NO305908B1 - Enantiomerer av 1-[(4-klorfenyl)fenylmethyl]-4-[(4-methylfenyl)sulfonyl]piperazin og fremgangsmåte for fremstilling av disse - Google Patents

Enantiomerer av 1-[(4-klorfenyl)fenylmethyl]-4-[(4-methylfenyl)sulfonyl]piperazin og fremgangsmåte for fremstilling av disse

Info

Publication number: NO305908B1
Authority: NO; Norway
Prior art keywords: chlorophenyl; methylphenyl; ethyl; enantiomers; phenylmethyl
Prior art date: 1993-03-15

Application number

NO940881A

Other languages

English (en)

Other versions

NO940881D0 (no

NO940881L (no

Inventor

Eric Cossement

Guy Bodson

Jean Gobert

Original Assignee

Ucb Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-15

Filing date

1994-03-11

Publication date

1999-08-16

1994-03-11 Application filed by Ucb Sa filed Critical Ucb Sa

1994-03-11 Publication of NO940881D0 publication Critical patent/NO940881D0/no

1994-09-16 Publication of NO940881L publication Critical patent/NO940881L/no

1999-08-16 Publication of NO305908B1 publication Critical patent/NO305908B1/no

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Dermatology (AREA)
Anesthesiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

NO940881A 1993-03-15 1994-03-11 Enantiomerer av 1-[(4-klorfenyl)fenylmethyl]-4-[(4-methylfenyl)sulfonyl]piperazin og fremgangsmåte for fremstilling av disse NO305908B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB939305282A GB9305282D0 (en)	1993-03-15	1993-03-15	Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine

Publications (3)

Publication Number	Publication Date
NO940881D0 NO940881D0 (no)	1994-03-11
NO940881L NO940881L (no)	1994-09-16
NO305908B1 true NO305908B1 (no)	1999-08-16

Family

ID=10732080

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
NO940881A NO305908B1 (no)	1993-03-15	1994-03-11	Enantiomerer av 1-[(4-klorfenyl)fenylmethyl]-4-[(4-methylfenyl)sulfonyl]piperazin og fremgangsmåte for fremstilling av disse
NO990351A NO306616B1 (no)	1993-03-15	1999-01-26	Fremgangsmåte for fremstilling av den venstredreiende og höyredreiende enantiomer av et 1-[(4-klorfenyl)fenylmetyl]-piperazin

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
NO990351A NO306616B1 (no)	1993-03-15	1999-01-26	Fremgangsmåte for fremstilling av den venstredreiende og höyredreiende enantiomer av et 1-[(4-klorfenyl)fenylmetyl]-piperazin

Country Status (23)

Country	Link
US (17)	US5478941A (no)
EP (3)	EP0955295B1 (no)
JP (3)	JP3267434B2 (no)
KR (1)	KR100322415B1 (no)
AT (2)	ATE193889T1 (no)
AU (1)	AU678426B2 (no)
CA (2)	CA2443216C (no)
DE (2)	DE69424893T2 (no)
DK (1)	DK0617028T3 (no)
ES (2)	ES2221262T3 (no)
FI (3)	FI105477B (no)
GB (1)	GB9305282D0 (no)
GR (1)	GR3034340T3 (no)
HU (1)	HU219230B (no)
NO (2)	NO305908B1 (no)
NZ (1)	NZ260062A (no)
PL (1)	PL178546B1 (no)
PT (1)	PT617028E (no)
RU (1)	RU2118320C1 (no)
SG (1)	SG43683A1 (no)
SI (2)	SI0955295T1 (no)
TW (1)	TW237452B (no)
ZA (1)	ZA941724B (no)

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WO2001040211A1 (en) *	1999-11-30	2001-06-07	EGIS Gyógyszergyár Rt.	A PROCESS FOR THE PREPARATION OF {2-[4-(α-PHENYL-p-CHLOROBENZYL)PIPERAZIN-1-YL]ETHOXY}ACETIC ACID AND NOVEL INTERMEDIATES THEREFOR
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US7577727B2 (en) *	2003-06-27	2009-08-18	Newisys, Inc.	Dynamic multiple cluster system reconfiguration
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EP1858866B1 (en) *	2005-03-03	2009-06-10	Ucb Farchim, S.A.	Pyroglutamate salts and their use in the optical resolution of intermediates for the synthesis of dextrocetirizine and levocetirizine
HU227074B1 (en) *	2005-12-08	2010-06-28	Egis Gyogyszergyar Nyrt	An optically active carbamic acid derivative, method for producing the same and use as a pharmaceutical intermediate
WO2008110586A2 (en)	2007-03-12	2008-09-18	Krka, Tovarna Zdravil, D.D., Novo Mesto	New process for the preparation of levocetirizine and intermediates thereof
US8084606B2 (en) *	2007-06-15	2011-12-27	Symed Labs Limited	Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates
US20090062305A1 (en) *	2007-08-29	2009-03-05	Protia, Llc	Deuterium-enriched cetirizine
US20090082364A1 (en) *	2007-09-26	2009-03-26	Protia, Llc	Deuterium-enriched levocedtirizine
KR101427100B1 (ko)	2007-10-23	2014-08-08	주식회사 씨트리	광학활성을 갖는 1-[(4-클로로페닐)페닐메틸]-피페라진의제조방법
EP2062881B1 (en)	2007-11-21	2011-02-23	Synthon B.V.	Process for making N-(diphenylmethyl)piperazines
US7989623B2 (en) *	2007-11-21	2011-08-02	Synthon Bv	Process for making n-(diphenylmethyl)piperazines
KR100954755B1 (ko) *	2007-12-17	2010-04-27	한미약품 주식회사	(ｒ)-(-)-1-[(4-클로로페닐)페닐메틸]피페라진의 제조방법
WO2009147389A2 (en) *	2008-06-02	2009-12-10	Cipla Limited	Processes for the synthesis of levocetirizine and intermediates for use therein
KR100998067B1 (ko)	2008-09-08	2010-12-03	주식회사 삼오제약	비스(1-[(4-클로로페닐)페닐메틸]피페라진)-2,3-디벤조일 타르타르산 신규 중간체 염 및 이를 이용한 광학 활성적으로 순수한 1-[(4-클로로페닐)페닐메틸]피페라진을 분리하는 분리방법
US20100145049A1 (en) *	2008-11-21	2010-06-10	Jie Zhu	Process for making n-(diphenylmethyl)piperazines
SG2014005110A (en) *	2009-04-22	2014-03-28	Axikin Pharmaceuticals Inc	Arylsulfonamide ccr3 antagonists
CN101928223A (zh) *	2009-06-26	2010-12-29	华东理工大学	一种(r)-(-)-4-氯二苯甲胺的拆分方法
WO2012101475A1 (en)	2011-01-27	2012-08-02	Jubilant Life Sciences Limited	An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
KR101418404B1 (ko)	2012-01-06	2014-07-10	한미약품 주식회사	레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 함유하는 안정한 경구투여용 약학 제제
US11224618B2 (en)	2012-04-16	2022-01-18	Zemtsov Enterprises, Llc	Formulations and methods for treatment of acne and inflammatory skin conditions
CN103613567A (zh) *	2012-11-09	2014-03-05	焦作福瑞堂制药有限公司	盐酸氯环利嗪的合成工艺
KR102226833B1 (ko)	2013-06-28	2021-03-12	한미약품 주식회사	레보세티리진 및 몬테루카스트를 포함하는 안정성이 개선된 복합 과립 제형
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1993
- 1993-03-15 GB GB939305282A patent/GB9305282D0/en active Pending
1994
- 1994-03-08 TW TW083102003A patent/TW237452B/zh active
- 1994-03-08 US US08/207,096 patent/US5478941A/en not_active Expired - Lifetime
- 1994-03-09 SI SI9430468T patent/SI0955295T1/xx unknown
- 1994-03-09 ES ES99109564T patent/ES2221262T3/es not_active Expired - Lifetime
- 1994-03-09 EP EP99109564A patent/EP0955295B1/fr not_active Expired - Lifetime
- 1994-03-09 DE DE69424893T patent/DE69424893T2/de not_active Expired - Fee Related
- 1994-03-09 AT AT94870043T patent/ATE193889T1/de not_active IP Right Cessation
- 1994-03-09 SI SI9430329T patent/SI0617028T1/xx unknown
- 1994-03-09 EP EP04002438A patent/EP1413307A1/fr not_active Withdrawn
- 1994-03-09 SG SG1995002010A patent/SG43683A1/en unknown
- 1994-03-09 EP EP94870043A patent/EP0617028B1/fr not_active Expired - Lifetime
- 1994-03-09 ES ES94870043T patent/ES2147569T3/es not_active Expired - Lifetime
- 1994-03-09 DE DE69433802T patent/DE69433802T2/de not_active Expired - Fee Related
- 1994-03-09 DK DK94870043T patent/DK0617028T3/da active
- 1994-03-09 AT AT99109564T patent/ATE267185T1/de not_active IP Right Cessation
- 1994-03-09 PT PT94870043T patent/PT617028E/pt unknown
- 1994-03-10 NZ NZ260062A patent/NZ260062A/en not_active IP Right Cessation
- 1994-03-10 FI FI941134A patent/FI105477B/fi active
- 1994-03-11 CA CA002443216A patent/CA2443216C/en not_active Expired - Fee Related
- 1994-03-11 ZA ZA941724A patent/ZA941724B/xx unknown
- 1994-03-11 HU HU9400727A patent/HU219230B/hu not_active IP Right Cessation
- 1994-03-11 NO NO940881A patent/NO305908B1/no not_active IP Right Cessation
- 1994-03-11 PL PL94302565A patent/PL178546B1/pl not_active IP Right Cessation
- 1994-03-11 AU AU57771/94A patent/AU678426B2/en not_active Ceased
- 1994-03-11 CA CA002118859A patent/CA2118859C/en not_active Expired - Fee Related
- 1994-03-14 RU RU94008618A patent/RU2118320C1/ru active
- 1994-03-14 JP JP04254794A patent/JP3267434B2/ja not_active Expired - Fee Related
- 1994-03-14 KR KR1019940005172A patent/KR100322415B1/ko not_active Expired - Fee Related
1995
- 1995-06-05 US US08/460,844 patent/US5703082A/en not_active Expired - Fee Related
1997
- 1997-10-09 US US08/947,859 patent/US5792770A/en not_active Expired - Fee Related
1999
- 1999-01-26 NO NO990351A patent/NO306616B1/no not_active IP Right Cessation
- 1999-07-19 US US09/356,865 patent/US6436942B1/en not_active Expired - Fee Related
- 1999-08-16 FI FI991730A patent/FI105915B/fi active
- 1999-08-16 FI FI991729A patent/FI105914B/fi active
2000
- 2000-09-06 GR GR20000402028T patent/GR3034340T3/el not_active IP Right Cessation
2001
- 2001-11-22 JP JP2001356849A patent/JP3880842B2/ja not_active Expired - Fee Related
2002
- 2002-05-10 US US10/141,933 patent/US20030105112A1/en not_active Abandoned
- 2002-06-06 US US10/162,576 patent/US20030105113A1/en not_active Abandoned
2003
- 2003-03-12 US US10/385,522 patent/US20030204089A1/en not_active Abandoned
- 2003-10-07 US US10/679,376 patent/US20040072845A1/en not_active Abandoned
- 2003-12-02 US US10/724,640 patent/US20040122021A1/en not_active Abandoned
- 2003-12-02 US US10/724,611 patent/US20040122023A1/en not_active Abandoned
2005
- 2005-04-15 US US11/106,456 patent/US20050182070A1/en not_active Abandoned
- 2005-04-15 US US11/106,613 patent/US20050176732A1/en not_active Abandoned
- 2005-04-15 US US11/106,528 patent/US20050182069A1/en not_active Abandoned
2006
- 2006-06-16 US US11/453,987 patent/US20060229319A1/en not_active Abandoned
- 2006-06-16 US US11/453,986 patent/US20060229320A1/en not_active Abandoned
- 2006-07-17 US US11/487,331 patent/US20060252934A1/en not_active Abandoned
- 2006-09-29 JP JP2006266195A patent/JP2006342190A/ja not_active Abandoned
2007
- 2007-01-11 US US11/652,092 patent/US20070142400A1/en not_active Abandoned

Also Published As

Publication number	Publication date
FI105915B (fi)	2000-10-31
FI19991729L (fi)	1999-08-16
US20030204089A1 (en)	2003-10-30
US6436942B1 (en)	2002-08-20
US20050182070A1 (en)	2005-08-18
US20070142400A1 (en)	2007-06-21
CA2118859C (en)	2004-07-13
CA2443216A1 (en)	1994-09-16
HK1024232A1 (en)	2000-10-05
NO940881D0 (no)	1994-03-11
US20050176732A1 (en)	2005-08-11
SI0617028T1 (en)	2000-10-31
US20030105112A1 (en)	2003-06-05
US20030105113A1 (en)	2003-06-05
NO990351L (no)	1999-01-26
US5703082A (en)	1997-12-30
SI0955295T1 (en)	2004-10-31
DE69424893D1 (de)	2000-07-20
DK0617028T3 (da)	2000-09-04
CA2118859A1 (en)	1994-09-16
US20040072845A1 (en)	2004-04-15
JP2002201187A (ja)	2002-07-16
JP3880842B2 (ja)	2007-02-14
ATE267185T1 (de)	2004-06-15
HU9400727D0 (en)	1994-06-28
EP1413307A1 (fr)	2004-04-28
US20040122021A1 (en)	2004-06-24
FI941134A0 (fi)	1994-03-10
US20060252934A1 (en)	2006-11-09
GB9305282D0 (en)	1993-05-05
AU5777194A (en)	1994-09-22
US20040122023A1 (en)	2004-06-24
JPH072816A (ja)	1995-01-06
ATE193889T1 (de)	2000-06-15
KR100322415B1 (ko)	2002-06-20
FI941134L (fi)	1994-09-16
DE69433802T2 (de)	2005-05-12
ZA941724B (en)	1994-10-13
GR3034340T3 (en)	2000-12-29
NO306616B1 (no)	1999-11-29
TW237452B (no)	1995-01-01
JP3267434B2 (ja)	2002-03-18
ES2147569T3 (es)	2000-09-16
EP0617028A1 (fr)	1994-09-28
NO990351D0 (no)	1999-01-26
FI19991730L (fi)	1999-08-16
US20050182069A1 (en)	2005-08-18
PT617028E (pt)	2000-11-30
RU2118320C1 (ru)	1998-08-27
FI105914B (fi)	2000-10-31
ES2221262T3 (es)	2004-12-16
DE69433802D1 (de)	2004-06-24
PL178546B1 (pl)	2000-05-31
NZ260062A (en)	1995-09-26
CA2443216C (en)	2007-05-08
NO940881L (no)	1994-09-16
EP0617028B1 (fr)	2000-06-14
FI105477B (fi)	2000-08-31
HU219230B (en)	2001-03-28
SG43683A1 (en)	1997-11-14
EP0955295B1 (fr)	2004-05-19
DE69424893T2 (de)	2000-10-12
EP0955295A1 (fr)	1999-11-10
US5792770A (en)	1998-08-11
HUT70959A (en)	1995-11-28
US20060229319A1 (en)	2006-10-12
JP2006342190A (ja)	2006-12-21
US20060229320A1 (en)	2006-10-12
US5478941A (en)	1995-12-26
AU678426B2 (en)	1997-05-29

Publication	Publication Date	Title
NO305908B1 (no)	1999-08-16	Enantiomerer av 1-[(4-klorfenyl)fenylmethyl]-4-[(4-methylfenyl)sulfonyl]piperazin og fremgangsmåte for fremstilling av disse
GR1000553B (el)	1992-08-26	Μεθοδος παρασκευης του 2-(2-(4-((4-χλωριοφαινυλ)φαινυλμεθυλ)-1-πιπεραζινυλ)αιθοξυ) οξικου οξεος και του διυδροχλωρικου αλατιου του.
ATE116312T1 (de)	1995-01-15	Antimigräne alkoxypyrimidinderivate.
HUP9900926A2 (hu)	1999-09-28	Új (4-oxialkoxi-fenil)-3-oxi-piperidinek, szív- és veseelégtelenség kezelésére
NO20061562L (no)	2001-11-26	Anvendelse av 1- [4-(5-cyanindol-3yl)butyl ] -4-(2-karbamoylbenzofuran-5-yl)-piperazin og dets fysiologisk akseptable salter
DK586589A (da)	1990-05-24	Fremgangsmaade til fremstilling af 2-(2-(4-((4-chlorphenyl)phenylmethyl)-1-piperazinyl)ethoxy)eddikesyre og dens dihydrochlorid
FI932173A0 (fi)	1993-05-13	4-(1,2-benzisoxazolyl)piperidinantipsykotiska medel
ES2054823T3 (es)	1994-08-16	Agentes ansioliticos.
MX9205186A (es)	1993-03-01	Derivados de 4-[4-[4-(4-hidroxifenil)-1-piperazinil]-fenil]-5-metil-3h-1,2,4-triazo l-3-ona
NO20005498L (no)	2000-11-01	Form av 1-(6-klornaft-2-ytsulfonyl)-4-[4-(4- pyridyl)benzoyl]piperazin med redusert partikkelstörrelse
FI870925L (fi)	1987-09-06	4-(2-pyrimidinyl)-1-piperazinyl -heterocykliska karbonylderivater.

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