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NO20076219L - Farmasoytisk formulering med apomorfin for bukkal administrering - Google Patents

Farmasoytisk formulering med apomorfin for bukkal administrering

Info

Publication number
NO20076219L
NO20076219L NO20076219A NO20076219A NO20076219L NO 20076219 L NO20076219 L NO 20076219L NO 20076219 A NO20076219 A NO 20076219A NO 20076219 A NO20076219 A NO 20076219A NO 20076219 L NO20076219 L NO 20076219L
Authority
NO
Norway
Prior art keywords
apomorphine
buccal administration
pharmaceutical formulation
formulation
pharmaceutically acceptable
Prior art date
Application number
NO20076219A
Other languages
English (en)
Other versions
NO339404B1 (no
Inventor
Anthony Clarke
Original Assignee
Amarin Pharmaceuticals Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amarin Pharmaceuticals Ireland filed Critical Amarin Pharmaceuticals Ireland
Publication of NO20076219L publication Critical patent/NO20076219L/no
Publication of NO339404B1 publication Critical patent/NO339404B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Den foreliggende oppfinnelse tilveiebringer et sett som omfatter, i separate avdelinger i en beholder, følgende komponenter (a) og (b): (a) en kombinasjon av apomorfin eller et farmasøytisk akseptabelt syreaddisjonssalt derav og en farmasøytisk akseptabel eksipient eller bærer; og (b) en løsning som omfatter et fortynningsmiddel og et pH-modifiserende middel; hvor komponentene er presentert slik at de kan kombineres på tidspunktet for anvendelse til en formulering som er justert til en pH som varierer fra svakt sur til alkalisk og som er egnet for bukal administrering. Formuleringen er nyttig til å behandle Parkinsons sykdom og til å fremme seksuell fiinksjon.
NO20076219A 2005-05-06 2007-12-03 Farmasøytisk formulering med apomorfin for bukkal administrering NO339404B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0509317.4A GB0509317D0 (en) 2005-05-06 2005-05-06 Pharmaceutical formulation of apomorphine
PCT/GB2006/001665 WO2006120412A1 (en) 2005-05-06 2006-05-08 Pharmaceutical formulation of apomorphine for buccal administration

Publications (2)

Publication Number Publication Date
NO20076219L true NO20076219L (no) 2007-12-03
NO339404B1 NO339404B1 (no) 2016-12-12

Family

ID=34685218

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20076219A NO339404B1 (no) 2005-05-06 2007-12-03 Farmasøytisk formulering med apomorfin for bukkal administrering

Country Status (20)

Country Link
US (2) US20090023766A1 (no)
EP (1) EP1885333B1 (no)
JP (1) JP5116665B2 (no)
KR (1) KR101365458B1 (no)
CN (1) CN101217936A (no)
AT (1) ATE545407T1 (no)
AU (1) AU2006245564A1 (no)
BR (1) BRPI0611258A2 (no)
CA (1) CA2607802C (no)
DK (1) DK1885333T3 (no)
ES (1) ES2383433T3 (no)
GB (1) GB0509317D0 (no)
IL (1) IL187183A0 (no)
MX (1) MX2007013890A (no)
NO (1) NO339404B1 (no)
PT (1) PT1885333E (no)
RU (1) RU2007140701A (no)
SI (1) SI1885333T1 (no)
WO (1) WO2006120412A1 (no)
ZA (1) ZA200709474B (no)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0819530D0 (en) * 2008-10-24 2008-12-03 Univ Sheffield Methods and compositions
FI2442650T4 (fi) * 2009-06-12 2025-08-06 Sunovion Pharmaceuticals Inc Kielen alle annettava apomorfiini
DK2651357T3 (da) * 2010-12-16 2020-06-02 Sunovion Pharmaceuticals Inc Sublinguale film
EP2545788A1 (de) * 2011-07-13 2013-01-16 Martin Hulliger Diätisches Mehrkomponentensystem
US20150328258A1 (en) * 2012-05-30 2015-11-19 Ibh Ventures, Llc Polyphenol-reactive oxygen species compositions and methods
NZ703341A (en) * 2012-06-05 2016-11-25 Neuroderm Ltd Compositions comprising apomorphine and organic acids and uses thereof
US20160296463A1 (en) 2013-11-11 2016-10-13 Impax Laboratories, Inc. Rapidly disintegrating formulations and methods thereof
JP6042794B2 (ja) * 2013-12-03 2016-12-14 本田技研工業株式会社 車両制御方法
US10493027B2 (en) 2014-08-07 2019-12-03 Mucodel Pharma Llc Chemically stable compositions of a pharmaceutical active agent in a multi- chambered delivery system for mucosal delivery
WO2016022816A1 (en) * 2014-08-07 2016-02-11 Mucodel Pharma Llc Chemically stable and oromucosally absorbable gel compositions of a pharmaceutical active agent in a multi-chambered delivery system
EP3285771B1 (en) 2015-04-21 2025-02-12 Sunovion Pharmaceuticals Inc. Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa
EP3355887A1 (en) 2015-09-28 2018-08-08 EVER Neuro Pharma GmbH Aqueous composition of apomorphine for subcutaneous administration
WO2018148382A1 (en) * 2017-02-10 2018-08-16 Mucodel Pharma Llc Chemically stable compositions of a pharmaceutical active agent in a multi-chambered delivery system for mucosal delivery
GB201912686D0 (en) 2019-09-04 2019-10-16 Reown Pharma Inc Pharmaceutical composition
US20240335379A1 (en) * 2021-08-05 2024-10-10 Zydus Lifesciences Limited Stable pharmaceutical compositions of apomorphine
JP2025520542A (ja) 2022-06-15 2025-07-03 エバー ニューロ ファーマ ゲーエムベーハー アポモルヒネプロドラッグおよびその使用
WO2025259725A1 (en) * 2024-06-11 2025-12-18 Nano Pharmasolutions, Inc. Apomorphine compositions and therapeutic applications

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0865789T3 (da) * 1993-03-26 2005-07-18 Franciscus Wilhelmus He Merkus Farmaceutiske præparater til intranasal administration af dihydroergotamin
US6121276A (en) * 1994-04-22 2000-09-19 Pentech Pharmaceuticals, Inc. Apomorphine-containing dosage forms for ameliorating male erectile dysfunction
GB9517062D0 (en) * 1995-08-18 1995-10-25 Scherer Ltd R P Pharmaceutical compositions
CA2285948A1 (en) * 1997-04-28 1998-11-05 The University Of British Columbia Method and composition for modulating amyloidosis
US6436950B1 (en) * 1998-08-14 2002-08-20 Nastech Pharmaceutical Company, Inc. Nasal delivery of apomorphine
MXPA02006034A (es) * 1999-12-30 2004-08-23 Tap Holdings Inc Formas de dosis mucosaloral de apomorfina.
HUP0302825A3 (en) * 2000-07-13 2005-02-28 Takeda Pharmaceutical Lipid-rich plaque inhibitors
US20040028613A1 (en) * 2001-06-25 2004-02-12 Nastech Pharmaceutical Company Inc Dopamine agonist formulations for enhanced central nervous system delivery
US20030068356A1 (en) * 2001-07-10 2003-04-10 Pather S. Indiran Sequential drug delivery systems
EP1539208A2 (en) * 2002-06-28 2005-06-15 Nastech Pharmaceutical Company Inc. Compositions and methods for modulating physiology of epithelial junctional adhesion molecules for enhanced mucosal delivery of therapeutic compounds
US20040126448A1 (en) * 2002-08-05 2004-07-01 Nils-Olof Lindberg Sexual dysfunction compounds
SE0202365D0 (sv) * 2002-08-05 2002-08-05 Pharmacia Ab New formulation and use thereof
GB0403938D0 (en) * 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution

Also Published As

Publication number Publication date
HK1113086A1 (en) 2008-09-26
EP1885333B1 (en) 2012-02-15
RU2007140701A (ru) 2009-06-20
CA2607802A1 (en) 2006-11-16
MX2007013890A (es) 2008-04-04
KR101365458B1 (ko) 2014-02-19
AU2006245564A1 (en) 2006-11-16
ATE545407T1 (de) 2012-03-15
CN101217936A (zh) 2008-07-09
PT1885333E (pt) 2012-05-14
ZA200709474B (en) 2008-12-31
GB0509317D0 (en) 2005-06-15
KR20080016608A (ko) 2008-02-21
US20130131098A1 (en) 2013-05-23
BRPI0611258A2 (pt) 2010-11-23
JP5116665B2 (ja) 2013-01-09
US20090023766A1 (en) 2009-01-22
SI1885333T1 (sl) 2012-07-31
CA2607802C (en) 2015-02-10
US8772309B2 (en) 2014-07-08
JP2008540392A (ja) 2008-11-20
DK1885333T3 (da) 2012-05-14
WO2006120412A1 (en) 2006-11-16
EP1885333A1 (en) 2008-02-13
ES2383433T3 (es) 2012-06-21
IL187183A0 (en) 2008-02-09
NO339404B1 (no) 2016-12-12

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