[go: up one dir, main page]

NO20071508L - Thermodynamisk stabil form for BAY 43-9006 tosylat. - Google Patents

Thermodynamisk stabil form for BAY 43-9006 tosylat.

Info

Publication number
NO20071508L
NO20071508L NO20071508A NO20071508A NO20071508L NO 20071508 L NO20071508 L NO 20071508L NO 20071508 A NO20071508 A NO 20071508A NO 20071508 A NO20071508 A NO 20071508A NO 20071508 L NO20071508 L NO 20071508L
Authority
NO
Norway
Prior art keywords
thermodynamically stable
tosylate
bay
stable form
amino
Prior art date
Application number
NO20071508A
Other languages
English (en)
Other versions
NO344272B1 (no
Inventor
Alfons Grunenberg
Jana Lenz
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35482258&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20071508(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Publication of NO20071508L publication Critical patent/NO20071508L/no
Publication of NO344272B1 publication Critical patent/NO344272B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Paper (AREA)
  • Catalysts (AREA)
  • Glass Compositions (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)

Abstract

Den foreliggende oppfinnelsen angår til en hittil ukjent form, termodynamisk stabil ved romtemperatur, av tosylatsaltet av 4-{4-[({[4-klor-3-(trifluormetyl)fenyl]amino}kar-bonyl)amino]fenoksy}-N-metylpyridin-2-karboksamid, til prosesser for dets frem-stillelse, til medikamenter som omfatter det og til dets anvendelse i kontrollen av sykdommer.
NO20071508A 2004-09-29 2007-03-22 Termodynamisk stabil form av BAY 43-9006 tosylat NO344272B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04023130 2004-09-29
PCT/EP2005/010119 WO2006034797A1 (en) 2004-09-29 2005-09-20 Thermodynamically stable form of bay 43-9006 tosylate

Publications (2)

Publication Number Publication Date
NO20071508L true NO20071508L (no) 2007-06-22
NO344272B1 NO344272B1 (no) 2019-10-21

Family

ID=35482258

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071508A NO344272B1 (no) 2004-09-29 2007-03-22 Termodynamisk stabil form av BAY 43-9006 tosylat

Country Status (32)

Country Link
US (1) US8877933B2 (no)
EP (1) EP1797038B1 (no)
JP (2) JP5215666B2 (no)
KR (4) KR20070058537A (no)
CN (1) CN101065360B (no)
AR (1) AR051301A1 (no)
AU (1) AU2005289100B2 (no)
BR (1) BRPI0515946A (no)
CA (1) CA2581843C (no)
CU (1) CU20070068A7 (no)
CY (1) CY1113598T1 (no)
DK (1) DK1797038T3 (no)
EC (1) ECSP077356A (no)
ES (1) ES2387812T3 (no)
GT (1) GT200500270A (no)
HN (1) HN2005000722A (no)
HR (1) HRP20120662T1 (no)
IL (1) IL181734A (no)
MA (1) MA28880B1 (no)
MY (1) MY176929A (no)
NO (1) NO344272B1 (no)
NZ (1) NZ553804A (no)
PE (3) PE20100445A1 (no)
PL (1) PL1797038T3 (no)
PT (1) PT1797038E (no)
SG (1) SG155996A1 (no)
SI (1) SI1797038T1 (no)
TW (1) TWI382016B (no)
UA (1) UA91520C2 (no)
UY (1) UY29144A1 (no)
WO (1) WO2006034797A1 (no)
ZA (1) ZA200702510B (no)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1042251B (en) 1999-01-13 2012-07-20 Bayer Healthcare Llc Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US10653684B2 (en) 2002-02-11 2020-05-19 Bayer Healthcare Llc Aryl ureas with angiogenisis inhibiting activity
EP1478358B1 (en) 2002-02-11 2013-07-03 Bayer HealthCare LLC Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis
UY28213A1 (es) 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
PT1626714E (pt) * 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diarilureias para doenças mediadas por pdgfr
DE602004010407T2 (de) 2003-07-23 2008-10-16 Bayer Pharmaceuticals Corp., West Haven Fluorsubstituierter omega-carboxyaryldiphenylharnstoff zur behandlung und prävention von krankheiten und leiden
PL1797038T3 (pl) 2004-09-29 2012-11-30 Bayer Healthcare Llc Termodynamicznie trwała postać tosylanu bay 43-9006
MX2007010856A (es) 2005-03-07 2007-11-12 Bayer Healthcare Ag Composicion farmaceutica que comprende una difenilurea sustituida con omega-carboxiarilo para el tratamiento del cancer.
EP1968589A2 (en) 2005-10-31 2008-09-17 Bayer Pharmaceuticals Corporation Combinations comprising sorafenib and interferon for the treatment of cancer
AR062927A1 (es) * 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
WO2008058644A1 (en) * 2006-11-14 2008-05-22 Bayer Schering Pharma Aktiengesellschaft Polymorph ii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide
CN101220024A (zh) * 2007-12-11 2008-07-16 杜晓敏 一组抑制激酶的抗癌化合物
EP2231612A1 (en) * 2008-01-17 2010-09-29 Sicor, Inc. Polymorph form iii of sorafenib tosylate, sorafenib tosylate methanol solvate and sorafenib tosylate ethanol solvate, and processes for preparation thereof
WO2009106825A1 (en) * 2008-02-27 2009-09-03 Cipla Limited Polymorphs of sorafenib and salts thereof
WO2010079498A2 (en) * 2009-01-12 2010-07-15 Hetero Research Foundation Novel polymorph of sorafenib tosylate
AU2009344660A1 (en) * 2009-04-15 2011-11-17 Fondazione Irccs Istituto Nazionale Dei Tumori Use of multi-kinase inhibitors in the treatment of vascular hyperpermeability
WO2010142678A2 (en) * 2009-06-12 2010-12-16 Ratiopharm Gmbh Polymorphs of 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methyl-pyridine-2-carboxamide
CA2775296A1 (en) 2009-09-24 2011-03-31 Ranbaxy Laboratories Limited Polymorphs of sorafenib acid addition salts
EP2480534A1 (en) 2009-09-24 2012-08-01 Ranbaxy Laboratories Limited Process for the preparation of sorafenib tosylate
EP2499116A1 (en) 2009-11-12 2012-09-19 Ranbaxy Laboratories Limited Sorafenib ethylsulfonate salt, process for preparation and use
WO2011076711A2 (en) 2009-12-23 2011-06-30 Ratiopharm Gmbh Polymorphs of 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-n-methylpyridine-2-carboxamide
US8618305B2 (en) 2010-01-29 2013-12-31 Ranbaxy Laboratories Limited Sorafenib dimethyl sulphoxide solvate
AR081060A1 (es) 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
MX2013003695A (es) 2010-10-01 2013-05-20 Bayer Ip Gmbh Combinaciones que contienen n-(2-arilamino) arilsulfonamida sustituida.
WO2012071425A1 (en) 2010-11-22 2012-05-31 Teva Pharmaceutical Industries Ltd. Solid state forms of sorafenib besylate, and processes for preparations thereof
EP2726057A1 (en) 2011-06-28 2014-05-07 Bayer HealthCare LLC Topical ophthalmological pharmaceutical composition containing sorafenib
EP2559431A1 (en) 2011-08-17 2013-02-20 Ratiopharm GmbH Pharmaceutical composition comprising 4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
PL2806860T3 (pl) 2012-01-23 2023-09-11 Sandoz Ag Kompozycja farmaceutyczna zawierająca krystaliczny tosylan sorafenibu
EP2852574B1 (en) * 2012-05-21 2020-02-05 Hetero Research Foundation Process for sorafenib tosylate polymorph iii
AU2012380672B2 (en) * 2012-05-23 2015-05-14 Shilpa Medicare Limited Process for preparing crystalline Sorafenib tosylate
CN103570613B (zh) * 2012-07-18 2016-06-15 苏州泽璟生物制药有限公司 氘代ω-二苯基脲或其盐的多晶型物
CN103896833B (zh) * 2012-12-27 2016-12-28 上海创诺制药有限公司 索拉非尼对甲苯磺酸盐溶剂化物多晶型物及其制法和用途
WO2014118807A1 (en) * 2013-02-04 2014-08-07 Intas Pharmaceuticals Limited A novel process for the preparation of sorafenib tosylate form iii
WO2014138905A1 (en) * 2013-03-14 2014-09-18 Apotex Technologies Inc. Forms of sorafenib tosylate and processes for the preparation thereof
US9765723B2 (en) 2013-05-10 2017-09-19 Denso Corporation Fuel injection control device and fuel injection system
CN104761492A (zh) * 2014-01-03 2015-07-08 正大天晴药业集团股份有限公司 对甲苯磺酸索拉非尼的晶型及其制备方法
US20170114323A1 (en) * 2014-06-19 2017-04-27 Whitehead Institute For Biomedical Research Uses of kinase inhibitors for inducing and maintaining pluripotency
CN104177292A (zh) * 2014-08-08 2014-12-03 亿腾药业（泰州）有限公司 一种工业化生产甲苯磺酸索拉非尼多晶型ⅰ的方法
CN105439947A (zh) * 2014-12-01 2016-03-30 石药集团中奇制药技术（石家庄）有限公司 一种甲苯磺酸索拉非尼新晶型及其制备方法
RU2568638C1 (ru) * 2015-02-26 2015-11-20 Индивидуальный предприниматель Михайлов Олег Ростиславович КРИСТАЛЛИЧЕСКАЯ β-МОДИФИКАЦИЯ 4-[4-({ [4-ХЛОРО-3-(ТРИФТОРОМЕТИЛ) ФЕНИЛ]КАРБАМОИЛ} АМИНО)ФЕНОКСИ]-N-МЕТИЛ-ПИРИДИН-2-КАРБОКСАМИДА п-ТОЛУОЛСУЛЬФОНАТА, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ЕЁ ОСНОВЕ
EP3109236B1 (en) 2015-06-23 2017-08-09 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Scalable process for the preparation of sorafenib tosylate ethanol solvate and sorafenib tosylate form iii
CN106336377A (zh) * 2015-07-17 2017-01-18 苏州亚宝药物研发有限公司 一种甲苯磺酸索拉非尼晶型ⅱ的制备方法
CN105503715A (zh) * 2015-12-03 2016-04-20 神威药业集团有限公司 一种索拉非尼半甲苯磺酸盐多晶型及其制备方法
CN105585523A (zh) * 2015-12-29 2016-05-18 上海北卡医药技术有限公司 一种对甲苯磺酸索拉非尼的新晶型及其制备方法和用途
CN107759517A (zh) * 2016-08-23 2018-03-06 广州白云山医药集团股份有限公司白云山制药总厂 一种甲苯磺酸索拉非尼晶型ⅰ的制备方法
CN107840823B (zh) * 2016-09-20 2021-08-17 意大利合成制造有限公司 用于制备甲苯磺酸索拉非尼乙醇溶剂化物和iii型甲苯磺酸索拉非尼的可变规模的方法
CN108164459B (zh) * 2016-12-07 2021-07-27 上海创诺制药有限公司 甲苯磺酸索拉非尼晶型iii的制备方法
AU2018205285C9 (en) 2017-01-05 2024-05-23 Radius Pharmaceuticals, Inc. Polymorphic forms of RAD1901-2HCl
CN109796400B (zh) * 2017-11-16 2022-07-29 四川科伦药物研究院有限公司 一种甲苯磺酸索拉菲尼晶型及其制备方法
US11179322B2 (en) 2018-07-10 2021-11-23 Novocure Gmbh Methods and compositions for treating tumors with TTFields and sorafenib
WO2018211336A2 (en) 2018-09-07 2018-11-22 Alvogen Malta Operations (Row) Ltd Solid dosage form containing sorafenib tosylate
JP2022515705A (ja) 2018-11-01 2022-02-22 サイロス ファーマシューティカルズ， インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の非共有結合性阻害剤を用いてバイオマーカーにより特定された患者におけるがんを処置する方法
CN110156671A (zh) * 2019-06-06 2019-08-23 杭州中美华东制药有限公司 新型的索拉非尼共晶及其制备方法
CA3149796A1 (en) 2019-08-02 2021-02-11 Onehealthcompany, Inc. Anti-cancer agents for the treatment of canine cancers
KR102887639B1 (ko) * 2019-10-25 2025-11-18 한미약품 주식회사 생산성 및 용출성이 개선된 소라페닙 토실레이트염의 제제 및 그 제조 방법
CN117088809A (zh) * 2022-05-12 2023-11-21 浙江工业大学 一种索拉非尼-丙二酸共晶及其制备方法

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
CO4410191A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
AU1153097A (en) * 1996-06-07 1998-01-05 Eisai Co. Ltd. Stable polymorphs of donepezil (1-benzyl-4-{(5,6-dimethoxy-1-indanon)-2-yl}methylpiperidine ) hydrochloride and process for production
CN1146567C (zh) 1996-09-23 2004-04-21 伊莱利利公司 奥氮平二水合物d
US6187799B1 (en) * 1997-05-23 2001-02-13 Onyx Pharmaceuticals Inhibition of raf kinase activity using aryl ureas
US6344476B1 (en) * 1997-05-23 2002-02-05 Bayer Corporation Inhibition of p38 kinase activity by aryl ureas
US7517880B2 (en) * 1997-12-22 2009-04-14 Bayer Pharmaceuticals Corporation Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
US7329670B1 (en) * 1997-12-22 2008-02-12 Bayer Pharmaceuticals Corporation Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
ME00275B (me) * 1999-01-13 2011-02-10 Bayer Corp ω-KARBOKSIARIL SUPSTITUISANI DIFENIL KARBAMIDI KAO INHIBITORI RAF KINAZE
HK1042251B (en) 1999-01-13 2012-07-20 Bayer Healthcare Llc Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
WO2000042012A1 (en) 1999-01-13 2000-07-20 Bayer Corporation φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
US8124630B2 (en) * 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7928239B2 (en) * 1999-01-13 2011-04-19 Bayer Healthcare Llc Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas
US7235576B1 (en) * 2001-01-12 2007-06-26 Bayer Pharmaceuticals Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
US7371763B2 (en) 2001-04-20 2008-05-13 Bayer Pharmaceuticals Corporation Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
RS52500B (sr) 2001-12-03 2013-04-30 Bayer Healthcare Llc Aril urea jedinjenja u kombinaciji sa drugim citostatičkim ili citotoksičnim agensima za tretiranje humanih kancera
GB0129876D0 (en) 2001-12-13 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
US20030207872A1 (en) * 2002-01-11 2003-11-06 Bayer Corporation Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
AU2003209119A1 (en) * 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
EP1478358B1 (en) * 2002-02-11 2013-07-03 Bayer HealthCare LLC Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis
AU2003209118A1 (en) * 2002-02-11 2003-09-04 Bayer Pharmaceuticals Corporation Aryl ureas as kinase inhibitors
GB0203412D0 (en) 2002-02-13 2002-04-03 Pharmagene Lab Ltd 5-HT 2B receptor antagonists
CN1533566A (zh) 2002-03-29 2004-09-29 索尼株式会社 光盘识别装置和方法、光盘记录装置和光盘再现装置
EP1504047B1 (en) * 2002-05-03 2007-12-12 Janssen Pharmaceutica N.V. Polymeric microemulsions
US7351534B2 (en) * 2003-01-27 2008-04-01 Oregon Health & Sciences University Gene mutation associated with age-related macular degeneration
UY28213A1 (es) * 2003-02-28 2004-09-30 Bayer Pharmaceuticals Corp Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos.
US7378233B2 (en) * 2003-04-12 2008-05-27 The Johns Hopkins University BRAF mutation T1796A in thyroid cancers
PT1626714E (pt) * 2003-05-20 2007-08-24 Bayer Pharmaceuticals Corp Diarilureias para doenças mediadas por pdgfr
DE602004010407T2 (de) * 2003-07-23 2008-10-16 Bayer Pharmaceuticals Corp., West Haven Fluorsubstituierter omega-carboxyaryldiphenylharnstoff zur behandlung und prävention von krankheiten und leiden
ATE517885T1 (de) * 2004-04-30 2011-08-15 Bayer Healthcare Llc Substituierte pyrazolyl-harnstoff-derivate zur behandlung von krebs
MY191349A (en) * 2004-08-27 2022-06-17 Bayer Pharmaceuticals Corp New pharmaceutical compositions for the treatment of hyper-proliferative disorders
WO2006026501A1 (en) * 2004-08-27 2006-03-09 Bayer Pharmaceuticals Corporation New pharmaceutical compositions for the treatment of cancer
PL1797038T3 (pl) 2004-09-29 2012-11-30 Bayer Healthcare Llc Termodynamicznie trwała postać tosylanu bay 43-9006
AU2005289099B2 (en) 2004-09-29 2012-07-19 Bayer Healthcare Llc Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide
US7271763B2 (en) * 2005-03-03 2007-09-18 The United States Of America As Represented By The Secretary Of The Army Hybrid-phased communication array
MX2007010856A (es) * 2005-03-07 2007-11-12 Bayer Healthcare Ag Composicion farmaceutica que comprende una difenilurea sustituida con omega-carboxiarilo para el tratamiento del cancer.
US8329408B2 (en) * 2005-10-31 2012-12-11 Bayer Healthcare Llc Methods for prognosis and monitoring cancer therapy
WO2007053573A2 (en) * 2005-10-31 2007-05-10 Bayer Pharmaceuticals Corporation Treatment of cancer with sorafenib
CA2628849A1 (en) * 2005-11-10 2007-05-18 Bayer Healthcare Ag Diaryl urea for treating pulmonary hypertension
JP2009515978A (ja) * 2005-11-14 2009-04-16 バイエル ヘルスケア エルエルシー Ｋｉｔ阻害剤に対する獲得耐性を伴う癌の治療
AR062927A1 (es) * 2006-10-11 2008-12-17 Bayer Healthcare Ag 4- [4-( [ [ 4- cloro-3-( trifluorometil) fenil) carbamoil] amino] -3- fluorofenoxi) -n- metilpiridin-2- carboxamida monohidratada
JP2010509253A (ja) * 2006-11-09 2010-03-25 バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト ４−［４−（｛［４−クロロ−３−（トリフルオロメチル）フェニル］カルバモイル｝アミノ）−３−フルオロフェノキシ］−ｎ−メチルピリジン−２−カルボキサミドの多形ｉｉｉ
WO2008058644A1 (en) * 2006-11-14 2008-05-22 Bayer Schering Pharma Aktiengesellschaft Polymorph ii of 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenoxy]-n-methylpyridine-2-carboxamide
DE602007012589D1 (de) * 2006-12-20 2011-03-31 Bayer Healthcare Llc 4-ä4-Ä(ä3-TERT-BUTYL-1-Ä3-(HYDROXYMETHYL)-PHENYLÜ-1H-PYRAZOL-5-YLü-CARBAMOYL)-AMINOÜ-3-FLUOROPHENOXYü -N-METHYLPYRIDIN-2-CARBOXAMID SOWIE PRODRUGS UND
US8680124B2 (en) * 2007-01-19 2014-03-25 Bayer Healthcare Llc Treatment of cancers with acquired resistance to kit inhibitors
WO2008089388A2 (en) * 2007-01-19 2008-07-24 Bayer Healthcare Llc Treatment of cancers having resistance to chemotherapeutic agents
EP2231612A1 (en) * 2008-01-17 2010-09-29 Sicor, Inc. Polymorph form iii of sorafenib tosylate, sorafenib tosylate methanol solvate and sorafenib tosylate ethanol solvate, and processes for preparation thereof
WO2010048304A2 (en) * 2008-10-21 2010-04-29 Bayer Healthcare Llc Identification of signature genes associated with hepatocellular carcinoma
AR081060A1 (es) * 2010-04-15 2012-06-06 Bayer Schering Pharma Ag Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida
US20130183268A1 (en) * 2010-07-19 2013-07-18 Bayer Healthcare Llc Drug combinations with fluoro-substituted omega-carboxyaryl diphenyl urea for the treatment and prevention of diseases and conditions
MX2013003695A (es) * 2010-10-01 2013-05-20 Bayer Ip Gmbh Combinaciones que contienen n-(2-arilamino) arilsulfonamida sustituida.
EP2726057A1 (en) 2011-06-28 2014-05-07 Bayer HealthCare LLC Topical ophthalmological pharmaceutical composition containing sorafenib
CU24163B1 (es) 2011-06-28 2016-03-31 Bayer Healthcare Llc Composición farmacéutica oftalmológica tópica que contiene regorafenib

Also Published As

Publication number Publication date
JP5215666B2 (ja) 2013-06-19
CA2581843C (en) 2012-05-15
US20090215833A1 (en) 2009-08-27
HK1114605A1 (en) 2008-11-07
SG155996A1 (en) 2009-10-29
AU2005289100B2 (en) 2011-11-03
PE20100445A1 (es) 2010-07-04
PL1797038T3 (pl) 2012-11-30
KR101381454B1 (ko) 2014-04-04
ECSP077356A (es) 2007-04-26
ES2387812T3 (es) 2012-10-02
TWI382016B (zh) 2013-01-11
NO344272B1 (no) 2019-10-21
KR20100061869A (ko) 2010-06-09
JP2013100302A (ja) 2013-05-23
IL181734A0 (en) 2007-07-04
HRP20120662T1 (hr) 2012-09-30
KR101239489B1 (ko) 2013-03-06
EP1797038A1 (en) 2007-06-20
KR20090018224A (ko) 2009-02-19
AU2005289100A1 (en) 2006-04-06
MY176929A (en) 2020-08-27
PT1797038E (pt) 2012-08-14
CY1113598T1 (el) 2016-06-22
KR20130004385A (ko) 2013-01-09
GT200500270A (es) 2006-04-25
PE20142042A1 (es) 2014-12-03
SI1797038T1 (sl) 2012-10-30
CN101065360A (zh) 2007-10-31
UA91520C2 (en) 2010-08-10
MA28880B1 (fr) 2007-09-03
BRPI0515946A (pt) 2008-08-12
JP2008514658A (ja) 2008-05-08
AR051301A1 (es) 2007-01-03
US8877933B2 (en) 2014-11-04
ZA200702510B (en) 2008-07-30
KR20070058537A (ko) 2007-06-08
CU20070068A7 (es) 2010-01-22
DK1797038T3 (da) 2012-09-03
HN2005000722A (es) 2010-08-19
PE20060699A1 (es) 2006-08-12
NZ553804A (en) 2010-07-30
EP1797038B1 (en) 2012-06-13
CA2581843A1 (en) 2006-04-06
WO2006034797A1 (en) 2006-04-06
UY29144A1 (es) 2006-04-28
CN101065360B (zh) 2011-08-03
TW200626552A (en) 2006-08-01
IL181734A (en) 2015-10-29

Similar Documents

Publication Publication Date Title
NO20071508L (no) Thermodynamisk stabil form for BAY 43-9006 tosylat.
MX2009002642A (es) 4-[4-({[4-cloro-3-(trifluorometil)fenil]carbamoil}amino)-3-fluoro fenoxi]-n-metilpiridina-2-carboxamida monohidrato.
TW200626551A (en) Process
LTC1793824I2 (lt) Naujos farmacinės kompozicijos, apimančios 4-(4-(3-(4-chlor-3-trifluormetilfenil)ureido)-3-fluorfenoksi)piridin-2-karboksirūgštį, hiperproliferacinių sutrikimų gydymui
NO20090834L (no) Anvendelse av azabicykloheksanderivater
NO20082684L (no) F-, G-, H-, I- og K-krystallformer av imatinibmesylat
DK1485094T3 (da) Doseringsform til oral indgivelse af 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phanylamino]-methyl}-1-methyl-1h-benzimi dazol-5-carbonyl)-pyridin-2-yl-amino]-propionsyre-ethylester eller dets salte
ZA200710513B (en) Control of parasites in animals by N-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and N-[(phenylsulfanyl)-phenyl]-1, 1, 1-trifluoromethanesulfonamide derivatives
DE60213114D1 (de) Herbizidzusammensetzung,umfassend herbizide verbindung in säureform und ansäuerndes mittel,applizierverfahren und herstellungsverfahren davon
FI20045392A0 (fi) Sykemittari, menetelmä ja tietokoneohjelmistotuote
IS7479A (is) Afleiður af N-[fenýl(píperidín-2-ýl)metýl]bensamíð, aðferð við framleiðslu þeirra og notkun í læknismeðferðum
NO20093039L (no) Indolizineddiksyrederivater som CRTH2 antagonister
DE60220603D1 (de) Relay Server, Relay Server Methode und Relay Server Computer Programmprodukt
DK1696913T3 (da) Vinfluninholdigt farmaceutisk præparat til parenteral administration, fremgangsmåde til fremstilling deraf og dets anvendelse
NO20052813L (no) Celecoxib-promedikament
SE0401657D0 (sv) Chemical compounds
CY1112390T1 (el) Διαδικασια και ενδιαμεσα παρασκευης παραγωγων της ν-(1-βενζυδρυλ-αζετιδιν-3-υλ)-ν-φαινυλ-μεθυλσουλφοναμιδης
AU2003235814A1 (en) Novel process for the preparation of trans-3- ethyl-2,5- dihydro-4- methyl-n-(2-( 4-(((((4-methyl cyclohexyl) amino)carbonyl) amino)sulfonyl) phenyl)ethyl) -2-oxo-1h-pyrrole -1-carboxamide
IS5075A (is) 1-fenýlalkýl-1,2,3,6-tetrahýdrópýrídín til meðhöndlunar Alzheimer-sjúkdómsins
NO20063790L (no) Substituerte azetidin sammensetninger som cyclooxygenase-1-cyclooxygenase-2-inhibitorer, og deres fremstilling og anvendelse som medikamenter
MA27812A1 (fr) Utilisation d'un inhibiteur de tyrosine kinase c-abl, pdgf-r ou c-kit dans le traitement du diabete
IL187430A (en) Derivatives of the affluent carboxylic acid carboxylic acid (sulfoam alkyl) process, their formulation, their pharmaceutical preparation and its use in the preparation of drugs to inhibit factor xa for the effect of blood clotting or fibrinolysis
NO20061290L (no) Nye forbindelser
Bloom New FDA xenotransplantation documents: a proposed rule and a draft guidance
HK40088491A (en) Processes and intermediates for the preparation of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropane-2-yl)-1h-pyrazole-4-carboxamide

Legal Events

Date Code Title Description
CHAD Change of the owner's name or address (par. 44 patent law, par. patentforskriften)

Owner name: BAYER HEALTHCARE LLC, US