NO20081729L - Nye diazaspiroalkaner og deres anvendelse for behandling av CCR8-medierte sykdommer - Google Patents

Nye diazaspiroalkaner og deres anvendelse for behandling av CCR8-medierte sykdommer

Info

Publication number: NO20081729L
Authority: NO; Norway
Prior art keywords: treatment; diazaspiroalkanes; ccr8; new; mediated diseases
Prior art date: 2005-09-06

Application number

NO20081729A

Other languages

English (en)

Norwegian (no)

Inventor

Stephen Connolly

Henrik Johansson

Lena Borjesson

Anna Kristoffersson

Tero Linnanen

Igor Shamovsky

Marco Skrinjar

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-06

Filing date

2008-04-07

Publication date

2008-05-16

2008-04-07 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2008-05-16 Publication of NO20081729L publication Critical patent/NO20081729L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO20081729A 2005-09-06 2008-04-07 Nye diazaspiroalkaner og deres anvendelse for behandling av CCR8-medierte sykdommer NO20081729L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE0501967		2005-09-06
PCT/SE2006/001012 WO2007030061A1 (fr)	2005-09-06	2006-09-04	Nouveaux diazaspiroalcanes et leur utilisation pour le traitement de maladies mediees par ccr8

Publications (1)

Publication Number	Publication Date
NO20081729L true NO20081729L (no)	2008-05-16

Family

ID=37836107

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20081729A NO20081729L (no)	2005-09-06	2008-04-07	Nye diazaspiroalkaner og deres anvendelse for behandling av CCR8-medierte sykdommer

Country Status (17)

Country	Link
US (1)	US20090156575A1 (fr)
EP (1)	EP1926730A4 (fr)
JP (1)	JP2009507070A (fr)
KR (1)	KR20080043396A (fr)
CN (1)	CN101305005A (fr)
AR (1)	AR055630A1 (fr)
AU (1)	AU2006287976A1 (fr)
BR (1)	BRPI0615634A2 (fr)
CA (1)	CA2621187A1 (fr)
EC (1)	ECSP088329A (fr)
IL (1)	IL189528A0 (fr)
NO (1)	NO20081729L (fr)
RU (1)	RU2008110915A (fr)
TW (1)	TW200800999A (fr)
UY (1)	UY29781A1 (fr)
WO (1)	WO2007030061A1 (fr)
ZA (1)	ZA200801511B (fr)

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CN102933579B (zh)	2009-12-17	2015-07-15	贝林格尔.英格海姆国际有限公司	新的ccr2受体拮抗剂及其用途
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CN102942570A (zh) *	2012-12-05	2013-02-27	武汉药明康德新药开发有限公司	1-三氟甲基-2,8-二氮杂-螺[4.5]癸烷衍生物及其制备方法
AR095079A1 (es)	2013-03-12	2015-09-16	Hoffmann La Roche	Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
NO3074400T3 (fr)	2013-11-26	2018-04-14
KR20160128345A (ko)	2014-03-26	2016-11-07	에프. 호프만-라 로슈 아게	오토탁신(atx) 및 리소포스파티드산(lpa) 생성 억제제로서 이환형 화합물
SG11201607845RA (en)	2014-03-26	2016-10-28	Hoffmann La Roche	Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
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TW201607923A (zh)	2014-07-15	2016-03-01	歌林達有限公司	被取代之氮螺環（４．５）癸烷衍生物
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JP6886967B2 (ja)	2015-09-04	2021-06-16	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	フェノキシメチル誘導体
JP6876685B2 (ja)	2015-09-24	2021-05-26	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	Ａｔｘ阻害剤としての二環式化合物
KR20180054830A (ko)	2015-09-24	2018-05-24	에프. 호프만-라 로슈 아게	오토탁신(atx) 억제제로서의 이환형 화합물
KR20180054634A (ko)	2015-09-24	2018-05-24	에프. 호프만-라 로슈 아게	이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물
EP3353181B1 (fr)	2015-09-24	2021-08-11	F. Hoffmann-La Roche AG	Composes bicycliques utiles comme inhibiteurs atx
CN106908559B (zh) *	2015-12-23	2020-08-11	重庆华邦胜凯制药有限公司	卡泊三醇中间体l及相关杂质的分离与测定方法
DK3538525T3 (da) *	2016-11-08	2022-08-29	Bristol Myers Squibb Co	3-substituerede propionsyrer som alpha-v-integrinhæmmere
CN108456208B (zh) *	2017-02-22	2021-04-16	广州市恒诺康医药科技有限公司	氮杂螺环类化合物及其制备方法和应用
CN106928092B (zh) *	2017-02-28	2019-02-15	上海微巨实业有限公司	一种间氰甲基苯甲酸甲酯的制备方法
CR20190423A (es)	2017-03-16	2019-11-01	Hoffmann La Roche	Nuevos compuestos biciclícos como inhibidores dobles de atx/ca
WO2018166855A1 (fr)	2017-03-16	2018-09-20	Basf Se	Dihydroisoxazoles à substitution hétérobicyclique
CN110382484B (zh)	2017-03-16	2022-12-06	豪夫迈·罗氏有限公司	新的作为atx抑制剂的二环化合物
WO2019084075A1 (fr) *	2017-10-24	2019-05-02	The Trustees Of The University Of Pennsylvania	Antagonistes sélectifs du récepteur de la dopamine et leurs procédés d'utilisation
EP3758695A4 (fr)	2018-02-28	2021-10-06	The Trustees Of The University Of Pennsylvania	Agents cytotoxiques dépendant de la poly(ad-ribose) polymérase-1 de faible affinité
WO2020048827A1 (fr)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	Composés de la 1,3,9-triazaspiro[5.5]undécan-2-one
WO2020048828A1 (fr)	2018-09-03	2020-03-12	Bayer Pharma Aktiengesellschaft	Composés du 5-hétéroaryl-3,9-diazaspiro[5.5]undécane
TW202024083A (zh)	2018-09-03	2020-07-01	德商拜耳廠股份有限公司	3,9-二氮雜螺[5.5]十一烷化合物
CN110963955A (zh) *	2018-09-30	2020-04-07	南京富润凯德生物医药有限公司	一种单氟代螺环化合物的合成方法及其中间体
CN111087336A (zh) *	2018-10-24	2020-05-01	南京富润凯德生物医药有限公司	一种双氟代螺环化合物的合成方法及其中间体
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2006
- 2006-08-25 TW TW095131396A patent/TW200800999A/zh unknown
- 2006-09-04 BR BRPI0615634-7A patent/BRPI0615634A2/pt not_active IP Right Cessation
- 2006-09-04 WO PCT/SE2006/001012 patent/WO2007030061A1/fr not_active Ceased
- 2006-09-04 KR KR1020087008256A patent/KR20080043396A/ko not_active Withdrawn
- 2006-09-04 US US12/065,822 patent/US20090156575A1/en not_active Abandoned
- 2006-09-04 RU RU2008110915/04A patent/RU2008110915A/ru not_active Application Discontinuation
- 2006-09-04 CA CA002621187A patent/CA2621187A1/fr not_active Abandoned
- 2006-09-04 CN CNA2006800413949A patent/CN101305005A/zh active Pending
- 2006-09-04 EP EP06784143A patent/EP1926730A4/fr not_active Withdrawn
- 2006-09-04 JP JP2008529954A patent/JP2009507070A/ja active Pending
- 2006-09-04 AU AU2006287976A patent/AU2006287976A1/en not_active Abandoned
- 2006-09-05 UY UY29781A patent/UY29781A1/es unknown
- 2006-09-06 AR ARP060103885A patent/AR055630A1/es unknown
2008
- 2008-02-14 IL IL189528A patent/IL189528A0/en unknown
- 2008-02-14 ZA ZA200801511A patent/ZA200801511B/xx unknown
- 2008-03-28 EC EC2008008329A patent/ECSP088329A/es unknown
- 2008-04-07 NO NO20081729A patent/NO20081729L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
AU2006287976A1 (en)	2007-03-15
IL189528A0 (en)	2008-08-07
TW200800999A (en)	2008-01-01
BRPI0615634A2 (pt)	2011-05-24
WO2007030061A1 (fr)	2007-03-15
CA2621187A1 (fr)	2007-03-15
UY29781A1 (es)	2007-04-30
AR055630A1 (es)	2007-08-29
EP1926730A4 (fr)	2011-02-16
ECSP088329A (es)	2008-04-28
RU2008110915A (ru)	2009-10-20
EP1926730A1 (fr)	2008-06-04
JP2009507070A (ja)	2009-02-19
CN101305005A (zh)	2008-11-12
KR20080043396A (ko)	2008-05-16
ZA200801511B (en)	2008-11-26
US20090156575A1 (en)	2009-06-18

Publication	Publication Date	Title
NO20081729L (no)	2008-05-16	Nye diazaspiroalkaner og deres anvendelse for behandling av CCR8-medierte sykdommer
NO20081217L (no)	2008-04-15	Nye benzotiazolonderivater
NO20073572L (no)	2007-09-12	Nye forbindelser
NO20092412L (no)	2009-08-19	Hydantoinderivater anvendes som MMP-inhibitorer
NO20054329L (no)	2005-11-21	Adamantanderivater, fremgangsmater for deres fremstilling og farmasoytiske sammensetninger som innbefatter slike
NO20071504L (no)	2007-05-25	Pyrimidinderivanter.
NO20065456L (no)	2007-01-04	Substituerte morfolinforbindelser for behandling av sykdommer i sentralnervesystemet
NO20074275L (no)	2007-09-27	2- (4-okso-4H-kinazolin-3-yl) acetamider og deres anvendelse som Vasopressin-V3-antagonister
NO20090628L (no)	2009-04-21	Pyridizinon derivativater
NO20080675L (no)	2008-03-13	P38-Map kinaseinhibitorer og metoder for deres anvendelse
NO20076059L (no)	2008-01-30	2,4-Diamino-pyrimidiner anvendt som aurorainhibitorer
NO20071776L (no)	2007-04-25	Kinoksaliner som B RAF inhibitorer.
NO20071246L (no)	2007-05-24	Kinazolinonderivater og deres anvendelse som B-RAF-inhibitorer.
NO20074592L (no)	2007-10-19	Acetylenyl-pyrazolo-pyrimidinderivater som mGluR2-antagonister
NO20073859L (no)	2007-10-03	Pyrrolopyrazoler, potente kinaseinhibitorer
NO20073101L (no)	2007-07-19	Nye pyridinforbindelser
TW200745084A (en)	2007-12-16	Novel compounds
NO20061743L (no)	2006-06-21	Kinazolinderivater
NO20084712L (no)	2008-12-30	Nye farmasoytiske forbindelser
NO20083845L (no)	2008-12-11	2,4-diaminopyrimidiner som celle-cyklus kinase inhibitorer
NO20073571L (no)	2007-09-12	Nye hydantoinderivater som metallproteinaseinhibitorer
NO20071245L (no)	2007-05-24	Kinazolinonderivater og deres anvendelse som b-RAF-inhibitorer.
TW200801003A (en)	2008-01-01	Novel compounds
NO20084202L (no)	2008-10-08	4-anilinoquinolin-3-carboksamider som CSF-1R kinase inhibitorer
NO20070570L (no)	2007-04-10	Forbindelser.

Legal Events

Date	Code	Title	Description
2010-04-26	FC2A	Withdrawal, rejection or dismissal of laid open patent application