NO301362B1 - Kosmetisk fukteblanding - Google Patents

Kosmetisk fukteblanding Download PDF

Info

Publication number: NO301362B1
Authority: NO; Norway
Prior art keywords: mixture; bioadhesive; approx; water; polymer
Prior art date: 1989-10-31

Application number

NO921686A

Other languages

English (en)

Norwegian (no)

Other versions

NO921686L (no

NO921686D0 (no

Inventor

Joseph R Robinson

Original Assignee

Columbia Lab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-31

Filing date

1992-04-29

Publication date

1997-10-20

1992-04-29 Application filed by Columbia Lab Inc filed Critical Columbia Lab Inc

1992-04-29 Publication of NO921686D0 publication Critical patent/NO921686D0/no

1992-06-29 Publication of NO921686L publication Critical patent/NO921686L/no

1997-10-20 Publication of NO301362B1 publication Critical patent/NO301362B1/no

Links

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235000011152 sodium sulphate Nutrition 0.000 description 1
239000002904 solvent Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
229910001220 stainless steel Inorganic materials 0.000 description 1
239000010935 stainless steel Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
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238000003860 storage Methods 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
229940044609 sulfur dioxide Drugs 0.000 description 1
235000010269 sulphur dioxide Nutrition 0.000 description 1
210000004243 sweat Anatomy 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
229920001864 tannin Polymers 0.000 description 1
235000018553 tannin Nutrition 0.000 description 1
239000001648 tannin Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
230000008719 thickening Effects 0.000 description 1
230000009974 thixotropic effect Effects 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 description 1
230000005068 transpiration Effects 0.000 description 1
AKYUZBFQLWFNOB-UHFFFAOYSA-K trisodium 2-hydroxypropane-1,2,3-tricarboxylate hydrochloride Chemical compound [Na+].[Na+].[Na+].Cl.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O AKYUZBFQLWFNOB-UHFFFAOYSA-K 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
229940045136 urea Drugs 0.000 description 1
239000008371 vanilla flavor Substances 0.000 description 1
239000012808 vapor phase Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000004520 water soluble gel Substances 0.000 description 1
229920003176 water-insoluble polymer Polymers 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1
229940045860 white wax Drugs 0.000 description 1
230000002087 whitening effect Effects 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000011701 zinc Chemical class 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
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Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Birds (AREA)
Dermatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Reproductive Health (AREA)
Inorganic Chemistry (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Gynecology & Obstetrics (AREA)
Oral & Maxillofacial Surgery (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Endocrinology (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Materials For Medical Uses (AREA)
Adhesives Or Adhesive Processes (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NO921686A 1989-10-31 1992-04-29 Kosmetisk fukteblanding NO301362B1 (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US42975589A	1989-10-31	1989-10-31
US42977089A	1989-10-31	1989-10-31
PCT/US1990/006087 WO1991006283A1 (en)	1989-10-31	1990-10-24	Tissue moisturizing composition and method

Publications (3)

Publication Number	Publication Date
NO921686D0 NO921686D0 (no)	1992-04-29
NO921686L NO921686L (no)	1992-06-29
NO301362B1 true NO301362B1 (no)	1997-10-20

Family

ID=27028332

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO921686A NO301362B1 (no)	1989-10-31	1992-04-29	Kosmetisk fukteblanding

Country Status (26)

Country	Link
US (1)	US5968500A (pt)
EP (1)	EP0500807B1 (pt)
JP (1)	JP2510052B2 (pt)
KR (1)	KR100218654B1 (pt)
AR (1)	AR243728A1 (pt)
AT (1)	ATE181824T1 (pt)
AU (1)	AU639069B2 (pt)
BR (1)	BR9007807A (pt)
CA (1)	CA2072148C (pt)
DE (1)	DE69033199T2 (pt)
DK (1)	DK0500807T3 (pt)
ES (1)	ES2134769T3 (pt)
FI (1)	FI103764B1 (pt)
GR (1)	GR3031288T3 (pt)
HU (3)	HUT68635A (pt)
IE (1)	IE62386B1 (pt)
IL (1)	IL96148A (pt)
MA (1)	MA22756A1 (pt)
MC (1)	MC2204A1 (pt)
MY (1)	MY105322A (pt)
NO (1)	NO301362B1 (pt)
NZ (2)	NZ272331A (pt)
PE (1)	PE27891A1 (pt)
PT (1)	PT95729B (pt)
RU (1)	RU2104034C1 (pt)
WO (1)	WO1991006283A1 (pt)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5143724A (en) *	1990-07-09	1992-09-01	Biomatrix, Inc.	Biocompatible viscoelastic gel slurries, their preparation and use
US5686094A (en) *	1991-04-01	1997-11-11	Theratech, Inc.	Controlled release formulations for the treatment of xerostomia
ES2088500T3 (es) *	1990-08-21	1996-08-16	Theratech Inc	Composiciones de liberacion controlada.
DE4113684B4 (de) *	1991-04-26	2005-02-03	Sommermeyer, Klaus, Dr.	Spraybares Mund- und Rachenpflegemittel gegen Trockenheit der Schleimhaut
IT1250748B (it) *	1991-08-02	1995-04-21	Poli Ind Chimica Spa	Formulazioni utili per il trattamento della secchezza vaginale
IL101056A (en) *	1992-02-24	1997-03-18	Res & Dev Co Ltd	Composition for nasal treatment
GR1002418B (el) *	1992-07-29	1996-08-21	Johnson & Johnson Consumer Products Inc.	Βιοεπισυναπτομενες συνθεσεις θεραπειας και μεθοδοι χρησης.
GR1001412B (el) *	1992-10-12	1993-11-30	Poli Ind Chimica Spa	Συν?έσεις χρήσιμες δια την ?εραπευτική αγωγή της ξηρότητος του κόλπου.
ES2049665B1 (es) *	1992-10-13	1994-11-01	Poli Ind Chimica Spa	Formulaciones utiles para el tratamiento de la sequedad viginal.
US5667492A (en) *	1994-10-07	1997-09-16	Columbia Laboratories, Inc.	Use and composition of an anti-sexually transmitted diseases formulation
US6596777B1 (en)	1997-05-29	2003-07-22	Mcneil-Ppc, Inc.	Moisture containing compositions that are spreadable onto and adherable to biomembranes
US6869938B1 (en)	1997-06-17	2005-03-22	Fziomed, Inc.	Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US20050074495A1 (en) *	1997-06-17	2005-04-07	Fziomed, Inc.	Compositions of polyacids and methods for their use in reducing adhesions
US7192984B2 (en) *	1997-06-17	2007-03-20	Fziomed, Inc.	Compositions of polyacids and polyethers and methods for their use as dermal fillers
US20040096422A1 (en) *	1997-06-17	2004-05-20	Schwartz Herbert E.	Compositions of polyacids and polyethers and methods for their use in reducing pain
US6958148B1 (en)	1998-01-20	2005-10-25	Pericor Science, Inc.	Linkage of agents to body tissue using microparticles and transglutaminase
US6919076B1 (en)	1998-01-20	2005-07-19	Pericor Science, Inc.	Conjugates of agents and transglutaminase substrate linking molecules
CA2366880C (en) *	1999-04-02	2013-02-12	Fziomed, Inc.	Compositions of polyacids and polyethers and methods for their use in reducing adhesions
US6479045B2 (en)	1999-12-22	2002-11-12	Columbia Laboratories, Inc.	Vaginal pH buffering for preventing miscarriage and premature labor, by treating or preventing bacterial vaginosis
US6566345B2 (en)	2000-04-28	2003-05-20	Fziomed, Inc.	Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6284235B1 (en)	2000-02-11	2001-09-04	National Starch And Chemical Company Investment Holding Corporation	Bioadhesive composition
WO2001082863A2 (en) *	2000-04-28	2001-11-08	Fziomed, Inc.	Polyacid/polyalkylene oxide foams and gels and methods for their delivery
US6592860B1 (en) *	2000-05-30	2003-07-15	Soluble Systems, Llc	Composition and applicator for topical substance delivery
DE10051858A1 (de) *	2000-10-19	2002-06-06	Guenther Beisel	Verwendung von biologisch abbaubaren, substituierten Kohlenwasserstoffen deren Ester, Ether und/oder Amide als Nasensalbe oder Nasentropfen zur Prophylaxe von inhalationsallergischen Reaktionen und zur Pflege der Nasenschleimhaut
DE10064950A1 (de) *	2000-12-23	2002-07-11	Impetus Ag Basel	Thixotropes Nasenspray
CA2441352C (en) *	2001-02-15	2010-05-25	Access Pharmaceuticals, Inc.	Liquid formulations for the prevention and treatment of mucosal diseases and disorders
US7544348B2 (en) *	2001-02-15	2009-06-09	Access Pharmaceuticals, Inc.	Liquid formulations for the prevention and treatment of mucosal diseases and disorders
ATE478653T1 (de) *	2001-05-17	2010-09-15	Unilever Nv	Behandlungsmittel für die nasse haut
US6585997B2 (en)	2001-08-16	2003-07-01	Access Pharmaceuticals, Inc.	Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
US20060073174A1 (en) *	2001-08-16	2006-04-06	Access Pharmaceuticals, Inc.	Adherent and erodible film to treat a moist surface of a body tissue
CA2463384A1 (en) *	2001-10-12	2003-04-17	Cns, Incorporated	Hydrating nasal gel and applicator
US8425892B2 (en)	2001-10-29	2013-04-23	Columbia Laboratories, Inc.	Extended, controlled-release pharmaceutical compositions using charged polymers
US7846478B2 (en) *	2002-01-31	2010-12-07	Henkel Ag & Co. Kgaa	Bioadhesive composition
CA2485530A1 (en) *	2002-02-15	2003-08-28	Cns, Inc.	Throat spray
US20030204180A1 (en) *	2002-04-30	2003-10-30	Kimberly-Clark Worldwide, Inc.	Temperature responsive delivery systems
US8524200B2 (en)	2002-09-11	2013-09-03	The Procter & Gamble Company	Tooth whitening products
US20060140992A1 (en) *	2002-10-31	2006-06-29	Idemitsu Technofine Co., Ltd.	Cosmetics excellent in texture and oil-dispersibility
ES2237298B1 (es)	2003-07-16	2006-11-01	Italfarmaco, S.A.	Formulaciones mucoadhesivas semisolidas.
US20050202097A1 (en) *	2004-03-12	2005-09-15	Melbj Holdings, Llc, Florida	Lubricant for the ocular surface
US8455016B2 (en) *	2004-03-12	2013-06-04	Melbj Holdings, Llc	Treatment for meibomian gland dysfunction or obstruction
US8703198B2 (en) *	2005-03-02	2014-04-22	Aquatrove Biosciences	Water-based personal moisturizers and lubricants, in particular vaginal lubricants, and uses thereof
US7252834B2 (en) *	2005-04-25	2007-08-07	Clemson University Research Foundation (Curf)	Elastin stabilization of connective tissue
AU2013277007B2 (en) *	2006-03-01	2016-04-14	Mancini Holdings Pty Ltd	Aqueous moisturizers and lubircants and uses thereof
BRPI0714155A2 (pt) *	2006-07-07	2012-12-25	Bausch & Lomb	composiÇço, e, uso de um agonista do receptor de glucocorticàide dissociado (digra), uma prà-droga do mesmo, ou um sal farmaceuticamente aceitÁvel do mesmo
US10512597B2 (en) *	2007-09-06	2019-12-24	Colgate-Palmolive Company	Controlled surface gelling of mucoadhesive polymers on oral mucosa
US20090155337A1 (en) *	2007-11-12	2009-06-18	Endologix, Inc.	Method and agent for in-situ stabilization of vascular tissue
EP2257274A4 (en) *	2008-02-21	2011-07-20	Vatrix Medical Inc	TREATMENT OF ANEURYSMA USING A BIND WEAVE STABILIZING AGENT COMBINED WITH A DISPENSER
US20100016833A1 (en) *	2008-07-15	2010-01-21	Ogle Matthew F	Devices for the Treatment of Vascular Aneurysm
US20100119605A1 (en) *	2008-11-12	2010-05-13	Isenburg Jason C	Compositions for tissue stabilization
GB0905677D0 (en) *	2009-04-01	2009-05-20	Yes Syzygy Ltd	Intimate lubrication kit
WO2011044455A1 (en) *	2009-10-09	2011-04-14	Vatrix Medical, Inc.	In vivo chemical stabilization of vulnerable plaque
US8444624B2 (en) *	2009-10-19	2013-05-21	Vatrix Medical, Inc.	Vascular medical devices with sealing elements and procedures for the treatment of isolated vessel sections
EP2544543A1 (en) *	2010-03-12	2013-01-16	Scott Cordray	Method of treatment
US8911468B2 (en)	2011-01-31	2014-12-16	Vatrix Medical, Inc.	Devices, therapeutic compositions and corresponding percutaneous treatment methods for aortic dissection
US9937255B2 (en)	2011-05-18	2018-04-10	Nectero Medical, Inc.	Coated balloons for blood vessel stabilization
US9283241B2 (en)	2012-07-10	2016-03-15	Clemson University	Treatment to render implants resistant to diabetes
CN107532050B (zh) *	2015-02-06	2021-03-02	诺芬药品公司	用于透皮给药的压敏粘合剂
WO2018038472A1 (ko) *	2016-08-25	2018-03-01	문득곤	화장료 조성물 및 피부에 유용성분을 공급하는 방법
JP2023539940A (ja)	2020-09-08	2023-09-20	アルタミラメディカ，アーゲー	感染を防止するための組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL88710C (pt) *	1954-01-25
NL7500072A (nl) *	1974-04-20	1975-10-22	Henkel & Cie Gmbh	Toepassing van carboxyl- respectievelijk car- boxylaat- en aldehydegroepen bezittende poly- meren als huidvochtretentiemiddel in huidver- zorgings- en huidbeschermingsmiddelen.
US4863725A (en) *	1982-10-27	1989-09-05	Deckner George E	Novel clear oil-free moisturizer composition
US4548990A (en) *	1983-08-15	1985-10-22	Ciba-Geigy Corporation	Crosslinked, porous polymers for controlled drug delivery
EP0501523B1 (en) *	1983-11-14	1997-04-09	Columbia Laboratories, Inc.	Bioadhesive compositions
US4552755A (en) *	1984-05-18	1985-11-12	Minnesota Mining And Manufacturing Company	Substantive moisturizing compositions
JPS6172706A (ja) *	1984-09-18	1986-04-14	Showa Denko Kk	化粧料
JPH0744940B2 (ja) *	1986-12-24	1995-05-17	ライオン株式会社	口腔貼付用基材
WO1989000451A1 (fr) *	1987-07-15	1989-01-26	Himeji Denshi Kabushiki Kaisha	Dispositif de reformage de fluide
IE63392B1 (en) *	1988-02-08	1995-04-19	Insite Vision Inc	Ophthalmic suspensions

1990
- 1990-10-24 AU AU70331/91A patent/AU639069B2/en not_active Ceased
- 1990-10-24 WO PCT/US1990/006087 patent/WO1991006283A1/en not_active Ceased
- 1990-10-24 DE DE69033199T patent/DE69033199T2/de not_active Expired - Fee Related
- 1990-10-24 ES ES91901558T patent/ES2134769T3/es not_active Expired - Lifetime
- 1990-10-24 HU HU9201465A patent/HUT68635A/hu unknown
- 1990-10-24 DK DK91901558T patent/DK0500807T3/da active
- 1990-10-24 JP JP3501917A patent/JP2510052B2/ja not_active Expired - Lifetime
- 1990-10-24 CA CA002072148A patent/CA2072148C/en not_active Expired - Lifetime
- 1990-10-24 AT AT91901558T patent/ATE181824T1/de not_active IP Right Cessation
- 1990-10-24 RU SU5052115A patent/RU2104034C1/ru active
- 1990-10-24 HU HU9201465A patent/HU9201465D0/hu unknown
- 1990-10-24 MC MC906087A patent/MC2204A1/xx unknown
- 1990-10-24 HU HU9201465A patent/HU227563B1/hu unknown
- 1990-10-24 KR KR1019920701044A patent/KR100218654B1/ko not_active Expired - Fee Related
- 1990-10-24 BR BR909007807A patent/BR9007807A/pt not_active IP Right Cessation
- 1990-10-24 EP EP91901558A patent/EP0500807B1/en not_active Expired - Lifetime
- 1990-10-29 PT PT95729A patent/PT95729B/pt not_active IP Right Cessation
- 1990-10-29 IL IL9614890A patent/IL96148A/en not_active IP Right Cessation
- 1990-10-30 IE IE389190A patent/IE62386B1/en not_active IP Right Cessation
- 1990-10-30 MA MA22264A patent/MA22756A1/fr unknown
- 1990-10-30 MY MYPI90001895A patent/MY105322A/en unknown
- 1990-10-30 PE PE1990176770A patent/PE27891A1/es not_active Application Discontinuation
- 1990-10-31 NZ NZ272331A patent/NZ272331A/en unknown
- 1990-10-31 AR AR90318259A patent/AR243728A1/es active
- 1990-10-31 NZ NZ235903A patent/NZ235903A/en unknown
1992
- 1992-04-29 NO NO921686A patent/NO301362B1/no not_active IP Right Cessation
- 1992-04-29 FI FI921932A patent/FI103764B1/fi active
1997
- 1997-10-15 US US08/950,835 patent/US5968500A/en not_active Expired - Lifetime
1999
- 1999-09-22 GR GR990402386T patent/GR3031288T3/el unknown

Also Published As

Publication number	Publication date
JP2510052B2 (ja)	1996-06-26
FI921932L (fi)	1992-04-29
GR3031288T3 (en)	1999-12-31
IL96148A (en)	1995-08-31
IE62386B1 (en)	1995-01-25
NO921686L (no)	1992-06-29
FI103764B (fi)	1999-09-30
JPH05504338A (ja)	1993-07-08
PT95729A (pt)	1991-09-13
EP0500807B1 (en)	1999-07-07
ES2134769T3 (es)	1999-10-16
FI921932A0 (fi)	1992-04-29
NZ235903A (en)	1996-11-26
KR920703010A (ko)	1992-12-17
PT95729B (pt)	1998-05-29
CA2072148C (en)	2002-04-23
MY105322A (en)	1994-09-30
MC2204A1 (fr)	1992-11-26
US5968500A (en)	1999-10-19
ATE181824T1 (de)	1999-07-15
CA2072148A1 (en)	1991-05-01
AU639069B2 (en)	1993-07-15
RU2104034C1 (ru)	1998-02-10
KR100218654B1 (ko)	1999-09-01
NZ272331A (en)	1996-11-26
PE27891A1 (es)	1991-10-29
DE69033199T2 (de)	1999-10-28
EP0500807A1 (en)	1992-09-02
AR243728A1 (es)	1993-09-30
HUT68635A (en)	1995-07-28
IE903891A1 (en)	1991-05-08
MA22756A1 (fr)	1993-10-01
DE69033199D1 (de)	1999-08-12
NO921686D0 (no)	1992-04-29
BR9007807A (pt)	1992-09-29
AU7033191A (en)	1991-05-31
WO1991006283A1 (en)	1991-05-16
IL96148A0 (en)	1991-07-18
HU227563B1 (en)	2011-08-29
HU9201465D0 (en)	1992-07-28
DK0500807T3 (da)	2000-02-07
FI103764B1 (fi)	1999-09-30

Publication	Publication Date	Title
NO301362B1 (no)	1997-10-20	Kosmetisk fukteblanding
US5474768A (en)	1995-12-12	Vaginal tissue moisturizing composition and method
US6017521A (en)	2000-01-25	Use of polycarboxylic acid polymers to treat vaginal infections
US6280750B1 (en)	2001-08-28	Solid cosmetic composition and uses thereof
EP1055406B1 (fr)	2004-12-01	Composition sous forme d'émulsion huile-dans-eau et ses utilisations notamment cosmétiques
US20040143026A1 (en)	2004-07-22	Bioadhesive hydrophilic composition for treatment of mammalian skin
JPH06100467A (ja)	1994-04-12	生物接着剤治療組成物およびその使用法
IL115891A (en)	2001-04-30	Hemorrhoidal compositions and their use
JP2000119131A (ja)	2000-04-25	親水性の増粘化合物と増粘コポリマ―を含有するエマルション及び該エマルションを含有する組成物及びその使用
US6180122B1 (en)	2001-01-30	Solid cosmetic composition and uses thereof
WO1998006438A9 (en)	1998-07-23	Composition for pharmaceutical applications
KR20000023228A (ko)	2000-04-25	친수성 증점 화합물 및 다당 알킬 에테르를 함유한 유제,상기 유제를 함유한 조성물 및 이의 용도
US6312702B2 (en)	2001-11-06	Solid cosmetic composition free of fillers, containing low amounts of gelling agents
CN101926743A (zh)	2010-12-29	不含矿物油,聚合性稳定的卸妆用品
DE69012955T2 (de)	1995-02-09	Verfahren zur Feuchthaltung von Gewebe und Mittel dazu.
JP3990541B2 (ja)	2007-10-17	保湿用のゲル状組成物
CN1246369A (zh)	2000-03-08	组织增湿组合物和方法
CN1246339A (zh)	2000-03-08	阴道组织润湿组合物和方法
JPH04230613A (ja)	1992-08-19	化粧用パック剤
JPH0818966B2 (ja)	1996-02-28	皮膜形成型化粧用パック剤

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