NO2013016I2 - Okriplasmin - Google Patents
OkriplasminInfo
- Publication number
- NO2013016I2 NO2013016I2 NO2013016C NO2013016C NO2013016I2 NO 2013016 I2 NO2013016 I2 NO 2013016I2 NO 2013016 C NO2013016 C NO 2013016C NO 2013016 C NO2013016 C NO 2013016C NO 2013016 I2 NO2013016 I2 NO 2013016I2
- Authority
- NO
- Norway
- Prior art keywords
- eye
- reduce
- vitreous
- plasmin
- disorder
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 3
- 108010088842 Fibrinolysin Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229940012957 plasmin Drugs 0.000 abstract 2
- 206010029113 Neovascularisation Diseases 0.000 abstract 1
- PLGPSDNOLCVGSS-UHFFFAOYSA-N Tetraphenylcyclopentadienone Chemical compound O=C1C(C=2C=CC=CC=2)=C(C=2C=CC=CC=2)C(C=2C=CC=CC=2)=C1C1=CC=CC=C1 PLGPSDNOLCVGSS-UHFFFAOYSA-N 0.000 abstract 1
- 210000001742 aqueous humor Anatomy 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 abstract 1
- 230000002008 hemorrhagic effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 108010068982 microplasmin Proteins 0.000 abstract 1
- 108010015052 miniplasmin Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 210000004127 vitreous body Anatomy 0.000 abstract 1
- 208000000318 vitreous detachment Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/484—Plasmin (3.4.21.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01023—Beta-galactosidase (3.2.1.23), i.e. exo-(1-->4)-beta-D-galactanase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01035—Hyaluronoglucosaminidase (3.2.1.35), i.e. hyaluronidase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24007—Interstitial collagenase (3.4.24.7), i.e. matrix metalloprotease 1 or MMP1
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02004—Chondroitin ABC lyase (4.2.2.4), i.e. chondroitinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02005—Chondroitin AC lyase (4.2.2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y402/00—Carbon-oxygen lyases (4.2)
- C12Y402/02—Carbon-oxygen lyases (4.2) acting on polysaccharides (4.2.2)
- C12Y402/02019—Chondroitin B lyase (4.2.2.19)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Inorganic Insulating Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0228409.9A GB0228409D0 (en) | 2002-12-06 | 2002-12-06 | Pharmacological vitreolysis |
| PCT/US2003/038714 WO2004052228A2 (en) | 2002-12-06 | 2003-12-05 | Pharmacological vitreolysis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO2013016I1 NO2013016I1 (no) | 2013-11-19 |
| NO2013016I2 true NO2013016I2 (no) | 2017-06-28 |
Family
ID=9949140
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20052988A NO333837B1 (no) | 2002-12-06 | 2005-06-17 | Anvendelse av en sammensetning som omfatter et trunkert plasminprotein for fremstilling av et medikament for behandling av en lidelse i et øye samt sammensetning og sett. |
| NO20121170A NO20121170A1 (no) | 2002-12-06 | 2012-10-12 | Farmakologisk vitreolyse |
| NO20121169A NO343759B1 (no) | 2002-12-06 | 2012-10-12 | Første preparat omfattende et trunkert plasminprotein (TPCD) omfattende en katalytisk domene av plasmin og et andre preparat omfattende et ytterligere middel for anvendelse, samt sett. |
| NO2013016C NO2013016I2 (no) | 2002-12-06 | 2013-11-19 | Okriplasmin |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20052988A NO333837B1 (no) | 2002-12-06 | 2005-06-17 | Anvendelse av en sammensetning som omfatter et trunkert plasminprotein for fremstilling av et medikament for behandling av en lidelse i et øye samt sammensetning og sett. |
| NO20121170A NO20121170A1 (no) | 2002-12-06 | 2012-10-12 | Farmakologisk vitreolyse |
| NO20121169A NO343759B1 (no) | 2002-12-06 | 2012-10-12 | Første preparat omfattende et trunkert plasminprotein (TPCD) omfattende en katalytisk domene av plasmin og et andre preparat omfattende et ytterligere middel for anvendelse, samt sett. |
Country Status (24)
| Country | Link |
|---|---|
| US (11) | US7547435B2 (no) |
| EP (3) | EP2327415B1 (no) |
| JP (4) | JP5426063B2 (no) |
| CN (1) | CN100577202C (no) |
| AT (1) | ATE534400T1 (no) |
| AU (1) | AU2003300821C1 (no) |
| BE (1) | BE2013C055I2 (no) |
| BR (2) | BRPI0310144A8 (no) |
| CA (1) | CA2508606C (no) |
| CY (2) | CY1112561T1 (no) |
| DK (1) | DK1581254T3 (no) |
| ES (2) | ES2731625T3 (no) |
| FR (1) | FR13C0052I2 (no) |
| GB (1) | GB0228409D0 (no) |
| HU (1) | HUS1300040I1 (no) |
| IL (3) | IL169008A (no) |
| LU (1) | LU92273I2 (no) |
| MX (1) | MXPA05006038A (no) |
| NO (4) | NO333837B1 (no) |
| NZ (1) | NZ541075A (no) |
| PT (2) | PT1581254E (no) |
| SI (1) | SI1581254T1 (no) |
| WO (1) | WO2004052228A2 (no) |
| ZA (1) | ZA200505193B (no) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7152975B2 (en) * | 2000-11-10 | 2006-12-26 | Cooper Vision, Inc. | Junctionless ophthalmic lenses and methods for making same |
| GB0228409D0 (en) | 2002-12-06 | 2003-01-08 | Thromb X Nv | Pharmacological vitreolysis |
| ES2349555T3 (es) | 2004-04-22 | 2011-01-05 | Talecris Biotherapeutics, Inc. | Plasmina modificada recombinántemente. |
| JP4796787B2 (ja) | 2005-04-28 | 2011-10-19 | 富士フイルム株式会社 | ラビリンチュラ類への遺伝子導入法 |
| US20060257391A1 (en) * | 2005-05-11 | 2006-11-16 | Bausch & Lomb Incorporated | Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions |
| US20080248021A1 (en) * | 2005-06-30 | 2008-10-09 | Ista Pharmaceuticals, Inc. | Use of Hyaluronidase in Combination with Plasmin for the Induction of Posterior Vitreous Detachment |
| WO2007047874A2 (en) * | 2005-10-20 | 2007-04-26 | Talecris Biotherapeutics, Inc. | Recombinantly modified plasmin |
| US20070134230A1 (en) * | 2005-12-13 | 2007-06-14 | Jani Dharmendra M | Method for prolonging activity of autodegradable enzymes |
| US20070134231A1 (en) * | 2005-12-13 | 2007-06-14 | Jani Dharmendra M | Method for prolonging activity of autodegradable enzymes and compositions thereof |
| US20070196350A1 (en) * | 2006-02-22 | 2007-08-23 | Bartels Stephen P | Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment |
| US20070212358A1 (en) * | 2006-03-10 | 2007-09-13 | Bartels Stephen P | Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment |
| CA2651194A1 (en) * | 2006-05-04 | 2007-11-15 | Fondation Ophthalmologique Aldolphe De Rothschild | Methods for treating neovascular diseases |
| CA2707266C (en) * | 2007-11-29 | 2013-12-31 | Talecris Biotherapeutics, Inc. | Recombinantly modified plasmin |
| US20110142819A1 (en) * | 2008-01-22 | 2011-06-16 | Omnio Healer Ab | Method of improving would healing |
| US20110097421A1 (en) * | 2008-03-31 | 2011-04-28 | Bruno Gogly | Method for the Cosmetic Treatment of Skin Ageing |
| NZ589557A (en) | 2008-06-04 | 2012-08-31 | Talecris Biotherapeutics Inc | Immobilised streptokinase, method and kit for preparing plasmin |
| HUE025670T2 (en) | 2009-03-03 | 2016-04-28 | Grifols Therapeutics Inc | A method for producing plasminogen |
| US8858924B2 (en) * | 2009-03-26 | 2014-10-14 | Warsaw Orthopedic, Inc. | Compositions and methods for treatment of hemorrhage |
| EP2451835A1 (en) | 2009-07-10 | 2012-05-16 | ThromboGenics N.V. | Variants of plasminogen and plasmin |
| EP2480249B1 (en) | 2009-08-28 | 2015-01-28 | ThromboGenics N.V. | Plasmin for the treatment of filtration failure after trabeculectomy |
| US20110135626A1 (en) * | 2009-12-08 | 2011-06-09 | Alcon Research, Ltd. | Localized Chemical Lysis of Ocular Tissue |
| RU2435553C1 (ru) * | 2010-03-10 | 2011-12-10 | Арсений Александрович Кожухов | Способ лечения центральных субретинальных кровоизлияний |
| BR112013017172A2 (pt) | 2011-01-05 | 2016-10-11 | Thrombogenics Nv | variantes de plasminogênio e plasmina |
| EP2720691A1 (en) * | 2011-06-17 | 2014-04-23 | Allergan, Inc. | D -serine for the treatment of visual system disorders |
| JP6000353B2 (ja) | 2011-08-12 | 2016-09-28 | スロンボジェニックス・ナムローゼ・フェンノートシャップThromboGenics NV | プラスミノーゲンおよびプラスミンの変異体 |
| RU2484795C2 (ru) * | 2011-08-18 | 2013-06-20 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" | Способ индукции задней отслойки стекловидного тела с помощью миниплазмина |
| PL2785739T3 (pl) | 2011-12-01 | 2017-10-31 | Thrombogenics Nv | Poprawa wyniku trabekulektomii |
| CN103205410B (zh) * | 2012-01-13 | 2018-03-06 | 蔺莹莹 | 重组微纤维蛋白溶酶及其制备方法和应用 |
| KR20150005631A (ko) | 2012-04-24 | 2015-01-14 | 쓰롬보제닉스 엔.브이. | 항-pdgf-c 항체 |
| WO2014160281A2 (en) * | 2013-03-14 | 2014-10-02 | Wayne State University | Method of enhancing delivery of therapeutic compounds to the eye |
| US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
| US9459201B2 (en) | 2014-09-29 | 2016-10-04 | Zyomed Corp. | Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing |
| FR3034992A1 (fr) | 2015-04-15 | 2016-10-21 | Arcadophta | Milieu plasmatique ex vivo autologue riche en plasmine et procede d'obtention |
| TWI653981B (zh) | 2015-12-18 | 2019-03-21 | 深圳瑞健生命科學硏究院有限公司 | Use of plasminogen for the preparation of a medicament for preventing or treating a condition associated with diabetic nerve injury |
| JP6682008B2 (ja) | 2015-12-18 | 2020-04-15 | タレンゲン インターナショナル リミテッドTalengen International Limited | 糖尿病性腎症を予防及び治療するための方法 |
| CA3008691A1 (en) * | 2015-12-18 | 2017-06-22 | Talengen International Limited | Method for preventing or treating diabetic retinopathy |
| JP7088454B2 (ja) | 2015-12-30 | 2022-06-21 | コディアック サイエンシーズ インコーポレイテッド | 抗体および抗体複合体 |
| RU2619991C1 (ru) * | 2016-02-18 | 2017-05-22 | Павел Владимирович Лыскин | Способ лечения витреомакулярного тракционного синдрома |
| CN108779173A (zh) | 2016-03-10 | 2018-11-09 | 思罗姆博基因股份有限公司 | 通过拮抗胎盘生长因子抑制眼后部纤维化 |
| US9554738B1 (en) | 2016-03-30 | 2017-01-31 | Zyomed Corp. | Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing |
| US11129880B2 (en) | 2016-12-15 | 2021-09-28 | Talengen International Limited | Method for promoting insulin secretion |
| CN110506105B (zh) | 2017-03-28 | 2023-03-24 | 森永乳业株式会社 | 新型双歧杆菌属细菌 |
| RU2674926C1 (ru) * | 2018-02-01 | 2018-12-13 | Федеральное государственное автономное учреждение "Национальный медицинский исследовательский центр "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации (ФГАУ "НМИЦ "МНТК "Микрохирургия глаза" им. акад. С.Н. | Способ оценки эффективности витреолизиса помутнений стекловидного тела |
| JP2021514656A (ja) | 2018-03-02 | 2021-06-17 | コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. | Il−6抗体ならびにその融合構築物およびコンジュゲート |
| CN110361242B (zh) * | 2019-08-14 | 2022-01-18 | 武汉赛维尔生物科技有限公司 | 一种用于眼球组织的固定液以及眼球组织制片的预处理方法 |
| EP4041312A4 (en) | 2019-10-10 | 2023-12-20 | Kodiak Sciences Inc. | METHOD FOR TREATING AN EYE DISORDER |
| CN116716251A (zh) * | 2023-06-20 | 2023-09-08 | 中国医学科学院北京协和医院 | 一种玻璃体样本的单细胞处理方法及其应用 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US658972A (en) * | 1900-04-09 | 1900-10-02 | Interchangeable Brake Beam Company | Brake-beam. |
| US2624691A (en) * | 1946-04-22 | 1953-01-06 | Parke Davis & Co | Fibrinolysin derived from blood and methods of obtaining the same |
| DK98833C (da) | 1961-04-25 | 1964-05-25 | Novo Terapeutisk Labor As | Fremgangsmåde til stabilisering af terapeutisk anvendelige plasminopløsninger. |
| US3234106A (en) * | 1962-12-03 | 1966-02-08 | Cutter Lab | Soluble, purified profibrinolysin and fibrinolysin and method of producing same |
| US3950513A (en) * | 1965-12-03 | 1976-04-13 | Novo Terapeutisk Laboratorium A/S | Process of stabilizing therapeutically useful plasmin solutions |
| IT1194135B (it) * | 1981-01-05 | 1988-09-14 | Novo Industri As | Composizioni di plasmina stabilizzata e metodo per la loro preparazione |
| GB8504025D0 (en) | 1985-02-16 | 1985-03-20 | Biopharm Ltd | Hyaluronidase |
| US4774087A (en) | 1987-08-14 | 1988-09-27 | Northwestern University | Micro-size fibrinolytic plasmin |
| US5288485A (en) * | 1989-08-31 | 1994-02-22 | Kao Corporation | Vasodilating agent |
| ZA912770B (en) | 1990-04-16 | 1992-01-29 | Bethesda Eye Inst | Enzymatic disinsertion of vitreous body |
| US5288489A (en) * | 1991-08-28 | 1994-02-22 | Orion Therapeutic Systems, Inc. | Fibrinolysis and fibrinogenolysis treatment |
| AU4661493A (en) * | 1992-07-01 | 1994-01-31 | Beth Israel Hospital Boston | Enhancement of thrombolytic therapy with deglycosylated plasminogen |
| US5304118A (en) * | 1992-12-16 | 1994-04-19 | Trese Michael T | Method for performing a vitrectomy on an eye |
| US5866120A (en) | 1995-11-22 | 1999-02-02 | Advanced Corneal Systems, Inc. | Method for accelerating clearance of hemorrhagic blood from the vitreous humor with hyaluronidase |
| US6610292B2 (en) | 1995-11-22 | 2003-08-26 | Ista Pharmaceuticals, Inc. | Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders |
| US5973779A (en) | 1996-03-29 | 1999-10-26 | Ansari; Rafat R. | Fiber-optic imaging probe |
| US6207066B1 (en) * | 1996-07-23 | 2001-03-27 | Nuvue Technologies, L.L.C. | Method for purification of a blood component |
| US6051698A (en) * | 1997-06-06 | 2000-04-18 | Janjic; Nebojsa | Vascular endothelial growth factor (VEGF) nucleic acid ligand complexes |
| US5722428A (en) * | 1996-10-29 | 1998-03-03 | Washington University | Method for producing a posterior vitreous detachment |
| US6596725B2 (en) * | 1997-02-10 | 2003-07-22 | Inspire Pharmaceuticals, Inc. | Use of certain dinucleotides to stimulate removal of fluid in retinal detachment and retinal edema |
| CN1257430A (zh) | 1997-05-22 | 2000-06-21 | 先进角膜系统公司 | 透明质酸酶在制备用于治疗眼科疾病中液化玻璃体液的眼用制剂中的应用 |
| ATE294865T1 (de) | 1998-02-04 | 2005-05-15 | Thromb X N V | Identifizierung, produktion und verwendung von staphylokinase derivaten mit reduzierter immunogenizität und/oder reduzierter 'clearance' |
| US6378526B1 (en) | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
| US6462071B1 (en) | 2000-03-02 | 2002-10-08 | Vitreo-Retinal Technologies, Inc. | Agents for intravitreal administration to treat or prevent disorders of the eye |
| US6585972B2 (en) * | 1999-03-09 | 2003-07-01 | Gholam A. Peyman | Process for crosslinking of collagen in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina |
| US6899877B2 (en) * | 1999-03-09 | 2005-05-31 | Minu, L.L.C. | Process for generating plasmin in the vitreous of the eye and inducing separation of the posterior hyaloid from the retina |
| US6733750B1 (en) * | 1999-03-09 | 2004-05-11 | Minu, L.L.C. | Process and composition for inducing posterior vitreous detachment |
| US20040081643A1 (en) * | 1999-03-09 | 2004-04-29 | Peyman Gholam A. | Process for inhibiting vascular proliferation in the eye |
| EP1229116A4 (en) | 1999-11-10 | 2003-01-22 | Ct For Advanced Science & Tech | METHOD FOR PRODUCING A CELL FACTION CONTAINING HEMANGIOBLASTES |
| US6964764B2 (en) * | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
| US6355243B1 (en) * | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
| ES2260234T3 (es) * | 2000-05-12 | 2006-11-01 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Utilizacion de inhibidores del factor de crecimiento placentario para el tratamiento de la angiogenesis patologica, de la arteriogenesis patologica, de la inflamacion, de la formacion tumoral y/o de la perdida vascular. |
| US7122181B2 (en) | 2000-12-19 | 2006-10-17 | Research Development Foundation | Lentiviral vector-mediated gene transfer and uses thereof |
| ES2296705T3 (es) | 2000-12-21 | 2008-05-01 | Thrombogenics N.V. | Vector de expresion de levadura y metodo de produccion de una proteina recombinada por la expresion de una celula de levadura. |
| US20020139378A1 (en) * | 2001-03-28 | 2002-10-03 | Trese Michael T. | Method for creating a separation of posterior cortical vitreous from the retina of the eye |
| FI20011132A0 (fi) | 2001-05-30 | 2001-05-30 | Innovationsagentur | Markkeri hematopoieettisten kantasolujen tunnistamiseen |
| US7776026B2 (en) * | 2002-02-06 | 2010-08-17 | Nuvue Technologies, Inc. | Method for vitreous liquefaction |
| US6787135B2 (en) * | 2002-03-13 | 2004-09-07 | William Beaumont Hospital | Modification of vitreal matrix metalloproteinase activity |
| WO2004045558A2 (en) * | 2002-11-18 | 2004-06-03 | President And Fellows Of Harvard College | Compositions and methods for treating thrombotic disorders |
| GB0228409D0 (en) | 2002-12-06 | 2003-01-08 | Thromb X Nv | Pharmacological vitreolysis |
| US20060257391A1 (en) | 2005-05-11 | 2006-11-16 | Bausch & Lomb Incorporated | Non-surgical method for preventing or reducing the rate of the progression of non-proliferative diabetic retinopathy and the treatment of other ocular conditions |
| US20070212358A1 (en) * | 2006-03-10 | 2007-09-13 | Bartels Stephen P | Compositions and Methods for Effecting Controlled Posterior Vitreous Detachment |
-
2002
- 2002-12-06 GB GBGB0228409.9A patent/GB0228409D0/en not_active Ceased
-
2003
- 2003-12-05 EP EP11152403.9A patent/EP2327415B1/en not_active Expired - Lifetime
- 2003-12-05 WO PCT/US2003/038714 patent/WO2004052228A2/en not_active Ceased
- 2003-12-05 EP EP03812818A patent/EP1581254B1/en not_active Expired - Lifetime
- 2003-12-05 DK DK03812818.7T patent/DK1581254T3/da active
- 2003-12-05 ES ES11152414T patent/ES2731625T3/es not_active Expired - Lifetime
- 2003-12-05 AT AT03812818T patent/ATE534400T1/de active
- 2003-12-05 EP EP11152414.6A patent/EP2327416B1/en not_active Expired - Lifetime
- 2003-12-05 SI SI200332111T patent/SI1581254T1/sl unknown
- 2003-12-05 NZ NZ541075A patent/NZ541075A/en not_active IP Right Cessation
- 2003-12-05 MX MXPA05006038A patent/MXPA05006038A/es active IP Right Grant
- 2003-12-05 PT PT03812818T patent/PT1581254E/pt unknown
- 2003-12-05 ES ES03812818T patent/ES2377965T3/es not_active Expired - Lifetime
- 2003-12-05 BR BRPI0310144A patent/BRPI0310144A8/pt not_active Application Discontinuation
- 2003-12-05 CA CA2508606A patent/CA2508606C/en not_active Expired - Lifetime
- 2003-12-05 US US10/729,475 patent/US7547435B2/en not_active Expired - Lifetime
- 2003-12-05 JP JP2004559328A patent/JP5426063B2/ja not_active Expired - Fee Related
- 2003-12-05 AU AU2003300821A patent/AU2003300821C1/en not_active Expired
- 2003-12-05 CN CN200380108773A patent/CN100577202C/zh not_active Expired - Fee Related
- 2003-12-05 PT PT11152414T patent/PT2327416T/pt unknown
- 2003-12-05 BR BR0317033-0A patent/BR0317033A/pt unknown
-
2005
- 2005-06-05 IL IL169008A patent/IL169008A/en active Protection Beyond IP Right Term
- 2005-06-17 NO NO20052988A patent/NO333837B1/no not_active IP Right Cessation
- 2005-06-20 ZA ZA200505193A patent/ZA200505193B/xx unknown
-
2007
- 2007-04-11 US US11/786,250 patent/US7803368B2/en not_active Expired - Fee Related
- 2007-04-11 US US11/786,354 patent/US7914783B2/en not_active Expired - Fee Related
-
2008
- 2008-06-05 US US12/156,907 patent/US8460655B2/en not_active Expired - Fee Related
- 2008-06-05 US US12/156,911 patent/US7867489B2/en not_active Expired - Fee Related
-
2009
- 2009-12-20 IL IL202851A patent/IL202851A/en active Protection Beyond IP Right Term
-
2010
- 2010-06-04 JP JP2010128670A patent/JP5451533B2/ja not_active Expired - Fee Related
- 2010-11-22 US US12/951,787 patent/US8383105B2/en not_active Expired - Fee Related
-
2011
- 2011-04-29 US US13/097,985 patent/US8747842B2/en not_active Expired - Fee Related
- 2011-06-29 IL IL213838A patent/IL213838A0/en active IP Right Grant
-
2012
- 2012-02-21 CY CY20121100179T patent/CY1112561T1/el unknown
- 2012-10-12 NO NO20121170A patent/NO20121170A1/no not_active Application Discontinuation
- 2012-10-12 NO NO20121169A patent/NO343759B1/no not_active IP Right Cessation
- 2012-11-29 US US13/689,025 patent/US8834869B2/en not_active Expired - Fee Related
- 2012-11-30 US US13/690,427 patent/US20130202613A1/en not_active Abandoned
-
2013
- 2013-03-14 US US13/827,986 patent/US9186394B2/en not_active Expired - Fee Related
- 2013-08-01 JP JP2013160571A patent/JP5739487B2/ja not_active Expired - Fee Related
- 2013-08-15 HU HUS1300040C patent/HUS1300040I1/hu unknown
- 2013-08-23 CY CY2013033C patent/CY2013033I2/el unknown
- 2013-08-29 LU LU92273C patent/LU92273I2/fr unknown
- 2013-08-29 BE BE2013C055C patent/BE2013C055I2/fr unknown
- 2013-08-29 FR FR13C0052C patent/FR13C0052I2/fr active Active
- 2013-11-19 NO NO2013016C patent/NO2013016I2/no unknown
-
2014
- 2014-06-27 US US14/318,232 patent/US9770494B2/en not_active Expired - Fee Related
-
2015
- 2015-03-24 JP JP2015060570A patent/JP5996026B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NO2013016I1 (no) | Okriplasmin | |
| ATE426413T1 (de) | Verfahren und zusammensetzungen zur behandlung von okularer neovaskularisierung und nervenverletzungen | |
| ATE429914T1 (de) | Verwendung von makroliden zur wiederherstellung der kornealempfindungen | |
| BR0317774A (pt) | Uso de rimexolona no tratamento de olho seco | |
| DK1515741T3 (da) | Anvendelse af kollagen-hydrolysat til viskositetssænkning af en sammensætning omfattende guargummi | |
| CY1114048T1 (el) | Συνδυασμος βριμονιδινης και τιμολολης για τοπικη οφθαλμικη χρηση | |
| AR036199A1 (es) | Metodos y composiciones para el tratamiento de enfermedades oftalmicas | |
| ATE535257T1 (de) | Ophthalmologische formulierung mit methylsulfonylmethan und ciprofloxacin | |
| WO2004069181A3 (en) | Composition for the treatment of intraocular pressure | |
| DK1263363T3 (da) | Farvet viskoelastisk sammensætning | |
| CY1106409T1 (el) | Παραγωγα κινολινης | |
| ATE550015T1 (de) | Verfahren und zusammensetzung zur behandlung von rhinitis | |
| AR031288A1 (es) | Metodos y composiciones para el tratamiento de enfermedades oftalmicas | |
| DE60317098D1 (de) | Carbostyril-derivate mit selektiven serotonin-aufnahme inhibitoren, zur behandlung von gemütskrankheiten | |
| UY28202A1 (es) | Utilización de esteroides en el tratamiento de personas que sufren trastonos oculares. | |
| MX2007010295A (es) | Composiciones oftalmologicas novedosas y metodo para su uso. | |
| Yoon et al. | Recurrent herpes simplex keratitis after verteporfin photodynamic therapy for corneal neovascularization | |
| RU2005104096A (ru) | Способ лечения пролиферативной витреоретинопатии | |
| PL430675A1 (pl) | Bromokryptyna do zastosowania w leczeniu chorób oczu związanych z podwyższonym poziomem śródbłonkowego czynnika wzrostu naczyń (VEGF) oraz kompozycja farmaceutyczna zawierająca bromokryptynę | |
| UA39527A (uk) | Спосіб лікування опіку очей |