NO20063218L - Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus reproduction - Google Patents
Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus reproductionInfo
- Publication number
- NO20063218L NO20063218L NO20063218A NO20063218A NO20063218L NO 20063218 L NO20063218 L NO 20063218L NO 20063218 A NO20063218 A NO 20063218A NO 20063218 A NO20063218 A NO 20063218A NO 20063218 L NO20063218 L NO 20063218L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen
- 6alkyloxy
- alkyl
- ar1c1
- r4ar4b
- Prior art date
Links
- JWYUFVNJZUSCSM-UHFFFAOYSA-N 2-aminobenzimidazole Chemical class C1=CC=C2NC(N)=NC2=C1 JWYUFVNJZUSCSM-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001556 benzimidazoles Chemical class 0.000 title abstract 2
- 241000725643 Respiratory syncytial virus Species 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 8
- 239000001257 hydrogen Substances 0.000 abstract 8
- 150000002431 hydrogen Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- -1 Ar1C1-6alkyloxy Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000002618 bicyclic heterocycle group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002184 metal Chemical class 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Aminobenzimidazoler og benzimidazoler som har hemmende aktivitet på RSV-reproduksjon, og som har formelen prodrogene, N-oksidene, addisjonssaltene, de kvaternære aminer, metallkompleksene og de stereokjemisk isomere former derav; hvori G er en direkte binding eller C1-10alkandiyl valgfritt substituert med en eller flere hydroksy, C1-6 alkyloksy, Ar1C1-6alkyloksy, C1-6alkyltio, Ar1C1-6alkyltio, HO(-CH2-CH2-O)n-, C1-6a1kyloksy(-CH2-CH2-O)n- eller Ar1C1-6alkyloksy(-CH2-CH2-O)n-; R1 er Ar1 eller en monocyklisk eller bicyklisk heterocyklus; Q er hydrogen, amino eller mono- eller di(C1-4alkyl)amino; én av R2a og R3a er valgt fra halo, valgfritt mono- eller polysubstituert C1-6alkyl, valgfritt mono- eller polysubstituert C2-6alkenyl, nitro, hydroksy, Ar2, N(R4aR4b), N(R4aR4b )sulfonyl, N(R4aR4b)karbonyl, C1-6alkyloksy, Ar2oksy, Ar2C1-6alkyloksy, karboksyl, C1-6alkyloksykarbonyl eller -C(=Z)Ar2 ; og den andre av R2a og R3a er hydrogen; i tilfelle R2a er forskjellig fra hydrogen, da er R2b hydrogen, C1-6alkyl eller halogen, og R3b er hydrogen; i tilfelle R3a er forskjellig fra hydrogen, da er R3b hydrogen, C1-6alkyl eller halogen, og R2b er hydrogen. Sammensetninger inneholdende disse forbindelser som aktiv ingrediens og prosesser for å fremstille disse forbindelser og sammensetninger.Aminobenzimidazoles and benzimidazoles which have inhibitory activity on RSV reproduction and have the formula prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; wherein G is a direct bond or C1-10alkanediyl optionally substituted with one or more hydroxy, C1-6 alkyloxy, Ar1C1-6alkyloxy, C1-6alkylthio, Ar1C1-6alkylthio, HO (-CH2-CH2-O) n-, C1-6aalkyloxy (-CH2-CH2 -O) n- or Ar1C1-6alkyloxy (-CH2-CH2 -O) n-; R 1 is Ar 1 or a monocyclic or bicyclic heterocycle; Q is hydrogen, amino or mono- or di (C 1-4 alkyl) amino; one of R2a and R3a is selected from halo, optionally mono- or polysubstituted C1-6 alkyl, optionally mono- or polysubstituted C2-6alkenyl, nitro, hydroxy, Ar2, N (R4aR4b), N (R4aR4b) sulfonyl, N (R4aR4b) carbon , C1-6alkyloxy, Ar2oxy, Ar2C1-6alkyloxy, carboxyl, C1-6alkyloxycarbonyl or -C (= Z) Ar2; and the other of R 2a and R 3a is hydrogen; in case R2a is different from hydrogen, then R2b is hydrogen, C1-6 alkyl or halogen, and R3b is hydrogen; in case R3a is different from hydrogen, then R3b is hydrogen, C1-6 alkyl or halogen, and R2b is hydrogen. Compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104797 | 2003-12-18 | ||
| US56683404P | 2004-04-30 | 2004-04-30 | |
| PCT/EP2004/053613 WO2005058869A1 (en) | 2003-12-18 | 2004-12-20 | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20063218L true NO20063218L (en) | 2006-07-11 |
Family
ID=34702355
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20063218A NO20063218L (en) | 2003-12-18 | 2006-07-11 | Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus reproduction |
Country Status (5)
| Country | Link |
|---|---|
| KR (1) | KR101187441B1 (en) |
| DE (1) | DE602004021850D1 (en) |
| IL (1) | IL176063A0 (en) |
| MX (1) | MXPA06007108A (en) |
| NO (1) | NO20063218L (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20014574A3 (en) * | 1999-06-28 | 2002-05-15 | Janssen Pharmaceutica N. V. | Respiratory syncytial virus replication inhibitors |
| EP1383760A1 (en) * | 2001-04-30 | 2004-01-28 | Fujisawa Pharmaceutical Co., Ltd. | Biarylcarboxamide compounds as apolipoprotein b inhibitors |
-
2004
- 2004-12-20 MX MXPA06007108A patent/MXPA06007108A/en active IP Right Grant
- 2004-12-20 DE DE602004021850T patent/DE602004021850D1/en not_active Expired - Lifetime
- 2004-12-20 KR KR1020067014232A patent/KR101187441B1/en not_active Expired - Fee Related
-
2006
- 2006-05-31 IL IL176063A patent/IL176063A0/en unknown
- 2006-07-11 NO NO20063218A patent/NO20063218L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004021850D1 (en) | 2009-08-13 |
| IL176063A0 (en) | 2006-10-05 |
| KR101187441B1 (en) | 2012-10-02 |
| MXPA06007108A (en) | 2006-08-18 |
| KR20060127879A (en) | 2006-12-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |