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NO20081883L - Modulasjon av glukokortikoidreseptorekspresjon - Google Patents

Modulasjon av glukokortikoidreseptorekspresjon

Info

Publication number
NO20081883L
NO20081883L NO20081883A NO20081883A NO20081883L NO 20081883 L NO20081883 L NO 20081883L NO 20081883 A NO20081883 A NO 20081883A NO 20081883 A NO20081883 A NO 20081883A NO 20081883 L NO20081883 L NO 20081883L
Authority
NO
Norway
Prior art keywords
glucocorticoid receptor
modulation
receptor expression
compounds
expression
Prior art date
Application number
NO20081883A
Other languages
English (en)
Inventor
Susan M Freier
Brett P Monia
Robert Mckay
Sanjay Bhanot
Lynnetta Watts
Original Assignee
Johnson & Johnson Pharm Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson & Johnson Pharm Res filed Critical Johnson & Johnson Pharm Res
Publication of NO20081883L publication Critical patent/NO20081883L/no

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Sammendrag Forbindelser, sammensetninger og fremgangsmåter er tilveiebrakt for modulering av ekspresjonen av glukokortikoidreseptor. Sammensetningene omfatter antisensforbindelser, spesielt antisens oligonukleotider som har bestemte in vivo egenskaper, målrettet til nukleinsyrer kodende for glukokortikoidreseptor. Fremgangsmåter for å benytte disse forbindelsene for modulering av glukokortikoldreseptor ekspresjon og for behandling av sykdommer er tilveiebrakt.
NO20081883A 2005-09-19 2008-04-18 Modulasjon av glukokortikoidreseptorekspresjon NO20081883L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71868505P 2005-09-19 2005-09-19
PCT/US2006/036527 WO2007035759A1 (en) 2005-09-19 2006-09-19 Modulation of glucocorticoid receptor expression

Publications (1)

Publication Number Publication Date
NO20081883L true NO20081883L (no) 2008-06-11

Family

ID=37491694

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081883A NO20081883L (no) 2005-09-19 2008-04-18 Modulasjon av glukokortikoidreseptorekspresjon

Country Status (15)

Country Link
US (2) US20070066557A1 (no)
EP (2) EP1941040A1 (no)
JP (1) JP2009508527A (no)
KR (1) KR20080065617A (no)
CN (1) CN101313066A (no)
AU (1) AU2006292293B2 (no)
BR (1) BRPI0616370A2 (no)
CA (1) CA2623772A1 (no)
CR (1) CR9906A (no)
EA (1) EA200800868A1 (no)
EC (1) ECSP088298A (no)
IL (1) IL190281A0 (no)
NO (1) NO20081883L (no)
WO (1) WO2007035759A1 (no)
ZA (1) ZA200803452B (no)

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US20070066557A1 (en) 2007-03-22
AU2006292293A1 (en) 2007-03-29
EP1941040A1 (en) 2008-07-09
US20100222412A1 (en) 2010-09-02
BRPI0616370A2 (pt) 2011-06-14
CN101313066A (zh) 2008-11-26
EA200800868A1 (ru) 2008-10-30
KR20080065617A (ko) 2008-07-14
EP2368988A1 (en) 2011-09-28
IL190281A0 (en) 2011-08-01
ECSP088298A (es) 2008-05-30
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CR9906A (es) 2009-01-16
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