NO326207B1 - Anvendelse av forbindelsen Cetrorelix for fremstilling av et middel for behandling av prostatahypertrofi og prostatakreft - Google Patents

Anvendelse av forbindelsen Cetrorelix for fremstilling av et middel for behandling av prostatahypertrofi og prostatakreft Download PDF

Info

Publication number: NO326207B1
Authority: NO; Norway
Prior art keywords: cetrorelix; treatment; weeks; medicament; bph
Prior art date: 1996-09-12

Application number

NO19991192A

Other languages

English (en)

Norwegian (no)

Other versions

NO991192D0 (no

NO991192L (no

Inventor

Juergen Engel

Thomas Reissmann

Hilde Riethmueller-Winzen

Juergen Rawert

Original Assignee

Zentaris Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-09-12

Filing date

1999-03-11

Publication date

2008-10-20

1999-03-11 Application filed by Zentaris Gmbh filed Critical Zentaris Gmbh

1999-03-11 Publication of NO991192D0 publication Critical patent/NO991192D0/no

1999-04-28 Publication of NO991192L publication Critical patent/NO991192L/no

2008-10-20 Publication of NO326207B1 publication Critical patent/NO326207B1/no

Links

238000011282 treatment Methods 0.000 title claims description 63
SBNPWPIBESPSIF-MHWMIDJBSA-N cetrorelix Chemical compound C([C@@H](C(=O)N[C@H](CCCNC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 SBNPWPIBESPSIF-MHWMIDJBSA-N 0.000 title claims description 57
108700008462 cetrorelix Proteins 0.000 title claims description 56
229960003230 cetrorelix Drugs 0.000 title claims description 55
239000003814 drug Substances 0.000 title claims description 27
206010060862 Prostate cancer Diseases 0.000 title claims description 17
229940079593 drug Drugs 0.000 title claims description 15
208000000236 Prostatic Neoplasms Diseases 0.000 title claims description 14
150000001875 compounds Chemical class 0.000 title claims description 13
210000002307 prostate Anatomy 0.000 title description 12
238000002360 preparation method Methods 0.000 title description 3
206010020880 Hypertrophy Diseases 0.000 title 1
238000002347 injection Methods 0.000 claims description 20
239000007924 injection Substances 0.000 claims description 20
239000003087 receptor blocking agent Substances 0.000 claims description 16
229940123934 Reductase inhibitor Drugs 0.000 claims description 13
238000004519 manufacturing process Methods 0.000 claims description 12
230000002123 temporal effect Effects 0.000 claims description 5
239000003795 chemical substances by application Substances 0.000 claims description 4
206010004446 Benign prostatic hyperplasia Diseases 0.000 description 26
208000004403 Prostatic Hyperplasia Diseases 0.000 description 26
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 18
230000006872 improvement Effects 0.000 description 11
229960003604 testosterone Drugs 0.000 description 9
230000002280 anti-androgenic effect Effects 0.000 description 8
239000000051 antiandrogen Substances 0.000 description 8
XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical class C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 description 8
101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 description 7
102100024028 Progonadoliberin-1 Human genes 0.000 description 7
101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 description 7
239000003112 inhibitor Substances 0.000 description 7
230000000694 effects Effects 0.000 description 6
239000000556 agonist Substances 0.000 description 5
210000002700 urine Anatomy 0.000 description 5
229940124041 Luteinizing hormone releasing hormone (LHRH) antagonist Drugs 0.000 description 4
201000010099 disease Diseases 0.000 description 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
238000000034 method Methods 0.000 description 4
239000000902 placebo Substances 0.000 description 4
229940068196 placebo Drugs 0.000 description 4
230000009467 reduction Effects 0.000 description 4
230000001629 suppression Effects 0.000 description 4
238000001356 surgical procedure Methods 0.000 description 4
NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 description 3
229960003473 androstanolone Drugs 0.000 description 3
229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 3
230000008901 benefit Effects 0.000 description 3
206010013990 dysuria Diseases 0.000 description 3
239000002474 gonadorelin antagonist Substances 0.000 description 3
201000001514 prostate carcinoma Diseases 0.000 description 3
208000024891 symptom Diseases 0.000 description 3
239000002677 5-alpha reductase inhibitor Substances 0.000 description 2
HRRBJVNMSRJFHQ-UHFFFAOYSA-N Naftopidil Chemical compound COC1=CC=CC=C1N1CCN(CC(O)COC=2C3=CC=CC=C3C=CC=2)CC1 HRRBJVNMSRJFHQ-UHFFFAOYSA-N 0.000 description 2
206010038967 Retrograde ejaculation Diseases 0.000 description 2
206010046543 Urinary incontinence Diseases 0.000 description 2
238000009825 accumulation Methods 0.000 description 2
239000003098 androgen Substances 0.000 description 2
239000005557 antagonist Substances 0.000 description 2
239000003886 aromatase inhibitor Substances 0.000 description 2
229940046844 aromatase inhibitors Drugs 0.000 description 2
239000002981 blocking agent Substances 0.000 description 2
239000008280 blood Substances 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
238000002648 combination therapy Methods 0.000 description 2
230000007423 decrease Effects 0.000 description 2
230000001419 dependent effect Effects 0.000 description 2
DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 2
229960004039 finasteride Drugs 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
230000027939 micturition Effects 0.000 description 2
229950005705 naftopidil Drugs 0.000 description 2
108020003175 receptors Proteins 0.000 description 2
102000005962 receptors Human genes 0.000 description 2
210000005070 sphincter Anatomy 0.000 description 2
150000003431 steroids Chemical class 0.000 description 2
230000000638 stimulation Effects 0.000 description 2
239000000126 substance Substances 0.000 description 2
230000002483 superagonistic effect Effects 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
108010070743 3(or 17)-beta-hydroxysteroid dehydrogenase Proteins 0.000 description 1
JXZZEXZZKAWDSP-UHFFFAOYSA-N 3-(2-(4-Benzamidopiperid-1-yl)ethyl)indole Chemical compound C1CN(CCC=2C3=CC=CC=C3NC=2)CCC1NC(=O)C1=CC=CC=C1 JXZZEXZZKAWDSP-UHFFFAOYSA-N 0.000 description 1
150000000520 4-azasteroids Chemical class 0.000 description 1
108060003345 Adrenergic Receptor Proteins 0.000 description 1
102000017910 Adrenergic receptor Human genes 0.000 description 1
RHLJLALHBZGAFM-UHFFFAOYSA-N Bunazosinum Chemical compound C1CN(C(=O)CCC)CCCN1C1=NC(N)=C(C=C(OC)C(OC)=C2)C2=N1 RHLJLALHBZGAFM-UHFFFAOYSA-N 0.000 description 1
108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 description 1
102100034067 Dehydrogenase/reductase SDR family member 11 Human genes 0.000 description 1
108700012941 GNRH1 Proteins 0.000 description 1
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 1
206010020843 Hyperthermia Diseases 0.000 description 1
206010023424 Kidney infection Diseases 0.000 description 1
102000008238 LHRH Receptors Human genes 0.000 description 1
108010021290 LHRH Receptors Proteins 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
208000000693 Neurogenic Urinary Bladder Diseases 0.000 description 1
206010029279 Neurogenic bladder Diseases 0.000 description 1
-1 Prozosin Chemical compound 0.000 description 1
206010037596 Pyelonephritis Diseases 0.000 description 1
208000032023 Signs and Symptoms Diseases 0.000 description 1
206010046555 Urinary retention Diseases 0.000 description 1
230000002411 adverse Effects 0.000 description 1
229960004607 alfuzosin Drugs 0.000 description 1
WNMJYKCGWZFFKR-UHFFFAOYSA-N alfuzosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(C)CCCNC(=O)C1CCCO1 WNMJYKCGWZFFKR-UHFFFAOYSA-N 0.000 description 1
229940046836 anti-estrogen Drugs 0.000 description 1
230000001833 anti-estrogenic effect Effects 0.000 description 1
150000001534 azasteroids Chemical class 0.000 description 1
230000002146 bilateral effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229960002467 bunazosin Drugs 0.000 description 1
239000002775 capsule Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
201000003146 cystitis Diseases 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
229960001389 doxazosin Drugs 0.000 description 1
RUZYUOTYCVRMRZ-UHFFFAOYSA-N doxazosin Chemical compound C1OC2=CC=CC=C2OC1C(=O)N(CC1)CCN1C1=NC(N)=C(C=C(C(OC)=C2)OC)C2=N1 RUZYUOTYCVRMRZ-UHFFFAOYSA-N 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
230000002124 endocrine Effects 0.000 description 1
229940011871 estrogen Drugs 0.000 description 1
239000000262 estrogen Substances 0.000 description 1
239000000328 estrogen antagonist Substances 0.000 description 1
229960002074 flutamide Drugs 0.000 description 1
MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000005556 hormone Substances 0.000 description 1
230000036031 hyperthermia Effects 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
229960002056 indoramin Drugs 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
238000011866 long-term treatment Methods 0.000 description 1
230000010534 mechanism of action Effects 0.000 description 1
238000011474 orchiectomy Methods 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
230000001817 pituitary effect Effects 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
208000026455 prostate symptom Diseases 0.000 description 1
238000002271 resection Methods 0.000 description 1
230000028327 secretion Effects 0.000 description 1
230000035936 sexual power Effects 0.000 description 1
239000000243 solution Substances 0.000 description 1
238000011272 standard treatment Methods 0.000 description 1
229960001693 terazosin Drugs 0.000 description 1
VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 description 1
239000000647 testicular hormone Substances 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids
- A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Diabetes (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NO19991192A 1996-09-12 1999-03-11 Anvendelse av forbindelsen Cetrorelix for fremstilling av et middel for behandling av prostatahypertrofi og prostatakreft NO326207B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US2599096P	1996-09-12	1996-09-12
US4322897P	1997-04-10	1997-04-10
PCT/EP1997/004740 WO1998010781A1 (en)	1996-09-12	1997-09-01	Means for treating prostate hypertrophy and prostate cancer

Publications (3)

Publication Number	Publication Date
NO991192D0 NO991192D0 (no)	1999-03-11
NO991192L NO991192L (no)	1999-04-28
NO326207B1 true NO326207B1 (no)	2008-10-20

Family

ID=26700570

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19991192A NO326207B1 (no)	1996-09-12	1999-03-11	Anvendelse av forbindelsen Cetrorelix for fremstilling av et middel for behandling av prostatahypertrofi og prostatakreft

Country Status (28)

Country	Link
US (4)	US6054432A (is)
EP (1)	EP0925069B1 (is)
JP (1)	JP2001500500A (is)
KR (1)	KR100546235B1 (is)
CN (1)	CN1126566C (is)
AR (1)	AR009757A1 (is)
AT (1)	ATE370743T1 (is)
AU (1)	AU738306B2 (is)
BR (1)	BR9713197A (is)
CA (1)	CA2215015A1 (is)
CZ (1)	CZ298738B6 (is)
DE (1)	DE69738045T2 (is)
DK (1)	DK0925069T3 (is)
EE (1)	EE04000B1 (is)
ES (1)	ES2289764T3 (is)
HU (1)	HUP0000261A3 (is)
IL (3)	IL128331A0 (is)
IS (1)	IS4978A (is)
MX (1)	MXPA99002420A (is)
NO (1)	NO326207B1 (is)
NZ (1)	NZ334540A (is)
PL (1)	PL193184B1 (is)
PT (1)	PT925069E (is)
RU (1)	RU2215537C2 (is)
SK (1)	SK286174B6 (is)
TR (1)	TR199900556T2 (is)
TW (1)	TWI224002B (is)
WO (1)	WO1998010781A1 (is)

Families Citing this family (25)

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Publication number	Priority date	Publication date	Assignee	Title
US6828415B2 (en)	1993-02-19	2004-12-07	Zentaris Gmbh	Oligopeptide lyophilisate, their preparation and use
US6054432A (en) *	1996-09-12	2000-04-25	Asta Medica Aktiengesellschaft	Means for treating prostate hypertrophy and prostate cancer
FR2768055A1 (fr) *	1997-09-11	1999-03-12	Synthelabo	Utilisation de derives de sulfonanilide pour obtenir un medicament destine au traitement de l'ejaculation retrograde ou de l'aspermie
TW536402B (en) *	1998-06-26	2003-06-11	Yamanouchi Pharma Co Ltd	Pharmaceutical composition for the therapy of voiding dysfunction
DE19911771B4 (de) *	1999-03-17	2006-03-30	Zentaris Gmbh	LHRH-Antagonist, Verfahren zu seiner Herstellung und seiner Verwendung
US6545034B1 (en) *	1999-07-23	2003-04-08	The Regents Of The University Of California	Use of etodolac for the treatment of chronic lymphocytic leukemia
US7129262B2 (en) *	1999-07-23	2006-10-31	The Regents Of The University Of California	Indole compounds useful for the treatment of cancer
US7105560B1 (en)	1999-07-23	2006-09-12	The Regents Of The University Of California	Use of etodolac in the treatment of multiple myeloma
US7151100B1 (en) *	1999-07-23	2006-12-19	The Regents Of The University Of California	Indole compounds useful for the treatment of cancer
US7361680B2 (en) *	1999-07-23	2008-04-22	The Regents Of The University Of California	Indole compounds useful for the treatment of cancer
ID30249A (id) *	1999-08-09	2001-11-15	Yamanouchi Pharma Co Ltd	Komposisi farmasi untuk terapi gejala-gejala penyakit pelaksanaan fungsi saluran air kencing bawah
CA2669753C (en)	1999-09-30	2012-06-26	Hollis-Eden Pharmaceuticals, Inc.	Therapeutic treatment of androgen receptor driven conditions
US20040152672A1 (en) *	2000-08-09	2004-08-05	Carson Dennis A.	Indole compounds useful for the treatment of cancer
DE10040700A1 (de) *	2000-08-17	2002-02-28	Asta Medica Ag	Salze von biologisch aktiven Peptiden, ihre Herstellung und Verwendung
KR100876538B1 (ko) *	2000-08-17	2008-12-31	아에테르나 젠타리스 게엠베하	Ｌｈｒｈ 길항제의 염의 제조방법
JP2001288115A (ja) *	2001-02-07	2001-10-16	Yamanouchi Pharmaceut Co Ltd	下部尿路症治療剤
DE10137174A1 (de) *	2001-07-31	2003-02-13	Zentaris Ag	Verwendung von LHRH-Antagonisten in nichtkastrierenden Dosen zur Verbesserung der T-Zellen-vermittelten Immunität
US7211599B2 (en) *	2002-09-19	2007-05-01	The Regents Of The University Of California	Use of etodolac to treat hyperplasia
GB0301016D0 (en) *	2003-01-16	2003-02-19	Univ London	Treatment of benign prostatic hyperplasia
MXPA05007572A (es)	2003-01-17	2005-11-17	Threshold Pharmaceuticals Inc	Tratamiento de hiperplasia prostatica benigna.
CN101677975B (zh) *	2006-05-03	2013-06-26	威斯康星校友研究基金会	N1,n4-双(丁-1,3-二烯基)丁-1,4-二胺药物组合物及其方法
EP1891964A1 (en) *	2006-08-08	2008-02-27	AEterna Zentaris GmbH	Application of initial doses of LHRH analogues and maintenance doses of LHRH antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits
EP1967202A1 (en) *	2007-03-05	2008-09-10	AEterna Zentaris GmbH	Use of LHRH Antagonists for the Treatment of Lower Urinary Tract Symptoms, in particular Overactive Bladder and/or Detrusor Overactivity
EP2095818A1 (en) *	2008-02-29	2009-09-02	AEterna Zentaris GmbH	Use of LHRH antagonists at non-castrating doses
US10585101B2 (en)	2016-03-10	2020-03-10	Wavesense, Inc.	Prostatic liquid biopsy for the detection of prostate cancer and benign prostatic hyperplasia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2465486A1 (fr) *	1979-09-21	1981-03-27	Roussel Uclaf	Nouvelle application utilisant la lh-rh ou des agonistes
HU199694B (en) *	1988-05-10	1990-03-28	Innofinance Altalanos Innovaci	Process for producing citostatic pharmaceutical compositions containing gonadoliberin derivatives
DE3918543A1 (de) *	1989-06-07	1990-12-13	Boehringer Mannheim Gmbh	Verwendung von naftopidil zur therapie der dysurie bei benigner prostata-hypertrophie
IL101245A0 (en) *	1991-03-20	1992-11-15	Merck & Co Inc	Pharmaceutical compositions for the treatment of prostatic cancer
IL101243A (en) *	1991-03-20	1999-12-22	Merck & Co Inc	Pharmaceutical preparations for the treatment of benign prostatic hyperplasia containing steroid history
US6054432A (en) *	1996-09-12	2000-04-25	Asta Medica Aktiengesellschaft	Means for treating prostate hypertrophy and prostate cancer

1997
- 1997-08-07 US US08/908,198 patent/US6054432A/en not_active Expired - Fee Related
- 1997-09-01 MX MXPA99002420A patent/MXPA99002420A/es unknown
- 1997-09-01 EE EEP199900121A patent/EE04000B1/xx not_active IP Right Cessation
- 1997-09-01 RU RU99107280/14A patent/RU2215537C2/ru not_active IP Right Cessation
- 1997-09-01 CN CN97197904A patent/CN1126566C/zh not_active Expired - Fee Related
- 1997-09-01 BR BR9713197-0A patent/BR9713197A/pt not_active Application Discontinuation
- 1997-09-01 KR KR1019997002053A patent/KR100546235B1/ko not_active Expired - Lifetime
- 1997-09-01 ES ES97944818T patent/ES2289764T3/es not_active Expired - Lifetime
- 1997-09-01 SK SK301-99A patent/SK286174B6/sk not_active IP Right Cessation
- 1997-09-01 JP JP10513204A patent/JP2001500500A/ja active Pending
- 1997-09-01 AT AT97944818T patent/ATE370743T1/de not_active IP Right Cessation
- 1997-09-01 CZ CZ80899A patent/CZ298738B6/cs not_active IP Right Cessation
- 1997-09-01 EP EP97944818A patent/EP0925069B1/en not_active Expired - Lifetime
- 1997-09-01 DE DE69738045T patent/DE69738045T2/de not_active Expired - Lifetime
- 1997-09-01 PL PL332085A patent/PL193184B1/pl not_active IP Right Cessation
- 1997-09-01 IL IL12833197A patent/IL128331A0/xx unknown
- 1997-09-01 WO PCT/EP1997/004740 patent/WO1998010781A1/en not_active Ceased
- 1997-09-01 NZ NZ334540A patent/NZ334540A/xx unknown
- 1997-09-01 AU AU46198/97A patent/AU738306B2/en not_active Ceased
- 1997-09-01 HU HU0000261A patent/HUP0000261A3/hu unknown
- 1997-09-01 DK DK97944818T patent/DK0925069T3/da active
- 1997-09-01 PT PT97944818T patent/PT925069E/pt unknown
- 1997-09-01 TR TR1999/00556T patent/TR199900556T2/xx unknown
- 1997-09-10 TW TW086113121A patent/TWI224002B/zh active
- 1997-09-10 CA CA002215015A patent/CA2215015A1/en not_active Abandoned
- 1997-09-11 AR ARP970104168A patent/AR009757A1/es not_active Application Discontinuation
1998
- 1998-04-09 US US09/057,458 patent/US5998377A/en not_active Expired - Fee Related
- 1998-04-20 US US09/062,704 patent/US6071882A/en not_active Expired - Fee Related
1999
- 1999-02-02 IL IL128331A patent/IL128331A/en not_active IP Right Cessation
- 1999-02-16 IS IS4978A patent/IS4978A/is unknown
- 1999-03-11 NO NO19991192A patent/NO326207B1/no not_active IP Right Cessation
- 1999-09-22 US US09/401,851 patent/US6300313B1/en not_active Expired - Fee Related
2008
- 2008-01-30 IL IL189132A patent/IL189132A0/en unknown

Also Published As

Publication number	Publication date
EP0925069B1 (en)	2007-08-22
IL128331A0 (en)	2000-01-31
PL332085A1 (en)	1999-08-30
CA2215015A1 (en)	1998-03-12
IS4978A (is)	1999-02-16
HK1021937A1 (en)	2000-07-21
US6071882A (en)	2000-06-06
HUP0000261A2 (hu)	2000-10-28
CN1230121A (zh)	1999-09-29
MXPA99002420A (es)	2004-08-27
NO991192D0 (no)	1999-03-11
DE69738045D1 (de)	2007-10-04
DE69738045T2 (de)	2008-05-15
CN1126566C (zh)	2003-11-05
US6054432A (en)	2000-04-25
HUP0000261A3 (en)	2001-03-28
WO1998010781A1 (en)	1998-03-19
NZ334540A (en)	2000-07-28
PT925069E (pt)	2007-10-17
ATE370743T1 (de)	2007-09-15
ES2289764T3 (es)	2008-02-01
TWI224002B (en)	2004-11-21
AU4619897A (en)	1998-04-02
AU738306B2 (en)	2001-09-13
IL128331A (en)	2010-05-31
CZ298738B6 (cs)	2008-01-09
EE9900121A (et)	1999-10-15
BR9713197A (pt)	2000-04-04
PL193184B1 (pl)	2007-01-31
RU2215537C2 (ru)	2003-11-10
JP2001500500A (ja)	2001-01-16
US6300313B1 (en)	2001-10-09
EP0925069A1 (en)	1999-06-30
IL189132A0 (en)	2008-06-05
CZ80899A3 (cs)	1999-11-17
DK0925069T3 (da)	2007-10-29
US5998377A (en)	1999-12-07
NO991192L (no)	1999-04-28
TR199900556T2 (xx)	1999-07-21
SK30199A3 (en)	2000-03-13
KR100546235B1 (ko)	2006-01-26
EE04000B1 (et)	2003-04-15
AR009757A1 (es)	2000-05-03
KR20010029495A (ko)	2001-04-06
SK286174B6 (sk)	2008-04-07

Publication	Publication Date	Title
NO326207B1 (no)	2008-10-20	Anvendelse av forbindelsen Cetrorelix for fremstilling av et middel for behandling av prostatahypertrofi og prostatakreft
Denis	1993	Prostate cancer. Primary hormonal treatment
Boccardo et al.	1993	Goserelin acetate with or without flutamide in the treatment of patients with locally advanced or metastatic prostate cancer
Smith Jr	1994	A prospective comparison of treatments for symptomatic hot flushes following endocrine therapy for carcinoma of the prostate
Wu et al.	2018	Progesterone, 5a-dihydropogesterone and allopregnanolone's effects on seizures: a review of animal and clinical studies
Crawford	1992	Challenges in the management of prostate cancer
JP2971950B2 (ja)	1999-11-08	良性前立腺肥大症の処置方法
Ray et al.	1964	Surgical treatment of acromegaly
Ahlman et al.	1987	Use of a somatostatin analogue in association with surgery and hepatic arterial embolisation in the treatment of the carcinoid syndrome
Trachtenberg	1987	Hormonal management of stage D carcinoma of the prostate
Rasmusson et al.	1994	Therapeutic control of androgen action
UA62941C2 (en)	2004-01-15	A regime for therapeutic management of a benign prostatic hyperplasia and prostatic cancer employs Cetrorelix alone or in combination with inhibitors or blocking agents. The regimen reduces the volume of the prostate and avoids the side effects associated with testosterone levels being in a castration range. Cetrorelix is administered at dosages between 0.5 mg/day and 20 mg/week or about 0.014 mg/kg body weight per day to 0.30 mg/kg body weight per week or at levels of about 25 to 120 mg of Cetrorelix per month or 0.376 mg/kg to 1.71 mg/kg per month. Cetrorelix can be administered with inhibitors or blocking agents.
RU2181289C2 (ru)	2002-04-20	Способ восстановления гипоталамо-гипофизарной регуляции у мужчин пожилого возраста
Leewansangtong et al.	1998	Maximal androgen withdrawal for prostate cancer therapy: current status and future potential
JP2020525528A (ja)	2020-08-27	急性尿閉を治療するための組成物を含むシリンジ
Trachtenberg	1987	Hormonal therapy in metastatic prostatic cancer
de Klerk	1983	Human trials of endocrine management
HK1021937B (en)	2004-04-02	Use of luteinizing hormone releasing hormone in the manufacture of a medicament for treating benign hypertrophy and prostate cancer
Al-Enezi et al.	2007	Luteinizing hormone-releasing hormone analogue-induced cataract in a patient with prostate cancer
Stage III et al.	0	Hormone Therapy
CN102836164A (zh)	2012-12-26	防治前列腺增生的组合药物

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