NO2699580T3 - - Google Patents
Info
- Publication number
- NO2699580T3 NO2699580T3 NO12774761A NO12774761A NO2699580T3 NO 2699580 T3 NO2699580 T3 NO 2699580T3 NO 12774761 A NO12774761 A NO 12774761A NO 12774761 A NO12774761 A NO 12774761A NO 2699580 T3 NO2699580 T3 NO 2699580T3
- Authority
- NO
- Norway
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Epoxy Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461931090P | 2014-01-24 | 2014-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO2699580T3 true NO2699580T3 (fr) | 2018-02-24 |
Family
ID=52432834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO12774761A NO2699580T3 (fr) | 2014-01-24 | 2012-04-15 |
Country Status (39)
| Country | Link |
|---|---|
| US (18) | US9522894B2 (fr) |
| EP (4) | EP4548972A3 (fr) |
| JP (7) | JP6469711B2 (fr) |
| KR (1) | KR102417684B1 (fr) |
| CN (2) | CN110483492B (fr) |
| AP (1) | AP2016009322A0 (fr) |
| AR (1) | AR099177A1 (fr) |
| AU (4) | AU2015208932C1 (fr) |
| BR (1) | BR112016016224B1 (fr) |
| CA (1) | CA2935625C (fr) |
| CL (1) | CL2016001889A1 (fr) |
| CR (1) | CR20160327A (fr) |
| CY (2) | CY1120049T1 (fr) |
| DK (3) | DK3744714T3 (fr) |
| DO (1) | DOP2016000175A (fr) |
| EA (1) | EA032794B1 (fr) |
| ES (3) | ES2808060T3 (fr) |
| FI (1) | FI3744714T3 (fr) |
| HK (1) | HK1225730B (fr) |
| HR (3) | HRP20180116T1 (fr) |
| HU (3) | HUE070606T2 (fr) |
| IL (3) | IL246614B (fr) |
| LT (3) | LT3744714T (fr) |
| MX (1) | MX368840B (fr) |
| MY (1) | MY194850A (fr) |
| NO (1) | NO2699580T3 (fr) |
| NZ (2) | NZ734768A (fr) |
| PE (1) | PE20161218A1 (fr) |
| PH (1) | PH12016501439B1 (fr) |
| PL (3) | PL3323814T3 (fr) |
| PT (3) | PT3744714T (fr) |
| RS (3) | RS56919B1 (fr) |
| SG (2) | SG10201701056QA (fr) |
| SI (3) | SI3323814T1 (fr) |
| SM (3) | SMT201800058T1 (fr) |
| TW (1) | TWI690517B (fr) |
| UY (1) | UY35963A (fr) |
| WO (1) | WO2015110826A1 (fr) |
| ZA (2) | ZA201605856B (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2699580T3 (fr) | 2014-01-24 | 2018-02-24 | ||
| JP2019522039A (ja) * | 2016-07-29 | 2019-08-08 | インスメッド インコーポレイテッド | 気管支拡張症の処置のための特定の(2s)−n−[(1s)−1−シアノ−2−フェニルエチル]−1,4−オキサゼパン−2−カルボキサミド |
| AU2019217870A1 (en) * | 2018-02-07 | 2020-08-27 | Insmed Incorporated | Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating ANCA associated vasculitides |
| CN112055593B (zh) * | 2018-03-01 | 2024-04-09 | 阿斯利康(瑞典)有限公司 | 药物组合物 |
| KR20210032439A (ko) * | 2018-07-17 | 2021-03-24 | 인스메드 인코포레이티드 | 염증성 장 질환을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드 |
| EP3823627A4 (fr) * | 2018-07-17 | 2022-04-20 | Insmed Incorporated | Certains (2s)-n-[(1s)-1-cyano-2-phényléthyl]-1,4-oxazépane-2-carboxamides pour le traitement d'une néphropathie lupique |
| CN111689923B (zh) * | 2019-03-12 | 2022-11-08 | 中国科学院上海药物研究所 | 一个具有逆转肿瘤多药耐药活性的环脂肽化合物、其制备方法及用途 |
| MX2022004809A (es) * | 2019-10-23 | 2022-05-16 | Chong Kun Dang Pharmaceutical Corp | Composiciones para prevenir o tratar enfermedad pulmonar obstructiva cronica (epoc). |
| AU2021314104A1 (en) * | 2020-07-20 | 2023-01-19 | Insmed, Inc. | Methods for extracting neutrophil serine proteases and treating dipeptidyl peptidase 1-mediated conditions |
| EP4497473A3 (fr) * | 2020-08-26 | 2025-04-23 | Haisco Pharmaceuticals Pte. Ltd. | Dérivé de nitrile qui agit en tant qu'inhibiteur de la dipeptidyl peptidase 1 et son utilisation |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| CN114159446A (zh) * | 2020-09-11 | 2022-03-11 | 中国科学院上海营养与健康研究所 | 组织蛋白酶c抑制剂在治疗肿瘤转移中的应用 |
| CN114591315A (zh) * | 2020-12-04 | 2022-06-07 | 瑞石生物医药有限公司 | 一种组织蛋白酶c小分子抑制剂 |
| EP4257588A4 (fr) * | 2020-12-04 | 2024-10-16 | Reistone Biopharma Company Limited | Inhibiteur à petites molécules de la cathepsine c et son utilisation médicinale |
| WO2022140516A1 (fr) * | 2020-12-22 | 2022-06-30 | Insmed Incorporated | Certains ((25)-iv-[(ls')~ i-c yan0-2-phényléthyl·]-1,4-oxazépane-2-carboxamides pour le traitement de la maladie de behçet |
| JP7693817B2 (ja) * | 2021-02-05 | 2025-06-17 | エス-インフィニティ ファーマシューティカルズ カンパニー リミテッド | 1,4-オキサゼパンを含む縮合環誘導体 |
| EP4329767A4 (fr) * | 2021-04-29 | 2025-03-12 | Insmed Incorporated | <smallcaps/>? ? ?n? ? ? ? ?certains-(1-cyano-2-phényléthyl)-1,4-oxazépane-2-carboxamides pour le traitement de la fibrose kystique |
| CN115925696A (zh) * | 2021-10-29 | 2023-04-07 | 瑞石生物医药有限公司 | 一种1-氰基-2-苯基乙基甲酰胺衍生物及其用途 |
| US20250049813A1 (en) * | 2021-10-29 | 2025-02-13 | Insmed Incorporated | Certain n-(1-cyan0-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating chronic rhinosinusitis |
| CN116332937A (zh) * | 2021-12-23 | 2023-06-27 | 杭州邦顺制药有限公司 | 二肽基肽酶ⅰ抑制剂及其用途 |
| US20250101011A1 (en) * | 2022-01-11 | 2025-03-27 | Shanghai Yidian Pharmaceutical Technology Development Co., Ltd | Peptidyl nitrile compound and use thereof |
| IL314769A (en) * | 2022-02-16 | 2024-10-01 | Insmed Inc | Certain n-(1-cyano-2-phenylethyl)-1,4-oxazepane-2-carboxamides for treating hidradenitis suppurativa |
| JP2025505824A (ja) | 2022-02-22 | 2025-02-28 | ハイスコ ファーマスーティカル プライベート リミテッド | ジペプチジルペプチダーゼ1阻害剤結晶多形体及びその製造方法と用途 |
| CN118742547A (zh) | 2022-02-22 | 2024-10-01 | 西藏海思科制药有限公司 | 一种含氮杂环化合物的制备方法 |
| CN118660873A (zh) * | 2022-02-22 | 2024-09-17 | 西藏海思科制药有限公司 | 二肽基肽酶抑制剂化合物的盐及晶型 |
| CN114644562B (zh) * | 2022-04-29 | 2023-08-22 | 常州大学 | 具有红移荧光发射的有机小分子荧光化合物、制备方法及应用 |
| EP4538271A4 (fr) | 2022-06-07 | 2025-10-08 | Reistone Biopharma Company Ltd | Polymorphe de composé benzo[c]chromane, son procédé de préparation et son utilisation |
| AU2023285191A1 (en) | 2022-06-07 | 2024-12-12 | Reistone Biopharma Company Limited | Pharmaceutically acceptable salt of benzo[c]chroman compound and polymorphic form and use of pharmaceutically acceptable salt |
| KR20250022023A (ko) | 2022-06-13 | 2025-02-14 | 알리벡시스 가부시키가이샤 | 아자사이클로알킬카보닐 환상 아민 화합물 |
| EP4551554A1 (fr) | 2022-07-06 | 2025-05-14 | Chiesi Farmaceutici S.p.A. | Dérivés d'azétidine et leur utilisation comme inhibiteurs de la dipeptidyl peptidase 1 |
| WO2024081889A1 (fr) | 2022-10-14 | 2024-04-18 | Genesis Therapeutics, Inc. | Dérivés de 4h-pyrido[1,2-a]pyrimidin-4-one pour le traitement du cancer |
| WO2024088307A1 (fr) * | 2022-10-26 | 2024-05-02 | 上海壹迪生物技术有限公司 | Nouveau composé peptidylnitrile et son utilisation |
| CN115785083A (zh) * | 2022-12-27 | 2023-03-14 | 瑞石生物医药有限公司 | 一种组织蛋白酶c小分子抑制剂及其制备方法 |
| AU2024206233A1 (en) | 2023-01-06 | 2025-08-21 | Insmed Incorporated | Novel, reversible dpp1 inhibitors and uses thereof |
| WO2024173556A2 (fr) * | 2023-02-15 | 2024-08-22 | Insmed Incorporated | Utilisations de certains 1,4-oxazépane-2-carboxamides en tant qu'inhibiteurs de dpp1 |
| AU2024241242A1 (en) | 2023-03-23 | 2025-11-06 | Haisco Pharmaceuticals Pte. Ltd. | Pharmaceutical composition containing dipeptidyl peptidase small molecule inhibitor |
| WO2025059526A1 (fr) * | 2023-09-15 | 2025-03-20 | Insmed Incorporated | Inhibiteurs de la dipeptidyl peptidase 1 et leurs utilisations |
| USD1099133S1 (en) * | 2024-02-01 | 2025-10-21 | Apple Inc. | Display screen or portion thereof showing a graphical user interface |
| WO2025214073A1 (fr) * | 2024-04-12 | 2025-10-16 | Insmed Incorporated | Inhibiteurs de la dipeptidyl peptidase 1 et leurs utilisations |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2782151B2 (ja) | 1993-07-16 | 1998-07-30 | 博 吉田 | 衝撃吸収柵用の端ストッパ |
| US6297239B1 (en) | 1997-10-08 | 2001-10-02 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| US6462076B2 (en) | 2000-06-14 | 2002-10-08 | Hoffmann-La Roche Inc. | Beta-amino acid nitrile derivatives as cathepsin K inhibitors |
| WO2002020804A1 (fr) | 2000-09-08 | 2002-03-14 | Prozymex A/S | Structure de cristal peptidase dipeptidyl i et son utilisation |
| AU9419701A (en) * | 2000-10-06 | 2002-04-22 | Tanabe Seiyaku Co | Aliphatic nitrogenous five-membered ring compounds |
| EP1217000A1 (fr) | 2000-12-23 | 2002-06-26 | Aventis Pharma Deutschland GmbH | Inhibiteurs du factor Xa et factor VIIa |
| EP1453801B1 (fr) | 2001-12-04 | 2007-03-21 | F. Hoffmann-La Roche Ag | 2-amino-cycloalkanecarboxamides substitues et leur utilisation en tant qu'inhibiteurs de la cysteine protease |
| US20040253311A1 (en) | 2002-12-18 | 2004-12-16 | Roger Berlin | Multi-layer tablet comprising non-steroidal anti-inflammatory drugs, decongestants and non-sedating antihist amines |
| WO2004076434A1 (fr) | 2003-02-28 | 2004-09-10 | Aic | Inhibiteurs de dipeptidyl peptidases |
| EP1608369B1 (fr) | 2003-03-28 | 2013-06-26 | Novartis Vaccines and Diagnostics, Inc. | Utilisation de composés organiques pour l'immunopotentialisation |
| ES2308181T3 (es) | 2003-05-30 | 2008-12-01 | Prozymex A/S | Inhibidores de proteasa. |
| WO2004110988A1 (fr) | 2003-06-18 | 2004-12-23 | Prozymex A/S | Inhibiteurs de la protease |
| NZ549990A (en) | 2004-04-07 | 2009-08-28 | Rinat Neuroscience Copr | Methods for treating bone cancer pain by administering a nerve growth factor antagonist |
| WO2005106012A2 (fr) | 2004-04-28 | 2005-11-10 | Bayer Healthcare Ag | Diagnostics et therapeutiques de maladies associees a la dipeptidyl-peptidase 1 (dpp1) |
| US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| SE0401657D0 (sv) | 2004-06-24 | 2004-06-24 | Astrazeneca Ab | Chemical compounds |
| CN101513391B (zh) | 2004-06-29 | 2013-03-13 | 奈科明丹麦股份有限公司 | 水不溶性药快速释放药物组合物的制造方法及通过本方法得到的药物组合物 |
| AU2005274852B2 (en) | 2004-07-19 | 2011-12-08 | The Johns Hopkins University | FLT3 inhibitors for immune suppression |
| BRPI0607809A2 (pt) | 2005-02-18 | 2009-06-13 | Abraxis Bioscience Inc | uso de uma composição compreendendo nanopartìculas, composição e kit |
| WO2007005668A2 (fr) | 2005-06-30 | 2007-01-11 | Amgen Inc. | Inhibiteurs de bis-aryl kinase et methode associee |
| US20080221094A1 (en) | 2007-03-07 | 2008-09-11 | Harald Bluhm | Metalloprotease inhibitors containing a squaramide moiety |
| TW200916447A (en) | 2007-08-29 | 2009-04-16 | Methylgene Inc | Sirtuin inhibitors |
| MX2010003263A (es) | 2007-09-25 | 2010-06-02 | Novartis Ag | Tratamiento de trastornos pulmonares con medicamentos aerosolizados tales como vancomicina. |
| KR20100098683A (ko) * | 2007-12-12 | 2010-09-08 | 아스트라제네카 아베 | 펩티딜 니트릴, 및 디펩티딜 펩티다제 i 억제제로서의 그의 용도 |
| US9315449B2 (en) | 2008-05-15 | 2016-04-19 | Duke University | Substituted pyrazoles as heat shock transcription factor activators |
| UY31867A (es) | 2008-06-06 | 2010-01-29 | Boehringer Ingelheim Int | Nuevas formulaciones farmacéuticas sólidas que comprenden bibw 2992 |
| RU2586212C2 (ru) | 2008-12-08 | 2016-06-10 | Мандифарма Интернэшнл Корпорейшн Лимитед | Композиции ингибиторов тирозинкиназных рецепторов белков |
| CN102438595B (zh) | 2009-04-01 | 2016-04-27 | 巴尔-波特拉及康邦亚股份有限公司 | 包括硝基儿茶酚衍生物的药物制剂及其制备方法 |
| EP2427445A1 (fr) * | 2009-05-07 | 2012-03-14 | AstraZeneca AB | Composés 1-cyanoéthylhétérocyclylcarboxamide substitués 750 |
| WO2010142985A1 (fr) * | 2009-06-10 | 2010-12-16 | Astrazeneca Ab | Composés 761 n-[1-cyano-2-(phényle)éthyle]pipéridine-2-ylcarboxamide substitués |
| CN106943403A (zh) | 2010-04-07 | 2017-07-14 | 弗特克斯药品有限公司 | 药物组合物和其给药方法 |
| WO2011154677A1 (fr) * | 2010-06-09 | 2011-12-15 | Astrazeneca Ab | Composés n-[1-cyano-2-(phényl)éthyl] 1-aminocycloalk-1-ylcarboxamide substitués - 760 |
| IT1404036B1 (it) | 2010-12-17 | 2013-11-08 | Oto Melara Spa | Veicolo armato con struttura migliorata. |
| EP2672821B9 (fr) | 2011-02-11 | 2016-11-23 | GlaxoSmithKline Intellectual Property Development Limited | Inhibiteurs de la cathepsine c |
| WO2012119941A1 (fr) | 2011-03-04 | 2012-09-13 | Prozymex A/S | Composés de peptidylnitrile à titre d'inhibiteurs de peptidases |
| US8999975B2 (en) | 2011-09-19 | 2015-04-07 | Boehringer Ingelheim International Gmbh | Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C |
| EP2817310B1 (fr) | 2012-02-21 | 2018-03-21 | Merck Patent GmbH | 2-amino-[1,2,4]triazolo[1,5-a]pyrazines substituées en 8ème position en tant qu'inhibiteurs de la tyrosine kinase syk et en tant qu'inhibiteurs de la sérine kinase gcn2 |
| MX355055B (es) | 2012-04-17 | 2018-04-03 | Astellas Pharma Inc | Compuesto heterociclico aromatico biciclico nitrogenado. |
| WO2014091443A1 (fr) | 2012-12-13 | 2014-06-19 | Glaxo Group Limited | Inhibiteurs de la cathepsine c pour traiter la mucoviscidose, la bronchectasie sans fibrose kystique, et la vascularite associée aux anca |
| EP2775304A1 (fr) | 2013-03-07 | 2014-09-10 | Universitätsspital Basel | Procédés de détection de troubles inflammatoires |
| US8877775B2 (en) | 2013-03-14 | 2014-11-04 | Boehringer Ingelheim International Gmbh | Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C |
| AU2014230814B2 (en) | 2013-03-14 | 2017-12-21 | Boehringer Ingelheim International Gmbh | Substituted 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of Cathepsin C |
| WO2014140078A1 (fr) | 2013-03-14 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Inhibiteurs de cathepsine c de type (cyano-méthyl)-amides d'acide 2-aza-bicyclo[2.2.1]heptane-3-carboxylique substitué |
| WO2014140081A1 (fr) | 2013-03-14 | 2014-09-18 | Boehringer Ingelheim International Gmbh | Inhibiteurs 1-acide carboxylique (benzyl-cyano-methyl)-amides bicycliques substitués de la cathépsine c |
| UY35400A (es) | 2013-03-15 | 2014-10-31 | Novartis Ag | Compuestos y composiciones para el tratamiento de enfermedades parasitarias |
| AU2014248455B2 (en) | 2013-04-01 | 2018-12-06 | Pulmatrix Operating Company, Inc. | Tiotropium dry powders |
| WO2015027039A1 (fr) | 2013-08-22 | 2015-02-26 | Emory University | Dispositifs et procédés relatifs à une inflammation des voies aériennes |
| CA2923484C (fr) | 2013-09-09 | 2022-09-06 | Prozymex A/S | Composes de peptidyl-nitrile en tant qu'inhibiteurs de dipeptidyl-peptidase i |
| WO2015032942A1 (fr) | 2013-09-09 | 2015-03-12 | Prozymex A/S | 3,3'-(biphényl-4,4'-diyl)bis-2-aminopropanenitriles substitués en n en tant qu'inhibiteurs dppi |
| GB201400034D0 (en) | 2014-01-02 | 2014-02-19 | Astrazeneca Ab | Pharmaceutical Compositions comprising AZD9291 |
| NO2699580T3 (fr) | 2014-01-24 | 2018-02-24 | ||
| GB201402070D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
| RU2020107732A (ru) | 2014-04-10 | 2020-03-30 | Новартис Аг | Схема дозирования модулятора s1p с немедленным высвобождением |
| AU2015258947B2 (en) | 2014-05-15 | 2020-04-09 | Insmed Incorporated | Methods for treating pulmonary non-tuberculous mycobacterial infections |
| WO2015180687A1 (fr) | 2014-05-30 | 2015-12-03 | The University Of Hong Kong | Procédés et compositions permettant d'utiliser l'élastase neutrophile et la protéinase 3 en tant que biomarqueurs de diagnostic |
| EP3174879B1 (fr) | 2014-08-01 | 2018-07-18 | Boehringer Ingelheim International GmbH | Oxétanes substitués et leur utilisation en tant qu'inhibiteurs de la cathépsine c |
| AP2017009733A0 (en) | 2014-09-12 | 2017-02-28 | Boehringer Ingelheim Int | Spirocyclic inhibitors of cathepsin c |
| CA2965566A1 (fr) | 2014-11-14 | 2016-05-19 | Boehringer Ingelheim International Gmbh | Amides de morpholine et de 1,4-oxazepane utilises en tant qu'agonistes du sous-type 4 du recepteur de la somatostatine (sstr4) |
| JP6783426B2 (ja) | 2015-03-05 | 2020-11-11 | ニュープロザイム・セラピューティクス・アンパルトセルスカブNeuprozyme Therapeutics ApS | ジペプチジルペプチダーゼi阻害剤としてのペプチジルニトリル化合物 |
| JP2019522039A (ja) | 2016-07-29 | 2019-08-08 | インスメッド インコーポレイテッド | 気管支拡張症の処置のための特定の(2s)−n−[(1s)−1−シアノ−2−フェニルエチル]−1,4−オキサゼパン−2−カルボキサミド |
| AU2019217870A1 (en) | 2018-02-07 | 2020-08-27 | Insmed Incorporated | Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating ANCA associated vasculitides |
| CN112055593B (zh) | 2018-03-01 | 2024-04-09 | 阿斯利康(瑞典)有限公司 | 药物组合物 |
| EP3823627A4 (fr) | 2018-07-17 | 2022-04-20 | Insmed Incorporated | Certains (2s)-n-[(1s)-1-cyano-2-phényléthyl]-1,4-oxazépane-2-carboxamides pour le traitement d'une néphropathie lupique |
| KR20210032439A (ko) | 2018-07-17 | 2021-03-24 | 인스메드 인코포레이티드 | 염증성 장 질환을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카복스아미드 |
| CN114206312A (zh) | 2019-04-17 | 2022-03-18 | 阿佐拉治疗股份有限公司 | 用于治疗炎性皮肤病的局部组合物和方法 |
| BR112021024310A2 (pt) | 2019-06-05 | 2022-02-15 | Univ Emory | Peptidomiméticos para o tratamento de infecções por coronavírus e picornavírus |
| WO2022140516A1 (fr) | 2020-12-22 | 2022-06-30 | Insmed Incorporated | Certains ((25)-iv-[(ls')~ i-c yan0-2-phényléthyl·]-1,4-oxazépane-2-carboxamides pour le traitement de la maladie de behçet |
| CN112920124B (zh) | 2021-01-29 | 2024-03-01 | 安徽医科大学 | 一种嘧啶-2,4-二胺类化合物及其制备方法与应用 |
| WO2022232420A1 (fr) | 2021-04-29 | 2022-11-03 | Insmed Incorporated | Certains n-(1-cyano-2-phényléthyl)-1,4-oxazépane-2-carboxamides pour le traitement du cancer |
| EP4329767A4 (fr) | 2021-04-29 | 2025-03-12 | Insmed Incorporated | <smallcaps/>? ? ?n? ? ? ? ?certains-(1-cyano-2-phényléthyl)-1,4-oxazépane-2-carboxamides pour le traitement de la fibrose kystique |
| US20250049813A1 (en) | 2021-10-29 | 2025-02-13 | Insmed Incorporated | Certain n-(1-cyan0-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating chronic rhinosinusitis |
| IL314769A (en) | 2022-02-16 | 2024-10-01 | Insmed Inc | Certain n-(1-cyano-2-phenylethyl)-1,4-oxazepane-2-carboxamides for treating hidradenitis suppurativa |
-
2012
- 2012-04-15 NO NO12774761A patent/NO2699580T3/no unknown
-
2015
- 2015-01-21 US US14/601,371 patent/US9522894B2/en active Active
- 2015-01-23 SI SI201531287T patent/SI3323814T1/sl unknown
- 2015-01-23 SI SI201530170T patent/SI3097086T1/en unknown
- 2015-01-23 NZ NZ734768A patent/NZ734768A/en unknown
- 2015-01-23 SM SM20180058T patent/SMT201800058T1/it unknown
- 2015-01-23 SG SG10201701056QA patent/SG10201701056QA/en unknown
- 2015-01-23 MY MYPI2016702657A patent/MY194850A/en unknown
- 2015-01-23 ES ES17195612T patent/ES2808060T3/es active Active
- 2015-01-23 HU HUE20173862A patent/HUE070606T2/hu unknown
- 2015-01-23 LT LTEP20173862.2T patent/LT3744714T/lt unknown
- 2015-01-23 PL PL17195612T patent/PL3323814T3/pl unknown
- 2015-01-23 HK HK16114117.1A patent/HK1225730B/en unknown
- 2015-01-23 PT PT201738622T patent/PT3744714T/pt unknown
- 2015-01-23 CN CN201910716882.4A patent/CN110483492B/zh active Active
- 2015-01-23 SI SI201532060T patent/SI3744714T1/sl unknown
- 2015-01-23 AR ARP150100202A patent/AR099177A1/es active IP Right Grant
- 2015-01-23 HR HRP20180116TT patent/HRP20180116T1/hr unknown
- 2015-01-23 DK DK20173862.2T patent/DK3744714T3/da active
- 2015-01-23 RS RS20180069A patent/RS56919B1/sr unknown
- 2015-01-23 EP EP25150988.1A patent/EP4548972A3/fr active Pending
- 2015-01-23 FI FIEP20173862.2T patent/FI3744714T3/fi active
- 2015-01-23 HR HRP20250302TT patent/HRP20250302T1/hr unknown
- 2015-01-23 PT PT157015777T patent/PT3097086T/pt unknown
- 2015-01-23 AP AP2016009322A patent/AP2016009322A0/en unknown
- 2015-01-23 PL PL20173862.2T patent/PL3744714T3/pl unknown
- 2015-01-23 CN CN201580005484.1A patent/CN105980367B/zh active Active
- 2015-01-23 DK DK15701577.7T patent/DK3097086T3/en active
- 2015-01-23 SG SG11201606052TA patent/SG11201606052TA/en unknown
- 2015-01-23 ES ES15701577.7T patent/ES2658516T3/es active Active
- 2015-01-23 CA CA2935625A patent/CA2935625C/fr active Active
- 2015-01-23 JP JP2016548068A patent/JP6469711B2/ja active Active
- 2015-01-23 PT PT171956121T patent/PT3323814T/pt unknown
- 2015-01-23 MX MX2016009349A patent/MX368840B/es active IP Right Grant
- 2015-01-23 RS RS20250323A patent/RS66709B1/sr unknown
- 2015-01-23 AU AU2015208932A patent/AU2015208932C1/en active Active
- 2015-01-23 LT LTEP17195612.1T patent/LT3323814T/lt unknown
- 2015-01-23 PE PE2016001236A patent/PE20161218A1/es unknown
- 2015-01-23 SM SM20250137T patent/SMT202500137T1/it unknown
- 2015-01-23 RS RS20200858A patent/RS60639B1/sr unknown
- 2015-01-23 EP EP17195612.1A patent/EP3323814B1/fr active Active
- 2015-01-23 EP EP20173862.2A patent/EP3744714B1/fr active Active
- 2015-01-23 WO PCT/GB2015/050155 patent/WO2015110826A1/fr not_active Ceased
- 2015-01-23 UY UY0001035963A patent/UY35963A/es not_active Application Discontinuation
- 2015-01-23 BR BR112016016224-2A patent/BR112016016224B1/pt active IP Right Grant
- 2015-01-23 NZ NZ722063A patent/NZ722063A/en unknown
- 2015-01-23 EA EA201691375A patent/EA032794B1/ru unknown
- 2015-01-23 TW TW104102345A patent/TWI690517B/zh active
- 2015-01-23 EP EP15701577.7A patent/EP3097086B1/fr active Active
- 2015-01-23 CR CR20160327A patent/CR20160327A/es unknown
- 2015-01-23 PL PL15701577T patent/PL3097086T3/pl unknown
- 2015-01-23 SM SM20200433T patent/SMT202000433T1/it unknown
- 2015-01-23 ES ES20173862T patent/ES3018635T3/es active Active
- 2015-01-23 DK DK17195612.1T patent/DK3323814T3/da active
- 2015-01-23 HU HUE17195612A patent/HUE052421T2/hu unknown
- 2015-01-23 KR KR1020167022665A patent/KR102417684B1/ko active Active
- 2015-01-23 HU HUE15701577A patent/HUE038274T2/hu unknown
- 2015-01-23 LT LTEP15701577.7T patent/LT3097086T/lt unknown
-
2016
- 2016-07-05 IL IL246614A patent/IL246614B/en active IP Right Grant
- 2016-07-13 DO DO2016000175A patent/DOP2016000175A/es unknown
- 2016-07-20 PH PH12016501439A patent/PH12016501439B1/en unknown
- 2016-07-25 CL CL2016001889A patent/CL2016001889A1/es unknown
- 2016-08-23 ZA ZA2016/05856A patent/ZA201605856B/en unknown
- 2016-11-08 US US15/346,411 patent/US9815805B2/en active Active
-
2017
- 2017-01-18 AU AU2017200338A patent/AU2017200338B2/en active Active
- 2017-06-11 IL IL252836A patent/IL252836A0/en active IP Right Grant
- 2017-09-19 US US15/708,634 patent/US10287258B2/en active Active
-
2018
- 2018-01-22 ZA ZA2018/00431A patent/ZA201800431B/en unknown
- 2018-02-05 CY CY20181100132T patent/CY1120049T1/el unknown
- 2018-04-30 AU AU2018202956A patent/AU2018202956B2/en active Active
-
2019
- 2019-01-16 JP JP2019005300A patent/JP6804570B2/ja active Active
- 2019-03-19 US US16/358,091 patent/US10669245B2/en active Active
- 2019-03-25 IL IL265611A patent/IL265611A/en unknown
- 2019-04-17 AU AU2019202675A patent/AU2019202675B2/en active Active
-
2020
- 2020-04-22 US US16/855,522 patent/US11117874B2/en active Active
- 2020-07-23 CY CY20201100674T patent/CY1123391T1/el unknown
- 2020-07-23 HR HRP20201147TT patent/HRP20201147T1/hr unknown
- 2020-12-02 JP JP2020200413A patent/JP7157791B2/ja active Active
-
2021
- 2021-02-08 US US17/170,641 patent/US11667615B2/en active Active
-
2022
- 2022-04-04 JP JP2022062548A patent/JP7336563B2/ja active Active
- 2022-09-09 US US17/942,111 patent/US11773069B2/en active Active
- 2022-09-09 US US17/942,106 patent/US11655221B2/en active Active
- 2022-09-10 US US17/942,120 patent/US11655222B2/en active Active
- 2022-09-10 US US17/942,112 patent/US11673871B2/en active Active
- 2022-09-10 US US17/942,121 patent/US11655223B2/en active Active
- 2022-09-10 US US17/942,123 patent/US11814359B2/en active Active
- 2022-09-10 US US17/942,122 patent/US11655224B2/en active Active
- 2022-09-15 US US17/946,024 patent/US11680049B2/en active Active
- 2022-09-16 US US17/946,112 patent/US11673872B2/en active Active
-
2023
- 2023-04-13 US US18/300,350 patent/US20230250071A1/en not_active Abandoned
- 2023-08-21 JP JP2023133935A patent/JP7628587B2/ja active Active
- 2023-12-08 US US18/533,894 patent/US12054465B2/en active Active
-
2024
- 2024-06-17 US US18/745,710 patent/US20240336582A1/en not_active Abandoned
-
2025
- 2025-01-29 JP JP2025012602A patent/JP7714823B2/ja active Active
- 2025-07-16 JP JP2025119347A patent/JP2025157389A/ja active Pending