[go: up one dir, main page]

NO324411B1 - Anvendelse av isolerte mulitipotente nervestamceller som prolifererer i et kulturmedium for fremstilling av et cellepreparat for a oppna remyelinering av et demyelinert akson in vivo. - Google Patents

Anvendelse av isolerte mulitipotente nervestamceller som prolifererer i et kulturmedium for fremstilling av et cellepreparat for a oppna remyelinering av et demyelinert akson in vivo. Download PDF

Info

Publication number
NO324411B1
NO324411B1 NO19951378A NO951378A NO324411B1 NO 324411 B1 NO324411 B1 NO 324411B1 NO 19951378 A NO19951378 A NO 19951378A NO 951378 A NO951378 A NO 951378A NO 324411 B1 NO324411 B1 NO 324411B1
Authority
NO
Norway
Prior art keywords
cells
remyelination
culture medium
cell
stem cells
Prior art date
Application number
NO19951378A
Other languages
English (en)
Norwegian (no)
Other versions
NO951378L (no
NO951378D0 (no
Inventor
Samuel Weiss
Brent A Reynolds
Joseph P Hammang
Original Assignee
Neurospheres Holdings Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurospheres Holdings Ltd filed Critical Neurospheres Holdings Ltd
Publication of NO951378L publication Critical patent/NO951378L/no
Publication of NO951378D0 publication Critical patent/NO951378D0/no
Publication of NO324411B1 publication Critical patent/NO324411B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/46—Amines, e.g. putrescine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/11—Epidermal growth factor [EGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO19951378A 1992-10-16 1995-04-07 Anvendelse av isolerte mulitipotente nervestamceller som prolifererer i et kulturmedium for fremstilling av et cellepreparat for a oppna remyelinering av et demyelinert akson in vivo. NO324411B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96181392A 1992-10-16 1992-10-16
PCT/CA1993/000428 WO1994009119A1 (fr) 1992-10-16 1993-10-15 Remyelination effectue a l'aide de cellules souches neurales

Publications (3)

Publication Number Publication Date
NO951378L NO951378L (no) 1995-04-07
NO951378D0 NO951378D0 (no) 1995-04-07
NO324411B1 true NO324411B1 (no) 2007-10-08

Family

ID=25505054

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19951378A NO324411B1 (no) 1992-10-16 1995-04-07 Anvendelse av isolerte mulitipotente nervestamceller som prolifererer i et kulturmedium for fremstilling av et cellepreparat for a oppna remyelinering av et demyelinert akson in vivo.

Country Status (13)

Country Link
EP (1) EP0664832B1 (fr)
JP (1) JPH08502172A (fr)
KR (1) KR950703639A (fr)
AT (1) ATE221117T1 (fr)
AU (1) AU683023B2 (fr)
CA (1) CA2147162C (fr)
DE (1) DE69332147T2 (fr)
DK (1) DK0664832T3 (fr)
ES (1) ES2180547T3 (fr)
FI (1) FI951677A0 (fr)
NO (1) NO324411B1 (fr)
PT (1) PT664832E (fr)
WO (1) WO1994009119A1 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849553A (en) * 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
US5693482A (en) * 1992-07-27 1997-12-02 California Institute Of Technology Neural chest stem cell assay
US6001654A (en) * 1994-01-28 1999-12-14 California Institute Of Technology Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors
WO1996004368A1 (fr) * 1994-07-29 1996-02-15 Dalhousie University Propagation et differenciation inductible de cellules souches du systeme nerveux central f×tal humain
GB9422643D0 (en) * 1994-11-08 1995-01-04 Stringer Bradley M J Neural cell lines
EP0792350A1 (fr) * 1994-11-14 1997-09-03 Neurospheres Holdings Ltd. Regulation de la proliferation de cellules souches neurales
US6969608B1 (en) 1996-08-26 2005-11-29 Mcgill University Pharmaceuticals containing multipotential precursor cells from tissues containing sensory receptors
US6787355B1 (en) 1996-08-26 2004-09-07 Mcgill University Multipotent neural stem cells from peripheral tissues and uses thereof
US6713247B1 (en) 1996-09-03 2004-03-30 Signal Pharmaceuticials, Inc. Human CNS cell lines and methods of use therefor
CA2216439A1 (fr) * 1996-09-25 1998-03-25 Derek Van Der Kooy Produits pharmaceutiques contenant des cellules souches retiniennes
US20020123143A1 (en) 1997-08-22 2002-09-05 Jean Toma Multipotent stem cells from peripheral tissues and uses thereof
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US8263402B1 (en) * 1998-10-19 2012-09-11 Cornell Research Foundation, Inc. Method for isolating and purifying oligodendrocytes and oligodendrocyte progenitor cells
US6238922B1 (en) * 1999-02-26 2001-05-29 Stemcells, Inc. Use of collagenase in the preparation of neural stem cell cultures
US7785882B2 (en) 2000-01-18 2010-08-31 Cornell Research Foundation, Inc. Neuronal progenitor cells from hippocampal tissue and a method for isolating and purifying them
US7544509B2 (en) 2000-01-24 2009-06-09 Mcgill University Method for preparing stem cell preparations
DE60142553D1 (de) 2000-02-11 2010-08-26 Children S Hospital Of Orange Isolierung und transplantation von retinalen stammzellen
US6613798B1 (en) 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
US7115653B2 (en) 2000-03-30 2006-10-03 Curis, Inc. Small organic molecule regulators of cell proliferation
US6683108B1 (en) 2000-03-30 2004-01-27 Curis, Inc. Agonists of hedgehog signaling pathways and uses related thereto
US8852937B2 (en) 2000-03-30 2014-10-07 Curis, Inc. Small organic molecule regulators of cell proliferation
CA2416700A1 (fr) * 2000-07-27 2002-02-07 The Mclean Hospital Corporation Therapie d'implantation cellulaire destinee aux troubles ou maladies neurologiques
US6908732B2 (en) 2000-10-13 2005-06-21 President & Fellows Of Harvard College Compounds and methods for regulating cell differentiation
JP2002204691A (ja) * 2001-01-09 2002-07-23 Japan Science & Technology Corp 神経細胞再髄鞘化のための移植用細胞キット
WO2002069975A1 (fr) * 2001-03-02 2002-09-12 Stem Cell Therapeutics Inc. Utilisation d'un oestrogene pour induire l'augmentation du nombre de cellules souches neurales
JP3993560B2 (ja) * 2001-08-30 2007-10-17 ステム セル セラピューティクス インコーポレイテッド 神経幹細胞の分化およびその治療用途
CA2460184A1 (fr) 2001-09-14 2003-03-27 Stem Cell Therapeutics Inc. Augmentation du nombre de cellules souche neuronales induites par la prolactine
EP1435779A4 (fr) 2001-09-24 2005-06-01 Sangamo Biosciences Inc Modulation de cellules souches au moyen de proteines a doigts de zinc (zfp)
CA2470853A1 (fr) * 2001-12-13 2003-06-19 Japan Science And Technology Agency Milieu de culture pour des cellules humaines et methode de culture
AU2003202988A1 (en) * 2002-01-14 2003-07-30 The Board Of Trustees Of The University Of Illinois Use of modified pyrimidine compounds to promote stem cell migration and proliferation
JP2005529876A (ja) 2002-04-22 2005-10-06 ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン Ｈｅｄｇｅｈｏｇシグナル伝達経路の調節因子、それに関連する組成物および使用
US7704737B2 (en) * 2002-07-30 2010-04-27 Stem Cell Therapeutics Inc. Oligodendrocyte production from multipotent neural stem cells
WO2004053084A2 (fr) 2002-12-09 2004-06-24 The Mclean Hospital Corporation Neurones dopaminergiques differencies a partir de cellules embryonnaires pour traiter des maladies neurodegeneratives
EP1670935B1 (fr) 2003-09-12 2010-12-29 StemCell Technologies Inc. Analyse de formation de colonies de neurones
EP1740202B1 (fr) 2004-02-13 2012-05-09 Stem Cell Therapeutics Corp. Utilisation de l'hormone de luteinisation (lh) et de la gonadotropine chorionique (hcg) pour la proliferation de cellules souches neuronales et la neurogenese
GB0509748D0 (en) * 2005-05-13 2005-06-22 Univ Glasgow Materials and methods relating to cell based therapies
WO2007036033A1 (fr) 2005-09-27 2007-04-05 Stem Cell Therapeutics Corp. Regulation par la prolactine de la proliferation des cellules precurseurs d'oligodendrocytes
EP2004212A4 (fr) 2006-03-17 2010-07-14 Stem Cell Therapeutics Corp Régimes de dosage continu pour agents de prolifération des cellules souches nerveuses et agents de différentiation desdites cellules
US20110218176A1 (en) 2006-11-01 2011-09-08 Barbara Brooke Jennings-Spring Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
US20100158878A1 (en) 2008-12-23 2010-06-24 Alexandra Capela Target populations of oligodendrocyte precursor cells and methods of making and using same
EP2380972B1 (fr) 2010-04-19 2012-09-19 Technische Universität Dresden Procédés et compositions pour l'expansion de cellules souches somatiques et de cellules progénitrices
BR112014019328A8 (pt) 2012-02-17 2017-07-11 The Schepens Eye Res Institute Perfil de fenótipo de células progenitoras retinais humanas
WO2017172976A1 (fr) * 2016-03-29 2017-10-05 The Regents Of The University Of California Méthodes pour favoriser la régénération d'oligodendrocytes et la remyélinisation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991002003A1 (fr) * 1989-08-04 1991-02-21 Board Of Regents, The University Of Texas System Procedes et compositions; preparation purifiee de facteur regulateur de l'ascendant neural
WO1991009936A1 (fr) * 1989-12-26 1991-07-11 Hana Biologics, Inc. Produit cellulaire progeniteur neuronal proliferee et procede
WO1993001275A1 (fr) * 1991-07-08 1993-01-21 Neurospheres Ltd. NOUVELLES CELLULES SOUCHES REAGISSANT AU FACTEUR DE CROISSANCE ET POUVANT PROLIFERER $i(IN VITRO)

Also Published As

Publication number Publication date
CA2147162A1 (fr) 1994-04-28
AU5147493A (en) 1994-05-09
NO951378L (no) 1995-04-07
KR950703639A (ko) 1995-09-20
DE69332147D1 (de) 2002-08-29
WO1994009119A1 (fr) 1994-04-28
ES2180547T3 (es) 2003-02-16
DK0664832T3 (da) 2002-11-11
AU683023B2 (en) 1997-10-30
CA2147162C (fr) 2002-04-30
FI951677L (fi) 1995-04-07
ATE221117T1 (de) 2002-08-15
FI951677A7 (fi) 1995-04-07
PT664832E (pt) 2002-12-31
DE69332147T2 (de) 2002-12-12
JPH08502172A (ja) 1996-03-12
NO951378D0 (no) 1995-04-07
EP0664832A1 (fr) 1995-08-02
EP0664832B1 (fr) 2002-07-24
FI951677A0 (fi) 1995-04-07

Similar Documents

Publication Publication Date Title
AU683023B2 (en) Remyelination using neural stem cells
EP0594669B9 (fr) Cellules précurseurs neurales réagissant au facteur de croissance et capables de proliférer in vitro.
JP4023822B2 (ja) ドーパミン作動性細胞のインビトロ誘導
AU716811B2 (en) Regulation of neural stem cell proliferation
ES2194016T5 (es) Factores biologicos y celulas germinales neurales.
Lachapelle et al. Transplantation of CNS fragments into the brain of shiverer mutant mice: Extensive myelination by implanted oligodendrocytes: I. Immunohistochemical studies
EP1261357B1 (fr) Isolation et transplantation de cellules souches retiniennes
US20020098585A1 (en) Hypoxia-mediated neurogenesis
AU2001234998A1 (en) Isolation and transplantation of retinal stem cells
Sakaguchi et al. Transplantation of neural progenitor cells into the developing retina of the Brazilian opossum: an in vivo system for studying stem/progenitor cell plasticity
WO1991009936A1 (fr) Produit cellulaire progeniteur neuronal proliferee et procede
WO2001076507A2 (fr) Utilisation de transporteurs d'oxygene pour ameliorer la survie de cellules greffees dans une transplantation neuronale
Hammang et al. Transplantation of epidermal growth factor-responsive neural stem cell progeny into the murine central nervous system
Madarász et al. In vitro formation of type 2 astrocytes derived from postnatal rat hypothalamus or cerebral cortex
WO1999055838A1 (fr) Compositions et procedes permettant de caracteriser et de transplanter des cellules souches retiniennes prelevees sur un mammifere
CA2399589A1 (fr) Nouvelles cellules souches sensibles au facteur de croissance qui peuvent proliferer in vitro
Dobrenis Preparation of fetal rat hindbrain neuronal cultures and effects of an astrocyte-derived trophic factor
MXPA97003493A (en) In vitro induction of dopaminergi cells