NO20073787L - Nye pyrimidin-nukleosidforbindelser eller dets salt - Google Patents
Nye pyrimidin-nukleosidforbindelser eller dets saltInfo
- Publication number
- NO20073787L NO20073787L NO20073787A NO20073787A NO20073787L NO 20073787 L NO20073787 L NO 20073787L NO 20073787 A NO20073787 A NO 20073787A NO 20073787 A NO20073787 A NO 20073787A NO 20073787 L NO20073787 L NO 20073787L
- Authority
- NO
- Norway
- Prior art keywords
- group
- pyrimidine nucleoside
- nucleoside compounds
- alkyl group
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Nye pyrimidinnukleosidforbindelser representert ved den følgende formel (1): [F1] (hvor én av X og Y representerer en cyanogruppe og den andre representerer et hydrogenatom; én av R1 og R2 representerer et hydrogenatom, en karbonylgruppe som har en C1-C6-alkylgruppe som er mono-substituert med en aminogruppe eller en gruppe representert ved (R3)(R4)(R5)Si-, og den andre representerer en silylgruppe representert ved (R6)(R7)(R8)Si-, eller R1 og R2 danner sammen en 6-leddet cyklisk gruppe representert ved -Si(R9)(R10)-; R3, R4, R5, R6, R7 og R8 hver representerer en alkylgruppe, en cyklisk alkylgruppe, en arylgruppe eller en alkylgruppe som er substituert med én eller to arylgrupper; og R9 og R10 hver representerer en alkylgruppe) eller et salt derav. De nye pyrimidinnukleosidforbindelsene oppviser utmerket anti-tumoreffekt sammenlignet med eksisterende pyrimidinnukleosidforbindelser.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005023278 | 2005-01-31 | ||
| PCT/JP2006/301483 WO2006080509A1 (ja) | 2005-01-31 | 2006-01-30 | 新規ピリミジンヌクレオシド化合物又はその塩 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20073787L true NO20073787L (no) | 2007-09-27 |
Family
ID=36740526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20073787A NO20073787L (no) | 2005-01-31 | 2007-07-20 | Nye pyrimidin-nukleosidforbindelser eller dets salt |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7825103B2 (no) |
| EP (1) | EP1845102A4 (no) |
| JP (1) | JP4966186B2 (no) |
| KR (1) | KR20070103012A (no) |
| CN (1) | CN101111509B (no) |
| AU (1) | AU2006209422B2 (no) |
| BR (1) | BRPI0607287A2 (no) |
| CA (1) | CA2596060A1 (no) |
| IL (1) | IL184779A0 (no) |
| MY (1) | MY142304A (no) |
| NO (1) | NO20073787L (no) |
| NZ (1) | NZ560252A (no) |
| RU (1) | RU2395517C2 (no) |
| TW (1) | TW200637870A (no) |
| WO (1) | WO2006080509A1 (no) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008010571A1 (fr) | 2006-07-21 | 2008-01-24 | Taiho Pharmaceutical Co., Ltd. | Composé nucléosidique de 2'cyanopyrimidine |
| GB0625283D0 (en) | 2006-12-19 | 2007-01-24 | Cyclacel Ltd | Combination |
| WO2008144472A1 (en) | 2007-05-18 | 2008-11-27 | Dharmacon, Inc. | Novel chromophoric silyl protecting groups and their use in the chemical synthesis of oligonucleotides |
| CN101787066B (zh) * | 2009-01-23 | 2013-07-31 | 高峰 | 阿糖胞苷衍生物及其在抗癌抗肿瘤中的用途 |
| KR102543559B1 (ko) * | 2016-05-31 | 2023-06-13 | 다이호야쿠힌고교 가부시키가이샤 | 설폰아미드화합물 또는 이의 염 |
| US10889555B2 (en) | 2016-05-31 | 2021-01-12 | Taiho Pharmaceutical Co., Ltd. | Sulfonamide compound or salt thereof |
| WO2018230479A1 (ja) * | 2017-06-13 | 2018-12-20 | 大原薬品工業株式会社 | ヌクレオシド系抗がん剤又は抗ウィルス剤の５'位シリルエーテル誘導体 |
| ES2969901T3 (es) | 2017-11-29 | 2024-05-23 | Taiho Pharmaceutical Co Ltd | Cocristal de ácido benzoico y compuesto de sulfonamida para el tratamiento de tumores |
| TWI748142B (zh) * | 2017-11-29 | 2021-12-01 | 日商大鵬藥品工業股份有限公司 | 抗腫瘤劑 |
| KR20190065139A (ko) * | 2017-12-01 | 2019-06-11 | 압타바이오 주식회사 | 혈액암 치료제 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE92499T1 (de) | 1984-12-04 | 1993-08-15 | Lilly Co Eli | Tumorbehandlung bei saeugetieren. |
| ZA859008B (en) | 1984-12-04 | 1987-07-29 | Lilly Co Eli | The treatment of tumors in mammals |
| EP0378706B1 (en) * | 1988-07-11 | 1994-12-28 | Taiho Pharmaceutical Company Limited | 5-substituted uridine derivatives and intermediates for their preparation |
| JP2559917B2 (ja) * | 1990-06-15 | 1996-12-04 | 三共株式会社 | ピリミジンヌクレオシド誘導体 |
| JP2664837B2 (ja) * | 1991-06-07 | 1997-10-22 | 三井東圧化学株式会社 | トリフルオロチミジン誘導体、その製造法およびそれを有効成分とする制ガン剤 |
| FI105556B (fi) * | 1991-09-30 | 2000-09-15 | Sankyo Co | Menetelmä lääkeaineina käyttökelpoisten pyrimidiiniukleosidijohdannaisten valmistamiseksi, joilla on kasvaimen vastaista vaikutusta |
| JPH07179491A (ja) | 1993-12-22 | 1995-07-18 | Sankyo Co Ltd | ５’−ホスファチジルピリミジンヌクレオチド誘導体 |
| JP2003113197A (ja) * | 2001-10-09 | 2003-04-18 | Mitsui Chemicals Inc | シチジンヌクレオシド誘導体の製造法 |
| JP4235182B2 (ja) | 2003-05-23 | 2009-03-11 | 富士通株式会社 | 光磁気記録媒体および光磁気記録媒体の製造方法並びに光磁気記録媒体駆動装置 |
-
2006
- 2006-01-27 MY MYPI20060419A patent/MY142304A/en unknown
- 2006-01-27 TW TW095103566A patent/TW200637870A/zh unknown
- 2006-01-30 RU RU2007132737/04A patent/RU2395517C2/ru not_active IP Right Cessation
- 2006-01-30 BR BRPI0607287-9A patent/BRPI0607287A2/pt not_active IP Right Cessation
- 2006-01-30 JP JP2007500639A patent/JP4966186B2/ja not_active Expired - Fee Related
- 2006-01-30 US US11/815,149 patent/US7825103B2/en not_active Expired - Fee Related
- 2006-01-30 WO PCT/JP2006/301483 patent/WO2006080509A1/ja not_active Ceased
- 2006-01-30 KR KR1020077017448A patent/KR20070103012A/ko not_active Ceased
- 2006-01-30 CA CA002596060A patent/CA2596060A1/en not_active Abandoned
- 2006-01-30 EP EP06712626A patent/EP1845102A4/en not_active Withdrawn
- 2006-01-30 NZ NZ560252A patent/NZ560252A/en not_active IP Right Cessation
- 2006-01-30 AU AU2006209422A patent/AU2006209422B2/en not_active Ceased
- 2006-01-30 CN CN2006800036007A patent/CN101111509B/zh not_active Expired - Fee Related
-
2007
- 2007-07-20 NO NO20073787A patent/NO20073787L/no not_active Application Discontinuation
- 2007-07-23 IL IL184779A patent/IL184779A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2007132737A (ru) | 2009-03-10 |
| EP1845102A1 (en) | 2007-10-17 |
| KR20070103012A (ko) | 2007-10-22 |
| RU2395517C2 (ru) | 2010-07-27 |
| IL184779A0 (en) | 2007-12-03 |
| US20090118222A1 (en) | 2009-05-07 |
| NZ560252A (en) | 2009-10-30 |
| CA2596060A1 (en) | 2006-08-03 |
| CN101111509A (zh) | 2008-01-23 |
| CN101111509B (zh) | 2011-02-16 |
| MY142304A (en) | 2010-11-15 |
| WO2006080509A1 (ja) | 2006-08-03 |
| TW200637870A (en) | 2006-11-01 |
| US7825103B2 (en) | 2010-11-02 |
| BRPI0607287A2 (pt) | 2009-08-25 |
| EP1845102A4 (en) | 2012-07-04 |
| JPWO2006080509A1 (ja) | 2008-06-19 |
| JP4966186B2 (ja) | 2012-07-04 |
| AU2006209422B2 (en) | 2010-08-12 |
| AU2006209422A1 (en) | 2006-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |