A/ko not_active Abandoned
- 2003-01-24 HR HR20040696A patent/HRP20040696A2/hr not_active Application Discontinuation
- 2003-01-24 CN CNB038061619A patent/CN1304416C/zh not_active Expired - Fee Related
- 2003-01-24 EA EA200400986A patent/EA007739B1/ru not_active IP Right Cessation
- 2003-01-24 MX MXPA04007446A patent/MXPA04007446A/es active IP Right Grant
- 2003-01-24 AU AU2003202348A patent/AU2003202348B2/en not_active Ceased
- 2003-01-24 JP JP2003564039A patent/JP4073872B2/ja not_active Expired - Fee Related
- 2003-01-24 UA UA20040807171A patent/UA77757C2/uk unknown
- 2003-01-24 BR BR0307517-6A patent/BR0307517A/pt not_active IP Right Cessation
- 2003-01-30 PE PE2003000105A patent/PE20030854A1/es not_active Application Discontinuation
- 2003-01-30 TW TW092102240A patent/TWI274056B/zh active
- 2003-01-30 MY MYPI20030338A patent/MY133719A/en unknown
- 2003-01-31 UY UY27638A patent/UY27638A1/es not_active Application Discontinuation
- 2003-01-31 AR ARP030100291A patent/AR038382A1/es unknown
- 2003-03-05 SA SA03240006A patent/SA03240006B1/ar unknown
2004
- 2004-07-28 ZA ZA200406014A patent/ZA200406014B/en unknown
- 2004-08-09 EC EC2004005224A patent/ECSP045224A/es unknown
- 2004-08-31 CO CO04085343A patent/CO5611112A2/es not_active Application Discontinuation
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Publication number	Publication date
KR20040081167A (ko)	2004-09-20
US20030191067A1 (en)	2003-10-09
NZ534730A (en)	2005-12-23
DE60315420D1 (de)	2007-09-20
ES2290425T3 (es)	2008-02-16
MXPA04007446A (es)	2004-10-14
AU2003202348B2 (en)	2008-01-17
DE60315420T2 (de)	2008-04-17
HRP20040696A2 (en)	2005-06-30
UA77757C2 (en)	2007-01-15
PE20030854A1 (es)	2003-11-25
AR038382A1 (es)	2005-01-12
WO2003064416A1 (en)	2003-08-07
CN1304416C (zh)	2007-03-14
EA007739B1 (ru)	2006-12-29
MY133719A (en)	2007-11-30
BR0307517A (pt)	2004-12-28
CO5611112A2 (es)	2006-02-28
UY27638A1 (es)	2003-09-30
RS67104A (sr)	2006-10-27
NO20043642L (no)	2004-08-31
JP4073872B2 (ja)	2008-04-09
TWI274056B (en)	2007-02-21
ATE369364T1 (de)	2007-08-15
TW200307680A (en)	2003-12-16
EP1474423A1 (en)	2004-11-10
PL371283A1 (en)	2005-06-13
HK1078870A1 (en)	2006-03-24
EA200400986A1 (ru)	2005-02-24
SA03240006B1 (ar)	2007-03-05
CA2369970A1 (en)	2003-08-01
ZA200406014B (en)	2006-05-31
CN1642951A (zh)	2005-07-20
JP2005529069A (ja)	2005-09-29
EP1474423B1 (en)	2007-08-08
ECSP045224A (es)	2004-09-28

Publication	Publication Date	Title
US7091184B2 (en)	2006-08-15	Hepatitis C inhibitor tri-peptides
NO326421B1 (no)	2008-12-01	Heterocykiske tripeptider, farmasoytisk preparat omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom
US6642204B2 (en)	2003-11-04	Hepatitis C inhibitor tri-peptides
EP1474441B1 (en)	2007-03-28	Tripeptides having a hydroxyproline ether of a substituted quinoline for the inhibition of ns3 (hepatitis c)
JP4040578B2 (ja)	2008-01-30	Ｃ型肝炎ウイルスに対して活性な大環状ペプチド
US7119072B2 (en)	2006-10-10	Macrocyclic peptides active against the hepatitis C virus
US6919423B2 (en)	2005-07-19	Hepatitis C inhibitor compound
AU2003202348A1 (en)	2003-09-18	Heterocyclic tripeptides as hepatitis c inhibitors
NO332056B1 (no)	2012-06-11	Hepatitt C inhibitor-forbindelser, farmasoytisk preparat inneholdende slike samt slike forbindelser for behandling av sykdom
AU2003202347A1 (en)	2003-09-18	Tripeptides having a hydroxyproline ether of a substituted quinoline for the inhibition of NS3 (Hepatitis C)
EP1599496A2 (en)	2005-11-30	Hepatitis c inhibitor peptide analogs
CA2474156C (en)	2011-09-20	Tripeptides having a hydroxyproline ether of a substituted quinoline for the inhibition of ns3 (hepatitis c)
CA2474031C (en)	2010-08-24	Heterocyclic tripeptides as hepatitis c inhibitors

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2011-09-05	MM1K	Lapsed by not paying the annual fees

NO326421B1 - Heterocykiske tripeptider, farmasoytisk preparat omfattende slike samt anvendelse av slike for fremstilling av medikamenter for behandling eller forebygging av sykdom - Google Patents

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