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NO20076319L - Farmasoytiske sammensetninger av et neuroaktivt steroid og anvendelse derav - Google Patents

Farmasoytiske sammensetninger av et neuroaktivt steroid og anvendelse derav

Info

Publication number
NO20076319L
NO20076319L NO20076319A NO20076319A NO20076319L NO 20076319 L NO20076319 L NO 20076319L NO 20076319 A NO20076319 A NO 20076319A NO 20076319 A NO20076319 A NO 20076319A NO 20076319 L NO20076319 L NO 20076319L
Authority
NO
Norway
Prior art keywords
pharmaceutical compositions
neuroactive steroid
regnan
methoxymethyl
imidazolyl
Prior art date
Application number
NO20076319A
Other languages
English (en)
Inventor
Richard M Woodward
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of NO20076319L publication Critical patent/NO20076319L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Inorganic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Foreliggende beskrivelse vedrører farmasøytiske sammensetninger av det neuroaktive steroid fra 3(?-hydroksy-3?-metoksymetyl-21-(1'-imidazolyl)-5?-pregnan-20-en eller et farmasøytisk akseptabelt salt eller solvat derav, med egenskaper som er ønskelig for anvendelse ved behandling av humørforstyrrelser og lignende. Den farmasøytiske sammensetningen tilveiebringer vedvarende terapeutiske plasmanivåer av 3?-hydroksy-3?-metoksymetyl-21-(1'-imidazolyl)-5?-pregnan-20-en. Foreliggende oppfinnelse vedrører også metoder for behandling av disse lidelser ved administrering av de farmasøytiske sammensetninger.
NO20076319A 2005-06-09 2007-12-07 Farmasoytiske sammensetninger av et neuroaktivt steroid og anvendelse derav NO20076319L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68890505P 2005-06-09 2005-06-09
PCT/EP2006/005574 WO2006131392A1 (en) 2005-06-09 2006-06-09 Pharmaceutical compositions of a neuroactive steroid and uses thereof

Publications (1)

Publication Number Publication Date
NO20076319L true NO20076319L (no) 2007-12-07

Family

ID=36790861

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076319A NO20076319L (no) 2005-06-09 2007-12-07 Farmasoytiske sammensetninger av et neuroaktivt steroid og anvendelse derav

Country Status (25)

Country Link
US (2) US20090131383A1 (no)
EP (3) EP1888080B1 (no)
JP (2) JP2008542419A (no)
KR (3) KR20120028407A (no)
CN (1) CN101193640A (no)
AT (2) ATE464054T1 (no)
AU (1) AU2006256851C1 (no)
BR (1) BRPI0612921A2 (no)
CA (1) CA2611430C (no)
CY (2) CY1110199T1 (no)
DE (1) DE602006013622D1 (no)
DK (2) DK1888080T3 (no)
EA (1) EA013744B1 (no)
ES (2) ES2344313T3 (no)
HR (2) HRP20100372T1 (no)
IL (3) IL187813A (no)
NO (1) NO20076319L (no)
NZ (1) NZ562979A (no)
PL (2) PL1888080T3 (no)
PT (2) PT2168585E (no)
RS (2) RS51304B (no)
SI (2) SI1888080T1 (no)
UA (1) UA94909C2 (no)
WO (1) WO2006131392A1 (no)
ZA (1) ZA200709188B (no)

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RU2700264C2 (ru) 2013-04-17 2019-09-16 Сейдж Терапьютикс, Инк. 19-нор нейроактивные стероиды и способы их применения
PT3498725T (pt) 2013-04-17 2021-09-09 Sage Therapeutics Inc Esteroides c21-n-pirazolilo 19-nor c3,3-dissubstituídos para uso em terapia
US9725481B2 (en) 2013-04-17 2017-08-08 Sage Therapeutics, Inc. 19-nor C3, 3-disubstituted C21-C-bound heteroaryl steroids and methods of use thereof
PL3021852T3 (pl) 2013-07-19 2021-07-05 Sage Therapeutics, Inc. Neuroaktywne steroidy, kompozycje i ich zastosowania
RU2696585C2 (ru) 2013-08-23 2019-08-05 Сейдж Терапьютикс, Инк. Нейроактивные стероиды, их композиции и применение
WO2015195962A1 (en) 2014-06-18 2015-12-23 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
CN118344424A (zh) * 2014-10-16 2024-07-16 萨奇治疗股份有限公司 靶向cns障碍的组合物和方法
LT3206493T (lt) 2014-10-16 2020-08-25 Sage Therapeutics, Inc. Kompozicijos ir būdai, skirti cns sutrikimams gydyti
EP3224269B1 (en) 2014-11-27 2020-02-26 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
JP6745274B2 (ja) 2015-01-26 2020-08-26 セージ セラピューティクス， インコーポレイテッド Ｃｎｓ障害を処置するための組成物および方法
EP3258939B1 (en) 2015-02-20 2022-09-07 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
ES2992037T3 (es) 2016-07-11 2024-12-05 Sage Therapeutics Inc Esteroides neuroactivos sustituidos en C7, C12 y C16 y sus procedimientos de utilización
NZ790226A (en) 2016-07-11 2025-08-29 Sage Therapeutics Inc C17, C20, and C21 substituted neuroactive steroids and their methods of use
CN111491637A (zh) * 2017-09-07 2020-08-04 萨奇治疗股份有限公司 神经活性甾类及其使用方法
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Also Published As

Publication number Publication date
RS51304B (sr) 2010-12-31
JP2008542419A (ja) 2008-11-27
PT2168585E (pt) 2012-03-05
BRPI0612921A2 (pt) 2010-12-07
CY1112499T1 (el) 2015-12-09
EA013744B1 (ru) 2010-06-30
EP1888080B1 (en) 2010-04-14
IL187813A (en) 2011-12-29
AU2006256851B2 (en) 2009-12-17
DK1888080T3 (da) 2010-07-19
AU2006256851C1 (en) 2010-07-15
US20090131383A1 (en) 2009-05-21
DE602006013622D1 (de) 2010-05-27
ES2380060T3 (es) 2012-05-08
IL187813A0 (en) 2008-08-07
PL1888080T3 (pl) 2010-09-30
IL211114A (en) 2014-04-30
EA200800007A1 (ru) 2008-04-28
KR20120028407A (ko) 2012-03-22
RS52199B (sr) 2012-10-31
DK2168585T3 (da) 2012-02-27
JP2012229261A (ja) 2012-11-22
CY1110199T1 (el) 2015-01-14
ZA200709188B (en) 2008-08-27
HK1140947A1 (en) 2010-10-29
WO2006131392A8 (en) 2007-02-15
EP1888080A1 (en) 2008-02-20
KR20100095661A (ko) 2010-08-31
IL216194A (en) 2013-09-30
HRP20120264T1 (hr) 2012-04-30
KR20080017091A (ko) 2008-02-25
US20120276196A1 (en) 2012-11-01
ATE464054T1 (de) 2010-04-15
ATE538797T1 (de) 2012-01-15
HRP20100372T1 (hr) 2010-08-31
EP2168585A1 (en) 2010-03-31
HK1118202A1 (en) 2009-02-06
SI2168585T1 (sl) 2012-04-30
ES2344313T3 (es) 2010-08-24
EP2168585B1 (en) 2011-12-28
EP2263675A3 (en) 2011-05-18
SI1888080T1 (sl) 2010-08-31
NZ562979A (en) 2010-11-26
UA94909C2 (ru) 2011-06-25
CA2611430C (en) 2013-09-10
PL2168585T3 (pl) 2012-05-31
CA2611430A1 (en) 2006-12-14
WO2006131392A1 (en) 2006-12-14
AU2006256851A1 (en) 2006-12-14
PT1888080E (pt) 2010-07-06
CN101193640A (zh) 2008-06-04
EP2263675A2 (en) 2010-12-22
IL216194A0 (en) 2012-01-31

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