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NO20083750L - Fremgangsmate for opplosning av racemiske blandinger og et diastereomerkompleks av et opplosende middel og en enantiomer av interesse - Google Patents

Fremgangsmate for opplosning av racemiske blandinger og et diastereomerkompleks av et opplosende middel og en enantiomer av interesse

Info

Publication number
NO20083750L
NO20083750L NO20083750A NO20083750A NO20083750L NO 20083750 L NO20083750 L NO 20083750L NO 20083750 A NO20083750 A NO 20083750A NO 20083750 A NO20083750 A NO 20083750A NO 20083750 L NO20083750 L NO 20083750L
Authority
NO
Norway
Prior art keywords
enantiomer
interest
racemic mixtures
solvent
complex
Prior art date
Application number
NO20083750A
Other languages
English (en)
Inventor
Elio Napolitano
Rita Fiaschi
Chiara Bechini
Gabriella Brunetto
Original Assignee
Abiogen Pharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abiogen Pharma Spa filed Critical Abiogen Pharma Spa
Publication of NO20083750L publication Critical patent/NO20083750L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/53—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having the nitrogen atom of at least one of the amino groups further bound to a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En fremgangsmåte for oppløsing av en forbindelse i racemisk form som omfatter følgende trinn, blir beskrevet: a) omsette en forbindelse i racemisk form med et oppløsingsreagens, b) danne et diastereoisomert kompleks av oppløsingsreagenset og en enantiomer av interesse, c) separere enantiomeren av interesse fra det oppnådde, diastereoisomere komplekset, hvori en slik fremgangsmåte er karakterisert ved at oppløsingsreagenset er en forbindelse med formel I: Et diastereoisomert kompleks mellom oppløsingsreagenset med formel I og enantiomeren av interesse beskrives også. Fremgangsmåten ifølge oppfinnelsen gjør det mulig å separere sure og basiske racemiske blandinger.
NO20083750A 2006-02-02 2008-08-29 Fremgangsmate for opplosning av racemiske blandinger og et diastereomerkompleks av et opplosende middel og en enantiomer av interesse NO20083750L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000179A ITMI20060179A1 (it) 2006-02-02 2006-02-02 Procedimento per la risoluzione di miscele racemiche e complesso diastereoisomerico di un agente risolvente e di unantiomero di interesse
PCT/IT2007/000067 WO2007088571A2 (en) 2006-02-02 2007-02-01 A process for resolving racemic mixtures and a diastereoisomeric complex of a resolving agent and an enantiomer of interest

Publications (1)

Publication Number Publication Date
NO20083750L true NO20083750L (no) 2008-10-29

Family

ID=38066627

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20083750A NO20083750L (no) 2006-02-02 2008-08-29 Fremgangsmate for opplosning av racemiske blandinger og et diastereomerkompleks av et opplosende middel og en enantiomer av interesse

Country Status (12)

Country Link
US (1) US7968748B2 (no)
EP (1) EP1986996A2 (no)
JP (1) JP2009525320A (no)
CN (1) CN101379029A (no)
AU (1) AU2007210787A1 (no)
BR (1) BRPI0707260A2 (no)
CA (1) CA2638014A1 (no)
IT (1) ITMI20060179A1 (no)
MX (1) MX2008009194A (no)
NO (1) NO20083750L (no)
RU (1) RU2008135466A (no)
WO (1) WO2007088571A2 (no)

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WO2010050499A1 (ja) * 2008-10-29 2010-05-06 三菱瓦斯化学株式会社 光学活性有機カルボン酸の製造方法
EP2417134B1 (en) 2009-04-08 2017-05-17 Idenix Pharmaceuticals LLC. Macrocyclic serine protease inhibitors
CA2769652A1 (en) 2009-08-05 2011-02-10 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv
EP2537825B1 (en) 2010-02-16 2016-09-14 API Corporation Method for producing 1-amino-1-alkoxycarbonyl-2-vinylcyclopropane
AR085352A1 (es) 2011-02-10 2013-09-25 Idenix Pharmaceuticals Inc Inhibidores macrociclicos de serina proteasa, sus composiciones farmaceuticas y su uso para tratar infecciones por hcv
US20120329836A1 (en) 2011-06-06 2012-12-27 The Ohio State University Methods for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
NO2686520T3 (no) 2011-06-06 2018-03-17
WO2012176715A1 (ja) 2011-06-21 2012-12-27 三菱瓦斯化学株式会社 １－アミノ－２－ビニルシクロプロパンカルボン酸アミドおよびその塩、ならびにその製造方法
EP2753371B1 (en) 2011-09-09 2021-08-04 Abyrx, Inc. Absorbable multi-putty bone cements and hemostatic compositions and methods of use
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HRP20200437T1 (hr) 2013-02-20 2020-09-04 Reuter Chemische Apparatebau E.K. Proces za pripremu enantiomerom obogaćenog 3-aminopiperidina
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JP6771853B2 (ja) * 2014-03-31 2020-10-21 小林製薬株式会社 ビタミンｂ６含有組成物
JP2018502882A (ja) 2015-01-23 2018-02-01 アケビア セラピューティクス インコーポレイテッドＡｋｅｂｉａ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． ２−（５−（３−フルオロフェニル）−３−ヒドロキシピコリンアミド）酢酸の固体形態、その組成物及び使用
HRP20211862T1 (hr) 2015-04-01 2022-03-04 Akebia Therapeutics, Inc. Pripravci za i postupci liječenja anemije
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US20190211150A1 (en) * 2016-08-31 2019-07-11 Khashayar Karimian Pegylated resolving agents for improved resolution of racemic mixture
CN107129435B (zh) * 2017-04-24 2019-07-23 万华化学集团股份有限公司 一种制备2-氨基-2-甲基-1-丙醇的方法
CN109206617B (zh) * 2017-07-05 2020-04-24 北京大学 一种通过分级结晶拆分外消旋化合物的方法
TWI822776B (zh) 2018-05-09 2023-11-21 美商阿克比治療有限公司 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法
ES2984182T3 (es) 2019-06-25 2024-10-29 Amtixbio Co Ltd Compuesto derivado que introduce un grupo bifenilo en un nuevo ácido aminoalcanoico y composición farmacéutica antifúngica que comprende el mismo
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Also Published As

Publication number Publication date
CN101379029A (zh) 2009-03-04
MX2008009194A (es) 2008-10-09
WO2007088571A3 (en) 2008-01-10
RU2008135466A (ru) 2010-03-10
JP2009525320A (ja) 2009-07-09
AU2007210787A1 (en) 2007-08-09
WO2007088571A2 (en) 2007-08-09
EP1986996A2 (en) 2008-11-05
US7968748B2 (en) 2011-06-28
US20090292129A1 (en) 2009-11-26
ITMI20060179A1 (it) 2007-08-03
CA2638014A1 (en) 2007-08-09
BRPI0707260A2 (pt) 2011-04-26

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