NO2014013I1 - Linaclotide - Google Patents

Linaclotide

Info

Publication number: NO2014013I1
Authority: NO; Norway
Prior art keywords: linaclotide
Prior art date: 2003-01-28

Application number

NO2014013C

Other languages

English (en)

Other versions

NO2014013I2 (no

Original Assignee

Ironwood Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-01-28

Filing date

2014-05-21

Publication date

2014-06-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32854294&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2014013(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-05-21 Application filed by Ironwood Pharmaceuticals Inc filed Critical Ironwood Pharmaceuticals Inc

2014-05-21 Publication of NO2014013I2 publication Critical patent/NO2014013I2/no

2014-06-02 Publication of NO2014013I1 publication Critical patent/NO2014013I1/no

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Cardiology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Immunology (AREA)
Oncology (AREA)
Vascular Medicine (AREA)
Otolaryngology (AREA)

NO2014013C 2003-01-28 2014-05-21 Linaclotide NO2014013I1 (no)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US44309803P	2003-01-28	2003-01-28
US47128803P	2003-05-15	2003-05-15
US51946003P	2003-11-12	2003-11-12
PCT/US2004/002390 WO2004069165A2 (en)	2003-01-28	2004-01-28	Methods and compositions for the treatment of gastrointestinal disorders

Publications (2)

Publication Number	Publication Date
NO2014013I2 NO2014013I2 (no)	2014-05-21
NO2014013I1 true NO2014013I1 (no)	2014-06-02

Family

ID=32854294

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
NO20053864A NO334112B1 (no)	2003-01-28	2005-08-18	Renset polypeptid og farmasøytisk blanding anvendelig for behandling av gastrointestinale forstyrrelser.
NO20130460A NO336768B1 (no)	2003-01-28	2013-04-05	Farmasøytisk preparat, fremgangsmåte for fremstilling og produsering av et polypeptid, samt polypeptidet.
NO2014013C NO2014013I1 (no)	2003-01-28	2014-05-21	Linaclotide

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
NO20053864A NO334112B1 (no)	2003-01-28	2005-08-18	Renset polypeptid og farmasøytisk blanding anvendelig for behandling av gastrointestinale forstyrrelser.
NO20130460A NO336768B1 (no)	2003-01-28	2013-04-05	Farmasøytisk preparat, fremgangsmåte for fremstilling og produsering av et polypeptid, samt polypeptidet.

Country Status (28)

Country	Link
US (3)	US20040266989A1 (no)
EP (3)	EP1911763B1 (no)
JP (3)	JP4584911B2 (no)
KR (2)	KR101227626B1 (no)
CN (2)	CN101787073B (no)
AT (2)	ATE477268T1 (no)
AU (2)	AU2004210161B2 (no)
BE (1)	BE2013C032I2 (no)
BR (2)	BRPI0407071B8 (no)
CA (1)	CA2514507C (no)
CY (5)	CY1110905T1 (no)
DE (2)	DE602004028678D1 (no)
DK (3)	DK1911763T3 (no)
ES (3)	ES2350123T3 (no)
FR (2)	FR13C0030I1 (no)
HU (1)	HUS1300022I1 (no)
IL (2)	IL169863A (no)
LT (1)	LTC1594517I2 (no)
LU (2)	LU92200I2 (no)
MX (1)	MXPA05008097A (no)
NL (1)	NL300593I2 (no)
NO (3)	NO334112B1 (no)
NZ (2)	NZ541595A (no)
PT (3)	PT1911763E (no)
RU (2)	RU2543350C2 (no)
SG (2)	SG168407A1 (no)
SI (3)	SI1911763T1 (no)
WO (1)	WO2004069165A2 (no)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1551760A (zh)	2001-03-29	2004-12-01	ҩ��Э�͹�˾	用于治疗组织炎症和癌变的鸟苷酸环化酶受体拮抗剂
US7772188B2 (en) *	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
US7304036B2 (en)	2003-01-28	2007-12-04	Microbia, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
US7371727B2 (en)	2003-01-28	2008-05-13	Microbia, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
US20060281682A1 (en) *	2003-01-28	2006-12-14	Currie Mark G	Methods and compositions for the treatment of gastrointestinal disorders
ES2350123T3 (es) *	2003-01-28	2011-01-18	Ironwood Pharmaceuticals, Inc.	Composiciones para el tratamiento de trastornos gastrointestinales.
US7494979B2 (en) *	2003-06-13	2009-02-24	Ironwood Pharmaceuticals, Inc.	Method for treating congestive heart failure and other disorders
PT1644021E (pt) *	2003-06-13	2013-01-30	Ironwood Pharmaceuticals Inc	Métodos e composições para o tratamento de distúrbios gastrointestinais
US20050266028A1 (en) *	2004-05-25	2005-12-01	University Of Georgia Research Foundation, Inc.	Compositions and methods for modulating an immune response
WO2006046746A1 (ja) *	2004-10-26	2006-05-04	Ajinomoto Co., Inc.	内臓痛予防・治療剤
CA2619650A1 (en) *	2005-08-19	2007-02-22	Microbia, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
RU2566708C2 (ru)	2005-09-29	2015-10-27	Ипсен Фарма С.А.С.	Композиции и способы стимуляции двигательной функции желудочно-кишечного тракта
US20090305993A1 (en) *	2006-02-24	2009-12-10	Ironwood Pharmaceuticals, Inc.	Methods and composition for the treatment of gastrointestinal disorders
WO2008106429A2 (en) *	2007-02-26	2008-09-04	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of heart failure and other disorders
CA2686414A1 (en) *	2007-05-04	2008-11-13	Ironwood Pharmaceuticals, Inc.	Compositions and methods for treating disorders associated with salt or fluid retention
CA2688161C (en)	2007-06-04	2020-10-20	Kunwar Shailubhai	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) *	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2009256156B2 (en)	2008-06-04	2014-09-18	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2328910B1 (en)	2008-06-04	2014-08-06	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2010005515A2 (en) *	2008-06-30	2010-01-14	Ironwood Pharmaceuticals Incorporated	Protein expression methods
EP3241839B1 (en)	2008-07-16	2019-09-04	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
SMT202000179T1 (it) *	2008-08-15	2020-05-08	Ironwood Pharmaceuticals Inc	Formulazioni contenenti linaclotide per la somministrazione orale
MX2011005245A (es)	2008-11-19	2011-06-17	Forest Lab Holdings Ltd	Forma cristalina de linaclotida.
ES2608050T3 (es) *	2008-12-03	2017-04-05	Synergy Pharmaceuticals Inc.	Formulaciones de agonistas de guanilato ciclasa C y métodos de uso
WO2010115916A1 (en)	2009-04-10	2010-10-14	F. Hoffmann-La Roche Ag	Process for isolating therapeutic peptide
MX2012001660A (es) *	2009-08-06	2012-03-26	Ironwood Pharmaceuticals Inc	Formulaciones que contienen linaclotida para adminstracion oral.
US20130045239A1 (en) *	2009-08-13	2013-02-21	Ironwood Pharmaceuticals, Inc.	Method for Modulating the Pharmacodynamic Effect of Orally Administered Guanylate Cyclase Receptor Agonists
KR20120115495A (ko)	2009-11-09	2012-10-18	아이언우드 파마슈티컬스, 인코포레이티드	위장 장애의 치료
JP5984675B2 (ja) *	2009-12-07	2016-09-06	アイアンウッドファーマシューティカルズインコーポレイテッド	胃腸障害の療法
WO2011103311A2 (en)	2010-02-17	2011-08-25	Ironwood Pharmaceuticals, Inc	Treatments for gastrointestinal disorders
WO2011145062A1 (en)	2010-05-21	2011-11-24	Link Research & Grants Corporation	Treatment of tinnitus and related auditory dysfunctions
US8748575B2 (en) *	2010-06-09	2014-06-10	Combimab, Inc.	Therapeutic peptides
JP5921545B2 (ja)	2010-08-11	2016-05-24	アイアンウッドファーマシューティカルズインコーポレイテッド	リナクロチドの安定な製剤
AU2011302006A1 (en)	2010-09-15	2013-03-07	Synergy Pharmaceuticals Inc.	Formulations of guanylate cyclase C agonists and methods of use
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
CA2835624A1 (en)	2011-05-11	2012-11-15	Ironwood Pharmaceuticals, Inc.	Treatments for gastrointestinal disorders
WO2012155114A1 (en)	2011-05-11	2012-11-15	Ironwood Pharmaceuticals, Inc.	Peptides derived from uroguanylin and their use in gastrointestinal disorders
US9527887B2 (en)	2011-06-08	2016-12-27	Ironwood Pharmaceutical, Inc.	Treatments for gastrointestinal disorders
US9617305B2 (en)	2011-06-08	2017-04-11	Ironwood Pharmaceuticals, Inc.	Treatments for gastrointestinal disorders
MD480Z (ro) *	2011-07-07	2012-09-30	Elvira Andon	Metoda de tratament al colitei ulceroase nespecifice acute
PL2776055T3 (pl)	2011-08-17	2017-06-30	Ironwood Pharmaceuticals, Inc.	Sposoby leczenia zaburzeń żołądkowo-jelitowych
EA022546B1 (ru) *	2011-09-28	2016-01-29	Федеральное Государственное Бюджетное Учреждение Науки Институт Биоорганической Химии Им. Академиков М.М. Шемякина И Ю.А. Овчинникова Российской Академии Наук	Способ торможения роста карциномы эрлиха у лабораторного животного
WO2014088623A1 (en) *	2012-07-12	2014-06-12	Forest Laboratories Holdings Limited	Linaclotide compositions
RU2528641C2 (ru) *	2012-08-22	2014-09-20	Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежская государственная медицинская академия им. Н.Н. Бурденко" Министерства здравоохранения и социального развития Российской Федерации	Способ лечения больных с синдромом диспепсии в сочетании с избыточной массой тела
CN102875655B (zh) *	2012-09-29	2014-12-17	深圳翰宇药业股份有限公司	一种合成利那洛肽的方法
US20150361139A1 (en)	2013-01-30	2015-12-17	Sandoz Ag	Crystalline form of linaclotide
WO2014151206A1 (en)	2013-03-15	2014-09-25	Synergy Pharmaceuticals Inc.	Agonists of guanylate cyclase and their uses
BR112016002789A2 (pt)	2013-08-09	2017-11-21	Ardelyx Inc	compostos e métodos para inibir transporte de fosfato
MD3288578T2 (ro) *	2015-05-01	2023-08-31	Ironwood Pharmaceuticals Inc	Compoziții pentru curățarea colonului și tratamentul tulburărilor gastrointestinale
EP3430056A4 (en) *	2016-03-15	2019-11-20	The Regents of the University of California	METHOD AND COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF ALPHA-8-BETA-1-INTEGRIN ASSOCIATED DISEASES
CN107929718A (zh) *	2017-10-19	2018-04-20	南京星银药业集团有限公司	Glp‑1类似物及gc‑c受体激动剂组合物缓释制剂及其制备方法
CN117599320A (zh) *	2018-10-23	2024-02-27	艾比科生物医学公司	输送装置
CN109467606A (zh) *	2018-11-15	2019-03-15	大连理工大学	一种大肠杆菌肠毒素STa-LTB-STb融合蛋白及其编码基因和应用
WO2020237096A1 (en)	2019-05-21	2020-11-26	Ardelyx, Inc.	Combination for lowering serum phosphate in a patient
RU2712761C1 (ru) *	2019-07-02	2020-01-31	Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр Российской академии наук" (Томский НИМЦ)	Средство для стимуляции регенерации эндотелия легких при сочетании метаболического синдрома и хронической обструктивной болезни легких
CN111265653B (zh) *	2020-02-09	2023-05-09	华中科技大学同济医学院附属协和医院	心房利钠肽在制备炎症性肠病治疗药物中的应用
US20230035733A1 (en) *	2020-03-26	2023-02-02	Dusa Pharmaceuticals, Inc.	Management of dermal neurofibromatosis lesions
EP4469468A1 (en)	2022-01-28	2024-12-04	Fresenius Kabi iPSUM S.r.l.	Process for the preparation of linaclotide
WO2025207484A1 (en) *	2024-03-25	2025-10-02	Merveille.Ai	Use of aprepitant and cyclic dipeptide for weight control

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US258687A (en) *		1882-05-30		Grain-binder
US232013A (en) *		1880-09-07		Henry h
US152868A (en) *		1874-07-07		Improvement in type-setting machines
US266989A (en) *		1882-11-07		Automatic fire
US32684A (en) *		1861-07-02		Stump-extkactob
US121961A (en) *		1871-12-19		Improvement in devices for supporting pipe-cores
US73628A (en) *		1868-01-21		mitchell
US3773919A (en)	1969-10-23	1973-11-20	Du Pont	Polylactide-drug mixtures
IE52535B1 (en)	1981-02-16	1987-12-09	Ici Plc	Continuous release pharmaceutical compositions
US6342373B1 (en) *	1983-11-21	2002-01-29	Ucp Gen-Pharma Ag	Process for preparing recombinant eglin, protease inhibitor
IT1217123B (it)	1987-02-05	1990-03-14	Rotta Research Lab	Derivati otticamente attivi dell acido 5 pentilammino 5 oxo pentanoico r ad attivita antagonista della colecistochinina e procedimento per la loro preparazione
GB2209937B (en)	1987-09-21	1991-07-03	Depiopharm S A	Water insoluble polypeptides
CH679207A5 (no)	1989-07-28	1992-01-15	Debiopharm Sa
CA2046830C (en)	1990-07-19	1999-12-14	Patrick P. Deluca	Drug delivery system involving inter-action between protein or polypeptide and hydrophobic biodegradable polymer
HUT64023A (en)	1991-03-22	1993-11-29	Sandoz Ag	Process for producing aminoguanidine derivatives and pharmaceutical compositions comprising such compounds
FR2674849B1 (fr)	1991-04-02	1994-12-23	Logeais Labor Jacques	Nouveaux derives de n-cyclohexyl benzamides ou thiobenzamides, leurs preparations et leurs applications en therapeutique.
CH683149A5 (fr)	1991-07-22	1994-01-31	Debio Rech Pharma Sa	Procédé pour la préparation de microsphères en matériau polymère biodégradable.
US5140102A (en)	1991-09-23	1992-08-18	Monsanto Company	Pentadecapeptide, guanylin, which stimulates intestinal guanylate cyclase
US5824645A (en)	1991-12-30	1998-10-20	Neurex Corporation	Method of treating inflammation
SG50624A1 (en)	1991-12-30	1998-07-20	Neurex Corp	Methods of producing analgesia and enhancing opiate analgesia
GB9211268D0 (en)	1992-05-28	1992-07-15	Ici Plc	Salts of basic peptides with carboxyterminated polyesters
US5969097A (en)	1992-06-23	1999-10-19	G. D. Searle & Co.	Human guanylin
RU2185393C2 (ru)	1993-01-06	2002-07-20	Кинертон Лимитед	Сложный полиэфир и конъюгат на его основе
US5672659A (en)	1993-01-06	1997-09-30	Kinerton Limited	Ionic molecular conjugates of biodegradable polyesters and bioactive polypeptides
US5395490A (en) *	1993-05-14	1995-03-07	Intertec, Ltd.	Method for treating materials by the application of electromagnetic energy at resonant absorption frequencies
DE69433564T2 (de) *	1993-10-26	2004-12-23	Thomas Jefferson University	Verbindungen, die kolorektale Krebszellen spezifisch binden, und Verfahren zu ihrer Verwendung
US5489670A (en) *	1993-10-29	1996-02-06	G. D. Searle & Co.	Human uroguanylin
US5610145A (en)	1994-04-15	1997-03-11	Warner-Lambert Company	Tachykinin antagonists
US5612052A (en)	1995-04-13	1997-03-18	Poly-Med, Inc.	Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US5795864A (en)	1995-06-27	1998-08-18	Neurex Corporation	Stable omega conopetide formulations
US6054429A (en)	1996-03-08	2000-04-25	Elan Pharmaceuticals, Inc.	Epidural method of producing analgesia
EP1336409B1 (en)	1995-06-27	2007-04-11	Eisai R&D Management Co., Ltd.	Compositions and formulations for producing analgesia and for inhibiting progression of neuropathic pain disorders
NZ323387A (en)	1995-11-24	2000-02-28	Smithkline Beecham Spa	Quinoline derivatives having neurokinin antagonist activity, preparation and use thereof
GB9524104D0 (en)	1995-11-24	1996-01-24	Smithkline Beecham Spa	Novel compounds
EP1479708A3 (en)	1996-04-23	2005-05-25	Ipsen Manufacturing Ireland Limited	Biodegradable polyesters and method for their preparation
US6589750B2 (en)	1997-02-20	2003-07-08	Institut Pasteur	Therapeutic use of the SMR1 protein, the SMR1 maturation products, specifically the QHNPR pentapeptide as well as its biologically active derivatives
DE59814173D1 (de)	1997-02-28	2008-04-03	Nycomed Gmbh	Synergistische kombination von pde-hemmern und adenylatcyclase-agonisten bzw. guanylcyclyse-agonisten
US5893985A (en)	1997-03-14	1999-04-13	The Lincoln Electric Company	Plasma arc torch
NZ329807A (en)	1997-04-23	2000-07-28	Pfizer	NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome
WO1999014239A1 (de)	1997-09-12	1999-03-25	Wolf Georg Forssmann	Zusammensetzung zur therapie von diabetes mellitus und fettsucht
US20010006972A1 (en)	1998-04-21	2001-07-05	Stephen A. Williams	Nk-1 receptor antagonists for the treatment of symptoms of irritable bowel syndrome
IT1304152B1 (it)	1998-12-10	2001-03-08	Mediolanum Farmaceutici Srl	Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato
ES2315753T3 (es)	1999-06-23	2009-04-01	Institut Pasteur	Composiciones para el tratamiento de problemas de relaciones interpersonales y trastornos del comportamiento.
HK1043308B (en)	1999-08-18	2004-03-05	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S	Sustained release formulation of a peptide
SE9903291D0 (sv)	1999-09-15	1999-09-15	Astra Ab	New process
AU7700400A (en)	1999-10-06	2001-05-10	Pharmacia Corporation	Uroguanylin as an intestinal cancer inhibiting agent
PT1225897E (pt)	1999-11-01	2005-01-31	John Rhodes	Composicao para o tratamento da obstipacao e do sindroma do intestino irritavel
AUPQ514600A0 (en)	2000-01-18	2000-02-10	James Cook University	Brain injury treatment
WO2001064212A1 (en)	2000-03-01	2001-09-07	University College London	Modulators of the endocannabinoid uptake and of the vallinoid receptors
ES2235806T3 (es)	2000-12-22	2005-07-16	Institut Pasteur	Procedimiento de seleccion de moleculas ligando que se unen especificamente al sitio de union nep para el prentapeptido qhnpr.
EP1365753A2 (en)	2001-02-02	2003-12-03	Pharmacia Corporation	Uroguanylin and cyclooxygenase-2 inhibitor combinations for inhibition of intestinal cancer
CN1551760A (zh)	2001-03-29	2004-12-01	ҩ��Э�͹�˾	用于治疗组织炎症和癌变的鸟苷酸环化酶受体拮抗剂
EP1451211A2 (en)	2001-03-30	2004-09-01	University of Copenhagen	Compositions and methods for modulating guanylyl cyclase signaling receptor (gc-c) activity and for treating meniere's disease
MY134211A (en)	2001-05-18	2007-11-30	Smithkline Beecham Corp	Novel use
WO2002098912A2 (de) *	2001-06-05	2002-12-12	Yalcin Cetin	Luftseitig verabreichte guanylat cyclase c liganden für atemwegserkrankungen
FR2830451B1 (fr)	2001-10-09	2004-04-30	Inst Nat Sante Rech Med	Utilisation de peptides analogues de la thymuline(pat)pour la fabrication de medicaments contre la douleur
EP1321142A1 (en)	2001-12-21	2003-06-25	Novartis AG	Solid pharmaceutical composition for oral administration of Tegaserod
US20040121961A1 (en)	2002-02-04	2004-06-24	Jaime Masferrer	Uroguanylin and cyclooxygenase-2 inhibitor combinations for inhibition of intestinal cancer
US20030232013A1 (en)	2002-02-22	2003-12-18	Gary Sieckman	Therapeutic and diagnostic targeting of cancers cells with tumor homing peptides
AU2003224644A1 (en)	2002-02-27	2003-09-09	The Government Of The United States Of America, Represented By The Secretary, Department Of Healtan	Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
US20030203055A1 (en)	2002-03-15	2003-10-30	Cypress Bioscience, Inc.	Methods of treating visceral pain syndromes
DK1505974T3 (da)	2002-05-17	2009-08-17	Tioga Pharmaceuticals Inc	Anvendelse af forbindelser, der er effektive som selektive opiatreceptormodulatorer
US7304036B2 (en)	2003-01-28	2007-12-04	Microbia, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
US7772188B2 (en)	2003-01-28	2010-08-10	Ironwood Pharmaceuticals, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
US20060281682A1 (en)	2003-01-28	2006-12-14	Currie Mark G	Methods and compositions for the treatment of gastrointestinal disorders
US7371727B2 (en)	2003-01-28	2008-05-13	Microbia, Inc.	Methods and compositions for the treatment of gastrointestinal disorders
ES2350123T3 (es)	2003-01-28	2011-01-18	Ironwood Pharmaceuticals, Inc.	Composiciones para el tratamiento de trastornos gastrointestinales.
US8206704B2 (en)	2003-02-10	2012-06-26	Thomas Jefferson University	Use of GCC ligands
CA2619650A1 (en)	2005-08-19	2007-02-22	Microbia, Inc.	Methods and compositions for the treatment of gastrointestinal disorders

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Also Published As

Publication number	Publication date
ATE477268T1 (de)	2010-08-15
CY2013021I1 (el)	2020-05-29
WO2004069165A3 (en)	2005-03-17
IL221380A0 (en)	2012-09-24
NL300593I2 (nl)	2020-04-15
CY1111058T1 (el)	2015-06-11
DK1911763T3 (da)	2010-11-15
DE602004007105D1 (de)	2007-08-02
IL169863A (en)	2012-10-31
BRPI0407071A (pt)	2006-01-24
ES2387848T3 (es)	2012-10-02
DK2246360T3 (da)	2012-08-13
RU2543350C2 (ru)	2015-02-27
DE602004028678D1 (de)	2010-09-23
AU2009235993A1 (en)	2009-11-26
NO20130460L (no)	2005-10-26
RU2014153593A3 (no)	2018-08-06
ES2285417T3 (es)	2007-11-16
BE2013C032I2 (no)	2023-08-22
BRPI0407071B8 (pt)	2021-05-25
US8080526B2 (en)	2011-12-20
US7704947B2 (en)	2010-04-27
CY2013022I1 (el)	2020-05-29
KR20110114682A (ko)	2011-10-19
CA2514507C (en)	2012-03-20
EP2246360A1 (en)	2010-11-03
RU2353383C2 (ru)	2009-04-27
BR122018074353B1 (pt)	2019-07-16
SG168407A1 (en)	2011-02-28
KR20050106404A (ko)	2005-11-09
PT1594517E (pt)	2007-07-20
CA2514507A1 (en)	2004-08-19
AU2004210161B2 (en)	2009-11-26
NO2014013I2 (no)	2014-05-21
CY1110905T1 (el)	2015-06-10
SI1911763T1 (sl)	2010-11-30
AU2004210161A1 (en)	2004-08-19
JP5563384B2 (ja)	2014-07-30
US20040266989A1 (en)	2004-12-30
CN100589839C (zh)	2010-02-17
CN101787073A (zh)	2010-07-28
RU2014153593A (ru)	2016-07-20
CN1795007A (zh)	2006-06-28
JP2010222377A (ja)	2010-10-07
CY2013021I2 (el)	2025-07-04
NO334112B1 (no)	2013-12-09
DE602004007105T2 (de)	2008-02-28
RU2005127058A (ru)	2006-03-10
EP2246360B1 (en)	2012-06-27
LU92201I2 (fr)	2013-11-22
JP4584911B2 (ja)	2010-11-24
EP1911763A2 (en)	2008-04-16
WO2004069165A2 (en)	2004-08-19
PT1911763E (pt)	2010-11-18
MXPA05008097A (es)	2006-02-08
EP1911763A3 (en)	2008-06-25
SG192300A1 (en)	2013-08-30
CY1113217T1 (el)	2016-04-13
DK1594517T3 (da)	2007-10-29
EP1594517B1 (en)	2007-06-20
EP1594517A2 (en)	2005-11-16
KR101227627B1 (ko)	2013-01-31
NO336768B1 (no)	2015-11-02
LU92200I1 (fr)	2020-06-02
ATE365174T1 (de)	2007-07-15
KR101227626B1 (ko)	2013-02-01
NZ570134A (en)	2010-02-26
AU2009235993B2 (en)	2013-07-04
HK1078768A1 (en)	2006-03-24
HUS1300022I1 (hu)	2019-11-28
JP2013116910A (ja)	2013-06-13
SI2246360T1 (sl)	2012-10-30
FR13C0029I2 (fr)	2024-04-19
SI1594517T1 (sl)	2007-10-31
ES2350123T3 (es)	2011-01-18
FR13C0029I1 (fr)	2013-07-05
EP1911763B1 (en)	2010-08-11
FR13C0030I1 (fr)	2013-07-05
JP2006516631A (ja)	2006-07-06
US20110124583A1 (en)	2011-05-26
PT2246360E (pt)	2012-08-31
NL300593I1 (nl)	2015-10-21
RU2763796C2 (ru)	2022-01-11
NO20053864L (no)	2005-10-26
US20090005534A1 (en)	2009-01-01
LTC1594517I2 (lt)	2020-03-10
CN101787073B (zh)	2013-12-25
BRPI0407071B1 (pt)	2019-02-12
BR122018074353B8 (pt)	2023-05-02
NO20053864D0 (no)	2005-08-18
EP1594517A4 (en)	2006-03-29
NZ541595A (en)	2008-08-29
LU92200I2 (fr)	2024-03-21
RU2008147983A (ru)	2010-06-10
JP5748791B2 (ja)	2015-07-15

Publication	Publication Date	Title
NO2014013I2 (no)	2014-05-21	Linaclotide
ATE363383T1 (de)	2007-06-15	Schlingenware
DE502004001683D1 (de)	2006-11-16	Kabelführung
AT502792A5 (de)	2007-05-15	Düsenanpressvorrichtung
DE502004007911D1 (de)	2008-10-02	Wischblatt
DE112004000620D2 (de)	2005-12-22	Struktoguss
DE502004008321D1 (de)	2008-12-04	Bandaufwickelverfahren
DE502004000672D1 (de)	2006-07-20	Pigmentpreparationen
DE10355350A8 (de)	2006-11-09	Elektromodul
DE502004001524D1 (de)	2006-11-02	Hydrolager
ATA662003A (de)	2005-11-15	Trink-mundstück
ATE446959T1 (de)	2009-11-15	Chromenonindole
DE502004001629D1 (de)	2006-11-16	Bremsenprüfstand
DE502004002978D1 (de)	2007-04-05	N-biarylamide
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DE502004006563D1 (de)	2008-04-30	Brieftaubenkonstatiersystem
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DE112004002227D2 (de)	2006-07-27	Nietverarbeitungsgerät
DE502004000518D1 (de)	2006-06-14	Mitgängergabelhubwagen
DE502004008889D1 (de)	2009-03-05	Schaltgabel
DE10394329D2 (de)	2006-10-05	Mäanderstent
ATE406350T1 (de)	2008-09-15	Prolinylarylacetamide
DE10329218B4 (de)	2007-05-16	Hotflue
DE502004007251D1 (de)	2008-07-03	En 2-arylpropenalen
DE502004002771D1 (de)	2007-03-15	Umlenkhebel